By Professor Richard Bryan Lock

Conference Papers

Lock RB; Bachmann PS; Piazza RG; Davies C; James M; Wong NC; Bhadri VA; Mogavero A; Magistroni V; Gambacorti-Passerini C; Saffery R; Craig JM; Pimanda JE; Marshall GM, 2009, 'Epigenetic Silencing of the Pro-Apoptotic Bim Gene in Glucocorticoid Poor-Responsive Pediatric Acute Lymphoblastic Leukemia, and Its Reversal by Histone Deacetylase Inhibition', in BLOOD, AMER SOC HEMATOLOGY, LA, New Orleans, pp. 387 - 388, presented at 51st Annual Meeting of the American-Society-of-Hematology, LA, New Orleans, 05 December 2009 - 08 December 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000272725801119&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mayer L; Carol H; Morton CL; Harasym T; Smith MA; Lock RB, 2009, 'Evaluation of CPX-351 (cytarabine:daunorubicin) liposome injection efficacy in acute lymphoblastic leukemia (ALL) xenograft models', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1535-7163.TARG-09-A135

Smith MA; Morton CL; Carol H; Gorlick RG; Kang MH; Keir ST; Kolb EA; Lock RB; Maris JM; Houghton PJ, 2009, 'Pediatric Preclinical Testing Program (PPTP) testing of the CENP-E inhibitor GSK923295A', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, FL, Orlando, presented at 45th Annual Meeting of the American-Society-of-Clinical-Oncology, FL, Orlando, 29 May 2009 - 02 June 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000276606606513&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dilda P; Decollogne S; Weerakoon L; Allen J; Lock R; Hogg P, 2009, 'Eliminating the pro-drug properties of the tumor angiogenesis inhibitor, 4-(N-(S-glutathionylacetyl)amino)phenylarsinous acid (GSAO), results in markedly enhanced anti-tumor activity', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702604245&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Nowak D; Akagi T; Papa R; Kawamata N; Thoennissen N; Okamoto R; Hofmann W; Kato M; Ogawa S; Lock R; Koeffler P, 2009, 'High density SNP array allelokaryotyping of human acute lymphoblastic leukemia (ALL) xenografts in immunodeficient mice reveals genomic changes upon in vivo induction of chemoresistance', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209701802253&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Morton C; Houghton P; Maris J; Courtright J; Kolb E; Gorlick R; Carol H; Lock R; Friedman H; Keir S; Kang M; Reynolds C; Smith M, 2009, 'Pediatric Preclinical Testing Program (PPTP) evaluation of PR-104', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702803489&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Carol H; Lock R; Houghton P; Morton C; Maris J; Courtright J; Kolb E; Gorlick R; Friedman H; Keir S; Kang M; Reynolds C; Smith M, 2009, 'Pediatric preclinical testing program (PPTP) evaluation of the Akt inhibitor GSK690693', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702803487&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Kolb E; Gorlick R; Houghton P; Morton C; Maris J; Courtright J; Carol H; Lock R; Friedman H; Keir S; Kang M; Reynolds C; Smith M, 2009, 'Pediatric Preclinical Testing Program (PPTP) evaluation of the multi-targeted kinase inhibitor Sorafenib', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702803490&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Maris J; Courtright J; Houghton P; Morton C; Kolb E; Gorlick R; Carol H; Lock R; Friedman H; Keir S; Kang M; Reynolds C; Smith M, 2009, 'Pediatric Preclinical Testing Program (PPTP) evaluation of the novel polyamine analogue PG11047', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702803488&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Houghton PJ; Morton CL; Maris JM; Keir ST; Lock RB; Carol H; Gorlick R; Kolb EA; Kang MH; Smith MA, 2008, 'Pediatric Preclinical Testing Program (PPTP) evaluation of rapamycin combined with cytotoxic drugs used frequently in treatment of childhood cancer', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, SWITZERLAND, Geneva, pp. 60 - 60, presented at 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, SWITZERLAND, Geneva, 21 October 2008 - 24 October 2008, http://dx.doi.org/10.1016/S1359-6349(08)72122-0

Lock R; Carol H; Houghton P; Morton C; Phelps D; Tucker C; Payne-Turner D; Zuany-Amorim C; Smith M, 2008, 'Pediatric Preclinical Testing Program (PPTP) evaluation of the anti-CD19-DM4 conjugated antibody SAR3419', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, SWITZERLAND, Geneva, pp. 61 - 61, presented at 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, SWITZERLAND, Geneva, 21 October 2008 - 24 October 2008, http://dx.doi.org/10.1016/S1359-6349(08)72124-4

Smith MA; Houghton PJ; Morton CL; Maris JM; Courtright J; Carol H; Lock RB; Yang Y; Manfredi MG, 2008, 'Pediatric Preclinical Testing Program (PPTP) stage 2 testing of the Aurora A kinase inhibitor MLN8237', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, SWITZERLAND, Geneva, pp. 92 - 93, presented at 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, SWITZERLAND, Geneva, 21 October 2008 - 24 October 2008, http://dx.doi.org/10.1016/S1359-6349(08)72220-1

Lock RB; Jin L; Lee EM; Ramshaw H; Busfield S; Peoppl A; Wilkinson L; Guthridge M; Boyd AW; Gearing D; Vairo G; Lopez A; Dick J, 2007, 'CD123 (IL-3 receptor a chain) neutralization by a monoclonal antibody selectively eliminates human acute myeloid leukemic stem tells', in Broze G (ed.), Blood, American Society of Hematology, USA, pp. 161 - 161, presented at 49th Annual Meeting of the American-Society-of-Hematology, Atlanta, Georgia USA, 08 December 2007 - 11 December 2007

Liaw T; Burke P; Chen X; LaVallee T; Lock RB; Kavallaris M, 2007, 'ENMD-1198 in combination with vincristine shows synergistic activity in leukemia cells and prolonged mouse survival in human leukemia xenografts', in Broze G (ed.), Blood, American Society of Hematology, USA, pp. 859 - 859, presented at 49th Annual Meeting of the American-Society-of-Hematology, Atlanta, Georgia USA, 08 December 2007 - 11 December 2007

Lock RB; Jin L; Lee EM; Ramshaw HS; Busfield S; Peoppl AG; Wilkinson L; Guthridge MA; Boyd A; Gearing D; Vairo G; Lopez A; Dick JE, 2007, 'CD123 (IL-3 receptor a chain) neutralization by a monoclonal antibody selectively eliminates human acute myeloid leukemic stem tells', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, pp. 55A - 55A, presented at 49th Annual Meeting of the American-Society-of-Hematology, GA, Atlanta, 08 December 2007 - 11 December 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000251100800162&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Liaw TTYE; Burke PPA; Chen X; LaVallee TTM; Lock R; Kavallaris M, 2007, 'ENMD-1198 in combination with vincristine shows synergistic activity in leukemia cells and prolonged mouse survival in human leukemia xenografts', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, pp. 263A - 263A, presented at 49th Annual Meeting of the American-Society-of-Hematology, GA, Atlanta, 08 December 2007 - 11 December 2007, http://dx.doi.org/10.1182/blood.V110.11.859.859

Smith MA; Maris JM; Keir ST; Lock RB; Carol H; Gorlick R; Kolb EA; Keshelava N; Reynolds CP; Morton C; Houghton PJ, 2007, 'Pediatric preclinical testing program (PPTP) efficacy and pharmacodynamic evaluation of the Hsp90 inhibitor 17-DMAG', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000455043700627&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hsu A; Kerr B; Lock R; Hart D; Rice A, 2007, 'Anti-leukaemic CTL control the kinetics of leukaemic growth in the NOD-SCID mouse model', in BONE MARROW TRANSPLANTATION, NATURE PUBLISHING GROUP, FRANCE, Lyon, pp. S31 - S32, presented at 33rd Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, FRANCE, Lyon, 25 March 2007 - 28 March 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245207400083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hsu AKW; Kerr BM; Lock RB; Hart DNJ; Rice AM, 2006, 'Anti-leukemic CTL generated by RNA loaded cord blood-derived dendritic cells control leukaemia in a NOD-SCID mouse model.', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, pp. 1057A - 1057A, presented at 48th Annual Meeting of the American-Society-of-Hematology, FL, Orlando, 09 December 2006 - 12 December 2006, http://dx.doi.org/10.1182/blood.V108.11.3699.3699

Hsu AK; Kerr BM; Lock RB; Hart DN; Rice AM, 2006, 'RNA transfected cord blood-derived dendritic cells generate anti-leukemic cytotoxic T lymphocytes', in BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, CARDEN JENNINGS PUBL CO LTD, HI, Honolulu, pp. 65 - 65, presented at 32nd Annual Meeting of the American-Society-for-Blood-and-Marrow-Transplantation, HI, Honolulu, 16 February 2006 - 20 February 2006, http://dx.doi.org/10.1016/j.bbmt.2005.11.204

Hsu AKW; Kerr BM; Lock RB; Hart DNJ; Rice AM, 2005, 'Assembling the players for evaluation of anti-leukemic CTL activity in NOD-SCID mice.', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, pp. 226B - 226B, presented at 47th Annual Meeting of the American-Society-of-Hematology, GA, Atlanta, 10 December 2005 - 13 December 2005, http://dx.doi.org/10.1182/blood.V106.11.4586.4586

Lock RB; Davies C; Bardell J, 2005, 'Differential sensitivity of childhood acute lymphoblastic leukemia xenografts to vorinostat reflects p21WAF1/CIP1 functional status.', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, pp. 8986S - 8986S, presented at AACR/NCI/EORTC International Conference on Molecular Targets and Cancer Therapeutics, PA, Philadelphia, 14 November 2005 - 18 November 2005, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000234382700092&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Houghton PJ; Maris JM; Friedman HS; Keir ST; Lock RB; Gorlick R; Kolb EA; Reynolds CP; Morton C; Smith MA, 2005, 'Evaluation of bortezomib against childhood tumor models by the pediatric preclinical testing program (PPTP)', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, pp. 8987S - 8988S, presented at 17th EORTC/AACR/NCI International Conference on Molecular Targets and Cancer Therapeutics, PA, Philadelphia, 14 November 2005 - 18 November 2005

Lock RB; Bachmann P, 2003, 'Induction of the pro-apoptotic Bcl-2 family member, Bim, is critical for glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells.', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MASSACHUSETTS, BOSTON, pp. 6211S - 6211S, presented at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, MASSACHUSETTS, BOSTON, 17 November 2003 - 21 November 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000187467300581&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lock RB; Liem N, 2003, 'Specific down regulatlon of stathmin in childhood acute leukemiaxenografts selected for vincristine resistance in vivo', in Blood, American Society of Hematology, pp. 591A - 591A

Bendall LJ; Khan NI; Bonnet C; Lock RB; Nilsson S; Bradstock KF; Gottlieb DJ, 2002, 'CD44v6 expression results in increased aggressiveness of acute lymphoblastic leukemia in NOD/SCID mice.', in BLOOD, AMER SOC HEMATOLOGY, PENNSYLVANIA, PHILADELPHIA, pp. 757A - 757A, presented at 44th Annual Meeting of the American-Society-of-Hematology, PENNSYLVANIA, PHILADELPHIA, 06 December 2002 - 10 December 2002, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179184702999&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lock RB; Liem N; Tajbakhsh M; Milross CG; Xue CY; Haber M; Norris MD; Marshall GM; Rice AM, 2001, 'Novel biological characteristics and disparate vincristine responses of primary childhood acute lymphoblastic leukemia cells engrafted into non-obese diabetic/severe combined immunodeficient mice.', in BLOOD, AMER SOC HEMATOLOGY, pp. 309A - 310A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172134101312&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lock R; Farnsworth M; Wood J; Milross C; Collins C; Rice A, 2000, 'Development of an in vivo model for the testing of novel antileukemic agents.', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, pp. 4498S - 4498S, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000165409000119&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Eastman A, 1986, 'AACR Special Conference in Cancer Research', in Cancer Research, pp. 2812 - 2818

Conference Posters

Doculara L; Evans K; Gooding JJ; Bayat N; Lock RB, 2024, 'Patient-Specific Circulating Tumor DNA for Monitoring Response to Menin Inhibitor Treatment in Preclinical Models of Infant Leukemia', Switzerland, Vol. 16, pp. 3990, Switzerland, http://dx.doi.org/10.3390/cancers16233990

Connerty P; Xie J; El-Najjar F; Mao J; Cadiz R; Tax G; Dolman MEM; Jayatilleke N; Mayoh C; Moore AS; Colgan J; Marshall GM; Lock RB, 2024, 'Development of a precision medicine platform for paediatric acute myeloid leukaemia', SPAIN, Barcelona, Vol. 211, pp. S103 - S103, presented at 36th European-Organisation-for-Research-and-Treatment-of-Cancer / National-Cancer-Institute / American-Association-for-Cancer-Research Symposium on Molecular Targets and Cancer Therapeutics (EORTC/NCI/AACR), SPAIN, Barcelona, 23 October 2024 - 25 October 2024, http://dx.doi.org/10.1016/j.ejca.2024.114784

Lock RB; Evans K; Watts B; Bowman EP; Neuhauser S; Stearns T; Chuang JH; Phillip VM; Jessen KA; Jocoy EL; Bult CJ; Teicher BA; Smith MA, 2024, 'The ROR1 antibody-drug conjugate, MK-2140, enhances the efficacy of established drugs in preclinical models of pediatric acute lymphoblastic leukemia', CA, San Diego, Vol. 84, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2024 - 10 April 2024, http://dx.doi.org/10.1158/1538-7445.AM2024-1905

Cheung L; Lock R; Kuek V; Kotecha R, 2024, '3049 – TARGETING BONE MARROW MICROENVIRONMENT FOR TREATMENT OF HIGH-RISK B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA', Vol. 137, pp. 104371 - 104371, http://dx.doi.org/10.1016/j.exphem.2024.104371

Cheung LC; Trinder S; Hughes A; Mullin B; Rashid S; Yuan J; Xu J; Duncan O; Lock RB; Malinge S; Kuek V; Kotecha RS, 2023, 'Targeting Bone Marrow Microenvironment for Treatment of High-Risk B-Cell Acute Lymphoblastic Leukemia', CA, San Diego, Vol. 142, presented at 65th Annual Meeting of the American-Society-of-Hematology (ASH), CA, San Diego, 09 December 2023 - 12 December 2023, http://dx.doi.org/10.1182/blood-2023-173503

Houghton PJ; Kurmasheva RT; Erickson S; Smith MA; Lock RB; Evans K; Toscan C, 2020, 'Prospective validation of single mouse testing (SMT) by the pediatric preclinical testing consortium (PPTC)', Vol. 138, pp. S18, http://dx.doi.org/10.1016/S0959-8049(20)31111-4

Karsa M; Failes T; Arndt GM; Kees UR; Haber M; Norris MD; Sutton R; Lock RB; Somers K; Henderson MJ, 2018, 'PO-405 Repositioning existing drugs as novel therapeutics for high-risk paediatric leukaemia', Vol. 3, pp. A181 - A181, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.431

Tuch B; Wu W; Brands K; Colvin E; Sung J; Williams L; Lock R; Wang R, 2008, 'EARLY HUMAN FETAL PANCREAS AS A THERAPY FOR DIABETES', Vol. 86, pp. 561 - 561, http://dx.doi.org/10.1097/01.tp.0000331028.21911.80

Conference Presentations

Shahbazi J; Scarlett CJ; Norris M; Liu B; Haber M; Tee AE; Carrier A; Biankin AV; London WB; Marshall GM; Lock R; Liu T, 2014, 'Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1', presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-5138

Smith M; Kang M; Reynolds P; Gorlick R; Kolb A; Maris J; Lock R; Carol H; Keir S; Billups C; Kurmasheva R; Houghton P, 2014, 'Pediatric preclinical testing program (PPTP) evaluation of BMN 673, an inhibitor of poly-adp ribose polymerase (PARP), with temozolomide (TMZ)', presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-3969

Maude SL; Dolai S; Delagdo-Martin C; Vincent T; Robbins A; Selvanathan A; Ryan T; Hunger SP; Loh ML; Mullighan CG; Wood BL; Hermiston ML; Grupp SA; Lock RB; Teachey DT, 2014, 'Targeting the Jak/Stat signaling pathway is highly effective in xenograft models of early T cell precursor (ETP) acute lymphoblastic leukemia (ALL)', presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-997

Conference Abstracts

Houghton PJ; Ghilu S; Robles A; Kurmasheva RT; Lock RB, 2025, 'Abstract IA017: Single mouse testing (SMT): An alternative approach to encompass clinical heterogeneity of pediatric cancers', in Cancer Research, American Association for Cancer Research (AACR), Vol. 85, pp. IA017 - IA017, http://dx.doi.org/10.1158/1538-7445.genfunc25-ia017

McKay C; Power P; Staunton J; Sriharan S; Jessop S; Zhukova N; Trinder S; Govender D; Barahona P; Gifford AJ; Mignone C; Xie A; Tax G; Tsoli M; Dolman E; Mayoh C; Wong M; Cowley M; Marshall G; Trahair T; Lock RB; Ekert P; Haber M; Tyrell V; Lau L; Manoharan N; Ziegler DS; Khuong-Quang D-A, 2024, 'PRECISION GUIDED THERAPY PROVIDES CLINICAL BENEFIT IN H3K27-ALTERED DIFFUSE MIDLINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.101

Lock RB; Toscan CE; McCalmont H; Evans K; Doculara L; Kosasih HJ; Gifford AJ; Ashoorzadeh A; Lin X; Trahair TN; De Bock CE; Patterson AV; Smaill JB, 2023, 'The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia', in BLOOD, ELSEVIER, CA, San Diego, Vol. 142, presented at 65th Annual Meeting of the American-Society-of-Hematology (ASH), CA, San Diego, 09 December 2023 - 12 December 2023, http://dx.doi.org/10.1182/blood-2023-181298

Lock RB; Mohamed SMA; Schofield P; Friedrich K-H; Christ D; Kavallaris M; Bayat N, 2023, 'Abstract B134: Targeting Philadelphia chromosome-like acute lymphoblastic leukemia with a novel CRLF2 antibody fragment-drug conjugate', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), Vol. 22, pp. B134 - B134, http://dx.doi.org/10.1158/1535-7163.targ-23-b134

Lock RB; Evans K; Gawan-Taylor S; Watts B; Stearns T; Earley EJ; Jocoy EL; Bult CJ; Teicher BA; McGeehan GM; Smith MA, 2023, 'The menin inhibitor VTP-50469 enhances the in vivo efficacy of established drugs against preclinical models of aggressive infant MLL-r acute lymphoblastic leukemia', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, Vol. 22, http://dx.doi.org/10.1158/1535-7163.TARG-23-C095

Truong P; Shen S; Joshi S; Afrasiabi A; Zhong L; Raftery MJ; Larsson J; Lock RB; Walkley CR; Rokny HA; Thoms JAI; Jolly CJ; Pimanda JE, 2022, 'Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia', in BLOOD, AMER SOC HEMATOLOGY, LA, New Orleans, Vol. 140, presented at 64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), LA, New Orleans, 10 December 2022 - 13 December 2022, http://dx.doi.org/10.1182/blood-2022-165713

Lock RB; Evans K; El-Zein N; Lannutti BJ; Jessen KA; Earley EJ; Erickson SW; Smith MA; Kurmasheva R; Houghton PJ, 2021, 'Evaluation of ROR1-targeted antibody-drug conjugates against ROR1-expressing pediatric preclinical models - a report from the pediatric preclinical testing consortium (PPTC).', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 81, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000680263506373&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lock RB; Evans K; El-Zein N; Earley EJ; Erickson SW; Teicher BA; Smith MA, 2021, 'Pediatric preclinical testing consortium evaluation of the dual SYK/FLT3 inhibitor TAK-659 in xenograft models of pediatric acute lymphoblastic leukemia.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 81, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000680263506374&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lock RB; Evans K; El-Zein N; Earley EJ; Erickson SW; Teicher BA; Sung V; Smith MA, 2021, 'The differentiated CD47 monoclonal antibody AO-176 exhibits significant in vivo activity against xenograft models of pediatric acute lymphoblastic leukemia (ALL).', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 81, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000680263501401&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mohamed SMA; Sia K; Friedrich K-H; Wohlmann A; Savvides S; Schofield P; Christ D; Kavallaris M; Lock RB; Bayat N, 2020, 'A Novel Engineered Single-Chain Antibody Fragment for Targeting Pediatric Philadelphia Chromosome-like Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, ELECTR NETWORK, Vol. 136, presented at 62nd Annual Meeting of the American-Society-of-Hematology (ASH), ELECTR NETWORK, 05 December 2020 - 08 December 2020, http://dx.doi.org/10.1182/blood-2020-138421

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