By Associate Professor Orazio Vittorio

Conference Abstracts

Michniewicz F; Bell J; Saletta F; Watkinson T; Mercatelli D; Giorgi FM; Barlow CK; Faridi P; Tsoli M; Ziegler D; Vittorio O, 2022, 'COPPER CHELATION THERAPY TARGETS S-ADENOSYLMETHIONINE (SAM) METABOLISM AND EPIGENETIC REGULATORS IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, GERMANY, Hamburg, Vol. 24, pp. 22 - 22, presented at 20th International Symposium on Pediatric Neuro-Oncology (ISPNO) / Annual Meeting of the Brain-Tumor-Group-of-SIOP-Europe (SIOPE-BTG), GERMANY, Hamburg, 11 June 2022 - 15 June 2022

Holliday H; Ehteda A; Khan A; Krug B; Rouaen JRC; Jayatilleke N; Mayoh C; Vittorio O; Jabado N; Tsoli M; Ziegler DS, 2022, 'DIPG-06. Uncovering the FACTs in Diffuse Midline Glioma (DMG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 24, pp. i18 - i18, http://dx.doi.org/10.1093/neuonc/noac079.063

Michniewicz F; Bell J; Saletta F; Watkinson T; Mercatelli D; Giorgi FM; Barlow CK; Faridi P; Tsoli M; Ziegler D; Vittorio O, 2022, 'DIPG-20. Copper chelation therapy targets S-adenosylmethionine (SAM) metabolism and epigenetic regulators in diffuse intrinsic pontine glioma (DIPG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 24, pp. i22 - i22, http://dx.doi.org/10.1093/neuonc/noac079.077

Holliday H; Ehteda A; Khan A; Krug B; Rouaen JRC; Jayatilleke N; Mayoh C; Vittorio O; Jabado N; Tsoli M; Ziegler DS, 2022, 'UNCOVERING THE FACTS IN DIFFUSE MIDLINE GLIOMA (DMG)', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 24, pp. 18 - 18, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000840122400065&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Brown MP; Gargett T; Ebert LM; Truong N; Sedivakova K; Kollis PM; Yu W; Yeo E; Vittorio O; Ziegler DS, 2022, 'Immunotherapy: IN VITRO STUDIES IN SUPPORT OF GD2-SPECIFIC CAR-T CELL THERAPY FOR AGGRESSIVE ADULT AND PEDIATRIC BRAIN TUMORS', in Cytotherapy, Elsevier BV, Vol. 24, pp. S125 - S125, http://dx.doi.org/10.1016/s1465-3249(22)00336-x

Ehteda A; Simon S; Franshaw L; Giorgi FM; Liu J; Hayden E; Rouaen J; Pang CNI; Pandher R; Mayoh C; Tang Y; Khan A; Ung C; Kankean A; Lehmann R; Shen S; Gopalakrishnan A; Trebilcock P; Gurova K; Gudkov A; Norris MD; Haber M; Vittorio O; Tsoli M; Ziegler DS, 2021, 'TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION IN DIPG', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 23, pp. 18 - 19, http://dx.doi.org/10.1093/neuonc/noab090.075

Ung C; Tsoli M; Liu J; Cassano D; Upton D; Ehteda A; Mansfield F; Failes T; Kavallaris M; Arndt G; Vittorio O; Voliani V; Cirilo G; Ziegler DS, 2020, 'DDEL-12. NANOPARTICLE DELIVERY OF DOXORUBICIN FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii286 - iii286, http://dx.doi.org/10.1093/neuonc/noaa222.047

Ehteda A; Franshaw L; Liu J; Joshi S; Simon S; Pang CNI; Giorgi F; Pandher R; Ung C; Tolhurst O; Mayoh C; Khan A; Hayden E; Gopalakrishnan A; Trebilcock P; Upton D; Lehmann R; George S; Vittorio O; Tsoli M; Gurova K; Gudkov AG; Norris MD; Haber M; Ziegler DS, 2020, 'DIPG-27. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii292 - iii292, http://dx.doi.org/10.1093/neuonc/noaa222.076

Pascali G; Parmar A; Voli F; Lerra L; Lee E; Ahmed-Cox A; Kimpton K; Cirillo G; Arthur A; Zahra D; Rahardjo G; Liu G; Lengkeek N; Pellegrini P; Saletta F; Charil A; Kavallaris M; Vittorio O, 2019, '[Cu-64]CuCl2 PET metallomics for determining the anticancer mechanism of novel drug Dextran-Catechin', in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, WILEY, Vol. 62, pp. S526 - S527, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000468965200440&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Voli F; Lerra L; Kimpton K; Saletta F; Shen S; Cirillo G; Kavallaris M; Vittorio O, 2019, 'Copper homeostasis: A new player in anti-tumor immune response', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, GA, Atlanta, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), GA, Atlanta, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.SABCS18-3224

Voli F; Lerra L; Kimpton K; Saletta F; Cirillo G; Kavallaris M; Vittorio O, 2018, 'Harnessing copper in cancer to enhance anti-tumor immune response', in ANNALS OF ONCOLOGY, OXFORD UNIV PRESS, SWITZERLAND, Geneva, Vol. 29, pp. 35 - 35, presented at ESMO Immuno-Oncology Congress, SWITZERLAND, Geneva, 13 December 2018 - 16 December 2018

Yee EMH; Brandl MB; Pasquier E; Cirillo G; Kimpton K; Kavallaris M; Kumar N; Vittorio O, 2017, 'Dextran-Catechin inhibits angiogenesis by disrupting copper homeostasis in endothelial cells', in Scientific Reports, Springer Nature, England, Vol. 7, pp. 7638, England, http://dx.doi.org/10.1038/s41598-017-07452-w

Parmar A; Vittorio O; Charil A; Kavallaris M; Pascali G, 2016, 'Imaging neuroblastoma xenograft using [Cu-64]CuCl2 for evaluation of novel treatment based on Dextran/Catechin conjugate', in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, SPRINGER, SPAIN, Barcelona, Vol. 43, pp. S480 - S480, presented at Annual Congress of the European-Association-of-Nuclear-Medicine, SPAIN, Barcelona, 15 October 2016 - 19 October 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000391802400670&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Working Papers

Capraro A; Wong S; Adhikari A; Allan K; Patel H; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan R; Turville S; Vittorio O; Bull R; Kaakoush N; Rawlinson W; Tedla N; Vafaee F; Waters S, 2021, Ageing impairs the airway epithelium defence response to SARS-CoV-2, http://dx.doi.org10.1101/2021.04.05.437453

Preprints

Raninga P; Zeng B; Moi D; Saletta F; Venkat P; Mayoh C; D'Souza R; Day B; Shai-Hee T; Vittorio O; Mazzieri R; Dolcetti R; Khanna KK, 2024, CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers, http://dx.doi.org/10.21203/rs.3.rs-3957241/v1

Zhu J; Graziotto ME; Cottam V; Hawtrey T; Rouaen JRC; Ohno C; Heisler M; Vittorio O; Double KL; New EJ, 2023, A Near-Infrared Ratiometric Fluorescent Probe for Detecting Endogenous Cu2+ in the Brain, http://dx.doi.org/10.26434/chemrxiv-2023-mftg1

Rennie C; Sives C; Boyton I; Diaz D; Gorrie C; Vittorio O; Collins-Praino L; Care A, 2023, In vivofate of systemically administered encapsulin protein nanocages and implications for their use in targeted drug delivery, http://dx.doi.org/10.1101/2023.07.16.549228

Mayoh C; Gifford A; Terry R; Lau LMS; Wong M; Rao P; Shai-Hee T; Saletta F; Khuong-Quang D-A; Qin V; Mateos M; Meyran D; Miller K; Yuksel A; Mould EVA; Bowen-James R; Govender D; Senapati A; Zhukova N; Omer N; Dholaria H; Alvaro F; Tapp H; Diamond Y; Pozza LD; Moore A; Nicholls W; Gottardo N; McCowage G; Hansford J; Khaw S-L; Wood P; Catchpoole D; Cottrell C; Mardis E; Marshall G; Tyrrell V; Haber M; Ziegler D; Vittorio O; Trapani J; Cowley M; Neeson P; Ekert P, 2022, A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer, http://dx.doi.org/10.1101/2022.09.16.508179

Poursani EM; Mercatelli D; Raninga P; Bell JL; Saletta F; Kohane FV; Zheng Y; Rouaen J; Jue TR; Michniewicz FT; Kasiou E; Tsoli M; Cirillo G; Waters S; Shai-Hee T; Valli E; Brettle M; Whan R; Vahadat L; Ziegler D; Lock JG; Giorgi FM; Khanna KK; Vittorio O, 2022, Copper chelation inhibits TGF-βpathways and suppresses epithelial-mesenchymal transition in cancer, http://dx.doi.org/10.1101/2022.10.03.510707

Gargett T; Ebert L; Truong NTH; Kollis P; Sedivakova K; Yu W; Yeo ECF; Wittwer N; Gliddon B; Tea M; Ormsby R; Poonnoose S; Nowicki J; Vittorio O; Ziegler D; Pitson S; Brown M, 2022, GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma, http://dx.doi.org/10.1101/2022.05.01.490250

Ehteda A; Simon S; Franshaw L; Giorgi FM; Liu J; Hayden E; Joshi S; Ignatius Pang CN; Pandher R; Mayoh C; Tang Y; Rouaen J; Khan A; Ung C; Tolhurst O; Kankean A; Shen S; Gopalakrishnan A; Trebilcock P; Gurova K; Gudkov A; Norris M; Haber M; Vittorio O; Tsoli M; Ziegler DS, Dual Targeting of the Epigenome Via Facilitates Chromatin Transcription Complex (FACT) and Histone Deacetylase is a Potent Treatment Strategy for DIPG, http://dx.doi.org/10.2139/ssrn.3664176

Other

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Data from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.c.6512334.v1

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Data from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.c.6512334

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S1 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426440.v1

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S1 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426440

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S2 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426437

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S2 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426437.v1

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S3 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426434.v1

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S3 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426434

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S4 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426431

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S4 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426431.v1

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S5 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426428

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S5 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426428.v1

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S6 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426425

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S6 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426425.v1

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S7 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426422

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Figure S7 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426422.v1

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Master Regulator Analysis from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426419.v1

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2023, Master Regulator Analysis from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, http://dx.doi.org/10.1158/0008-5472.22426419

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