By Associate Professor Orazio Vittorio

Journal articles

Nguyen CC; Davies J; Ashok A; Hoang TT; Ehteda A; Dang TB; Nicotra E; Tran HA; Sharma B; Zhu K; Phan PT; Ji A; Wan J; Rnjak-Kovacina J; Vittorio O; Phan HP; Lovell NH; Do TN, 2025, 'Motor-Free Soft Robots for Cancer Detection, Surgery, and In Situ Bioprinting', Advanced Healthcare Materials, 14, http://dx.doi.org/10.1002/adhm.202404623

Tu C; Tan CW; Monkman J; Almeida AC; Antonio-Carreon G; Omer N; Hull G; Chung K; Mehdi A; Salerno A; Vittorio O; Mayer A; Machado de Souza C; de Almeida Brehm Pinhati F; Elifio-Esposito S; Nicholls W; de Noronha L; Kulasinghe A; Souza-Fonseca-Guimaraes F, 2025, 'Abstract 2705: Spatial profiling of tumor microenvironment uncovers potential novel therapeutic approach in pediatric neuroblastoma', Cancer Research, 85, pp. 2705 - 2705, http://dx.doi.org/10.1158/1538-7445.am2025-2705

Raninga PV; Zeng B; Moi D; Trethowan E; Saletta F; Venkat P; Mayoh C; D’Souza RCJ; Day BW; Shai-Hee T; Vittorio O; Mazzieri R; Dolcetti R; Khanna KK, 2025, 'CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers', Oncogene, 44, pp. 893 - 908, http://dx.doi.org/10.1038/s41388-024-03259-y

Raninga PV; Zeng B; Moi D; Trethowan E; Saletta F; Venkat P; Mayoh C; D’Souza RCJ; Day BW; Shai-Hee T; Vittorio O; Mazzieri R; Dolcetti R; Khanna KK, 2025, 'Correction to: CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers (Oncogene, (2025), 44, 13, (893-908), 10.1038/s41388-024-03259-y)', Oncogene, 44, pp. 927, http://dx.doi.org/10.1038/s41388-025-03319-x

Mateos MK; Ajuyah P; Fuentes-Bolanos N; El-Kamand S; Barahona P; Altekoester A-K; Mayoh C; Holliday H; Liu J; Cui L; Pfaff E; Mackay A; Resnick AC; Pinese M; Lau LMS; Khuong-Quang D-A; Dias K; Goudie C; Salkeld A; Rokita JL; Jones DTW; Juretic N; Hayden E; Pfister SM; Kramm CM; Blattner-Johnson M; Jabado N; Tsoli M; Vittorio O; Mueller S; Guo Y; Tucker K; Waszak SM; Perreault S; Jones C; Wong-Erasmus M; Cowley MJ; Ziegler DS, 2025, 'Germline analysis of an international cohort of pediatric diffuse midline glioma patients.', Neuro Oncol, http://dx.doi.org/10.1093/neuonc/noaf061

Jue TR; Descallar J; Pham VVH; Bell JL; Shai-Hee T; Cazzolli R; Nagabushan S; Koh ES; Vittorio O, 2025, 'Cuproplasia-related gene signature: Prognostic insights for glioma therapy', Neuro Oncology Advances, 7, http://dx.doi.org/10.1093/noajnl/vdae233

Ziegler DS; Fangusaro JR; Tsoli M; Vittorio O; Shai-Hee T; Minard C; Liu X; Reid JM; Yahya NA; Foster JH; Fox E; Weigel B, 2025, 'A phase 1 trial of the FACT inhibitor CBL0137 in pediatric patients with relapsed or refractory solid and CNS tumors: A report from the Children’s Oncology Group study PEPN2111.', Journal of Clinical Oncology, 43, pp. 10051 - 10051, http://dx.doi.org/10.1200/jco.2025.43.16_suppl.10051

Lam PY; Omer N; Wong JKM; Tu C; Alim L; Rossi GR; Victorova M; Tompkins H; Lin C-Y; Mehdi AM; Choo A; Elliott MR; Coleborn E; Sun J; Mercer T; Vittorio O; Dobson LJ; McLellan AD; Brooks A; Tuong ZK; Cheetham SW; Nicholls W; Souza-Fonseca-Guimaraes F, 2025, 'Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CAR.', Clin Transl Med, 15, pp. e70140, http://dx.doi.org/10.1002/ctm2.70140

Nguyen CC; Davies J; Ashok A; Hoang TT; Ehteda A; Dang TB; Nicotra E; Tran HA; Sharma B; Zhu K; Phan PT; Ji A; Wan J; Rnjak‐Kovacina J; Vittorio O; Phan H; Lovell NH; Do TN, 2025, 'Motor‐Free Soft Robots for Cancer Detection, Surgery, and In Situ Bioprinting (Adv. Healthcare Mater. 14/2025)', Advanced Healthcare Materials, 14, http://dx.doi.org/10.1002/adhm.202570083

Rouaen JRC; Salerno A; Shai-Hee T; Murray JE; Castrogiovanni G; McHenry C; Jue TR; Pham V; Bell JL; Poursani E; Valli E; Cazzoli R; Damstra N; Nelson DJ; Stevens KLP; Chee J; Slapetova I; Kasherman M; Whan R; Lin F; Cochran BJ; Tedla N; Veli FC; Yuksel A; Mayoh C; Saletta F; Mercatelli D; Chtanova T; Kulasinghe A; Catchpoole D; Cirillo G; Biro M; Lode HN; Luciani F; Haber M; Gray JC; Trahair TN; Vittorio O, 2024, 'Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma', Nature Communications, 15, pp. 10462, http://dx.doi.org/10.1038/s41467-024-54689-x

Pham VVH; Jue TR; Bell JL; Luciani F; Michniewicz F; Cirillo G; Vahdat L; Mayoh C; Vittorio O, 2024, 'A novel network-based method identifies a cuproplasia-related pan-cancer gene signature to predict patient outcome', Human Genetics, 143, pp. 1145 - 1162, http://dx.doi.org/10.1007/s00439-024-02673-2

Zhu J; Graziotto ME; Cottam V; Hawtrey T; Adair LD; Trist BG; Pham NTH; Rouaen JRC; Ohno C; Heisler M; Vittorio O; Double KL; New EJ, 2024, 'Near-Infrared Ratiometric Fluorescent Probe for Detecting Endogenous Cu2+ in the Brain', ACS Sensors, 9, pp. 2858 - 2868, http://dx.doi.org/10.1021/acssensors.3c02549

Poursani E; Cirillo G; Curcio M; Vittorio O; De Luca M; Leggio A; Nicoletta FP; Iemma F, 2024, 'Dual-responsive chondroitin sulfate self-assembling nanoparticles for combination therapy in metastatic cancer cells', International Journal of Pharmaceutics X, 7, http://dx.doi.org/10.1016/j.ijpx.2024.100235

Biagiotti G; Cazzoli R; Andreozzi P; Aresta G; Francesco M; Mangini C; di Gianvincenzo P; Tobia C; Recchia S; Polito L; Severi M; Vittorio O; Cicchi S; Moya SE; Ronca R; Albini A; Berti D; Orecchia R; Garibaldi C; Minucci S; Richichi B, 2024, 'Biocompatible cellulose nanocrystal-based Trojan horse enables targeted delivery of nano-Au radiosensitizers to triple negative breast cancer cells', Nanoscale Horizons, 9, pp. 1211 - 1218, http://dx.doi.org/10.1039/d4nh00042k

Bell JL; Abruzzese DK; Kasiou E; Pham VV; Bertoldo JB; Michniewicz F; Vittorio O, 2024, 'Abstract 3056: Copper chelation modulates YTHDF2 RNA-binding protein localization and global translation, in neuronal cancers', Cancer Research, 84, pp. 3056 - 3056, http://dx.doi.org/10.1158/1538-7445.am2024-3056

Brown MP; Gargett T; Truong NT; Vittorio O; Ziegler DS, 2024, 'Abstract 3636: Myeloid cell rebound associated with GD2-CAR-T cell therapy in solid tumor patients', Cancer Research, 84, pp. 3636 - 3636, http://dx.doi.org/10.1158/1538-7445.am2024-3636

Rennie C; Sives C; Boyton I; Diaz D; Gorrie C; Vittorio O; Collins-Praino L; Care A, 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery', Advanced Therapeutics, 7, http://dx.doi.org/10.1002/adtp.202300360

Koschmann C; Al-Holou WN; Alonso MM; Anastas J; Bandopadhayay P; Barron T; Becher O; Cartaxo R; Castro MG; Chung C; Clausen M; Dang D; Doherty R; Duchatel R; Dun M; Filbin M; Franson A; Galban S; Garcia Moure M; Garton H; Gowda P; Marques JG; Hawkins C; Heath A; Hulleman E; Ji S; Jones C; Kilburn L; Kline C; Koldobskiy MA; Lim D; Lowenstein PR; Lu QR; Lum J; Mack S; Magge S; Marini B; Martin D; Marupudi N; Messinger D; Mody R; Morgan M; Mota M; Muraszko K; Mueller S; Natarajan SK; Nazarian J; Niculcea M; Nuechterlein N; Okada H; Opipari V; Pai MP; Pal S; Peterson E; Phoenix T; Prensner JR; Pun M; Raju GP; Reitman ZJ; Resnick A; Rogawski D; Saratsis A; Sbergio SG; Souweidane M; Stafford JM; Tzaridis T; Venkataraman S; Vittorio O; Wadden J; Wahl D; Wechsler-Reya RJ; Yadav VN; Zhang X; Zhang Q; Venneti S, 2024, 'A road map for the treatment of pediatric diffuse midline glioma', Cancer Cell, 42, pp. 1 - 5, http://dx.doi.org/10.1016/j.ccell.2023.11.002

Rennie C; Sives C; Boyton I; Diaz D; Gorrie C; Vittorio O; Collins‐Praino L; Care A, 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery (Adv. Therap. 2/2024)', Advanced Therapeutics, 7, http://dx.doi.org/10.1002/adtp.202470003

Mayoh C; Gifford AJ; Terry R; Lau LMS; Wong M; Rao P; Shai-Hee T; Saletta F; Khuong-Quang DA; Qin V; Mateos MK; Meyran D; Miller KE; Yuksel A; Mould EVA; Bowen-James R; Govender D; Senapati A; Zhukova N; Omer N; Dholaria H; Alvaro F; Tapp H; Diamond Y; Pozza LD; Moore AS; Nicholls W; Gottardo NG; McCowage G; Hansford JR; Khaw SL; Wood PJ; Catchpoole D; Cottrell CE; Mardis ER; Marshall GM; Tyrrell V; Haber M; Ziegler DS; Vittorio O; Trapani JA; Cowley MJ; Neeson PJ; Ekert PG, 2023, 'A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer', Genome Medicine, 15, http://dx.doi.org/10.1186/s13073-023-01170-x

Poursani EM; Mercatelli D; Raninga P; Bell JL; Saletta F; Kohane FV; Neumann DP; Zheng Y; Rouaen JRC; Jue TR; Michniewicz FT; Schadel P; Kasiou E; Tsoli M; Cirillo G; Waters S; Shai-Hee T; Cazzoli R; Brettle M; Slapetova I; Kasherman M; Whan R; Souza-Fonseca-Guimaraes F; Vahdat L; Ziegler D; Lock JG; Giorgi FM; Khanna KK; Vittorio O, 2023, 'Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer', Cell and Bioscience, 13, pp. 132, http://dx.doi.org/10.1186/s13578-023-01083-7

Cazzoli R; Zamborlin A; Ermini ML; Salerno A; Curcio M; Nicoletta FP; Iemma F; Vittorio O; Voliani V; Cirillo G, 2023, 'Evolving approaches in glioma treatment: harnessing the potential of copper metabolism modulation', Rsc Advances, 13, pp. 34045 - 34056, http://dx.doi.org/10.1039/d3ra06434d

Di Luca M; Poursani E; Curcio M; Cirillo G; Salerno A; Bolognini S; De Filpo G; Filippi S; Vittorio O; Iemma F; Nicoletta FP, 2023, 'Evaluating the Efficiency of Chitosan-Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems', Macromolecular Materials and Engineering, 308, http://dx.doi.org/10.1002/mame.202300166

Cazzoli R; Romeo F; Pallavicini I; Peri S; Romanenghi M; Pérez-Valencia JA; Hagag E; Ferrucci F; Elgendy M; Vittorio O; Pece S; Foiani M; Westermarck J; Minucci S, 2023, 'Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition', Cell Reports, 42, http://dx.doi.org/10.1016/j.celrep.2023.112616

Kuppusamy R; Yasir M; Yu TT; Voli F; Vittorio O; Miller MJ; Lewis P; Black DSC; Willcox M; Kumar N, 2023, 'Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm', Antibiotics, 12, pp. 585, http://dx.doi.org/10.3390/antibiotics12030585

Allan KM; Astore MA; Kardia E; Wong SL; Fawcett LK; Bell JL; Visser S; Chen PC; Griffith R; Jaffe A; Sivam S; Vittorio O; Kuyucak S; Waters SA, 2023, 'Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient', Frontiers in Molecular Biosciences, 10, http://dx.doi.org/10.3389/fmolb.2023.1148501

Gargett T; Ebert LM; Truong NTH; Kollis PM; Sedivakova K; Yu W; Yeo ECF; Wittwer NL; Gliddon BL; Tea MN; Ormsby R; Poonnoose S; Nowicki J; Vittorio O; Ziegler DS; Pitson SM; Brown MP, 2022, 'GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma', Journal for Immunotherapy of Cancer, 10, http://dx.doi.org/10.1136/jitc-2022-005187

Curcio M; Vittorio O; Bell JL; Iemma F; Nicoletta FP; Cirillo G, 2022, 'Hyaluronic Acid within Self-Assembling Nanoparticles: Endless Possibilities for Targeted Cancer Therapy', Nanomaterials, 12, http://dx.doi.org/10.3390/nano12162851

Madeo LF; Sarogni P; Cirillo G; Vittorio O; Voliani V; Curcio M; Shai-Hee T; Büchner B; Mertig M; Hampel S, 2022, 'Curcumin and Graphene Oxide Incorporated into Alginate Hydrogels as Versatile Devices for the Local Treatment of Squamous Cell Carcinoma', Materials, 15, pp. 1648, http://dx.doi.org/10.3390/ma15051648

Noor H; Briggs NE; McDonald KL; Holst J; Vittorio O, 2021, 'Tp53 mutation is a prognostic factor in lower grade glioma and may influence chemotherapy efficacy', Cancers, 13, pp. 5362, http://dx.doi.org/10.3390/cancers13215362

Michniewicz F; Saletta F; Rouaen JRC; Hewavisenti RV; Mercatelli D; Cirillo G; Giorgi FM; Trahair T; Ziegler D; Vittorio O, 2021, 'Copper: An Intracellular Achilles’ Heel Allowing the Targeting of Epigenetics, Kinase Pathways, and Cell Metabolism in Cancer Therapeutics', Chemmedchem, 16, pp. 2315 - 2329, http://dx.doi.org/10.1002/cmdc.202100172

Bevacqua E; Curcio M; Saletta F; Vittorio O; Cirillo G; Tucci P, 2021, 'Dextran‐curcumin nanosystems inhibit cell growth and migration regulating the epithelial to mesenchymal transition in prostate cancer cells', International Journal of Molecular Sciences, 22, http://dx.doi.org/10.3390/ijms22137013

Ehteda A; Simon S; Franshaw L; Giorgi FM; Liu J; Joshi S; Rouaen JRC; Pang CNI; Pandher R; Mayoh C; Tang Y; Khan A; Ung C; Tolhurst O; Kankean A; Hayden E; Lehmann R; Shen S; Gopalakrishnan A; Trebilcock P; Gurova K; Gudkov AV; Norris MD; Haber M; Vittorio O; Tsoli M; Ziegler DS, 2021, 'Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG', Cell Reports, 35, pp. 108994, http://dx.doi.org/10.1016/j.celrep.2021.108994

Cirillo G; Pantuso E; Curcio M; Vittorio O; Leggio A; Iemma F; De Filpo G; Nicoletta FP, 2021, 'Alginate bioconjugate and graphene oxide in multifunctional hydrogels for versatile biomedical applications', Molecules, 26, pp. 1355, http://dx.doi.org/10.3390/molecules26051355

Ung C; Tsoli M; Liu J; Cassano D; Pocoví-Martínez S; Upton DH; Ehteda A; Mansfeld FM; Failes TW; Farfalla A; Katsinas C; Kavallaris M; Arndt GM; Vittorio O; Cirillo G; Voliani V; Ziegler DS, 2021, 'Doxorubicin-loaded gold nanoarchitectures as a therapeutic strategy against diffuse intrinsic pontine glioma', Cancers, 13, pp. 1 - 20, http://dx.doi.org/10.3390/cancers13061278

Curcio M; Cirillo G; Saletta F; Michniewicz F; Nicoletta FP; Vittorio O; Hampel S; Iemma F, 2021, 'Carbon Nanohorns as Effective Nanotherapeutics in Cancer Therapy', C-JOURNAL OF CARBON RESEARCH, 7, http://dx.doi.org/10.3390/c7010003

Michniewicz F; Saletta F; Rouen J; Ziegler D; Vittorio O, 2020, 'DIPG-83. USING COPPER CHELATING AGENTS TO TARGET RECEPTOR TYROSINE KINASE SIGNALLING IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', Neuro-Oncology, 22, pp. iii303 - iii303, http://dx.doi.org/10.1093/neuonc/noaa222.124

Curcio M; Cirillo G; Rouaen JRC; Saletta F; Nicoletta FP; Vittorio O; Iemma F, 2020, 'Natural polysaccharide carriers in brain delivery: Challenge and perspective', Pharmaceutics, 12, http://dx.doi.org/10.3390/pharmaceutics12121183

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2020, 'Intratumoral copper modulates PD-L1 expression and influences tumor immune evasion', Cancer Research, 80, pp. 4129 - 4144, http://dx.doi.org/10.1158/0008-5472.CAN-20-0471

Curcio M; Farfalla A; Saletta F; Valli E; Pantuso E; Nicoletta FP; Iemma F; Vittorio O; Cirillo G, 2020, 'Functionalized carbon nanostructures versus drug resistance: Promising scenarios in cancer treatment', Molecules, 25, http://dx.doi.org/10.3390/molecules25092102

Vittorio O; Kamili A; Valli E; Kavallaris M; LE GRAND M, 2020, 'Interplay between MycN and c-Myc regulates radioresistance and cancer stem cell phenotype in neuroblastoma upon glutamine deprivation', Theranostics, 10, pp. 6411 - 6429, http://dx.doi.org/10.7150/thno.42602

Curcio M; Cirillo G; Tucci P; Farfalla A; Bevacqua E; Vittorio O; Iemma F; Nicoletta FP, 2020, 'Dextran-curcumin nanoparticles as a methotrexate delivery vehicle: A step forward in breast cancer combination therapy', Pharmaceuticals, 13, pp. 2, http://dx.doi.org/10.3390/ph13010002

Liu A; Cohen J; Vittorio O, 2019, 'Poor dietary polyphenol intake in childhood cancer patients', Nutrients, 11, http://dx.doi.org/10.3390/nu11112835

Cirillo G; Vittorio O; Kunhardt D; Valli E; Voli F; Farfalla A; Curcio M; Spizzirri UG; Hampel S, 2019, 'Combining carbon nanotubes and chitosan for the vectorization of methotrexate to lung cancer cells', Materials, 12, http://dx.doi.org/10.3390/ma12182889

Makharza SA; Cirillo G; Vittorio O; Valli E; Voli F; Farfalla A; Curcio M; Iemma F; Nicoletta FP; El-Gendy AA; Goya GF; Hampel S, 2019, 'Magnetic graphene oxide nanocarrier for targeted delivery of cisplatin: A perspective for glioblastoma treatment', Pharmaceuticals, 12, http://dx.doi.org/10.3390/ph12020076

Cirillo G; Curcio M; Spizzirri UG; Vittorio O; Valli E; Farfalla A; Leggio A; Nicoletta FP; Iemma F, 2019, 'Chitosan–Quercetin Bioconjugate as Multi-Functional Component of Antioxidants and Dual-Responsive Hydrogel Networks', Macromolecular Materials and Engineering, 304, http://dx.doi.org/10.1002/mame.201800728

Di Luca M; Curcio M; Valli E; Cirillo G; Voli F; Butini ME; Farfalla A; Pantuso E; Leggio A; Nicoletta FP; Tavanti A; Iemma F; Vittorio O, 2019, 'Combining antioxidant hydrogels with self-assembled microparticles for multifunctional wound dressings', Journal of Materials Chemistry B, 7, pp. 4361 - 4370, http://dx.doi.org/10.1039/c9tb00871c

Lerra L; Farfalla A; Sanz B; Cirillo G; Vittorio O; Voli F; Grand ML; Curcio M; Nicoletta FP; Dubrovska A; Hampel S; Iemma F; Goya GF; LE GRAND M, 2019, 'Graphene oxide functional nanohybrids with magnetic nanoparticles for improved vectorization of doxorubicin to neuroblastoma cells', Pharmaceutics, 11, http://dx.doi.org/10.3390/pharmaceutics11010003

Yee EMH; Cirillo G; Brandl MB; Black DSC; Vittorio O; Kumar N, 2019, 'Synthesis of dextran–phenoxodiol and evaluation of its physical stability and biological activity', Frontiers in Bioengineering and Biotechnology, 7, http://dx.doi.org/10.3389/fbioe.2019.00183

Cirillo G; Peitzsch C; Vittorio O; Curcio M; Farfalla A; Voli F; Dubrovska A; Iemma F; Kavallaris M; Hampel S, 2019, 'When polymers meet carbon nanostructures: Expanding horizons in cancer therapy', Future Medicinal Chemistry, 11, pp. 2205 - 2231, http://dx.doi.org/10.4155/fmc-2018-0540

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