By Professor Minoti Vivek Apte

Journal articles

Lin Z; Pandol S; Apte M; Jiang Y, 2025, 'Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview', Frontiers in Physiology, 16, http://dx.doi.org/10.3389/fphys.2025.1622845

Jeon CY; Ye Y; Papachristou GI; Buxbaum JL; Pisegna JR; Cherpitel CJ; Adeniran EA; Apte M; Chang E; Dasyam AK; Jalluri GD; Lansky CA; Lugea A; Shah ZK; Waldron RT; Pandol SJ; Yadav D, 2025, 'Differential impact of recent heavy drinking on first and recurrent acute pancreatitis', Alcohol Clinical and Experimental Research, 49, pp. 1053 - 1063, http://dx.doi.org/10.1111/acer.70030

Apte M, 2025, 'PDAC: advances in tumour microenvironment, microbiome and AI: Pancreatic cancer in 2024', Nature Reviews Gastroenterology and Hepatology, 22, pp. 96 - 97, http://dx.doi.org/10.1038/s41575-024-01030-y

Porter G; Norris MD; Apte M; Merlot AM, 2025, 'Spatial profiling of endoplasmic reticulum stress markers in tumor associated cells predicts patient outcomes in pancreatic cancer', Neoplasia United States, 60, http://dx.doi.org/10.1016/j.neo.2024.101115

Binang H; Sarkar R; Wong W; Hardikar A; Xu Z; Rajan P; Pirola R; Wilson J; Perera C; Apte M, 2025, 'Tu1376: PICALM IN PANCREATIC STELLATE CELL AND CANCER CELL COCULTURE-DERIVED EXOSOMAL CARGO – MEDIATOR OF PANCREATIC CANCER-RELATED DIABETES?', Gastroenterology, 169, http://dx.doi.org/10.1016/s0016-5085(25)04128-9

Perera CJ; Hosen SZ; Khan T; Fang H; Mekapogu AR; Xu Z; Falasca M; Chari ST; Wilson JS; Pirola R; Greening DW; Apte MV, 2024, 'Proteomic profiling of small extracellular vesicles derived from mouse pancreatic cancer and stellate cells: Role in pancreatic cancer', Proteomics, 24, http://dx.doi.org/10.1002/pmic.202300067

Turner RC; Salomoni S; Neale RE; Neil A; Barreto SG; Ooi CY; Croagh D; Wilson JS; Pang T; Apte M, 2024, 'The epidemiology of acute pancreatitis in Tasmania over a 12-year period: Is this a disease of disadvantage?', Pancreatology, 24, pp. 522 - 527, http://dx.doi.org/10.1016/j.pan.2024.04.010

Apte M, 2023, 'A journey to and with the stars: The pancreatic stellate cell story', Pancreatology, 23, pp. 893 - 899, http://dx.doi.org/10.1016/j.pan.2023.10.024

Sarkar R; Xu Z; Perera CJ; Apte MV, 2023, 'Emerging role of pancreatic stellate cell-derived extracellular vesicles in pancreatic cancer', Seminars in Cancer Biology, 93, pp. 114 - 122, http://dx.doi.org/10.1016/j.semcancer.2023.05.007

Mastracci TL; Apte M; Amundadottir LT; Alvarsson A; Artandi S; Bellin MD; Bernal-Mizrachi E; Caicedo A; Campbell-Thompson M; Cruz-Monserrate Z; Ouaamari AE; Gaulton KJ; Geisz A; Goodarzi MO; Hara M; Hull-Meichle RL; Kleger A; Klein AP; Kopp JL; Kulkarni RN; Muzumdar MD; Naren AP; Oakes SA; Olesen SS; Phelps EA; Powers AC; Stabler CL; Tirkes T; Whitcomb DC; Yadav D; Yong J; Zaghloul NA; Pandol SJ; Sander M, 2023, 'Erratum to: Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings (Diabetes 2023; 72: 433–448)', Diabetes, 72, pp. 1173, http://dx.doi.org/10.2337/db23-er08

Mekapogu AR; Xu Z; Pothula S; Perera C; Pang T; Hosen SMZ; Damalanka V; Janetka J; Goldstein D; Pirola R; Wilson J; Apte M, 2023, 'HGF/c-Met pathway inhibition combined with chemotherapy increases cytotoxic T-cell infiltration and inhibits pancreatic tumour growth and metastasis', Cancer Letters, 568, http://dx.doi.org/10.1016/j.canlet.2023.216286

Binang HB; Perera CJ; Apte MV, 2023, 'Role of Pancreatic Tumour-Derived Exosomes and Their Cargo in Pancreatic Cancer-Related Diabetes', International Journal of Molecular Sciences, 24, pp. 10203, http://dx.doi.org/10.3390/ijms241210203

Mastracci TL; Apte M; Amundadottir LT; Alvarsson A; Artandi S; Bellin MD; Bernal-Mizrachi E; Caicedo A; Campbell-Thompson M; Cruz-Monserrate Z; Ouaamari AE; Gaulton KJ; Geisz A; Goodarzi MO; Hara M; Hull-Meichle RL; Kleger A; Klein AP; Kopp JL; Kulkarni RN; Muzumdar MD; Naren AP; Oakes SA; Olesen SS; Phelps EA; Powers AC; Stabler CL; Tirkes T; Whitcomb DC; Yadav D; Yong J; Zaghloul NA; Pandol SJ; Sander M, 2023, 'Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings', Diabetes, 72, pp. 433 - 448, http://dx.doi.org/10.2337/db22-0942

Hosen SMZ; Uddin MN; Xu Z; Buckley BJ; Perera C; Pang TCY; Mekapogu AR; Moni MA; Notta F; Gallinger S; Pirola R; Wilson J; Ranson M; Goldstein D; Apte M, 2022, 'Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU)', Frontiers in Immunology, 13, http://dx.doi.org/10.3389/fimmu.2022.1060957

Mastracci TL; Apte M; Amundadottir LT; Alvarsson A; Artandi S; Bellin MD; Bernal-Mizrachi E; Caicedo A; Campbell-Thompson M; Cruz-Monserrate Z; El Ouaamari A; Gaulton KJ; Geisz A; Goodarzi MO; Hara M; Hull-Meichle RL; Kleger A; Klein AP; Kopp JL; Kulkarni RN; Muzumdar MD; Naren AP; Oakes SA; Olesen SS; Phelps EA; Powers AC; Stabler CL; Tirkes T; Whitcomb DC; Yadav D; Yong J; Zaghloul NA; Sander M; Pandol SJ, 2022, 'Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings', Pancreas, 51, pp. 1061 - 1073, http://dx.doi.org/10.1097/MPA.0000000000002170

Channon LM; Tyma VM; Xu Z; Greening DW; Wilson JS; Perera CJ; Apte MV, 2022, 'Small extracellular vesicles (exosomes) and their cargo in pancreatic cancer: Key roles in the hallmarks of cancer', Biochimica Et Biophysica Acta Reviews on Cancer, 1877, pp. 188728, http://dx.doi.org/10.1016/j.bbcan.2022.188728

Geleta B; Tout FS; Lim SC; Sahni S; Jansson PJ; Apte MV; Richardson DR; Kovacevic Z, 2022, 'Targeting Wnt/tenascin C-mediated cross talk between pancreatic cancer cells and stellate cells via activation of the metastasis suppressor NDRG1', Journal of Biological Chemistry, 298, http://dx.doi.org/10.1016/j.jbc.2022.101608

Perera CJ; Falasca M; Chari ST; Greenfield JR; Xu Z; Pirola RC; Wilson JS; Apte MV, 2021, 'Role of pancreatic stellate cell-derived exosomes in pancreatic cancer-related diabetes: A novel hypothesis', Cancers, 13, pp. 5224, http://dx.doi.org/10.3390/cancers13205224

Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496

Pang TCY; Xu Z; Mekapogu AR; Pothula S; Becker T; Corley S; Wilkins MR; Goldstein D; Pirola R; Wilson J; Apte M, 2021, 'Hgf/c-met inhibition as adjuvant therapy improves outcomes in an orthotopic mouse model of pancreatic cancer', Cancers, 13, pp. 2763, http://dx.doi.org/10.3390/cancers13112763

Geleta B; Park KC; Jansson PJ; Sahni S; Maleki S; Xu Z; Murakami T; Pajic M; Apte MV; Richardson DR; Kovacevic Z, 2021, 'Breaking the cycle: Targeting of NDRG1 to inhibit bi-directional oncogenic cross-talk between pancreatic cancer and stroma', FASEB Journal, 35, http://dx.doi.org/10.1096/fj.202002279R

Pang TCY; Po JW; Becker TM; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2021, 'Circulating tumour cells in pancreatic cancer: A systematic review and meta-analysis of clinicopathological implications', Pancreatology, 21, pp. 103 - 114, http://dx.doi.org/10.1016/j.pan.2020.11.022

Pothula SP; Xu Z; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'Targeting hgf/c-met axis in pancreatic cancer', International Journal of Molecular Sciences, 21, pp. 1 - 18, http://dx.doi.org/10.3390/ijms21239170

Xu Z; Pothula S; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'Reply letter to comments on: Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis', British Journal of Cancer, 123, pp. 1466, http://dx.doi.org/10.1038/s41416-020-1004-6

Santoso F, 2020, 'Message from rector', ACM International Conference Proceeding Series

Pang TCY; Xu Z; Mekapogu AR; Pothula S; Becker TM; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'An Orthotopic Resectional Mouse Model of Pancreatic Cancer', Journal of Visualized Experiments, http://dx.doi.org/10.3791/61726-v

Pang TCY; Xu Z; Mekapogu AR; Pothula S; Becker TM; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'An orthotopic resectional mouse model of pancreatic cancer', Journal of Visualized Experiments, 2020, pp. 1 - 13, http://dx.doi.org/10.3791/61726

Xu Z; Pang TCY; Liu AC; Pothula SP; Mekapogu AR; Perera CJ; Murakami T; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis', British Journal of Cancer, 122, pp. 1486 - 1495, http://dx.doi.org/10.1038/s41416-020-0782-1

Williams JA; Groblewski GE; Gorelick FS; Mayerle J; Apte M; Gukovskaya AS, 2020, 'American Pancreatic Association Frank Brooks Symposium: Fifty Years of Pancreatic Cell Biology', Pancreas, 49, pp. 604 - 611, http://dx.doi.org/10.1097/MPA.0000000000001543

Pothula SP; Pirola RC; Wilson JS; Apte MV, 2020, 'Pancreatic stellate cells: Aiding and abetting pancreatic cancer progression', Pancreatology, 20, pp. 409 - 418, http://dx.doi.org/10.1016/j.pan.2020.01.003

Perera C; Xu Z; Mekapogu AR; Hosen SMZ; Pothula S; Greenfield J; Chari S; Goldstein D; Pirola R; Wilson J; Apte MV, 2020, '1133 PANCREATIC STELLATE CELL AND CANCER CELL DERIVED EXOSOMES IMPAIR BETA CELL FUNCTION: IMPLICATIONS FOR PANCREATIC CANCER RELATED DIABETES.', Gastroenterology, 158, pp. S - 221, http://dx.doi.org/10.1016/s0016-5085(20)31245-2

Zhu L; Dillon DL; Xu Z; Wightman CJ; Pirola R; Wilson J; Gukovskaya A; Apte MV; Mareninova OA, 2020, 'Mo1371 INFLAMMATORY RESPONSE IN EXPERIMENTAL PANCREATITIS INDUCED BY ALCOHOL AND CIGARETTE SMOKE IS MEDIATED THROUGH ROS-STAT3-P62 SIGNALING PATHWAY', Gastroenterology, 158, pp. S - 867, http://dx.doi.org/10.1016/s0016-5085(20)32848-1

Mekapogu AR; Pothula SP; Pirola RC; Wilson JS; Apte MV, 2019, 'Multifunctional role of pancreatic stellate cells in pancreatic cancer', Annals of Pancreatic Cancer, 2, http://dx.doi.org/10.21037/apc.2019.05.02

Neuzillet C; Tijeras-Raballand A; Ragulan C; Cros J; Patil Y; Martinet M; Erkan M; Kleeff J; Wilson J; Apte M; Tosolini M; Wilson AS; Delvecchio FR; Bousquet C; Paradis V; Hammel P; Sadanandam A; Kocher HM, 2019, 'Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma', Journal of Pathology, 248, pp. 51 - 65, http://dx.doi.org/10.1002/path.5224

Apte M, 2018, 'Message from editor', Pancreatology, 18, pp. vii - viii, http://dx.doi.org/10.1016/S1424-3903(18)30749-X

Buckley BJ; Aboelela A; Minaei E; Jiang LX; Xu Z; Ali U; Fildes K; Cheung CY; Cook SM; Johnson DC; Bachovchin DA; Cook GM; Apte M; Huang M; Ranson M; Kelso MJ, 2018, '6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer', Journal of Medicinal Chemistry, 61, pp. 8299 - 8320, http://dx.doi.org/10.1021/acs.jmedchem.8b00838

Pang T; Xu Z; Pothula S; Yang MH; Becker T; Goldstein D; Heeschen C; Pirola R; Wilson J; Apte MV, 2018, '517 - World-First Identification of Circulating Pancreatic Stellate Cells in Metastatic Pancreatic Cancer', Gastroenterology, 154, pp. S - 114, http://dx.doi.org/10.1016/s0016-5085(18)30816-3

Minoti Apte , 2018, 'Message from the editor', Pancreatology, 18, pp. vii - vii, http://dx.doi.org/10.1016/s1424-3903(18)30005-x

Lugea A; Gerloff A; Su HY; Xu Z; Go A; Hu C; French SW; Wilson JS; Apte MV; Waldron RT; Pandol SJ, 2017, 'The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells', Gastroenterology, 153, pp. 1674 - 1686, http://dx.doi.org/10.1053/j.gastro.2017.08.036

Pang TCY; Wilson JS; Apte MV, 2017, 'Pancreatic stellate cells: What's new?', Current Opinion in Gastroenterology, 33, pp. 366 - 373, http://dx.doi.org/10.1097/MOG.0000000000000378

Pang TCY; Xu Z; Pothula S; Becker T; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2017, 'Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research', Carcinogenesis, 38, pp. 588 - 591, http://dx.doi.org/10.1093/carcin/bgx030

Pothula SP; Xu Z; Goldstein D; Merrett N; Pirola RC; Wilson JS; Apte MV, 2017, 'Targeting the HGF/c-MET pathway: Stromal remodelling in pancreatic cancer', Oncotarget, 8, pp. 76722 - 76739, http://dx.doi.org/10.18632/oncotarget.20822

Apte MV; Wilson JS, 2016, 'Pancreatic cancer: A multipronged approach to pancreatic cancer treatment', Nature Reviews Gastroenterology and Hepatology, 13, pp. 385 - 387, http://dx.doi.org/10.1038/nrgastro.2016.75

Kleeff J; Korc M; Apte M; La Vecchia C; Johnson CD; Biankin AV; Neale RE; Tempero M; Tuveson DA; Hruban RH; Neoptolemos JP, 2016, 'Pancreatic cancer', Nature Reviews Disease Primers, 2, pp. 16022, http://dx.doi.org/10.1038/nrdp.2016.22

Pinho AV; Apte MV; Wilson JS; Rooman I, 2016, 'Role of the microenvironment in chronic pancreatitis and pancreatic cancer', Cancer Forum, 40, pp. 11 - 15

Pothula SP; Xu Z; Goldstein D; Biankin AV; Pirola RC; Wilson JS; Apte MV, 2016, 'Hepatocyte growth factor inhibition: A novel therapeutic approach in pancreatic cancer', British Journal of Cancer, 114, pp. 269 - 280, http://dx.doi.org/10.1038/bjc.2015.478

Pothula SP; Xu Z; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2016, 'Key role of pancreatic stellate cells in pancreatic cancer', Cancer Letters, http://dx.doi.org/10.1016/j.canlet.2015.10.035

Apte M, 2016, 'Message from the editor', Pancreatology, 16, pp. viii - ix, http://dx.doi.org/10.1016/S1424-3903(16)00024-7

Wilson J; Pirola R; Apte M, 2016, 'Alcoholic pancreatitis in the modern era', Hamdan Medical Journal, 9, pp. 297 - 297, http://dx.doi.org/10.7707/hmj.689

Lee ATK; Xu Z; Pothula SP; Patel MB; Pirola RC; Wilson JS; Apte MV, 2015, 'Alcohol and Cigarette Smoke Components Activate Human Pancreatic Stellate Cells: Implications for the Progression of Chronic Pancreatitis', Alcoholism Clinical and Experimental Research, 39, pp. 2123 - 2133, http://dx.doi.org/10.1111/acer.12882

Back to profile page