By Associate Professor Orazio Vittorio

Book Chapters

Vittorio O; Raffa V; Cuschieri A, 2017, 'Influence of Purity and Surface Oxidation on Cytotoxicity of Multiwalled Carbon Nanotubes with Human Neuroblastoma Cells', in Nanomedicine in Cancer, Pan Stanford, pp. 297 - 316, http://dx.doi.org/10.1201/b22358-11

, 2017, 'Chapter 10: Curcumin‒Loaded γ ‒Cyclodextrin Liposomal Nanoparticles as Delivery Vehicles for Osteosarcoma', in Dhule SS; Penfornis P; Frazier T; Walker R; Feldman J; Tan G; He J; Alb A; John V; Pochampally R (ed.), Nanomedicine in Cancer, CRC Press, pp. 265 - 296, http://dx.doi.org/10.1201/9781315114361-11

Vittorio O; Raffa V; Cuschieri A, 2017, 'Influence of Purity and Surface Oxidation on Cytotoxicity of Multiwalled Carbon Nanotubes with Human Neuroblastoma Cells', in Balogh LP (ed.), Nanomedicine in Cancer, PAN STANFORD PUBLISHING PTE LTD, pp. 297 - 316

Makharza S; Cirillo G; Vittorio O; Hampe S, 2017, 'Physiological and clinical considerations of drug delivery systems containing carbon nanotubes and graphene', in Drug Delivery Approaches and Nanosystems Volume 2 Drug Targeting Aspects of Nanotechnology, pp. 205 - 224, http://dx.doi.org/10.1201/9781315225364

Vittorio O; Kavallaris , 2013, 'Polyphenol Conjugate: Synthesis and Potential Biomedical Applications', in Recent Advances in Drug Delivery Research, Nova Science Publishers, USA

Vittorio O; Cecchini M; Parchi P; Li Santi M, 2012, 'Manipulation, Guidance and Tracking of Mesenchymal Stem Cells for Regenerative Medicine and Transplantation: The Role of Magnetic Nanoparticles', in Stem Cells and Cancer Stem Cells, Volume 7 Therapeutic Applications in Disease and Injury, Springer Science & Business Media

Vittorio O; Duce SL; Raffa V; Cuschieri A, 2011, 'Imaging and Biomedical Application of Magnetic Carbon Nanotubes', in Naraghi M (ed.), CARBON NANOTUBES - GROWTH AND APPLICATIONS, INTECH EUROPE, pp. 189 - 210, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000371131400009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Raffa V; Vittorio O; Riggio C; Ciofani G; Cuschieri A, 2011, 'Physical properties of carbon nanotubes for therapeutic applications', in Klingeler R; Sim RB (ed.), Carbon Nanostructures, pp. 3 - 26, http://dx.doi.org/10.1007/978-3-642-14802-6_1

Journal articles

Nguyen CC; Davies J; Ashok A; Hoang TT; Ehteda A; Dang TB; Nicotra E; Tran HA; Sharma B; Zhu K; Phan PT; Ji A; Wan J; Rnjak-Kovacina J; Vittorio O; Phan HP; Lovell NH; Do TN, 2025, 'Motor-Free Soft Robots for Cancer Detection, Surgery, and In Situ Bioprinting', Advanced Healthcare Materials, 14, http://dx.doi.org/10.1002/adhm.202404623

Tu C; Tan CW; Monkman J; Almeida AC; Antonio-Carreon G; Omer N; Hull G; Chung K; Mehdi A; Salerno A; Vittorio O; Mayer A; Machado de Souza C; de Almeida Brehm Pinhati F; Elifio-Esposito S; Nicholls W; de Noronha L; Kulasinghe A; Souza-Fonseca-Guimaraes F, 2025, 'Abstract 2705: Spatial profiling of tumor microenvironment uncovers potential novel therapeutic approach in pediatric neuroblastoma', Cancer Research, 85, pp. 2705 - 2705, http://dx.doi.org/10.1158/1538-7445.am2025-2705

Raninga PV; Zeng B; Moi D; Trethowan E; Saletta F; Venkat P; Mayoh C; D’Souza RCJ; Day BW; Shai-Hee T; Vittorio O; Mazzieri R; Dolcetti R; Khanna KK, 2025, 'CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers', Oncogene, 44, pp. 893 - 908, http://dx.doi.org/10.1038/s41388-024-03259-y

Raninga PV; Zeng B; Moi D; Trethowan E; Saletta F; Venkat P; Mayoh C; D’Souza RCJ; Day BW; Shai-Hee T; Vittorio O; Mazzieri R; Dolcetti R; Khanna KK, 2025, 'Correction to: CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers (Oncogene, (2025), 44, 13, (893-908), 10.1038/s41388-024-03259-y)', Oncogene, 44, pp. 927, http://dx.doi.org/10.1038/s41388-025-03319-x

Mateos MK; Ajuyah P; Fuentes-Bolanos N; El-Kamand S; Barahona P; Altekoester A-K; Mayoh C; Holliday H; Liu J; Cui L; Pfaff E; Mackay A; Resnick AC; Pinese M; Lau LMS; Khuong-Quang D-A; Dias K; Goudie C; Salkeld A; Rokita JL; Jones DTW; Juretic N; Hayden E; Pfister SM; Kramm CM; Blattner-Johnson M; Jabado N; Tsoli M; Vittorio O; Mueller S; Guo Y; Tucker K; Waszak SM; Perreault S; Jones C; Wong-Erasmus M; Cowley MJ; Ziegler DS, 2025, 'Germline analysis of an international cohort of pediatric diffuse midline glioma patients.', Neuro Oncol, http://dx.doi.org/10.1093/neuonc/noaf061

Jue TR; Descallar J; Pham VVH; Bell JL; Shai-Hee T; Cazzolli R; Nagabushan S; Koh ES; Vittorio O, 2025, 'Cuproplasia-related gene signature: Prognostic insights for glioma therapy', Neuro Oncology Advances, 7, http://dx.doi.org/10.1093/noajnl/vdae233

Ziegler DS; Fangusaro JR; Tsoli M; Vittorio O; Shai-Hee T; Minard C; Liu X; Reid JM; Yahya NA; Foster JH; Fox E; Weigel B, 2025, 'A phase 1 trial of the FACT inhibitor CBL0137 in pediatric patients with relapsed or refractory solid and CNS tumors: A report from the Children’s Oncology Group study PEPN2111.', Journal of Clinical Oncology, 43, pp. 10051 - 10051, http://dx.doi.org/10.1200/jco.2025.43.16_suppl.10051

Lam PY; Omer N; Wong JKM; Tu C; Alim L; Rossi GR; Victorova M; Tompkins H; Lin C-Y; Mehdi AM; Choo A; Elliott MR; Coleborn E; Sun J; Mercer T; Vittorio O; Dobson LJ; McLellan AD; Brooks A; Tuong ZK; Cheetham SW; Nicholls W; Souza-Fonseca-Guimaraes F, 2025, 'Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CAR.', Clin Transl Med, 15, pp. e70140, http://dx.doi.org/10.1002/ctm2.70140

Nguyen CC; Davies J; Ashok A; Hoang TT; Ehteda A; Dang TB; Nicotra E; Tran HA; Sharma B; Zhu K; Phan PT; Ji A; Wan J; Rnjak‐Kovacina J; Vittorio O; Phan H; Lovell NH; Do TN, 2025, 'Motor‐Free Soft Robots for Cancer Detection, Surgery, and In Situ Bioprinting (Adv. Healthcare Mater. 14/2025)', Advanced Healthcare Materials, 14, http://dx.doi.org/10.1002/adhm.202570083

Rouaen JRC; Salerno A; Shai-Hee T; Murray JE; Castrogiovanni G; McHenry C; Jue TR; Pham V; Bell JL; Poursani E; Valli E; Cazzoli R; Damstra N; Nelson DJ; Stevens KLP; Chee J; Slapetova I; Kasherman M; Whan R; Lin F; Cochran BJ; Tedla N; Veli FC; Yuksel A; Mayoh C; Saletta F; Mercatelli D; Chtanova T; Kulasinghe A; Catchpoole D; Cirillo G; Biro M; Lode HN; Luciani F; Haber M; Gray JC; Trahair TN; Vittorio O, 2024, 'Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma', Nature Communications, 15, pp. 10462, http://dx.doi.org/10.1038/s41467-024-54689-x

Pham VVH; Jue TR; Bell JL; Luciani F; Michniewicz F; Cirillo G; Vahdat L; Mayoh C; Vittorio O, 2024, 'A novel network-based method identifies a cuproplasia-related pan-cancer gene signature to predict patient outcome', Human Genetics, 143, pp. 1145 - 1162, http://dx.doi.org/10.1007/s00439-024-02673-2

Zhu J; Graziotto ME; Cottam V; Hawtrey T; Adair LD; Trist BG; Pham NTH; Rouaen JRC; Ohno C; Heisler M; Vittorio O; Double KL; New EJ, 2024, 'Near-Infrared Ratiometric Fluorescent Probe for Detecting Endogenous Cu2+ in the Brain', ACS Sensors, 9, pp. 2858 - 2868, http://dx.doi.org/10.1021/acssensors.3c02549

Poursani E; Cirillo G; Curcio M; Vittorio O; De Luca M; Leggio A; Nicoletta FP; Iemma F, 2024, 'Dual-responsive chondroitin sulfate self-assembling nanoparticles for combination therapy in metastatic cancer cells', International Journal of Pharmaceutics X, 7, http://dx.doi.org/10.1016/j.ijpx.2024.100235

Biagiotti G; Cazzoli R; Andreozzi P; Aresta G; Francesco M; Mangini C; di Gianvincenzo P; Tobia C; Recchia S; Polito L; Severi M; Vittorio O; Cicchi S; Moya SE; Ronca R; Albini A; Berti D; Orecchia R; Garibaldi C; Minucci S; Richichi B, 2024, 'Biocompatible cellulose nanocrystal-based Trojan horse enables targeted delivery of nano-Au radiosensitizers to triple negative breast cancer cells', Nanoscale Horizons, 9, pp. 1211 - 1218, http://dx.doi.org/10.1039/d4nh00042k

Bell JL; Abruzzese DK; Kasiou E; Pham VV; Bertoldo JB; Michniewicz F; Vittorio O, 2024, 'Abstract 3056: Copper chelation modulates YTHDF2 RNA-binding protein localization and global translation, in neuronal cancers', Cancer Research, 84, pp. 3056 - 3056, http://dx.doi.org/10.1158/1538-7445.am2024-3056

Brown MP; Gargett T; Truong NT; Vittorio O; Ziegler DS, 2024, 'Abstract 3636: Myeloid cell rebound associated with GD2-CAR-T cell therapy in solid tumor patients', Cancer Research, 84, pp. 3636 - 3636, http://dx.doi.org/10.1158/1538-7445.am2024-3636

Rennie C; Sives C; Boyton I; Diaz D; Gorrie C; Vittorio O; Collins-Praino L; Care A, 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery', Advanced Therapeutics, 7, http://dx.doi.org/10.1002/adtp.202300360

Koschmann C; Al-Holou WN; Alonso MM; Anastas J; Bandopadhayay P; Barron T; Becher O; Cartaxo R; Castro MG; Chung C; Clausen M; Dang D; Doherty R; Duchatel R; Dun M; Filbin M; Franson A; Galban S; Garcia Moure M; Garton H; Gowda P; Marques JG; Hawkins C; Heath A; Hulleman E; Ji S; Jones C; Kilburn L; Kline C; Koldobskiy MA; Lim D; Lowenstein PR; Lu QR; Lum J; Mack S; Magge S; Marini B; Martin D; Marupudi N; Messinger D; Mody R; Morgan M; Mota M; Muraszko K; Mueller S; Natarajan SK; Nazarian J; Niculcea M; Nuechterlein N; Okada H; Opipari V; Pai MP; Pal S; Peterson E; Phoenix T; Prensner JR; Pun M; Raju GP; Reitman ZJ; Resnick A; Rogawski D; Saratsis A; Sbergio SG; Souweidane M; Stafford JM; Tzaridis T; Venkataraman S; Vittorio O; Wadden J; Wahl D; Wechsler-Reya RJ; Yadav VN; Zhang X; Zhang Q; Venneti S, 2024, 'A road map for the treatment of pediatric diffuse midline glioma', Cancer Cell, 42, pp. 1 - 5, http://dx.doi.org/10.1016/j.ccell.2023.11.002

Rennie C; Sives C; Boyton I; Diaz D; Gorrie C; Vittorio O; Collins‐Praino L; Care A, 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery (Adv. Therap. 2/2024)', Advanced Therapeutics, 7, http://dx.doi.org/10.1002/adtp.202470003

Mayoh C; Gifford AJ; Terry R; Lau LMS; Wong M; Rao P; Shai-Hee T; Saletta F; Khuong-Quang DA; Qin V; Mateos MK; Meyran D; Miller KE; Yuksel A; Mould EVA; Bowen-James R; Govender D; Senapati A; Zhukova N; Omer N; Dholaria H; Alvaro F; Tapp H; Diamond Y; Pozza LD; Moore AS; Nicholls W; Gottardo NG; McCowage G; Hansford JR; Khaw SL; Wood PJ; Catchpoole D; Cottrell CE; Mardis ER; Marshall GM; Tyrrell V; Haber M; Ziegler DS; Vittorio O; Trapani JA; Cowley MJ; Neeson PJ; Ekert PG, 2023, 'A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer', Genome Medicine, 15, http://dx.doi.org/10.1186/s13073-023-01170-x

Poursani EM; Mercatelli D; Raninga P; Bell JL; Saletta F; Kohane FV; Neumann DP; Zheng Y; Rouaen JRC; Jue TR; Michniewicz FT; Schadel P; Kasiou E; Tsoli M; Cirillo G; Waters S; Shai-Hee T; Cazzoli R; Brettle M; Slapetova I; Kasherman M; Whan R; Souza-Fonseca-Guimaraes F; Vahdat L; Ziegler D; Lock JG; Giorgi FM; Khanna KK; Vittorio O, 2023, 'Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer', Cell and Bioscience, 13, pp. 132, http://dx.doi.org/10.1186/s13578-023-01083-7

Cazzoli R; Zamborlin A; Ermini ML; Salerno A; Curcio M; Nicoletta FP; Iemma F; Vittorio O; Voliani V; Cirillo G, 2023, 'Evolving approaches in glioma treatment: harnessing the potential of copper metabolism modulation', Rsc Advances, 13, pp. 34045 - 34056, http://dx.doi.org/10.1039/d3ra06434d

Di Luca M; Poursani E; Curcio M; Cirillo G; Salerno A; Bolognini S; De Filpo G; Filippi S; Vittorio O; Iemma F; Nicoletta FP, 2023, 'Evaluating the Efficiency of Chitosan-Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems', Macromolecular Materials and Engineering, 308, http://dx.doi.org/10.1002/mame.202300166

Cazzoli R; Romeo F; Pallavicini I; Peri S; Romanenghi M; Pérez-Valencia JA; Hagag E; Ferrucci F; Elgendy M; Vittorio O; Pece S; Foiani M; Westermarck J; Minucci S, 2023, 'Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition', Cell Reports, 42, http://dx.doi.org/10.1016/j.celrep.2023.112616

Kuppusamy R; Yasir M; Yu TT; Voli F; Vittorio O; Miller MJ; Lewis P; Black DSC; Willcox M; Kumar N, 2023, 'Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm', Antibiotics, 12, pp. 585, http://dx.doi.org/10.3390/antibiotics12030585

Allan KM; Astore MA; Kardia E; Wong SL; Fawcett LK; Bell JL; Visser S; Chen PC; Griffith R; Jaffe A; Sivam S; Vittorio O; Kuyucak S; Waters SA, 2023, 'Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient', Frontiers in Molecular Biosciences, 10, http://dx.doi.org/10.3389/fmolb.2023.1148501

Gargett T; Ebert LM; Truong NTH; Kollis PM; Sedivakova K; Yu W; Yeo ECF; Wittwer NL; Gliddon BL; Tea MN; Ormsby R; Poonnoose S; Nowicki J; Vittorio O; Ziegler DS; Pitson SM; Brown MP, 2022, 'GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma', Journal for Immunotherapy of Cancer, 10, http://dx.doi.org/10.1136/jitc-2022-005187

Curcio M; Vittorio O; Bell JL; Iemma F; Nicoletta FP; Cirillo G, 2022, 'Hyaluronic Acid within Self-Assembling Nanoparticles: Endless Possibilities for Targeted Cancer Therapy', Nanomaterials, 12, http://dx.doi.org/10.3390/nano12162851

Madeo LF; Sarogni P; Cirillo G; Vittorio O; Voliani V; Curcio M; Shai-Hee T; Büchner B; Mertig M; Hampel S, 2022, 'Curcumin and Graphene Oxide Incorporated into Alginate Hydrogels as Versatile Devices for the Local Treatment of Squamous Cell Carcinoma', Materials, 15, pp. 1648, http://dx.doi.org/10.3390/ma15051648

Noor H; Briggs NE; McDonald KL; Holst J; Vittorio O, 2021, 'Tp53 mutation is a prognostic factor in lower grade glioma and may influence chemotherapy efficacy', Cancers, 13, pp. 5362, http://dx.doi.org/10.3390/cancers13215362

Michniewicz F; Saletta F; Rouaen JRC; Hewavisenti RV; Mercatelli D; Cirillo G; Giorgi FM; Trahair T; Ziegler D; Vittorio O, 2021, 'Copper: An Intracellular Achilles’ Heel Allowing the Targeting of Epigenetics, Kinase Pathways, and Cell Metabolism in Cancer Therapeutics', Chemmedchem, 16, pp. 2315 - 2329, http://dx.doi.org/10.1002/cmdc.202100172

Bevacqua E; Curcio M; Saletta F; Vittorio O; Cirillo G; Tucci P, 2021, 'Dextran‐curcumin nanosystems inhibit cell growth and migration regulating the epithelial to mesenchymal transition in prostate cancer cells', International Journal of Molecular Sciences, 22, http://dx.doi.org/10.3390/ijms22137013

Ehteda A; Simon S; Franshaw L; Giorgi FM; Liu J; Joshi S; Rouaen JRC; Pang CNI; Pandher R; Mayoh C; Tang Y; Khan A; Ung C; Tolhurst O; Kankean A; Hayden E; Lehmann R; Shen S; Gopalakrishnan A; Trebilcock P; Gurova K; Gudkov AV; Norris MD; Haber M; Vittorio O; Tsoli M; Ziegler DS, 2021, 'Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG', Cell Reports, 35, pp. 108994, http://dx.doi.org/10.1016/j.celrep.2021.108994

Cirillo G; Pantuso E; Curcio M; Vittorio O; Leggio A; Iemma F; De Filpo G; Nicoletta FP, 2021, 'Alginate bioconjugate and graphene oxide in multifunctional hydrogels for versatile biomedical applications', Molecules, 26, pp. 1355, http://dx.doi.org/10.3390/molecules26051355

Ung C; Tsoli M; Liu J; Cassano D; Pocoví-Martínez S; Upton DH; Ehteda A; Mansfeld FM; Failes TW; Farfalla A; Katsinas C; Kavallaris M; Arndt GM; Vittorio O; Cirillo G; Voliani V; Ziegler DS, 2021, 'Doxorubicin-loaded gold nanoarchitectures as a therapeutic strategy against diffuse intrinsic pontine glioma', Cancers, 13, pp. 1 - 20, http://dx.doi.org/10.3390/cancers13061278

Curcio M; Cirillo G; Saletta F; Michniewicz F; Nicoletta FP; Vittorio O; Hampel S; Iemma F, 2021, 'Carbon Nanohorns as Effective Nanotherapeutics in Cancer Therapy', C-JOURNAL OF CARBON RESEARCH, 7, http://dx.doi.org/10.3390/c7010003

Michniewicz F; Saletta F; Rouen J; Ziegler D; Vittorio O, 2020, 'DIPG-83. USING COPPER CHELATING AGENTS TO TARGET RECEPTOR TYROSINE KINASE SIGNALLING IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', Neuro-Oncology, 22, pp. iii303 - iii303, http://dx.doi.org/10.1093/neuonc/noaa222.124

Curcio M; Cirillo G; Rouaen JRC; Saletta F; Nicoletta FP; Vittorio O; Iemma F, 2020, 'Natural polysaccharide carriers in brain delivery: Challenge and perspective', Pharmaceutics, 12, http://dx.doi.org/10.3390/pharmaceutics12121183

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2020, 'Intratumoral copper modulates PD-L1 expression and influences tumor immune evasion', Cancer Research, 80, pp. 4129 - 4144, http://dx.doi.org/10.1158/0008-5472.CAN-20-0471

Curcio M; Farfalla A; Saletta F; Valli E; Pantuso E; Nicoletta FP; Iemma F; Vittorio O; Cirillo G, 2020, 'Functionalized carbon nanostructures versus drug resistance: Promising scenarios in cancer treatment', Molecules, 25, http://dx.doi.org/10.3390/molecules25092102

Vittorio O; Kamili A; Valli E; Kavallaris M; LE GRAND M, 2020, 'Interplay between MycN and c-Myc regulates radioresistance and cancer stem cell phenotype in neuroblastoma upon glutamine deprivation', Theranostics, 10, pp. 6411 - 6429, http://dx.doi.org/10.7150/thno.42602

Curcio M; Cirillo G; Tucci P; Farfalla A; Bevacqua E; Vittorio O; Iemma F; Nicoletta FP, 2020, 'Dextran-curcumin nanoparticles as a methotrexate delivery vehicle: A step forward in breast cancer combination therapy', Pharmaceuticals, 13, pp. 2, http://dx.doi.org/10.3390/ph13010002

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