By Professor Paul De Souza

Journal articles

Wang H; Markman B; de Souza P; Dees EC; Gangadhar TC; Piha-Paul SA; Zamboni WC; Murphy C; Senderowicz A, 2016, 'A dose-escalation study of weekly intravenous CRLX301 in patients with advanced solid tumor malignancies', ANNALS OF ONCOLOGY, 27, http://dx.doi.org/10.1093/annonc/mdw368.56

Powles TB; Escudier B; de Souza P; Chowdhury S; Pook D; Harmenberg U; Basappa N; Geynisman D; Merchan J; Redman BG; Ryan C; Goodman O; Ho T; Singh P; Lougheed J; Patel M; Knox JJ; Motzer RJ; Choueiri TK, 2016, 'Efficacy of cabozantinib (cabo) vs everolimus (eve) by metastatic site and tumor burden in patients (pts) with advanced renal cell carcinoma (RCC) in the phase 3 METEOR trial', Annals of Oncology, 27, pp. vi284, http://dx.doi.org/10.1093/annonc/mdw373.41

de Souza P; Chua W; Clarke S; Goldstein D; Lee C, 2016, 'Inflammatory Markers Have a Role in Renal Cell Carcinoma Prognosis', European Urology Focus, 2, pp. 341 - 342, http://dx.doi.org/10.1016/j.euf.2016.04.007

de Souza P; Aslan P; Clark W; Patel M; Vass JA; Cade D; de Silva SJ, 2016, 'Phase 1 study of selective internal radiation therapy (SIRT) with yttrium-90 (Y-90) resin microspheres in patients (pts) with renal cell carcinoma (RCC): RESIRT', ANNALS OF ONCOLOGY, 27, http://dx.doi.org/10.1093/annonc/mdw373.31

Ma Y; Luk A; Young FP; Lynch D; Chua W; Balakrishnar B; de Souza P; Becker TM, 2016, 'Droplet digital PCR based androgen receptor variant 7 (AR-V7) detection from prostate cancer patient blood biopsies', International Journal of Molecular Sciences, 17, http://dx.doi.org/10.3390/ijms17081264

Caixeiro NJ; Byun HL; Descallar J; Levesque JV; De Souza P; Soon Lee C, 2016, 'Health professionals' opinions on supporting a cancer biobank: Identification of barriers to combat biobanking pitfalls', European Journal of Human Genetics, 24, pp. 626 - 632, http://dx.doi.org/10.1038/ejhg.2015.191

Lee CK; Davies L; Gebski VJ; Lord SJ; Di Leo A; Johnston S; Geyer C; Cameron D; Press MF; Ellis C; Loi S; Marschner I; Simes J; De Souza P, 2016, 'Serum human epidermal growth factor 2 extracellular domain as a predictive biomarker for lapatinib treatment efficacy in patients with advanced breast cancer', Journal of Clinical Oncology, 34, pp. 936 - 944, http://dx.doi.org/10.1200/JCO.2015.62.4767

De Souza P; Aslan P; Clark W; Patel M; Vass J; Cade D; De Silva S, 2016, 'RESIRT: A phase 1 study of Selective Internal Radiation Therapy (SIRT) using Yttrium-90 (Y-90) resin microspheres in patients with primary Renal Cell Carcinoma (RCC)', European Urology Supplements, 15, pp. e1541 - e1542, http://dx.doi.org/10.1016/s1569-9056(16)30374-8

De Souza PL; Lee CS, 2015, 'The Centre for Oncology Education and Research Translation (CONCERT) Biobank', Open Journal of Bioresources, 2, http://dx.doi.org/10.5334/ojb.ai

Hnit SST; Xie C; Yao M; Holst J; Bensoussan A; De Souza P; Li Z; Dong Q, 2015, 'P27Kip1 signaling: Transcriptional and post-translational regulation', International Journal of Biochemistry and Cell Biology, 68, pp. 9 - 14, http://dx.doi.org/10.1016/j.biocel.2015.08.005

Saad F; Shore N; Van Poppel H; Rathkopf DE; Smith MR; De Bono JS; Logothetis CJ; De Souza P; Fizazi K; Mulders PFA; Mainwaring P; Hainsworth JD; Beer TM; North S; Fradet Y; Griffin TA; De Porre P; Londhe A; Kheoh T; Small EJ; Scher HI; Molina A; Ryan CJ, 2015, 'Impact of bone-targeted therapies in chemotherapy-naïve metastatic castration-resistant prostate cancer patients treated with abiraterone acetate: Post hoc analysis of study COU-AA-302', European Urology, 68, pp. 570 - 577, http://dx.doi.org/10.1016/j.eururo.2015.04.032

Lim SH; Chua W; Henderson C; Ng W; Shin JS; Chantrill L; Asghari R; Lee CS; Spring KJ; de Souza P, 2015, 'Predictive and prognostic biomarkers for neoadjuvant chemoradiotherapy in locally advanced rectal cancer', Critical Reviews in Oncology Hematology, 96, pp. 67 - 80, http://dx.doi.org/10.1016/j.critrevonc.2015.05.003

Tut TG; Lim SHS; Dissanayake IU; Descallar J; Chua W; Ng W; De Souza P; Shin JS; Lee CS, 2015, 'Upregulated polo-like kinase 1 expression correlates with inferior survival outcomes in rectal cancer', Plos One, 10, http://dx.doi.org/10.1371/journal.pone.0129313

Sengupta S; Grimison P; Hayne D; Williams S; Chambers S; Desouza P; Stockler M; McJannett M; Toner G; Davis ID, 2015, 'The Australian and New Zealand Urogenital and Prostate (ANZUP) Cancer Trials Group - A new co-operative cancer trials group in genitourinary oncology', BJU International, 115, pp. 856 - 858, http://dx.doi.org/10.1111/bju.12925

Lickliter JD; Panizza B; Karapetis CS; Gordon VA; Reddell PW; Lingard KT; Cusack RM; De Souza P, 2015, 'Phase 1 dose-escalation study of EBC-46 given by intratumoral injection to patients with refractory cutaneous and subcutaneous tumors.', Journal of Clinical Oncology, 33, pp. TPS2616 - TPS2616, http://dx.doi.org/10.1200/jco.2015.33.15_suppl.tps2616

Morris MJ; Molina A; Small EJ; De Bono JS; Logothetis CJ; Fizazi K; De Souza P; Kantoff PW; Higano CS; Li J; Kheoh T; Larson SM; Matheny SL; Naini V; Burzykowski T; Griffin TW; Scher HI; Ryan CJ, 2015, 'Radiographic progression-free survival as a response biomarker in metastatic castration-resistant prostate cancer: COU-AA-302 results', Journal of Clinical Oncology, 33, pp. 1356 - 1363, http://dx.doi.org/10.1200/JCO.2014.55.3875

Lim SH; Spring KJ; De Souza P; Mackenzie S; Bokey L, 2015, 'Circulating tumour cells and circulating nucleic acids as a measure of tumour dissemination in non-metastatic colorectal cancer surgery', European Journal of Surgical Oncology, 41, pp. 309 - 314, http://dx.doi.org/10.1016/j.ejso.2014.12.005

Choueiri TK; Figueroa DJ; Fay AP; Signoretti S; Liu Y; Gagnon R; Deen K; Carpenter C; Benson P; Ho TH; Pandite L; De Souza P; Powles T; Motzer RJ, 2015, 'Correlation of PD-L1 tumor expression and treatment outcomes in patients with renal cell carcinoma receiving sunitinib or pazopanib: Results from COMPARZ, a randomized controlled trial', Clinical Cancer Research, 21, pp. 1071 - 1077, http://dx.doi.org/10.1158/1078-0432.CCR-14-1993

Ryan CJ; Smith MR; Fizazi K; Saad F; Mulders PFA; Sternberg CN; Miller K; Logothetis CJ; Shore ND; Small EJ; Carles J; Flaig TW; Taplin ME; Higano CS; de Souza P; de Bono JS; Griffin TW; De Porre P; Yu MK; Park YC; Li J; Kheoh T; Naini V; Molina A; Rathkopf DE, 2015, 'Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): Final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study', Lancet Oncology, 16, pp. 152 - 160, http://dx.doi.org/10.1016/S1470-2045(14)71205-7

Tognela A; Spring KJ; Becker T; Caixeiro NJ; Bray VJ; Yip PY; Chua W; Lim SH; de Souza P, 2015, 'Predictive and prognostic value of circulating tumor cell detection in lung cancer: A clinician's perspective', Critical Reviews in Oncology Hematology, 93, pp. 90 - 102, http://dx.doi.org/10.1016/j.critrevonc.2014.10.001

Scarano W; De Souza P; Stenzel MH, 2015, 'Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects: A double act for the treatment of multidrug-resistant cancer', Biomaterials Science, 3, pp. 163 - 174, http://dx.doi.org/10.1039/c4bm00272e

Tut TG; Lim S; Dissanayake I; Descallar J; Chua W; Ng W; De Souza P; Bokey L; Shin J-S; Soon Lee C, 2015, '14. Upregulated PLK1 expression confers radiation resistance and poor patient survival outcomes in rectal cancer', Pathology, 47, pp. S104 - S105, http://dx.doi.org/10.1097/01.pat.0000461623.74546.8a

Mulders PFA; Smith MR; Fizazi K; Saad F; Sternberg CN; Miller K; Logothetis CJ; Shore ND; Small EJ; Carles J; Flaig TW; Taplin M-E; Higano CS; De Souza P; De Bono JS; Griffin TW; De Porre P; Yu MK; Park YC; Li J; Kheoh T; Naini V; Molina A; Rathkopf DE; Ryan CJ, 2015, '556 Abiraterone acetate improves overall survival in chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC): Impact of crossover and baseline prognostic factors in the COU-AA-302 final analysis', European Urology Supplements, 14, pp. e556 - e556a, http://dx.doi.org/10.1016/s1569-9056(15)60549-8

Nayak L; Brandes A; Omuro A; Rieger J; Wick A; Phuphanich S; Sumrall A; Sahebjam S; Ahluwalia M; de Souza P; Sepulveda JM; Maio M; Grauer O; Vlahovic G; Baehring J; Dastani H; Latek R; Coric V; Reardon D, 2015, 'QOL-07DESCRIPTION OF CLINICAL AND PATIENT REPORTED OUTCOMES ASSESSMENTS FROM A PHASE 3, MULTICENTER, RANDOMIZED TRIAL EVALUATING NIVOLUMAB MONOTHERAPY VERSUS BEVACIZUMAB IN RECURRENT GLIOBLASTOMA: CHECKMATE-143', Neuro-Oncology, 17, pp. v189.2 - v189, http://dx.doi.org/10.1093/neuonc/nov230.07

Sebaratnam DF; Martin LK; Venugopal SS; Mangos G; Freiman J; de Souza P; Farnsworth A; Cheung K; Scolyer RA; Murrell DF, 2014, 'Diffuse melanosis cutis in the setting of BRAFV600E metastatic melanoma', International Journal of Dermatology, 53, pp. 1409 - 1411, http://dx.doi.org/10.1111/ijd.12614

Lim SHS; Chua W; Cheng C; Descallar J; Ng W; Solomon M; Bokey L; Wong K; Lee MT; De Souza P; Shin JS; Lee CS, 2014, 'Effect of neoadjuvant chemoradiation on tumor-infiltrating/associated lymphocytes in locally advanced rectal cancers', Anticancer Research, 34, pp. 6505 - 6513

Rathkopf DE; Smith MR; De Bono JS; Logothetis CJ; Shore ND; De Souza P; Fizazi K; Mulders PFA; Mainwaring P; Hainsworth JD; Beer TM; North S; Fradet Y; Van Poppel H; Carles J; Flaig TW; Efstathiou E; Yu EY; Higano CS; Taplin ME; Griffin TW; Todd MB; Yu MK; Park YC; Kheoh T; Small EJ; Scher HI; Molina A; Ryan CJ; Saad F, 2014, 'Updated interim efficacy analysis and long-term safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients without prior chemotherapy (COU-AA-302)', European Urology, 66, pp. 815 - 825, http://dx.doi.org/10.1016/j.eururo.2014.02.056

Lim SHS; Becker TM; Chua W; Ng WL; De Souza P; Spring KJ, 2014, 'Circulating tumour cells and the epithelial mesenchymal transition in colorectal cancer', Journal of Clinical Pathology, 67, pp. 848 - 853, http://dx.doi.org/10.1136/jclinpath-2014-202499

Mak G; Chin M; Nahar N; De Souza P, 2014, 'Cutaneous metastasis of prostate carcinoma treated with radiotherapy: A case presentation', BMC Research Notes, 7, pp. 505, http://dx.doi.org/10.1186/1756-0500-7-505

Becker TM; Caixeiro NJ; Lim SH; Tognela A; Kienzle N; Scott KF; Spring KJ; De Souza P, 2014, 'New frontiers in circulating tumor cell analysis: A reference guide for biomolecular profiling toward translational clinical use', International Journal of Cancer, 134, pp. 2523 - 2533, http://dx.doi.org/10.1002/ijc.28516

Lee C; Davies L; Marschner I; Gebski V; Lord S; Di Leo A; Johnston SRD; Geyer CE; Cameron DA; Press MF; Ellis CE; Loi S; Simes J; De Souza P, 2014, 'Prognostic, predictive, and surrogate value of HER2 extracellular domain (ECD) for progression-free survival (PFS) in advanced breast cancer treated with lapatinib (lap): A meta-analysis.', JOURNAL OF CLINICAL ONCOLOGY, 32, http://dx.doi.org/10.1200/jco.2014.32.15_suppl.630

Ho TH; Choueiri TK; D'Amelio A; Hsieh J; De Souza PL; Deen KC; Langmuir PB; Liu Y; Motzer RJ, 2014, 'The effect of SETD2 mutation (mts) on histone 3 lysine 36 trimethylation (H3K36me3) and correlation with clinical outcome in patients (pts) with metastatic clear cell renal cell carcinoma (ccRCC) enrolled in COMPARZ', JOURNAL OF CLINICAL ONCOLOGY, 32, http://dx.doi.org/10.1200/jco.2014.32.15_suppl.4583

Caixeiro NJ; Kienzle N; Lim SH; Spring KJ; Tognela A; Scott KF; de Souza P; Becker TM, 2014, 'Circulating tumour cells-a bona fide cause of metastatic cancer', Cancer and Metastasis Reviews, http://dx.doi.org/10.1007/s10555-014-9502-8

Lim SH; Becker TM; Chua W; Caixeiro NJ; Ng WL; Kienzle N; Tognela A; Lumba S; Rasko JEJ; De Souza P; Spring KJ, 2014, 'Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer', Cancer Letters, 346, pp. 24 - 33, http://dx.doi.org/10.1016/j.canlet.2013.12.019

Choueiri TK; Figueroa DJ; Liu Y; Gagnon RC; Deen KC; Carpenter C; Bartlett-Pandite AN; De Souza P; Powles T; Motzer RJ, 2014, 'Correlation of PDL1 tumor expression and treatment outcomes in patients with renal cell carcinoma (RCC) receiving tyrosine kinase inhibitors: COMPARZ study analysis.', JOURNAL OF CLINICAL ONCOLOGY, 32, http://dx.doi.org/10.1200/jco.2014.32.4_suppl.416

Caixeiro NJ; Kienzle N; Lim SH; Spring KJ; Tognela A; Scott KF; De Souza P; Becker TM, 2014, 'Circulating tumour cells - A bona fide cause of metastatic cancer', Cancer and Metastasis Reviews, 33, pp. 747 - 756, http://dx.doi.org/10.1007/s10555-014-9502-8

Tse BWC; Jovanovic L; Nelson CC; De Souza P; Power CA; Russell PJ, 2014, 'From Bench to Bedside: Immunotherapy for Prostate Cancer', Biomed Research International, 2014, http://dx.doi.org/10.1155/2014/981434

Hovey E; De Souza P; Marx G; Parente P; Rapke T; Hill A; Bonaventura A; Michele A; Craft P; Abdi E; Lloyd A, 2014, 'Phase III, randomized, double-blind, placebo-controlled study of modafinil for fatigue in patients treated with docetaxel-based chemotherapy', Supportive Care in Cancer, 22, pp. 1233 - 1242, http://dx.doi.org/10.1007/s00520-013-2076-0

Callari M; Aldrich-Wright JR; De Souza PL; Stenzel MH, 2014, 'Polymers with platinum drugs and other macromolecular metal complexes for cancer treatment', Progress in Polymer Science, 39, pp. 1614 - 1643, http://dx.doi.org/10.1016/j.progpolymsci.2014.05.002

Lim SHS; Ardern-Holmes S; McCowage G; De Souza P, 2014, 'Systemic therapy in neurofibromatosis type 2', Cancer Treatment Reviews, 40, pp. 857 - 861, http://dx.doi.org/10.1016/j.ctrv.2014.05.004

de Souza P, 2014, 'Convenor's Welcome', Asia-Pacific Journal of Clinical Oncology, 10, pp. 1 - 2, http://dx.doi.org/10.1111/ajco.12232

Lim SH; Delaney GP; Descallar J; Sayaloune P; Papadatos G; de Souza P, 2014, 'Outcomes of ethnic minority groups with node-positive, non-metastatic breast cancer in two tertiary referral centers in Sydney, Australia.', PLoS One, 9, pp. e95852, http://dx.doi.org/10.1371/journal.pone.0095852

Shore N; Rathkopf D; Smith MR; de Bono JS; Logothetis C; de Souza P; Fizazi K; Mulders PFA; Mainwaring P; Hainsworth JD; Beer TM; North S; Fradet Y; Griffin T; Park YC; Kheoh T; Small EJ; Scher HI; Molina A; Ryan CJ, 2014, 'PD27-01 EFFICACY AND LONG-TERM SAFETY ANALYSIS OF STUDY COU-AA-302: ABIRATERONE ACETATE PLUS PREDNISONE IN CHEMOTHERAPY-NAÏVE METASTATIC CASTRATION-RESISTANT PROSTATE CANCER', Journal of Urology, 191, http://dx.doi.org/10.1016/j.juro.2014.02.2100

Lim S; de Souza P, 2013, 'Imatinib in neurofibromatosis type 2.', BMJ case reports, 2013

De Souza P; Begbie S; Hovey L; Rashid P; Aslan P; Malouf D; Awad N; Clements A; Hadley A; Galettis P; O'malley L; Melbourne W; Johnson L; Tran K; Lynch W, 2013, 'Phase II Trial of Intravesical Gemcitabine and Biomarker Evaluation in Patients with Superficial Urothelial Carcinoma of the Bladder', World Journal of Cancer Research, 1, pp. 131 - 137, http://dx.doi.org/10.1166/wjcr.2013.1014

Won ACM; Gurney H; Marx G; De Souza P; Patel MI, 2013, 'Primary treatment of the prostate improves local palliation in men who ultimately develop castrate-resistant prostate cancer', BJU International, 112, pp. E250 - E255, http://dx.doi.org/10.1111/bju.12169

Weber MF; Smith DP; O'Connell DL; Patel MI; de Souza PL; Sitas F; Banks E, 2013, 'Risk factors for erectile dysfunction in a cohort of 108 477. Australian men', Medical Journal of Australia, 199, pp. 107 - 111, http://dx.doi.org/10.5694/mja12.11548

Fox P; Hudson M; Brown C; Lord S; Gebski V; De Souza P; Lee CK, 2013, 'Markers of systemic inflammation predict survival in patients with advanced renal cell cancer', British Journal of Cancer, 109, pp. 147 - 153, http://dx.doi.org/10.1038/bjc.2013.300

Rathkopf DE; Smith MR; De Bono JS; Logothetis C; Shore N; De Souza PL; Fizazi K; Mulders P; Mainwaring PN; Hainsworth JD; Beer TM; North SA; Fradet Y; Griffin TW; Park YC; Kheoh TS; Small EJ; Scher HI; Molina A; Ryan CJ, 2013, 'Long-term safety and efficacy analysis of abiraterone acetate (AA) plus prednisone (P) in metastatic castration-resistant prostate cancer (mCRPC) without prior chemotherapy (COU-AA-302).', Journal of Clinical Oncology, 31, pp. 5009 - 5009, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.5009

Yee GPC; De Souza PL; Khachigian LM, 2013, 'Reducing invasion potential of cervical cancer cells via targeted knockdown of c-Jun.', Journal of Clinical Oncology, 31, pp. e22005 - e22005, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22005

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