By Professor Christopher John Ormandy

Journal articles

Lee H; Ormandy CJ, 2012, 'Interplay between progesterone and prolactin in mammary development and implications for breast cancer', Molecular and Cellular Endocrinology, 357, pp. 101 - 107, http://dx.doi.org/10.1016/j.mce.2011.09.020

Lo JCY; Jamsai D; O'connor A; Borg C; Clark B; Whisstock J; Field M; Adams V; Ishikawa T; Aitken R; Whittle B; Goodnow CC; Ormandy CJ; O'bryan M, 2012, 'RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly', PLoS Genetics, 8, pp. e1002969, http://dx.doi.org/10.1371/journal.pgen.1002969

O'Toole S; Machalek DA; Shearer R; Millar E; Nair R; Schofield PR; McLeod D; Cooper CE; Mcneil CM; Mcfarland A; Nguyen A; Ormandy CJ; Qiu M; Rabinovich B; Martelotto L; Vu D; Hannigan GE; Musgrove EA; Christ DU; Sutherland RL; Watkins DJ; Swarbrick A, 2011, 'Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer', Cancer research, 71, pp. 4002 - 4014, http://dx.doi.org/10.1158/0008-5472.CAN-10-3738

Lee HJ; Hinshelwood R; Bouras T; Gallego-Ortega D; Valdes-Mora F; Blazek K; Visvader JE; Clark SJ; Ormandy CJ, 2011, 'Lineage specific methylation of the Elf5 promoter in mammary epithelial cells', Stem Cells, 29, pp. 1611 - 1619, http://dx.doi.org/10.1002/stem.706

Jamsai D; Smith SJ; O'Connor AE; Merriner DJ; Borg C; Clark B; Adams V; Ormandy CJ; O'Bryan MK, 2010, '169. THE MECHANISM OF SPERMATID MATURATION - A LINK TO TUMOUR SUPPRESSION', Reproduction, Fertility and Development, 22, pp. 87 - 87, http://dx.doi.org/10.1071/srb10abs169

Bhandari M; Thomas A; Hussey DJ; Xin L; Jaya SP; Woods C; Schloithe AC; Mayne GC; Carati CJ; Toouli J; Ormandy CJ; Saccone GTP, 2010, 'Galanin mediates the pathogenesis of cerulein-induced acute pancreatitis in the mouse', Pancreas, 39, pp. 182 - 187, http://dx.doi.org/10.1097/MPA.0b013e3181bdc152

Zardawi SJ; Zardawi I; Mcneil CM; Millar E; Mcleod D; Morey AL; Crea P; Murphy NC; Pinese M; Lopez-Knowles E; Oakes SR; Ormandy CJ; Qiu MR; Hamilton A; Spillane AJ; Lee CS; Sutherland RL; Musgrove EA; O'Toole S, 2010, 'High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype', Histopathology, 56, pp. 286 - 296, http://dx.doi.org/10.1111/j.1365-2559.2009.03475.x

Menzies KK; Lee HJ; Lefevre C; Ormandy CJ; Macmillan KL; Nicholas KR, 2010, 'Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants', Functional and Integrative Genomics, 10, pp. 87 - 95, http://dx.doi.org/10.1007/s10142-009-0140-0

Schramek D; Leibbrandt A; Sigl V; Kenner L; Pospisilik JA; Lee HJ; Hanada R; Joshi PA; Aliprantis A; Glimcher L; Pasparakis M; Khokha R; Ormandy CJ; Widschwendter M; Schett G; Penninger JM, 2010, 'Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer', Nature, 468, pp. 98 - 102

Chan C; Liu X; Ensslin MA; Dillehay DL; Ormandy CJ; Sohn P; Serra R; Ye K, 2010, 'PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development', European Molecular Biology Organization, 29, pp. 956 - 968, http://dx.doi.org/10.1038/emboj.2009.406

Alles MC; Gardiner-Garden M; Nott DJ; Foekens J; Wang Y; Sutherland RL; Musgrove EA; Ormandy CJ, 2009, 'Meta-analysis and gene set enrichment relative to ER status reveal elevated activity of MYC and E2F in the `Basal` breast cancer subgroup', PLoS One, 4

Musgrove EA; Sergio CM; Anderson LR; Inman CK; Mcneil CM; Alles MC; Gardiner-Garden M; Ormandy CJ; Butt A; Sutherland RL, 2008, 'Identification of downstream targets of estrogen and c-myc in breast cancer cells', , pp. 445 - 451

Musgrove EA; Sergio CM; Loi S; Inman CK; Anderson LR; Alles MC; Pinese M; Caldon CE; Schutte J; Gardiner-Garden M; Ormandy CJ; McArthur G; Butt A; Sutherland RL, 2008, 'Identification of functional networks of estrogen-and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer', PLoS One, 3, pp. 2987 - 2995

Hilton HN; Stanford PM; Harris J; Oakes SR; Kaplan W; Daly RJ; Ormandy CJ, 2008, 'KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling', Biochimica et Biophysica ACTA - Molecular Cell Research, 1783, pp. 383 - 393, http://dx.doi.org/10.1016/j.bbamcr.2007.12.007

Oakes SR; Rogers R; Naylor MJ; Ormandy CJ, 2008, 'Prolactin regulation of mammary gland development', Journal of Mammary Gland Biology and Neoplasia, 13, pp. 13 - 28, http://dx.doi.org/10.1007/s10911-008-9069-5

Oakes SR; Naylor MJ; Asselin-Labat M; Blazek K; Gardiner-Garden M; Hilton HN; Kazlauskas M; Pritchard M; Chodosh L; Pfeffer P; Lindeman GJ; Visvader J; Ormandy CJ, 2008, 'The Ets transcription factor Elf5 specifies mammary alveolar cell fate', Genes and Development, 22, pp. 581 - 586, http://dx.doi.org/10.1101/gad.1614608

Ramanathan P; Martin I; Gardiner-Garden M; Thomson P; Taylor R; Ormandy CJ; Moran C; Williamson P, 2008, 'Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 mice', BMC Genomics, 9, pp. 1 - 13, http://dx.doi.org/10.1186/1471-2164-9-197

Naylor MJ; Ormandy CJ, 2007, 'Gata-3 and mammary cell fate', Breast Cancer Research, 9

Oakes SR; Robertson FG; Kench JG; Gardiner-Garden M; Wand MP; Green JE; Ormandy CJ, 2007, 'Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions', Oncogene, 26, pp. 543 - 553

McNeil CM; Sergio CM; Anderson LR; Inman CK; Eggleton SA; Murphy NC; Millar EKA; Crea P; Kench JG; Alles MC; Gardiner-Garden M; Ormandy CJ; Butt AJ; Henshall SM; Musgrove EA; Sutherland RL, 2006, 'c-Myc overexpression and endocrine resistance in breast cancer', Journal of Steroid Biochemistry and Molecular Biology, 102, pp. 147 - 155, http://dx.doi.org/10.1016/j.jsbmb.2006.09.028

Mcneil CM; Anderson LR; Inman CK; Eggleton SA; Murphy NC; Millar E; Crea P; Kench JG; Alles MC; Gardiner-Garden M; Ormandy CJ; Butt A; Henshall SM; Musgrove EA; Sutherland RL; Sergio CM, 2006, 'c-Myc overexpression and endocrine resistance in breast cancer', Journal of Steroid Biochemistry and Molecular Biology, 18, pp. 284 - 289

Oakes SR; Hilton HN; Ormandy CJ, 2006, 'Key stages in mammary gland development - The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium', Breast Cancer Research, 8

Craven AJ; Nixon AJ; Ashby MG; Ormandy CJ; Blazek K; Wilkins RJ; Pearson AJ, 2006, 'Prolactin delays hair regrowth in mice', Journal of Endocrinology, 191, pp. 415 - 425

Harris J; Stanford PM; Sutherland K; Oakes SR; Naylor MJ; Robertson F; Blazek K; Kazlauskas M; Hilton HN; Wittlin S; Alexander WS; Lindeman GJ; Visvader J; Ormandy CJ, 2006, 'Socs2 and Elf5 mediate prolactin-induced mammary gland development', Molecular Endocrinology, 20, pp. 1177 - 1187

Ormandy C; Goffin V, 2005, 'Cancer', Drug Discovery Today Disease Models, 2, http://dx.doi.org/10.1016/j.ddmod.2005.05.022

Menzies KK; Macmillan KL; Nicholas KR; Lefevre C; Ormandy C, 2005, '281. The role of insulin in milk protein synthesis', Reproduction, Fertility and Development, 17, pp. 117 - 117, http://dx.doi.org/10.1071/srb05abs281

Zhou J; Chehab R; Tkalcevic J; Naylor MJ; Harris J; Wilson T; Tsao S; Tellis I; Zavarsek S; Xu D; Lapinskas E; Visvader J; Lindeman GJ; Thomas R; Ormandy CJ; Hertzog P; Kola I; Pritchard M, 2005, 'Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation', European Molecular Biology Organization, 24, pp. 635 - 644

Nilsson L; Binart N; Bohlooly-Y M; Bramnert M; Egecioglu E; Kindblom J; Kelly PA; Kopchick J; Ormandy CJ; Ling C; Billig H, 2005, 'Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue', Biochemical and Biophysical Research Communications, 331, pp. 1120 - 1126, http://www.sciencedirect.com/science/article/B6WBK-4FYGBBM-1/2/53f2f3ba0a766cd5714b305e659026fd

Ormandy CJ, 2005, 'Review of: Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone', Breast Cancer Online, 8, http://dx.doi.org/10.1017/s1470903105004475

Naylor MJ; Oakes SR; Gardiner-Garden M; Harris J; Blazek K; Ho TW; Li F; Wynick D; Walker AM; Ormandy CJ, 2005, 'Transcriptional changes underlying the secretory activation phase of mammary gland development', Molecular Endocrinology, 19, pp. 1868 - 1883

Saunders DN; Hird SL; Withington SL; Dunwoodie SL; Henderson MJ; Biben C; Sutherland RL; Ormandy CJ; Watts CKW, 2004, 'Erratum: Edd, the murine ortholog of the hyperplastic discs (hyd) gene, is essential for yolk sac vascularization and chorioallantoic fusion (Molecular and Cellular Biology (2004) 24: 16 (7225-7234))', Molecular and Cellular Biology, 24, pp. 9262, http://dx.doi.org/10.1128/MCB.24.20.9262.2004

Saunders DN; Hird S; Withington SL; Dunwoodie SL; Henderson M; Biben C; Sutherland RL; Ormandy CJ; Watts CK, 2004, 'Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion', Molecular and Cellular Biology, 24, pp. 7225 - 7234, http://dx.doi.org/10.1128/MCB.24.16.7225-7234.2004

Cooney GJ; Lyons RJ; Crew A; Jensen T; Molero JC; Mitchell CJ; Biden TJ; Ormandy CJ; James DE; Daly et A, 2004, 'Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice', EMBO Journal, 23, pp. 582 - 593, http://www.sciencedirect.com/science/article/B6WVB-4C6S53N-1D7/2/8969638193550a0dce7725a099aba822

Harris J; Stanford PM; Oakes SR; Ormandy CJ, 2004, 'Prolactin and the prolactin receptor: new targets of an old hormone', Annals of Medicine, 36, pp. 414 - 425, http://www.sciencedirect.com/science/article/B6WVB-4DPTTDJ-115/2/64c9f2829ad0aa962efbb9ba7f7f6f0c

Musgrove EA; Davison EA; Ormandy CJ, 2004, 'Role of the CDK Inhibitor p27 (Kip1) in Mammary Development and Carcinogenesis: Insights from Knockout Mice', Journal of Mammary Gland Biology and Neoplasia, 9, pp. 55 - 66, http://www.sciencedirect.com/science/article/B6WVB-4C82RMK-3D1/2/72b5e4398e846ea1a8f5ab7fa97d561a

Ormandy CJ; Musgrove EA; Hui R; Daly RJ; Sutherland RL, 2003, 'Cyclin D1, EMS1 and 11q13 amplication in breast cancer', Breast Cancer Research and Treatment, 78, pp. 323 - 335

Hovey RC; Harris J; Hadsell DL; Lee A; Ormandy CJ; Vonderhaar BK, 2003, 'Local insulin-like growth factor-II mediates prolactin-induced mammary gland development', Molecular Endocrinology, 17, pp. 460 - 471

Naylor MJ; Lockerfeer JA; Horseman NJ; Ormandy CJ, 2003, 'Prolactin regulates mammary epithelial cell proliferation via autocrine/paracrine mechanism', Endocrine, 20, pp. 111 - 114

Robertson F; Harris J; Naylor MJ; Oakes S; Kindblom J; Dillner K; Wennbo H; Tornell J; Kelly PA; Green J; Ormandy CJ, 2003, 'Prostate development and carcinogenesis in prolactin receptor knockout mice', Endocrinology, 144, pp. 3196 - 3205

Kindblom J; Dillner K; Sahlin L; Robertson F; Ormandy CJ; Tornell J; Wennbo H, 2003, 'Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin', Endocrinology, 144, pp. 2269 - 2278

Davison EA; Lee CM; Naylor MJ; Oakes SR; Sutherland RL; Henninghausen L; Ormandy CJ; Musgrove EA, 2003, 'The Cyclin-Dependent Kinase inhibitor p27 (Kip1) regulates both DNA synthesis and apoptosis in mammary epithelium but is not required for its functional development during pregnancy.', Molecular Endocrinology, 17, pp. 2436 - 2447

Naylor MJ; Ginsburg E; Iismaa T; Vonderhaar BK; Wynick D; Ormandy CJ, 2003, 'The neuropeptide galanin augments lobuloalveolar development', The Journal of Biological Chemistry, 278, pp. 29145 - 29152

Gass S; Harris J; Ormandy CJ; Brisken C, 2003, 'Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function', Journal of Mammary Gland Biology and Neoplasia, 8, pp. 269 - 285

Grimm SL; Seagroves TN; Kabotyanski EB; Hovey RC; Vonderhaar BK; Lydon JP; Miyoshi K; Hennighausen L; Ormandy CJ; Lee AV; Stull MA; Wood TL; Rosen JM, 2002, 'Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development', Molecular Endocrinology, 16, pp. 2675 - 2691, http://dx.doi.org/10.1210/me.2002-0239

Kelly PA; Bachelot A; Kedzia C; Hennighausen L; Ormandy CJ; Kopchick JJ; Binart N, 2002, 'The role of prolactin and growth hormone in mammary gland development', Molecular and Cellular Endocrinology, 197, pp. 127 - 131, http://dx.doi.org/10.1016/S0303-7207(02)00286-1

Naylor MJ; Ormandy CJ, 2002, 'Mouse strain-specific patterns of mammary epithelial ductal side branching are elicited by stromal factors', Developmental Dynamics, 225, pp. 100 - 105, http://dx.doi.org/10.1002/dvdy.10133

Sainsbury A; Schwarzer C; Couzens M; Jenkins A; Oakes SR; Ormandy CJ; Herzog H, 2002, 'Y4 receptor knockout rescues fertility in ob/ob mice', Genes and Development, 16, pp. 1077 - 1088, http://dx.doi.org/10.1101/gad.979102

Craven AJ; Ormandy CJ; Robertson FG; Wilkins RJ; Kelly PA; Nixon AJ; Pearson AJ, 2001, 'Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice*', Endocrinology, 142, pp. 2533 - 2539, http://dx.doi.org/10.1210/endo.142.6.8179

McClellan KA; Robertson FG; Kindblom J; Wennbo H; Tornell J; Bouchard B; Kelly PA; Ormandy CJ, 2001, 'Investigation of the role of prolactin in the development and function of the lacrimal and Harderian glands using genetically modified mice', Investigative Ophthalmology and Visual Science, pp. 23 - 30

Craven AJ; Ormandy CJ; Robertson FG; Wilkins RJ; Kelly PA; Nixon AJ; Pearson AJ, 2001, 'Prolactin signaling influences the timing mechanism of the hair follicle: analysis of molting cycles in prolactin receptor knockout mice.', Endocrinology, 142, pp. 2533 - 2539

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