By Dr John Walter Frew

Journal articles

Grand D; Navrazhina K; Frew JW, 2020, 'Integrating complement into the molecular pathogenesis of Hidradenitis Suppurativa', Experimental Dermatology, 29, pp. 86 - 92, http://dx.doi.org/10.1111/exd.14056

Garcet S; Frew JW; Navrazhina K; Krueger J, 2020, '062 Hidradenitis suppurativa RNA-seq skin transcriptome overlaps with psoriasis vulgaris and reveals a marked upregulation of multiple targetable cytokines', Journal of Investigative Dermatology, 140, pp. S7 - S7, http://dx.doi.org/10.1016/j.jid.2020.03.064

Navrazhina K; Frew JW; Grand D; Sullivan-Whalen MM; Gilleaudeau P; Krueger JG, 2020, '14928 Epithelialized tracts are active mediators of inflammation in hidradenitis suppurativa', Journal of the American Academy of Dermatology, 83, pp. AB24 - AB24, http://dx.doi.org/10.1016/j.jaad.2020.06.184

Grand D; Frew JW; Navrazhina K; Krueger J, 2020, '520 Establishing the analytical and clinical validity of sonographic biomarkers in hidradenitis suppurativa', Journal of Investigative Dermatology, 140, pp. S71 - S71, http://dx.doi.org/10.1016/j.jid.2020.03.529

Navrazhina K; Frew JW; Gulati N; Grand D; Garcet S; Mitsui H; Krueger JG, 2020, '703 Laser Capture Microdissection and genetic analysis identify dysplastic nevi as a subgroup of common nevi rather than a progressive state towards melanoma', Journal of Investigative Dermatology, 140, pp. S94 - S94, http://dx.doi.org/10.1016/j.jid.2020.03.715

Frew JW; Navrazhina K; Garcet S; Krueger J, 2020, '880 Targeted IL-17RA antagonism ameliorates histological and transcriptomic features of hidradenitis suppurativa: A proof of concept study', Journal of Investigative Dermatology, 140, pp. S115 - S115, http://dx.doi.org/10.1016/j.jid.2020.03.896

Jiang XY; Atkinson S; Pearson R; Leaning D; Cumming S; Burns A; Azzabi A; Frew J; McMenemin R; Pedley ID, 2020, 'Optimising Radium 223 Therapy for Metastatic Castration-Resistant Prostate Cancer-5-year Real-World Outcome: Focusing on Treatment Sequence and Quality of Life', CLINICAL ONCOLOGY, 32, pp. E177 - E187, http://dx.doi.org/10.1016/j.clon.2020.05.002

Frew JW; Navrazhina K; Byrd AS; Garg A; Ingram JR; Kirby JS; Lowes MA; Naik H; Piguet V; Prens EP, 2019, 'Defining lesional, perilesional and unaffected skin in hidradenitis suppurativa: proposed recommendations for clinical trials and translational research studies', British Journal of Dermatology, 181, pp. 1339 - 1341, http://dx.doi.org/10.1111/bjd.18309

Frew J; Wu X; Hsiung GY; Feldman HH; Mackenzie IR; Nygaard HB, 2019, 'Generation of an induced pluripotent stem cell line (UBCi001-A) from a presymptomatic individual carrying the R418X progranulin gene mutation', STEM CELL RESEARCH, 41, http://dx.doi.org/10.1016/j.scr.2019.101582

Frew JW; Navrazhina K, 2019, 'Into the (gluteal) fold: pilonidal disease and hidradenitis suppurativa – association or continuum?', British Journal of Dermatology, 181, pp. 1121, http://dx.doi.org/10.1111/bjd.18300

Byrd AS; Dina Y; Okoh UJ; Quartey QQ; Carmona-Rivera C; Williams DW; Kerns ML; Miller RJ; Petukhova L; Naik HB; Barnes LA; Shipman WD; Caffrey JA; Sacks JM; Milner SM; Aliu O; Broderick KP; Kim D; Liu H; Dillen CA; Ahn R; Frew JW; Kaplan MJ; Kang S; Garza LA; Miller LS; Alavi A; Lowes MA; Okoye GA, 2019, 'Specimen Collection for Translational Studies in Hidradenitis Suppurativa', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-48226-w

Grand D; Navrazhina K; Frew JW, 2019, 'A Scoping Review of Non-invasive Imaging Modalities in Dermatological Disease: Potential Novel Biomarkers in Hidradenitis Suppurativa', Frontiers in Medicine, 6, pp. 253, http://dx.doi.org/10.3389/fmed.2019.00253

FREW J; MURRELL DF, 2019, 'Improving clinical applications of quality of life scores in epidermolysis bullosa: defining clinically significant outcomes in the QOLEB questionnaire', Mucosa, 2, pp. 68 - 75, http://dx.doi.org/10.33204/mucosa.598339

Frew JW; Navrazhina K, 2019, 'In silico Analysis of Gamma-Secretase-Complex Mutations in Hidradenitis Suppurativa Demonstrates Disease-Specific Substrate Recognition and Cleavage Alterations', Frontiers in Medicine, 6, http://dx.doi.org/10.3389/fmed.2019.00206

Frew JW; Hawkes JE; Sullivan-Whalen M; Gilleaudeau P; Krueger JG, 2019, 'Inter-rater reliability of phenotypes and exploratory genotype–phenotype analysis in inherited hidradenitis suppurativa', British Journal of Dermatology, 181, pp. 566 - 571, http://dx.doi.org/10.1111/bjd.17695

Tatiane A; Slape D; Lawless R; Frew JW, 2019, 'A systematic review of reported cases of pachyonychia congenita tarda', Clinical and Experimental Dermatology, 44, pp. 606 - 612, http://dx.doi.org/10.1111/ced.13980

Frew JW, 2019, 'Assessing the efficacy of new biologic therapies in hidradenitis suppurativa: consistency vs. bias in outcome measures in moderate and severe disease', Journal of the European Academy of Dermatology and Venereology, 33, pp. e298 - e300, http://dx.doi.org/10.1111/jdv.15572

Frew JW; Navrazhina K; Marohn M; Lu PJC; Krueger JG, 2019, 'Contribution of fibroblasts to tunnel formation and inflammation in hidradenitis suppurativa/ acne inversa', Experimental Dermatology, 28, pp. 886 - 891, http://dx.doi.org/10.1111/exd.13978

Scarisbrick JJ; Quaglino P; Prince HM; Papadavid E; Hodak E; Bagot M; Servitje O; Berti E; Ortiz-Romero P; Stadler R; Patsatsi A; Knobler R; Guenova E; Child F; Whittaker S; Nikolaou V; Tomasini C; Amitay I; Naveh HP; Ram-Wolff C; Battistella M; Alberti-Violetti S; Stranzenbach R; Gargallo V; Muniesa C; Koletsa T; Jonak C; Porkert S; Mitteldorf C; Estrach T; Combalia A; Marschalko M; Csomor J; Szepesi A; Cozzio A; Dummer R; Pimpinelli N; Grandi V; Beylot-Barry M; Pham-Ledard A; Wobser M; Geissinger E; Wehkamp U; Weichenthal M; Cowan R; Parry E; Harris J; Wachsmuth R; Turner D; Bates A; Healy E; Trautinger F; Latzka J; Yoo J; Vydianath B; Amel-Kashipaz R; Marinos L; Oikonomidi A; Stratigos A; Vignon-Pennamen M-D; Climent F; Gonzalez-Barca E; Georgiou E; Senetta R; Zinzani P; Vakeva L; Ranki A; Busschots A-M; Hauben E; Bervoets A; Woei-A-Jin FJSH; Matin R; Collins G; Weatherhead S; Frew J; Bayne M; Dunnill G; McKay P; Arumainathan A; Azurdia R; Benstead K; Twigger R; Rieger K; Brown R; Sanchez JA; Miyashiro D; Akilov O; McCann S; Sahi H; Damasco M; Querfeld C; Folkes A; Bur C; Klemke C-D; Enz P; Pujol R; Quint K; Geskin L; Hong E; Evison F; Vermeer M; Cerroni L; Kempf W; Kim Y; Willemze R, 2019, 'The PROCLIPI international registry of early-stage mycosis fungoides identifies substantial diagnostic delay in most patients', BRITISH JOURNAL OF DERMATOLOGY, 181, pp. 350 - 357, http://dx.doi.org/10.1111/bjd.17258

Frew JW, 2019, 'Lack of photographic documentation undermines assessment of hidradenitis suppurativa phenotypes: reply from the author', British Journal of Dermatology, 181, pp. 225, http://dx.doi.org/10.1111/bjd.17934

Frew JW, 2019, 'Hidradenitis suppurativa and diabetes: big data bias masks a true association', Clinical and Experimental Dermatology, 44, pp. e151 - e152, http://dx.doi.org/10.1111/ced.13954

Slape D; Tang J; Lawless R; McCrossin I; Frew JW, 2019, 'A retrospective cohort study of melanoma prevalence stratified by body site in a Regional Australian Population 1994-2017: Site-specific protective mechanisms', Photodermatology Photoimmunology and Photomedicine, 35, pp. 135 - 140, http://dx.doi.org/10.1111/phpp.12436

Frew JW, 2019, 'Complement, hidradenitis suppurativa and pathogen-driven positive selection', British Journal of Dermatology, 180, pp. 685 - 686, http://dx.doi.org/10.1111/bjd.17426

Dearnaley D; Griffin CL; Lewis R; Mayles P; Mayles H; Naismith OF; Harris V; Scrase CD; Staffurth J; Syndikus I; Zarkar A; Ford DR; Rimmer YL; Horan G; Khoo V; Frew J; Venkitaraman R; Hall E, 2019, 'Toxicity and Patient-Reported Outcomes of a Phase 2 Randomized Trial of Prostate and Pelvic Lymph Node Versus Prostate only Radiotherapy in Advanced Localised Prostate Cancer (PIVOTAL)', INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 103, pp. 605 - 617, http://dx.doi.org/10.1016/j.ijrobp.2018.10.003

Frew JW, 2019, 'Commentary: Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2019.00302

Frew JW, 2019, 'We need to talk about Notch: Notch dysregulation as an epiphenomenon in inflammatory skin disease', British Journal of Dermatology, 180, pp. 431 - 432, http://dx.doi.org/10.1111/bjd.17414

Frew JW; Hawkes JE; Krueger JG, 2019, 'A systematic review and critical evaluation of immunohistochemical associations in hidradenitis suppurativa [version 2; peer review: 2 approved]', F1000Research, 7, http://dx.doi.org/10.12688/f1000research.17268.2

Frew JW, 2019, 'Commentary: Hidradenitis Commentary: Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory pathways into a cohensive pathogenic model', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2018.02965

Venning V; Yhao E; Huynh E; Frew JW, 2019, 'Cutaneous neonatal Langerhans cell histiocytosis: A systematic review of case reports [version 1; peer review: 1 approved with reservations, 1 not approved]', F1000Research, 8, http://dx.doi.org/10.12688/F1000RESEARCH.17664.1

Shavit E; Alavi A; Bechara FG; Bennett RG; Bourcier M; Cibotti R; Daveluy S; Frew JW; Garg A; Hamzavi I; Hoffman LK; Hsaio J; Kirby JS; Lev-Tov H; Martinez E; Micheletti R; Naik HB; Nassif A; Nicholson C; Parks-Miller A; Patel Z; Piguet V; Ramesh M; Resnik B; Sayed C; Schultz G; Siddiqui A; Tan J; Wortsman X; Lowes MA, 2019, 'Proceeding report of the Second Symposium on Hidradenitis Suppurativa Advances (SHSA) 2017', Experimental Dermatology, 28, pp. 94 - 103, http://dx.doi.org/10.1111/exd.13849

Frew JW, 2019, 'The hygiene hypothesis, old friends, and new genes', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2019.00388

Frew JW; Hawkes JE; Krueger JG, 2019, 'Topical, systemic and biologic therapies in hidradenitis suppurativa: pathogenic insights by examining therapeutic mechanisms', Therapeutic Advances in Chronic Disease, 10, http://dx.doi.org/10.1177/2040622319830646

Brand DH; Tree AC; Ostler P; van der Voet H; Loblaw A; Chu W; Ford D; Tolan S; Jain S; Martin A; Staffurth J; Camilleri P; Kancherla K; Frew J; Chan A; Dayes IS; Henderson D; Brown S; Cruickshank C; Burnett S; Duffton A; Griffin C; Hinder V; Morrison K; Naismith O; Hall E; van As N, 2019, 'Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial', LANCET ONCOLOGY, 20, pp. 1531 - 1543, http://dx.doi.org/10.1016/S1470-2045(19)30569-8

Frew J; Hawkes J; Krueger J, 2018, 'A systematic review and critical evaluation of immunohistochemical associations in hidradenitis suppurativa', F1000Research, 7, http://dx.doi.org/10.12688/f1000research.17268.1

Vekic DA; Frew J; Cains GD, 2018, 'Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 1', Australasian Journal of Dermatology, 59, pp. 267 - 277, http://dx.doi.org/10.1111/ajd.12770

Frew JW, 2018, 'New therapeutics for itch in dermatomyositis', British Journal of Dermatology, 179, pp. 559 - 560, http://dx.doi.org/10.1111/bjd.16811

Kim E; McCrossin I; Frew JW, 2018, 'HLA-B*1502 haplotype screening prior to carbamazepine administration in individuals of south-east Asian ancestry nears cost-effectiveness in preventing severe cutaneous adverse drug reactions', Australasian Journal of Dermatology, 59, pp. 245 - 246, http://dx.doi.org/10.1111/ajd.12754

Vekic DA; Frew JW, 2018, 'Pharmaceutical Benefits Scheme listing of adalimumab for hidradenitis suppurativa: Is hidradenitis suppurativa a life-changing drug or does lifestyle change the drug?', Australasian Journal of Dermatology, 59, pp. e243 - e244, http://dx.doi.org/10.1111/ajd.12767

Wain T; Choy B; Satchell AC; Woods JA; Frew JW, 2018, 'Secukinumab in pityriasis rubra pilaris: A case series demonstrating variable response and the need for minimal clinical datasets', Jaad Case Reports, 4, pp. 500 - 505, http://dx.doi.org/10.1016/j.jdcr.2018.02.007

Frew JW, 2018, 'Quality-of-Life Measures in Hidradenitis Suppurativa: The Importance of High-Quality Methodology and Standards', Journal of Cutaneous Medicine and Surgery, 22, pp. 368 - 368, http://dx.doi.org/10.1177/1203475418756372

Frew JW; Anstey A, 2018, 'BJD research letters: concise, thought provoking and of general interest', British Journal of Dermatology, 178, pp. 309 - 310, http://dx.doi.org/10.1111/bjd.16162

Frew JW; Hawkes JE; Krueger JG, 2018, 'A systematic review and critical evaluation of inflammatory cytokine associations in hidradenitis suppurativa .', F1000research, 7, http://dx.doi.org/10.12688/f1000research.17267.1

Frew JW; Vekic DA; Woods JA; Cains GD, 2018, 'Drug-associated hidradenitis suppurativa: A systematic review of case reports', Journal of the American Academy of Dermatology, 78, pp. 217 - 219.e2, http://dx.doi.org/10.1016/j.jaad.2017.08.046

Frew JW; Hawkes JE; Krueger JG, 2018, 'A systematic review and critical evaluation of immunohistochemical associations in hidradenitis suppurativa.', F1000Res, 7, pp. 1923, http://dx.doi.org/10.12688/f1000research.17268.2

Frew JW; Hawkes JE; Krueger JG, 2018, 'A systematic review and critical evaluation of inflammatory cytokine associations in hidradenitis suppurativa.', F1000Research, 7, pp. 1930, http://dx.doi.org/10.12688/f1000research.17267.1

Frew JW; Davidson M; Murrell DF, 2017, 'Disease-specific health related quality of life patient reported outcome measures in Genodermatoses: A systematic review and critical evaluation', Orphanet Journal of Rare Diseases, 12, pp. 189, http://dx.doi.org/10.1186/s13023-017-0739-5

Frew JW; Fallah H, 2017, 'Lichen amyloidosis involving the scalp', Australasian Journal of Dermatology, 58, pp. e260 - e261, http://dx.doi.org/10.1111/ajd.12582

Morris S; Scarisbrick J; Frew J; Irwin C; Grieve R; Humber C; Kuciejewska A; Bayne S; Weatherhead S; Child F; Wain M; Whittaker S, 2017, 'The Results of Low-Dose Total Skin Electron Beam Radiation Therapy (TSEB) in Patients With Mycosis Fungoides From the UK Cutaneous Lymphoma Group', INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 99, pp. 627 - 633, http://dx.doi.org/10.1016/j.ijrobp.2017.05.052

Frew JW; Vekic DA; Woods J; Cains GD, 2017, 'A systematic review and critical evaluation of reported pathogenic sequence variants in hidradenitis suppurativa', British Journal of Dermatology, 177, pp. 987 - 998, http://dx.doi.org/10.1111/bjd.15441

Frew JW; Murrell DF, 2017, 'Highly Resistant Acrodermatitis Continua of Hallopeau and Pustular Psoriasis', Skin Appendage Disorders, 3, pp. 179 - 181, http://dx.doi.org/10.1159/000464140

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