By Dr Charles Cox

Journal articles

Ridone P; Pandzic E; Vassalli M; Cox CD; Macmillan A; Gottlieb PA; Martinac B, 2020, 'Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters', Journal of General Physiology, 152, http://dx.doi.org/10.1085/jgp.201912515

Xue F; Cox CD; Bavi N; Rohde PR; Nakayama Y; Martinac B, 2020, 'Membrane stiffness is one of the key determinants of E. coli MscS channel mechanosensitivity', Biochimica Et Biophysica Acta Biomembranes, 1862, http://dx.doi.org/10.1016/j.bbamem.2020.183203

Baratchi S; Khoshmanesh K; Cox CD; Gomez GA, 2020, 'Editorial: Mechanobiology: Emerging Tools and Methods', Frontiers in Bioengineering and Biotechnology, 8, http://dx.doi.org/10.3389/fbioe.2020.00289

Patkunarajah A; Stear JH; Moroni M; Schroeter L; Blaszkiewicz J; Tearle JLE; Cox CD; Fuerst C; Sánchez-Carranza O; Fernández M; Fleischer R; Eravci M; Weise C; Martinac B; Biro M; Lewin GR; Poole K, 2020, 'TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration.', Elife, 9, pp. e53308, http://dx.doi.org/10.7554/eLife.53308

Cox CD; Gottlieb PA, 2019, 'Amphipathic molecules modulate PIEZO1 activity', Biochemical Society Transactions, 47, pp. 1833 - 1842, http://dx.doi.org/10.1042/BST20190372

Cox CD; Bavi N; Martinac B, 2019, 'Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction', Cell Reports, 29, pp. 1 - 12, http://dx.doi.org/10.1016/j.celrep.2019.08.075

Nikolaev YA; Cox CD; Ridone P; Rohde PR; Cordero-Morales JF; Vásquez V; Laver DR; Martinac B, 2019, 'Mammalian TRP ion channels are insensitive to membrane stretch', Journal of Cell Science, 132, http://dx.doi.org/10.1242/jcs.238360

Fatkin D; Cox CD; Huttner IG; Martinac B, 2018, 'Is There a Role for Genes in Exercise-Induced Atrial Cardiomyopathy?', Heart Lung and Circulation, 27, pp. 1093 - 1098, http://dx.doi.org/10.1016/j.hlc.2018.03.028

Cox CD; Bavi N; Martinac B, 2018, 'Bacterial Mechanosensors', Annual Review of Physiology, 80, pp. 71 - 93, http://dx.doi.org/10.1146/annurev-physiol-021317-121351

Nikolova-Krstevski V; Wagner S; Yu ZY; Cox CD; Cvetkovska J; Hill AP; Huttner IG; Benson V; Werdich AA; MacRae C; Feneley MP; Friedrich O; Martinac B; Fatkin D, 2017, 'Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk', Jacc Basic to Translational Science, 2, pp. 575 - 590, http://dx.doi.org/10.1016/j.jacbts.2017.05.006

Bavi N; Cox CD; Perozo E; Martinac B, 2017, 'Toward a structural blueprint for bilayer-mediated channel mechanosensitivity', Channels, 11, pp. 91 - 93, http://dx.doi.org/10.1080/19336950.2016.1224624

Gh MS; Cox CD; Wilhelm MJ; Dai H-L, 2017, 'In Vivo Nonlinear Light Scattering Probe of Drug-Induced Activation of Bacterial Mechanosensitive Channels', BIOPHYSICAL JOURNAL, 112, pp. 580A - 580A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000402375700885&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Cox CD; Bavi N; Martinac B, 2017, 'Origin of the Force: The Force-From-Lipids Principle Applied to Piezo Channels', Current Topics in Membranes, 79, pp. 59 - 96, http://dx.doi.org/10.1016/bs.ctm.2016.09.001

Syeda R; Florendo MN; Cox CD; Kefauver JM; Santos JS; Martinac B; Patapoutian A, 2016, 'Piezo1 Channels Are Inherently Mechanosensitive', Cell Reports, 17, pp. 1739 - 1746, http://dx.doi.org/10.1016/j.celrep.2016.10.033

Bavi N; Cortes DM; Cox CD; Rohde PR; Liu W; Deitmer JW; Bavi O; Strop P; Hill AP; Rees D; Corry B; Perozo E; Martinac B, 2016, 'The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels', Nature Communications, 7, http://dx.doi.org/10.1038/ncomms11984

Bavi O; Cox CD; Vossoughi M; Naghdabadi R; Jamali Y; Martinac B, 2016, 'Influence of Global and Local Membrane Curvature on Mechanosensitive Ion Channels: A Finite Element Approach', Membranes, 6, http://dx.doi.org/10.3390/membranes6010014

Gh MS; Cox CD; Wilhelm MJ; Sheffield JB; Dai H-L, 2016, 'Cell Membrane Integrity Examined by Nonlinear Light Scattering', BIOPHYSICAL JOURNAL, 110, pp. 160A - 160A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000375093800291&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Cox CD; Bae C; Ziegler L; Hartley S; Nikolova-Krstevski V; Rohde PR; Ng CA; Sachs F; Gottlieb PA; Martinac B, 2016, 'Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension', Nature Communications, 7, http://dx.doi.org/10.1038/ncomms10366

Abdulkareem ZA; Gee JMW; Cox CD; Wann KT, 2016, 'Knockdown of the small conductance Ca2+-activated K+ channels is potently cytotoxic in breast cancer cell lines', British Journal of Pharmacology, 173, pp. 177 - 190, http://dx.doi.org/10.1111/bph.13357

Nomura T; Cox CD; Bavi N; Sokabe M; Martinac B, 2015, 'Unidirectional incorporation of a bacterial mechanosensitive channel into liposomal membranes', FASEB Journal, 29, pp. 4334 - 4345, http://dx.doi.org/10.1096/fj.15-275198

Cox CD; Nakayama Y; Nomura T; Martinac B, 2015, 'The evolutionary ‘tinkering’ of MscS-like channels: generation of structural and functional diversity', Pflugers Archiv European Journal of Physiology, 467, pp. 3 - 13, http://dx.doi.org/10.1007/s00424-014-1522-2

Bavi N; Nakayama Y; Bavi O; Cox CD; Qin QH; Martinac B, 2014, 'Biophysical implications of lipid bilayer rheometry for mechanosensitive channels', Proceedings of the National Academy of Sciences of the United States of America, 111, pp. 13864 - 13869, http://dx.doi.org/10.1073/pnas.1409011111

Shaikh S; Cox CD; Nomura T; Martinac B, 2014, 'Energetics of gating MscS by membrane tension in azolectin liposomes and giant spheroplasts', Channels, 8, pp. 321 - 326, http://dx.doi.org/10.4161/chan.28366

Burley DS; Cox CD; Zhang J; Wann KT; Baxter GF, 2014, 'Natriuretic peptides modulate ATP-sensitive K+ channels in rat ventricular cardiomyocytes', Basic Research in Cardiology, 109, http://dx.doi.org/10.1007/s00395-014-0402-4

Cox CD; Wann KT; Martinac B, 2014, 'Selectivity mechanisms in MscS-like channels: From structure to function', Channels, 8, pp. 5 - 12, http://dx.doi.org/10.4161/chan.27107

Cox CD; Nomura T; Ziegler CS; Campbell AK; Wann KT; Martinac B, 2013, 'Selectivity mechanism of the mechanosensitive channel MscS revealed by probing channel subconducting states', Nature Communications, 4, http://dx.doi.org/10.1038/ncomms3137

Petrov E; Constantine M; Rohde PR; Nomura T; Boris M, 2013, 'Patch-clamp characterization of the Mscs-like mechanosensitive channel from silicibacter pomeroyi', Biophysical Journal, 104, pp. 1426 - 1434, http://dx.doi.org/10.1016/j.bpj.2013.01.055

Vassel N; Cox CD; Naseem R; Morse V; Evans RT; Power RL; Brancale A; Wann KT; Campbell AK, 2012, 'Enzymatic activity of albumin shown by coelenterazine chemiluminescence', Luminescence, 27, pp. 234 - 241, http://dx.doi.org/10.1002/bio.2357

Cox CD; Campbell AK; Wann KT, 2011, 'Outward Currents Through "low" Conductance Non-Mechanosensitive Channels in Escherichia Coli Membranes', BIOPHYSICAL JOURNAL, 100, pp. 278 - 278, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000306288602278&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Campbell AK; Matthews SB; Vassel N; Cox CD; Naseem R; Chaichi J; Holland IB; Green J; Wann KT, 2010, 'Bacterial metabolic 'toxins': A new mechanism for lactose and food intolerance, and irritable bowel syndrome', Toxicology, 278, pp. 268 - 276, http://dx.doi.org/10.1016/j.tox.2010.09.001

Conference Papers

Li J; Ng CA; Cheng D; Cox CD, 2021, 'Modified N-Linked Glycosylation Status Predicts Trafficking Defective', in BIOPHYSICAL JOURNAL, CELL PRESS, ELECTR NETWORK, pp. 236A - 237A, presented at 65th Annual Meeting of the Biophysical-Society (BPS), ELECTR NETWORK, 22 February 2021 - 26 February 2021, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000629601401400&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Nikolaev Y; Cox CD; Ridone P; Rohde PR; Cordero-Morales JF; Vasquez V; Laver DR; Martinac B, 2020, 'Mammalian TRP Ion Channels are Insensitive to Membrane Stretch', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Diego, pp. 22A - 22A, presented at 64th Annual Meeting of the Biophysical-Society, CA, San Diego, 15 February 2020 - 19 February 2020

Campbell A; Morse V; Vassel N; Cox C; Burley D; Brancale A; Peberdy C; Wann K, 2014, 'Darwin and coelenterazine bioluminescence: a model the evolution of a new enzyme', in LUMINESCENCE, WILEY-BLACKWELL, pp. 1 - 2, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000337617800003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Bavi N; Cox CD; Bavi O; Martinac B, 2014, 'Perturbation of Bilayer Surface Tension Differentially Modulates Mechanosensitive Ion Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, pp. 416A - 416A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2229

Cox CD; Campbell AK; Wann KT; Martinac B, 2013, 'The Selectivity of MscS is Determined by the Cytoplasmic Domain', in BIOPHYSICAL JOURNAL, CELL PRESS, PA, Philadelphia, pp. 469A - 469A, presented at 57th Annual Meeting of the Biophysical-Society, PA, Philadelphia, 02 February 2013 - 06 February 2013, http://dx.doi.org/10.1016/j.bpj.2012.11.2590

Burley DS; Cox CD; Wann KT; Baxter GF, 2012, 'Natriuretic peptide inhibition of sarcolemmal atp-sensitive potassium channel in rat cardiomyocytes', in CARDIOVASCULAR RESEARCH, OXFORD UNIV PRESS, ENGLAND, London, pp. S105 - S106, presented at 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, ENGLAND, London, 30 March 2012 - 01 April 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000301975800447&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Cox CD; Campbell AK; Wann KT; Martinac B, 2012, 'A Mechanosensitive Channel (MscS) with Multiple Conducting States Shows Stronger Selectivity for Anions in the Presence of Divalent Cations', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Diego, pp. 123A - 123A, presented at 56th Annual Meeting of the Biophysical-Society, CA, San Diego, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.688

Conference Abstracts

Cheng D; Zhou Z; Li J; Yao M; Cox CD, 2024, 'PIEZO1 channels as regulators of integrin-mediated focal adhesions in cardiac fibroblasts', in BIOPHYSICAL JOURNAL, CELL PRESS, PA, Philadelphia, Vol. 123, pp. 68A - 68A, presented at 68th Annual Meeting of the Biophysical-Society, PA, Philadelphia, 10 February 2024 - 14 February 2024

Cox CD; Zhang Y; Martinac B; Walz T, 2022, 'Cyclodextrins increase membrane tension and are universal activators of mechanosensitive channels', in BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 121, pp. 436A - 436A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000759523002663&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Yu Z-Y; Gong H; Kesteven S; Guo Y; Wu J; Li J; Iismaa S; Kaidonis X; Graham RM; Cox CD; Feneley MP; Martinac B, 2022, 'Piezo1 and TRPM4 work in tandem to initiate cardiac hypertrophic signalling in response to pressure overload', in BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 121, pp. 493A - 493A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000759523003214&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Li J; Ann Ng C; Cheng D; Cox CD, 2021, 'Modified N-Linked Glycosylation Status Predicts Trafficking Defective Piezo1 Channel Mutations', in Biophysical Journal, Elsevier BV, Vol. 120, pp. 236a - 237a, http://dx.doi.org/10.1016/j.bpj.2020.11.1562

Ridone P; Pandzic E; Vassalli M; Cox CD; Macmillan AM; Gottlieb PA; Martinac B, 2019, 'Cholesterol-Dependent Piezol Clusters are Essential for Efficient Cellular Mechanotransduction', in BIOPHYSICAL JOURNAL, CELL PRESS, MD, Baltimore, Vol. 116, pp. 377A - 377A, presented at 63rd Annual Meeting of the Biophysical-Society, MD, Baltimore, 02 March 2019 - 06 March 2019, http://dx.doi.org/10.1016/j.bpj.2018.11.2050

Buyan A; Cox CD; Barnoud J; Martinac B; Marrink S-J; Corry B, 2019, 'Understanding Piezo1's Relationship with Lipids', in BIOPHYSICAL JOURNAL, CELL PRESS, MD, Baltimore, Vol. 116, pp. 459A - 459A, presented at 63rd Annual Meeting of the Biophysical-Society, MD, Baltimore, 02 March 2019 - 06 March 2019, http://dx.doi.org/10.1016/j.bpj.2018.11.2481

Cox CD; Bavi N; Martinac B, 2018, 'Cytoskeleton-Associated Proteins Modulate the Tension Sensitivity of Piezo1', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, Vol. 114, pp. 111A - 111A, presented at 62nd Annual Meeting of the Biophysical-Society, CA, San Francisco, 17 February 2018 - 21 February 2018, http://dx.doi.org/10.1016/j.bpj.2017.11.641

Bavi N; Cox CD; Bavi O; Martinac B, 2017, 'The role of surface tension in ion channel mechanosensitivity', in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, SPRINGER, SCOTLAND, British Biophys Soc, Edinburgh, Vol. 46, pp. S243 - S243, presented at 19th IUPAB Congress / 11th EBSA Congress, SCOTLAND, British Biophys Soc, Edinburgh, 16 July 2017 - 20 July 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000416406201384&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Cox CD; Martinac B, 2016, 'Bending Piezo1: The Effect of Amphipaths on the Gating of a Mechanosensitive Channel', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, Los Angeles, Vol. 110, pp. 349A - 349A, presented at 60th Annual Meeting of the Biophysical-Society, CA, Los Angeles, 27 February 2016 - 02 March 2016, http://dx.doi.org/10.1016/j.bpj.2015.11.1880

Bavi N; Cox CD; Rohde PR; Hill AP; Corry B; Martinac B, 2016, 'The N-Terminal Helix Acts as a Dynamic Membrane Coupler in the Gating Cycle of the Mechanosensitive Channel MscL', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, Los Angeles, Vol. 110, pp. 116A - 116A, presented at 60th Annual Meeting of the Biophysical-Society, CA, Los Angeles, 27 February 2016 - 02 March 2016, http://dx.doi.org/10.1016/j.bpj.2015.11.677

Nikolaev YA; Rohde PR; Cox CD; Laver DR; Martinac B, 2015, 'Mechanosensitivity of TRPC6 Ion Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, MD, Baltimore, Vol. 108, pp. 564A - 564A, presented at 59th Annual Meeting of the Biophysical-Society, MD, Baltimore, 07 February 2015 - 11 February 2015, http://dx.doi.org/10.1016/j.bpj.2014.11.3088

Cox CD; Martinac B, 2015, 'Probing the Mechanosensitivity of Piezo1 Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, MD, Baltimore, Vol. 108, pp. 562A - 562A, presented at 59th Annual Meeting of the Biophysical-Society, MD, Baltimore, 07 February 2015 - 11 February 2015, http://dx.doi.org/10.1016/j.bpj.2014.11.3079

Ridone P; Cox C; Vassalli M; Pandzic E; Gottlieb P; Martinac B, 2014, 'Human Piezo1 Membrane Localization and Gating Kinetics are Modulated by Cholesetrol Levels', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, Vol. 112, pp. 533A - 533A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2883

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