By Professor Georgina Hold

Journal articles

Kennedy NA; Walker AW; Berry SH; Lamb CA; Lewis S; Mansfield JC; Parkes M; Parkhill J; Probert C; Read D; Satsangi J; Simpkins RL; Tomlinson D; Tremelling M; Nutland SL; Hold GL; Lees CW, 2015, 'Mo1816 The Impact of NOD2 Variants on Gut Microbiota in Crohn's Disease and Healthy Controls', Gastroenterology, 148, pp. S - 718, http://dx.doi.org/10.1016/s0016-5085(15)32446-x

Hold GL, 2014, 'The gut microbiota, dietary extremes and exercise', Gut, 63, pp. 1838 - 1839, http://dx.doi.org/10.1136/gutjnl-2014-307305

Hold GL; Berry S; Saunders KA; Drew J; Mayer C; Brookes H; Gay NJ; El-Omar EM; Bryant CE, 2014, 'The TLR4 D299G and T399I SNPs are constitutively active to up-regulate expression of Trif-dependent genes', Plos One, 9, pp. e111460, http://dx.doi.org/10.1371/journal.pone.0111460

Mactier KE; Glaire MA; Basavaraju U; El-Omar EM; Hold GL, 2014, 'MicroRNAs in gastrointestinal malignancy: A tool in cancer prevention?', European Journal of Cancer Prevention, 23, pp. 540 - 549, http://dx.doi.org/10.1097/CEJ.0000000000000014

Louis P; Hold GL; Flint HJ, 2014, 'The gut microbiota, bacterial metabolites and colorectal cancer', Nature Reviews Microbiology, 12, pp. 661 - 672, http://dx.doi.org/10.1038/nrmicro3344

Adams AT; Kennedy NA; Hansen R; Ventham NT; O'Leary KR; Drummond HE; Noble CL; El-Omar E; Russell RK; Wilson DC; Nimmo ER; Hold GL; Satsangi J, 2014, 'Two-stage genome-wide methylation profiling in childhood-onset Crohn's disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci', Inflammatory Bowel Diseases, 20, pp. 1784 - 1793, http://dx.doi.org/10.1097/MIB.0000000000000179

Kennedy NA; Walker AW; Berry SH; Duncan SH; Farquarson FM; Louis P; Thomson JM; Satsangi J; Flint HJ; Parkhill J; Lees CW; Hold GL, 2014, 'The impact of different DNA extraction kits and laboratories upon the assessment of human gut microbiota composition by 16S rRNA gene sequencing', Plos One, 9, http://dx.doi.org/10.1371/journal.pone.0088982

Hold GL; Smith M; Grange C; Watt ER; El-Omar EM; Mukhopadhya I, 2014, 'Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?', World Journal of Gastroenterology, 20, pp. 1192 - 1210, http://dx.doi.org/10.3748/wjg.v20.i5.1192

Kennedy NA; Adams AT; Hansen R; Ventham NT; O'Leary KR; Drummond H; Noble CL; El-Omar E; Russell RK; Wilson DC; Nimmo ER; Hold GL; Satsangi J, 2014, 'Epigenome-wide analysis in childhood-onset Crohn's disease implicates MIR21 in pathogenesis and identifies multiple methylation-based diagnostic biomarkers', JOURNAL OF CROHNS & COLITIS, 8, pp. S19 - S19, http://dx.doi.org/10.1016/S1873-9946(14)60035-0

Folmer F; Basavaraju U; Jaspars M; Hold G; El-Omar E; Dicato M; Diederich M, 2014, 'Anticancer effects of bioactive berry compounds', Phytochemistry Reviews, 13, pp. 295 - 322, http://dx.doi.org/10.1007/s11101-013-9319-z

Hold GL; Mukhopadhya I; Hansen R, 2014, 'Diet, the microbiome, and IBD', Inflammatory Bowel Disease Monitor, 14, pp. 39 - 43

Hold GL, 2014, 'Western lifestyle: A 'master' manipulator of the intestinal microbiota?', Gut, 63, pp. 5 - 6, http://dx.doi.org/10.1136/gutjnl-2013-304969

Lochhead PJ; Mayer C-D; Hold GL; El-Omar E, 2014, '946 Genome-Wide Analysis of DNA Methylation in Low-Grade Colorectal Adenomas and Normal Colonic Mucosa', Gastroenterology, 146, pp. S - 165, http://dx.doi.org/10.1016/s0016-5085(14)60588-6

Kostic AD; Chun E; Robertson L; Glickman JN; Gallini CA; Michaud M; Clancy TE; Chung DC; Lochhead P; Hold GL; El-Omar EM; Brenner D; Fuchs CS; Meyerson M; Garrett WS, 2013, 'Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment', Cell Host and Microbe, 14, pp. 207 - 215, http://dx.doi.org/10.1016/j.chom.2013.07.007

McLean MH; Thomson AJ; Murray GI; Fyfe N; Hold GL; El-Omar EM, 2013, 'Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression: A marker of malignant potential?', British Journal of Cancer, 108, pp. 2537 - 2541, http://dx.doi.org/10.1038/bjc.2013.264

Hansen R; Berry SH; Mukhopadhya I; Thomson JM; Saunders KA; Nicholl CE; Bisset WM; Loganathan S; Mahdi G; Kastner-Cole D; Barclay AR; Bishop J; Flynn DM; McGrogan P; Russell RK; El-Omar EM; Hold GL, 2013, 'The Microaerophilic Microbiota of De-Novo Paediatric Inflammatory Bowel Disease: The BISCUIT Study', Plos One, 8, pp. e58825, http://dx.doi.org/10.1371/journal.pone.0058825

Kennedy NA; Walker AW; Berry SH; Duncan SH; Farquarson F; Louis P; Satsangi J; Flint HJ; Lees CW; Hold GL, 2013, 'P705 Evaluation of the impact of different commercially available DNA extraction kits and laboratories for assessing bacterial community structure in fecal samples – implications for IBD research', Journal of Crohn's and Colitis, 7, pp. S294 - S294, http://dx.doi.org/10.1016/s1873-9946(13)60726-6

Kennedy N; Walker A; Berry S; Duncan S; Farquharson F; Louis P; Satsangi J; Flint H; Lees C; Hold G, 2013, 'PTU-072 Evaluation of the Impact of different Commercially available DNA Extraction Kits and Laboratories for Assessing Bacterial Community Structure in Faecal Samples – Implications for IBD Research', Gut, 62, pp. A74.1 - A74, http://dx.doi.org/10.1136/gutjnl-2013-304907.164

Kennedy NA; Hildebrand D; Berry SH; Satsangi J; Hold GL, 2013, 'PWE-108 Assessment of the Mucosal Microbiota in Inflammatory Bowel Disease', Gut, 62, pp. A174.2 - A175, http://dx.doi.org/10.1136/gutjnl-2013-304907.396

Hold GL; Hope M; Lochhead P; Meharg C; Berry SH; El-Omar E, 2013, 'Sa1972 Assessment of Bacterial Diversity in Colorectal Adenomatous Polyps', Gastroenterology, 144, pp. S - 348, http://dx.doi.org/10.1016/s0016-5085(13)61281-0

Hansen R; Mukhopadhya I; Meharg C; Russell RK; Berry SH; El-Omar E; Hold GL, 2013, 'Tu1704 The Role of the Fungal Microbiota in the Pathogenesis of De-Novo Pediatric Inflammatory Bowel Disease Using Next Generation Sequencing', Gastroenterology, 144, pp. S - 826, http://dx.doi.org/10.1016/s0016-5085(13)63068-1

Kennedy NA; Walker A; IBD Microbiota Consortia UK; IBD Genetics Consortia UK; Berry SH; Duncan SH; Farquharson F; Louis P; Satsangi J; Flint HJ; Lees CW; Hold GL, 2013, 'Tu1716 Evaluation of the Impact of Different Commercially Available DNA Extraction Kits and Laboratories for Assessing Bacterial Community Structure in Fecal Samples - Implications for IBD Research', Gastroenterology, 144, pp. S - 829, http://dx.doi.org/10.1016/s0016-5085(13)63080-2

Watt E; Berry SH; Farquharson F; Glaire MA; Thomson JM; El-Omar E; Louis P; Hold GL, 2013, 'Tu1729 Evaluation of Fecal Aspirate As a Proxy for Colonoscopy Biopsy Sampling to Assess Microbial Diversity', Gastroenterology, 144, pp. S - 832, http://dx.doi.org/10.1016/s0016-5085(13)63093-0

Hansen R; Russell RK; Reiff C; Louis P; McIntosh F; Berry SH; MGBRhopadhya I; Bisset WM; Barclay AR; Bishop J; Flynn DM; McGrogan P; Loganathan S; Mahdi G; Flint HJ; El-Omar EM; Hold GL, 2012, 'Microbiota of de-novo pediatric IBD: Increased faecalibacterium prausnitzii and reduced bacterial diversity in Crohn's but not in ulcerative colitis', American Journal of Gastroenterology, 107, pp. 1913 - 1922, http://dx.doi.org/10.1038/ajg.2012.335

Smith C; Lochhead P; Basavaraju U; Hold GL; Fyfe N; Murray GI; El-Omar EM, 2012, 'Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia: A case-control and immunohistochemical study', BMC Research Notes, 5, pp. 371, http://dx.doi.org/10.1186/1756-0500-5-371

Palmer AJ; Lochhead P; Hold GL; Rabkin CS; Chow WH; Lissowska J; Vaughan TL; Berry S; Gammon M; Risch H; El-Omar EM, 2012, 'Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations', European Journal of Cancer Prevention, 21, pp. 541 - 544, http://dx.doi.org/10.1097/CEJ.0b013e3283529b79

Smith C; Lochhead P; Basavaraju U; Hold G; Fyfe N; Murray G; El-Omar E, 2012, 'LACK OF ASSOCIATION BETWEEN THE PSCA RS2294008 POLYMORPHISM, OR PSCA EXPRESSION, AND COLORECTAL NEOPLASIA', GUT, 61, pp. A327 - A328, http://dx.doi.org/10.1136/gutjnl-2012-302514d.75

Mukhopadhya I; Hansen R; El-Omar EM; Hold GL, 2012, 'IBD-what role do Proteobacteria play?', Nature Reviews Gastroenterology and Hepatology, 9, pp. 219 - 230, http://dx.doi.org/10.1038/nrgastro.2012.14

Hird HJ; Chisholm J; Kaye J; Colyer A; Hold G; Conyers CM; Núñez JI; Macarthur R, 2012, 'Development of real-time PCR assays for the detection of Atlantic cod (Gadus morhua), Atlantic salmon (Salmo salar) and European plaice (Pleuronectes platessa) in complex food samples', European Food Research and Technology, 234, pp. 127 - 136, http://dx.doi.org/10.1007/s00217-011-1596-4

Raju D; Hussey S; Ang M; Terebiznik MR; Sibony M; Galindo-Mata E; Gupta V; Blanke SR; Delgado A; Romero-Gallo J; Ramjeet MS; Mascarenhas H; Peek RM; Correa P; Streutker C; Hold G; Kunstmann E; Yoshimori T; Silverberg MS; Girardin SE; Philpott DJ; El Omar E; Jones NL, 2012, 'Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote helicobacter pylori infection in humans', Gastroenterology, 142, pp. 1160 - 1171, http://dx.doi.org/10.1053/j.gastro.2012.01.043

Palmer AJ; Lochhead P; Hold GL; Rabkin CS; Vaughan TL; Lissowska J; Chow W-H; Berry SH; El-Omar E, 2012, 'Mo1584 Genetic Variation in C20orf54, PLCE1 and MUC1 and Risk of Upper Gastrointestinal Cancers in Caucasian Populations', Gastroenterology, 142, pp. S - 634, http://dx.doi.org/10.1016/s0016-5085(12)62439-1

Hansen R; El-Omar E; Hold GL, 2011, 'Characterizing the microbiota in IBD', Inflammatory Bowel Disease Monitor, 12, pp. 1 - 7

Mukhopadhya I; Hansen R; Nicholl CE; Alhaidan YA; Thomson JM; Berry SH; Pattinson C; Stead DA; Russell RK; El-Omar EM; Hold GL, 2011, 'A comprehensive evaluation of colonic mucosal isolates of sutterella wadsworthensis from inflammatory bowel disease', Plos One, 6, pp. e27076, http://dx.doi.org/10.1371/journal.pone.0027076

Smet A; Flahou B; Mukhopadhya I; Ducatelle R; Pasmans F; Haesebrouck F; Hold GL, 2011, 'The Other Helicobacters', Helicobacter, 16, pp. 70 - 75, http://dx.doi.org/10.1111/j.1523-5378.2011.00884.x

Mukhopadhya I; Thomson JM; Hansen R; Berry SH; El-Omar EM; Hold GL, 2011, 'Detection of Campylobacter concisus and other campylobacter species in colonic biopsies from adults with ulcerative colitis', Plos One, 6, pp. e21490, http://dx.doi.org/10.1371/journal.pone.0021490

Monie TP; Hold GL; Mukhopadhya I, 2011, 'Innate immune sensors and gastrointestinal bacterial infections', Clinical and Developmental Immunology, 2011, http://dx.doi.org/10.1155/2011/579650

Haag AF; Wehmeier S; Muszyński A; Kerscher B; Fletcher V; Berry SH; Hold GL; Carlson RW; Ferguson GP, 2011, 'Biochemical characterization of Sinorhizobium meliloti mutants reveals gene products involved in the biosynthesis of the unusual lipid A very long-chain fatty acid', Journal of Biological Chemistry, 286, pp. 17455 - 17466, http://dx.doi.org/10.1074/jbc.M111.236356

Thomson JM; Hansen R; Berry SH; Hope ME; Murray GI; Mukhopadhya I; McLean MH; Shen Z; Fox JG; El-Omar E; Hold GL, 2011, 'Enterohepatic Helicobacter in ulcerative colitis: Potential pathogenic entities?', Plos One, 6, pp. e17184, http://dx.doi.org/10.1371/journal.pone.0017184

Hansen R; Thomson JM; Fox JG; El-Omar EM; Hold GL, 2011, 'Could Helicobacter organisms cause inflammatory bowel disease?', FEMS Immunology and Medical Microbiology, 61, pp. 1 - 14, http://dx.doi.org/10.1111/j.1574-695X.2010.00744.x

McLean MH; Murray GI; Stewart KN; Norrie G; Mayer C; Hold GL; Thomson J; Fyfe N; Hope M; Mowat NAG; Drew JE; El-Omar EM, 2011, 'The inflammatory microenvironment in colorectal Neoplasia', Plos One, 6, pp. e15366, http://dx.doi.org/10.1371/journal.pone.0015366

Lochhead P; Frank B; Hold GL; Rabkin CS; Ng MTH; Vaughan TL; Risch HA; Gammon MD; Lissowska J; Weck MN; Raum E; Mller H; Illig T; Klopp N; Dawson A; McColl KE; Brenner H; Chow W; Elomar EM, 2011, 'Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals', Gastroenterology, 140, pp. 435 - 441, http://dx.doi.org/10.1053/j.gastro.2010.11.001

Lochhead P; Ng MTH; Hold GL; Rabkin CS; Vaughan TL; Gammon MD; Risch HA; Lissowska J; Mukhopadhya I; Chow WH; El-Omar EM, 2011, 'Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer', European Journal of Cancer Prevention, 20, pp. 54 - 57, http://dx.doi.org/10.1097/CEJ.0b013e328341e320

Hansen R; Reiff C; Russell RK; Bisset WM; Berry SH; Mukhopadhya I; Thomson JM; El-Omar E; Hold GL, 2011, 'Bacterial Diversity of the Colonic Microbiota in De-Novo Extensive Paediatric Ulcerative Colitis by Next-Generation Sequencing', Gastroenterology, 140, pp. S - 196, http://dx.doi.org/10.1016/s0016-5085(11)60792-0

Goddard M; Hansen R; Karcher AM; Munro MJ; Berry SH; Stevenson MH; El-Omar E; Hold GL, 2011, 'Bilirubin Has Anti-Bacterial Properties Against Gram-Positive Bacteria: A Potential Benefit of Physiological Jaundice?', Gastroenterology, 140, pp. S - 941, http://dx.doi.org/10.1016/s0016-5085(11)63902-4

Mukhopadhya I; Thomson JM; Hansen R; Berry SH; El-Omar E; Hold GL, 2011, 'Detection of Campylobacter Concisus in Colonic Biopsies From Adult Patients With Ulcerative Colitis', Gastroenterology, 140, pp. S - 268, http://dx.doi.org/10.1016/s0016-5085(11)61073-1

Hansen R; Mukhopadhya I; Russell RK; Bisset WM; Berry SH; Thomson JM; El-Omar E; Hold GL, 2011, 'The Role of the Microaerophilic Colonic Microbiota in De-Novo Paediatric Inflammatory Bowel Disease', Gastroenterology, 140, pp. S - 512, http://dx.doi.org/10.1016/s0016-5085(11)62122-7

Hansen R; Cameron FL; Hold GL; El-Omar EM; Russell RK, 2010, 'Inflammatory bowel disease', Paediatrics and Child Health, 20, pp. 473 - 478, http://dx.doi.org/10.1016/j.paed.2010.04.005

Ng MTH; Van't Hof R; Crockett JC; Hope ME; Berry S; Thomson J; McLean MH; McColl KEL; El-Omar EM; Hold GL, 2010, 'Increase in NF-κB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease', Infection and Immunity, 78, pp. 1345 - 1352, http://dx.doi.org/10.1128/IAI.01226-09

Hansen R; Thomson JM; El-Omar EM; Hold GL, 2010, 'The role of infection in the aetiology of inflammatory bowel disease', Journal of Gastroenterology, 45, pp. 266 - 276, http://dx.doi.org/10.1007/s00535-009-0191-y

FitzGerald MP; Wehmeier S; Gangloff M; Gay N; Berry SH; Ferguson GP; El-Omar E; Hold GL, 2010, 'S1640 Can Helicobacter pylori Lipopolysaccharide Lipid a Composition Affect Its Ability to Induce an Inflammatory Response Through Toll Like Receptor 4', Gastroenterology, 138, pp. S - 244, http://dx.doi.org/10.1016/s0016-5085(10)61110-9

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