By Professor Georgina Hold

Book Chapters

Hold GL; Rokkas T, 2022, '2.12 - Changes in Gut Microbiota Due to Gastrointestinal Surgery', in Comprehensive Gut Microbiota, pp. 139 - 144, http://dx.doi.org/10.1016/B978-0-12-819265-8.00075-9

Clegg F; Berry SH; Hansen R; Hold GL, 2018, 'Molecular analysis of the microbiome in colorectal cancer', in Colorectal Cancer, Springer, pp. 139 - 153, http://dx.doi.org/10.1007/978-1-4939-7765-9_8

McLean MH; Nicoll R; Saw C; Hold GL; El-Omar EM, 2016, 'Influence of host gene polymorphisms on development of gastroduodenal diseases', in Helicobacter pylori Research: From Bench to Bedside, pp. 339 - 362, http://dx.doi.org/10.1007/978-4-431-55936-8_14

Hold GL; Bryant CE, 2011, 'The Molecular Basis of Lipid A and Toll-Like Receptor 4 Interactions', in Knirel YA; Valvano MA (ed.), BACTERIAL LIPOPOLYSACCHARIDES: STRUCTURE, CHEMICAL SYNTHESIS, BIOGENESIS AND INTERACTION WITH HOST CELLS, SPRINGER-VERLAG WIEN, pp. 371 - 387, http://dx.doi.org/10.1007/978-3-7091-0733-1_12

Journal articles

Barnet MB; Jackson KJL; Masle-Farquhar E; Russell A; Burnett DL; Chye A; Jara CJ; Faulks M; Mawson A; Peters TJ; Brink R; Wright K; Allen I; Junankar S; Davis ID; Heller G; Khan Z; Bruce J; Yang C; Prokopec S; Pugh T; Behren A; Hold GL; Zhang F; Cooper WA; Gao B; Nagrial A; Joshua AM; John T; Peters G; Hui R; Boyer M; Blinman PL; Kao SC; Cebon J; Goodnow CC, 2025, 'Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy', Proceedings of the National Academy of Sciences of the United States of America, 122, pp. e2314258122, http://dx.doi.org/10.1073/pnas.2314258122

Sun J; Brooks EC; Houshyar Y; Connor SJ; Paven G; Grimm MC; Hold GL, 2025, 'Unravelling the Relationship Between Obesity and Inflammatory Bowel Disease.', Inflamm Bowel Dis, http://dx.doi.org/10.1093/ibd/izaf098

Noble A; Adams A; Nowak J; Cheng G; Nayak K; Quinn A; Kristiansen M; Kalla R; Ventham NT; Giachero F; Jayamanne C; Hansen R; Hold GL; El-Omar E; Croft NM; Wilson D; Beattie RM; Ashton JJ; Zilbauer M; Ennis S; Uhlig HH; Satsangi J, 2025, 'The Circulating Methylome in Childhood-Onset Inflammatory Bowel Disease', Journal of Crohn S and Colitis, 19, http://dx.doi.org/10.1093/ecco-jcc/jjae157

Lehr K; Oosterlinck B; Then CK; Gemmell MR; Gedgaudas R; Bornschein J; Kupcinskas J; Smet A; Hold G; Link A, 2025, 'Comparison of different microbiome analysis pipelines to validate their reproducibility of gastric mucosal microbiome composition', Msystems, 10, http://dx.doi.org/10.1128/msystems.01358-24

Porcari S; Mullish BH; Asnicar F; Ng SC; Zhao L; Hansen R; O'Toole PW; Raes J; Hold G; Putignani L; Hvas CL; Zeller G; Koren O; Tun H; Valles-Colomer M; Collado MC; Fischer M; Allegretti J; Iqbal T; Chassaing B; Keller J; Baunwall SM; Abreu M; Barbara G; Zhang F; Ponziani FR; Costello SP; Paramsothy S; Kao D; Kelly C; Kupcinskas J; Youngster I; Franceschi F; Khanna S; Vehreschild M; Link A; De Maio F; Pasolli E; Miguez AB; Brigidi P; Posteraro B; Scaldaferri F; Stojanovic MR; Megraud F; Malfertheiner P; Masucci L; Arumugam M; Kaakoush N; Segal E; Bajaj J; Leong R; Cryan J; Weersma RK; Knight R; Guarner F; Shanahan F; Cani PD; Elinav E; Sanguinetti M; de Vos WM; El-Omar E; Dorè J; Marchesi J; Tilg H; Sokol H; Segata N; Cammarota G; Gasbarrini A; Ianiro G, 2025, 'International consensus statement on microbiome testing in clinical practice', Lancet Gastroenterology and Hepatology, 10, pp. 154 - 167, http://dx.doi.org/10.1016/S2468-1253(24)00311-X

Koentgen S; Cosier D; Tavakoli P; Leach ST; Dutt S; Ghaly S; Connor SJ; Lemberg DA; Lambert K; Hold GL, 2025, 'P0018 Fat rich dietary habits: Further increasing IBD risk in first degree relatives', Journal of Crohn's and Colitis, 19, pp. i358 - i358, http://dx.doi.org/10.1093/ecco-jcc/jjae190.0192

Tearle J; Zhang F; Jackson K; Malhotra P; Tavakoli P; Koentgen S; Warren J; Williams C; Haque A; Arzivian A; Tedla N; Kim A; King H; Hold G; Ghaly S; James K, 2025, 'P0161 The primary sclerosing cholangitis and ulcerative colitis colonic mucosa defined through paired microbial and single-cell RNA sequencing', Journal of Crohn's and Colitis, 19, pp. i557 - i557, http://dx.doi.org/10.1093/ecco-jcc/jjae190.0335

Koentgen S; Zhang F; Wu N; Jayawardana T; Little R; Tavakoli P; Ghaly S; Connor SJ; Hold GL, 2025, 'P0203 Unique faecal & oral microbiota signatures in first degree relatives of inflammatory bowel disease patients', Journal of Crohn's and Colitis, 19, pp. i607 - i607, http://dx.doi.org/10.1093/ecco-jcc/jjae190.0377

Cosier D; Lambert K; Karen C; Batterham M; Little RD; Wu N; Tavakoli P; Ghaly S; Pipicella JL; Connor S; Leach S; Lemberg D; Houshyar Y; Jayawardana T; Koentgen S; Hold G, 2025, 'P0759 The interplay between dietary intake and disease activity in Australian adults with and without Inflammatory Bowel Disease', Journal of Crohn's and Colitis, 19, pp. i1465 - i1465, http://dx.doi.org/10.1093/ecco-jcc/jjae190.0933

Koentgen S; Zhang F; O’Brien C; Grimm M; Allen-Vercoe E; Hold GL, 2025, 'P1319 Multi-omic modelling of antibiotic perturbed faecal microbial communities demonstrates reduced microbial resilience in IBD', Journal of Crohn's and Colitis, 19, pp. i2377 - i2377, http://dx.doi.org/10.1093/ecco-jcc/jjae190.1493

Jayawardana T; Little RD; Zhang F; Koentgen S; Wu N; Tavakoli P; Sidhu S; Le A; Boussioutas A; Ward MG; Miles P S; Gibson PR; Ghaly S; Corte C; Talley NJ; Leach S; Lemberg D; Dutt S; Paramsothy S; Leong R; Connor SJ; Hold G, 2025, 'P1327 Microbial signatures associated with Inflammatory Bowel Disease in Australia: baseline data from the Australian IBD Microbiome study', Journal of Crohn's and Colitis, 19, pp. i2388 - i2389, http://dx.doi.org/10.1093/ecco-jcc/jjae190.1501

Rimmer P; Zhang F; Scott G; Hold G; Gordon M; Iqbal T; Hansen R, 2025, 'P1330 The gut microbiome at the onset of inflammatory bowel disease: A systematic review of the literature and unified bioinformatic synthesis of sequencing data from >1000 treatment naïve patients', Journal of Crohn's and Colitis, 19, pp. i2394 - i2395, http://dx.doi.org/10.1093/ecco-jcc/jjae190.1504

Koentgen S; Zhang F; Khadka S; O'Brien C; Grimm M; Allen-Vercoe E; Hold GL, 2025, 'P1337 High fat diet drives increased dysbiosis in IBD compared to healthy controls', Journal of Crohn's and Colitis, 19, pp. i2406 - i2406, http://dx.doi.org/10.1093/ecco-jcc/jjae190.1511

Little R; Jayawardana T; Zhang F; Koentgen S; Wu N; Tavakoli P; Chung A; Ho A; Read S; Boussioutas A; Ward M; Sparrow M; Gibson P; Ghaly S; Corte C; Talley N; Leach S; Lemberg D; Dutt S; Paramsothy S; Leong R; Connor S; Hold G, 2025, 'P1340 Gut microbiota changes are associated with type of advanced therapy in patients with Inflammatory Bowel Disease: baseline data from the Australian IBD Microbiome study', Journal of Crohn's and Colitis, 19, pp. i2410 - i2412, http://dx.doi.org/10.1093/ecco-jcc/jjae190.1514

Jayawardana T; Little RD; Zhang F; Koentgen S; Wu N; Houshyar Y; Tavakoli P; Boussioutas A; Ward MG; Sparrow MP; Gibson PR; Ghaly S; Corte C; Talley NJ; Leach S; Lemberg D; Dutt S; Paramsothy S; Leong R; Connor SJ; Hold G, 2025, 'P1344 Impaired health-related quality of life is associated with alterations in gut microbiota signatures in patients with Inflammatory Bowel Disease: baseline data from the Australian IBD Microbiome study', Journal of Crohn's and Colitis, 19, pp. i2419 - i2421, http://dx.doi.org/10.1093/ecco-jcc/jjae190.1518

Little R; Jayawardana T; Zhang F; Houshyar Y; Koentgen S; Wu N; Ellepola A; Tavakoli P; Chung A; Ho A; Read S; Boussioutas A; Ward M; Sparrow M; Gibson P; Ghaly S; Corte C; Talley N; Leach S; Lemberg D; Dutt S; Paramsothy S; Leong R; Connor S; Hold G, 2025, 'P1345 Association of gut microbiota changes and disease activity in patients with Crohn’s disease and ulcerative colitis: baseline data from the Australian IBD Microbiome study', Journal of Crohn's and Colitis, 19, pp. i2422 - i2423, http://dx.doi.org/10.1093/ecco-jcc/jjae190.1519

Li P; Xie L; Zheng H; Feng Y; Mai F; Tang W; Wang J; Lan Z; Lv S; Jayawardana T; Koentgen S; Xu S; Wan Z; Chen Y; Xu H; Shen S; Zhang F; Yang Y; Hold G; He F; El-Omar EM; Yu G; Chen X, 2025, 'Gut microbial-derived 3,4-dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome', Imeta, http://dx.doi.org/10.1002/imt2.70065

Kamath S; Bryant RV; Costello SP; Day AS; Forbes B; Haifer C; Hold G; Kelly CR; Li A; Pakuwal E; Stringer A; Tucker EC; Wardill HR; Joyce P, 2025, 'Translational strategies for oral delivery of faecal microbiota transplantation', Gut, http://dx.doi.org/10.1136/gutjnl-2025-335077

Jayawardana TC; Little RD; Zhang F; Koentgen S; Wu N; Houshyar Y; Tavakoli P; Boussioutas A; Ward M; Sparrow M; Gibson PR; Ghaly S; Corte C; Talley NJ; Leach ST; Lemberg DA; Dutt S; Paramsothy S; Leong RW; Connor SJ; Hold GL, 2025, 'Mo1960: IMPAIRED HEALTH-RELATED QUALITY OF LIFE IS ASSOCIATED WITH ALTERATIONS IN GUT MICROBIOTA SIGNATURES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: BASELINE DATA FROM THE AUSTRALIAN IBD MICROBIOME STUDY.', Gastroenterology, 169, pp. S - 1243, http://dx.doi.org/10.1016/s0016-5085(25)03747-3

Little RD; Jayawardana TC; Zhang F; Koentgen S; Wu N; Tavakoli P; Chung A; Ho A; Read S; Boussioutas A; Ward M; Sparrow M; Gibson PR; Ghaly S; Corte C; Talley NJ; Leach ST; Lemberg DA; Dutt S; Paramsothy S; Leong R; Connor SJ; Hold GL, 2025, 'Sa1795: GUT MICROBIOTA CHANGES ARE ASSOCIATED WITH TYPE OF ADVANCED THERAPY IN PATIENTS WITH IBD: BASELINE DATA FROM THE AUSTRALIAN IBD MICROBIOME STUDY', Gastroenterology, 169, pp. S - 532, http://dx.doi.org/10.1016/s0016-5085(25)02163-8

Fitzpatrick J; Little RD; Zhang F; Koentgen S; Gibson PR; Taylor KM; Hold GL; Halmos EP, 2025, 'Sa1921: IMPACT OF HIGH- AND LOW-EMULSIFIER DIETS ON GUT MICROBIOTA IN HEALTHY ADULTS', Gastroenterology, 169, http://dx.doi.org/10.1016/s0016-5085(25)02283-8

Little RD; Jayawardana TC; Zhang F; Houshyar Y; Koentgen S; Dutt S; Leach ST; Lemberg DA; Hold GL, 2025, 'Tu2093: DISTINCT MICROBIAL SIGNATURES ARE ASSOCIATED WITH PEDIATRIC INFLAMMATORY BOWEL DISEASE - BASELINE DATA FROM THE AUSTRALIAN IBD MICROBIOME STUDY', Gastroenterology, 169, http://dx.doi.org/10.1016/s0016-5085(25)04560-3

Cosier D; Lambert K; Charlton K; Batterham M; Little RD; Wu N; Tavakoli P; Ghaly S; Pipicella JL; Connor S; Leach S; Lemberg DA; Houshyar Y; Jayawardana T; Koentgen S; Hold GL, 2024, 'Dietary Patterns and Fibre Intake Are Associated with Disease Activity in Australian Adults with Inflammatory Bowel Disease: An Exploratory Dietary Pattern Analysis †', Nutrients, 16, http://dx.doi.org/10.3390/nu16244349

Gemmell MR; Jayawardana T; Koentgen S; Brooks E; Kennedy N; Berry S; Lees C; Hold GL, 2024, 'Optimised human stool sample collection for multi-omic microbiota analysis', Scientific Reports, 14, http://dx.doi.org/10.1038/s41598-024-67499-4

Katsoudas N; Tavakoli P; Wu N; Shapiro A; Leach ST; Williams AJ; Paramsothy R; Ghaly S; Connor SJ; Samocha-Bonet D; Lambert K; Hold GL, 2024, 'Dietary Emulsifier Exposure in People with Inflammatory Bowel Disease Compared with Healthy Controls: Is There a Cause for Concern?', Inflammatory Bowel Diseases, 30, pp. 1241 - 1250, http://dx.doi.org/10.1093/ibd/izad318

Little RD; McKenzie J; Srinivasan A; Hilley P; Gilmore RB; Chee D; Sandhu M; Saitta D; Chow E; Thin L; Walker GJ; Moore GT; Lynch K; Andrews J; An YK; Bryant RV; Connor SJ; Garg M; Wright EK; Hold G; Segal JP; Boussioutas A; De Cruz P; Ward MG; Sparrow MP, 2024, 'Switching from Dose-Intensified intravenous to SubCutaneoUS infliximab in Inflammatory Bowel Disease (DISCUS-IBD): protocol for a multicentre randomised controlled trial', BMJ Open, 14, http://dx.doi.org/10.1136/bmjopen-2023-081787

Ariaee A; Koentgen S; Wardill HR; Hold GL; Prestidge CA; Armstrong HK; Joyce P, 2024, 'Prebiotic selection influencing inflammatory bowel disease treatment outcomes: A review of the preclinical and clinical evidence', Egastroenterology, 2, http://dx.doi.org/10.1136/egastro-2023-100055

Little RD; Jayawardana T; Koentgen S; Zhang F; Connor SJ; Boussioutas A; Ward MG; Gibson PR; Sparrow MP; Hold GL, 2024, 'Pathogenesis and precision medicine for predicting response in inflammatory bowel disease: Advances and future directions', Egastroenterology, 2, http://dx.doi.org/10.1136/egastro-2023-100006

Rimmer P; Scott G; Quraishi MN; Hazel K; Cooney R; Zhang F; Hold GL; Gordon M; Iqbal T; Hansen R, 2024, 'Sa1887 IS DIVERSITY IMPORTANT IN THE GUT MICROBIOME AT IBD ONSET? A SYSTEMATIC REVIEW OF THE LITERATURE AND META-ANALYSIS OF ALPHA-DIVERSITY DATA', Gastroenterology, 166, http://dx.doi.org/10.1016/s0016-5085(24)01772-4

Oosterlinck B; Ceuleers H; Arras W; De Man JG; Geboes K; De Schepper H; Peeters M; Lebeer S; Skieceviciene J; Hold GL; Kupcinskas J; Link A; De Winter BY; Smet A, 2023, 'Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer', Microbiome, 11, http://dx.doi.org/10.1186/s40168-023-01534-w

Baumdick ME; Niehrs A; Degenhardt F; Schwerk M; Hinrichs O; Jordan-Paiz A; Padoan B; Wegner LHM; Schloer S; Zecher BF; Malsy J; Joshi VR; Illig C; Schröder-Schwarz J; Möller KJ; Akar A; Flemming C; Felix ; Flomm ; Flosbach M; Jäger J; Jeromin N; Jung J; Ohms M; Reinshagen K; Rische J; Sagebiel A; Sandfort D; Steinert F; Tomuschat C; Wesche J; Martin MP; Yuki Y; Ozawa M; Sauter J; Schmidt AH; Perez D; Giannou AD; Carrington M; Davis RS; Schumacher U; Sauter G; Huber S; Puelles VG; Melling N; Franke A; Shifteh Abedian ; Abraham C; Achkar JP; Ahmad T; Alberts R; Alizadeh B; Amininejad L; Ananthakrishnan AN; Andersen V; Anderson CA; Andrews JM; Annese V; Aumais G; Baidoo L; Baldassano RN; Bampton PA; Barclay M; Barrett JC; Bethge J; Bewshea C; Bis JC; Bitton A; BK T; Boucher G; Brain O; Brand S; Brant SR; Cheon JH; Chew A; Cho JH; Cleynen I; Cohain A; Cooney R; Croft A; Daly MJ; D'Amato M; Danese S; Daryani NE; Datta LW; Denapiene G; Denson LA; Devaney KL; Dewit O; D'Inca R; Drummond HE; Dubinsky M; Duerr RH; Edwards C; Ellinghaus D; Ellul P; Esaki M; Essers J; Ferguson LR; Festen EA, 2023, 'HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis', Gastroenterology, 165, pp. 946 - 962.e13, http://dx.doi.org/10.1053/j.gastro.2023.06.034

Rokkas T; Hold GL, 2023, 'A systematic review, pairwise meta-analysis and network meta-analysis of randomized controlled trials exploring the role of fecal microbiota transplantation in irritable bowel syndrome', European Journal of Gastroenterology and Hepatology, 35, pp. 471 - 479, http://dx.doi.org/10.1097/MEG.0000000000002519

Mah C; Jayawardana T; Leong G; Koentgen S; Lemberg D; Connor SJ; Rokkas T; Grimm MC; Leach ST; Hold GL, 2023, 'Assessing the Relationship between the Gut Microbiota and Inflammatory Bowel Disease Therapeutics: A Systematic Review', Pathogens, 12, http://dx.doi.org/10.3390/pathogens12020262

Zhang F; Gia A; Chen G; Gong L; Behary J; Hold GL; Zekry A; Tang X; Sun Y; El-Omar E; Jiang XT, 2023, 'Critical Assessment of Whole Genome and Viral Enrichment Shotgun Metagenome on the Characterization of Stool Total Virome in Hepatocellular Carcinoma Patients', Viruses, 15, pp. 53, http://dx.doi.org/10.3390/v15010053

Oosterlinck B; Arras W; De Man J; Geboes K; De Schepper HU; Peeters M; Lebeer S; Skieceviciene J; Hold GL; Kupcinskas J; Link A; De Winter BY; Smet A, 2023, 'Sa1865 MUCIN-MICROBIOME SIGNATURES SHAPE THE TUMOUR MICROENVIRONMENT IN GASTRIC CANCER', Gastroenterology, 164, pp. S - 468, http://dx.doi.org/10.1016/s0016-5085(23)02079-6

O'Donnell M; Teasdale S; Chua X-Y; Hardman J; Wu N; Curtis J; Samaras K; Bolton P; Morris M; Shannon-Weickert C; Purves-Tyson T; El-Assaad F; Jiang X; Hold G; El-Omar E; Wu N, 2022, 'The role of the microbiome in the metabolic health of people with schizophrenia and related psychoses: cross-sectional and pre-post lifestyle intervention analyses', Pathogens, 11, pp. 1279, http://dx.doi.org/10.3390/pathogens11111279

Little RD; Ward MG; Wright E; Jois AJ; Boussioutas A; Hold GL; Gibson PR; Sparrow MP, 2022, 'Therapeutic Drug Monitoring of Subcutaneous Infliximab in Inflammatory Bowel Disease—Understanding Pharmacokinetics and Exposure Response Relationships in a New Era of Subcutaneous Biologics', Journal of Clinical Medicine, 11, http://dx.doi.org/10.3390/jcm11206173

Carserides C; Smith K; Zinicola M; Kumar A; Swedrowska M; Scala C; Cameron G; Riches Z; Iannelli F; Pozzi G; Hold GL; Forbes B; Kelly C; Hijazi K, 2022, 'Comprehensive Study of Antiretroviral Drug Permeability at the Cervicovaginal Mucosa via an In Vitro Model', Pharmaceutics, 14, http://dx.doi.org/10.3390/pharmaceutics14091938

Gulliver EL; Young RB; Chonwerawong M; D'Adamo GL; Thomason T; Widdop JT; Rutten EL; Rossetto Marcelino V; Bryant RV; Costello SP; O'Brien CL; Hold GL; Giles EM; Forster SC, 2022, 'Review article: the future of microbiome-based therapeutics', Alimentary Pharmacology and Therapeutics, 56, pp. 192 - 208, http://dx.doi.org/10.1111/apt.17049

Breugelmans T; Oosterlinck B; Arras W; Ceuleers H; De Man J; Hold GL; De Winter BY; Smet A, 2022, 'The role of mucins in gastrointestinal barrier function during health and disease', Lancet Gastroenterology and Hepatology, 7, pp. 455 - 471, http://dx.doi.org/10.1016/S2468-1253(21)00431-3

James KR; Elmentaite R; Teichmann SA; Hold GL, 2022, 'Redefining intestinal immunity with single-cell transcriptomics', Mucosal Immunology, 15, pp. 531 - 541, http://dx.doi.org/10.1038/s41385-021-00470-y

James KR; Elmentaite R; Teichmann SA; Hold GL, 2022, 'Correction to: Redefining intestinal immunity with single-cell transcriptomics (Mucosal Immunology, (2021), 10.1038/s41385-021-00470-y)', Mucosal Immunology, 15, pp. 526 - 526, http://dx.doi.org/10.1038/s41385-022-00483-1

Amorim N; McGovern E; Raposo A; Khatiwada S; Shen S; Koentgen S; Hold G; Behary J; El-Omar E; Zekry A, 2022, 'Refining a Protocol for Faecal Microbiota Engraftment in Animal Models After Successful Antibiotic-Induced Gut Decontamination', Frontiers in Medicine, 9, http://dx.doi.org/10.3389/fmed.2022.770017

Shaw S; Berry S; Thomson J; Murray GI; El-Omar E; Hold GL, 2022, 'Gut Mucosal Microbiome Signatures of Colorectal Cancer Differ According to BMI Status', Frontiers in Medicine, 8, http://dx.doi.org/10.3389/fmed.2021.800566

Smet A; Kupcinskas J; Link A; Hold GL; Bornschein J, 2022, 'The Role of Microbiota in Gastrointestinal Cancer and Cancer Treatment: Chance or Curse?', Cellular and Molecular Gastroenterology and Hepatology, 13, pp. 857 - 874, http://dx.doi.org/10.1016/j.jcmgh.2021.08.013

Wu N; Mah C; Koentgen S; Zhang L; Grimm MC; El-Omar E; Hold GL, 2021, 'Inflammatory bowel disease and the gut microbiota', Proceedings of the Nutrition Society, 80, pp. 424 - 434, http://dx.doi.org/10.1017/S002966512100197X

Back to profile page