By Professor Michael John Rogers

Journal articles

Räikkönen J; Crockett JC; Rogers MJ; Mönkkönen H; Auriola S; Mönkkönen J, 2009, 'Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro', British Journal of Pharmacology, 157, pp. 427 - 435, http://dx.doi.org/10.1111/j.1476-5381.2009.00160.x

Hirbe AC; Roelofs AJ; Floyd DH; Deng H; Becker SN; Lanigan LG; Apicelli AJ; Xu Z; Prior JL; Eagleton MC; Piwnica-Worms D; Rogers MJ; Weilbaecher K, 2009, 'The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts', Bone, 44, pp. 908 - 916, http://dx.doi.org/10.1016/j.bone.2009.01.010

Sutherland KA; Rogers HL; Tosh D; Rogers MJ, 2009, 'RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro', Arthritis Research and Therapy, 11, http://dx.doi.org/10.1186/ar2681

Baron RA; Tavaré R; Figueiredo AC; Błazewska KM; Kashemirov BA; McKenna CE; Ebetino FH; Taylor A; Rogers MJ; Coxon FP; Seabra MC, 2009, 'Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase', Journal of Biological Chemistry, 284, pp. 6861 - 6868, http://dx.doi.org/10.1074/jbc.M806952200

Roelofs AJ; Jauhiainen M; Mönkkönen H; Rogers MJ; Mönkkönen J; Thompson K, 2009, 'Peripheral blood monocytes are responsible for γδ T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP', British Journal of Haematology, 144, pp. 245 - 250, http://dx.doi.org/10.1111/j.1365-2141.2008.07435.x

Roelofs AJ; Boyde A; Lundy MW; McKenna CE; Blazewska K; Sun ST; Kashemirov BA; Russell RGG; Ebetino FH; Rogers MJ; Coxon FP, 2009, 'Bone mineral affinity influences the distribution of a bisphosphonate and a lower affinity analogue in vivo', Bone, 44, pp. S430 - S431, http://dx.doi.org/10.1016/j.bone.2009.03.377

Thompson K; Keech F; McLernon D; Vinod K; Tosh D; Simpson WG; Rogers MJ; Reid DM, 2009, 'Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women', Bone, 44, pp. S236 - S237, http://dx.doi.org/10.1016/j.bone.2009.03.093

Mellis DJ; Guerrini MM; Greenhorn J; Vezzoni P; Villa A; Rogers MJ; Helfrich MH; Crockett JC, 2009, 'Functional analysis of mutations in rank that result in diseases with opposite phenotypes', Bone, 44, pp. S325 - S325, http://dx.doi.org/10.1016/j.bone.2009.03.617

Whyte L; Ryberg E; Sims NA; Ridge S; Mackie K; Greasley P; Ross RA; Rogers MJ, 2009, 'GPR55: A novel cannabinoid receptor involved in the regulation of osteoclast function and bone mass', Bone, 44, pp. S138 - S138, http://dx.doi.org/10.1016/j.bone.2009.01.305

Moriceau G; Roelofs AJ; Brion R; Ebetino HF; Rogers M; Heymann D, 2009, 'Synergistic effect of apomine and lovastatin on osteosarcoma cell growth', Bone, 44, pp. S273 - S273, http://dx.doi.org/10.1016/j.bone.2009.03.479

Boyde A; Lundy MW; Coxon FP; McKenna CE; Roelofs A; Bala J; Rogers MJ; Blazewska K; Russell RGG; Ebetino FH, 2009, 'The differential distribution in vivo of fluorescently-labeled bisphosphonate analogues with different mineral affinity to bone surfaces', Bone, 44, pp. S57 - S57, http://dx.doi.org/10.1016/j.bone.2009.01.016

Kashemirov BA; Bala JLF; Chen X; Ebetino FH; Xia Z; Russell RGG; Coxon FP; Roelofs AJ; Rogers MJ; McKenna CE, 2008, 'Fluorescently labeled risedronate and related analogues: "Magic linker" synthesis', Bioconjugate Chemistry, 19, pp. 2308 - 2310, http://dx.doi.org/10.1021/bc800369c

Fournier PGJ; Daubiné F; Lundy MW; Rogers MJ; Ebetino FH; Clézardin P, 2008, 'Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo', Cancer Research, 68, pp. 8945 - 8953, http://dx.doi.org/10.1158/0008-5472.CAN-08-2195

Guerrini MM; Sobacchi C; Cassani B; Abinun M; Kilic SS; Pangrazio A; Moratto D; Mazzolari E; Clayton-Smith J; Orchard P; Coxon FP; Helfrich MH; Crockett JC; Mellis D; Vellodi A; Tezcan I; Notarangelo LD; Rogers MJ; Vezzoni P; Villa A; Frattini A, 2008, 'Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations', American Journal of Human Genetics, 83, pp. 64 - 76, http://dx.doi.org/10.1016/j.ajhg.2008.06.015

Russell RGG; Watts NB; Ebetino FH; Rogers MJ, 2008, 'Mechanisms of action of bisphosphonates: Similarities and differences and their potential influence on clinical efficacy', Osteoporosis International, 19, pp. 733 - 759, http://dx.doi.org/10.1007/s00198-007-0540-8

Coxon FP; Thompson K; Roelofs AJ; Ebetino FH; Rogers MJ, 2008, 'Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells', Bone, 42, pp. 848 - 860, http://dx.doi.org/10.1016/j.bone.2007.12.225

Dunford JE; Kwaasi AA; Rogers MJ; Barnett BL; Ebetino FH; Russell RGG; Oppermann U; Kavanagh KL, 2008, 'Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: Time-dependent inhibition of human farnesyl pyrophosphate synthase', Journal of Medicinal Chemistry, 51, pp. 2187 - 2195, http://dx.doi.org/10.1021/jm7015733

Holmes S; Smith S; Borthwick L; Dunford J; Rogers M; Bishop N; Grabowski PS, 2008, 'CMT3 alters mitochondrial function in murine osteoclast lineage cells', Biochemical and Biophysical Research Communications, 365, pp. 840 - 845, http://dx.doi.org/10.1016/j.bbrc.2007.11.054

Ory B; Moriceau G; Trichet V; Blanchard F; Berreur M; Rédini F; Rogers M; Heymann D, 2008, 'Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells', Journal of Cellular and Molecular Medicine, 12, pp. 928 - 941, http://dx.doi.org/10.1111/j.1582-4934.2008.00141.x

Tavare R; Baron R; Taylor A; Seabra MC; Blazewska KM; McKenna CE; Kashemirov BA; Ebetino FH; Rogers MJ; Coxon FP, 2008, 'Characterisation of the inhibition of rab prenylation by phosphonocarboxylates', Bone, 42, pp. S88 - S89, http://dx.doi.org/10.1016/j.bone.2007.12.167

A. Stewart C; Baron R; Blazewska KM; Kashemirov BA; Ebetino FH; Navea JR; Rogers MJ; McKenna CE; Coxon FP, 2008, 'Differential inhibition of rab geranylgeranyl transferase by stereoisomers of phosphonocarboxylates', Bone, 42, pp. S87 - S87, http://dx.doi.org/10.1016/j.bone.2007.12.164

Ory B; Moriceau G; Trichet V; Blanchard F; Berreur M; Redini F; Rogers M; Heymann D, 2008, 'Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells', JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 12, pp. 928 - 941, http://dx.doi.org/10.1111/j.1582-4934.2008.00141.x

Coxon FP; Bala JL; Kashemirov BA; Lundy MW; Chen X; Xia Z; Dunford JE; Russell GG; Roelofs AJ; Rogers MJ; McKenna CE; Ebetino FH, 2008, 'Fluorescently labeled risedronate and related analogs: Design and evaluation as imaging probes', Bone, 42, pp. S36 - S36, http://dx.doi.org/10.1016/j.bone.2007.12.054

Guerrini MM; Sobacchi C; Cassani B; Abinun M; Kilic SS; Pangrazio A; Moratto D; Mazzolari E; Clayton-Smith J; Orchard P; Coxon FP; Helfrich MH; Crockett JC; Mellis D; Vellodi A; Tezcan I; Notarangelo LD; Rogers MJ; Vezzoni P; Villa A; Frattini A, 2008, 'Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations', AMERICAN JOURNAL OF HUMAN GENETICS, 83, pp. 64 - 76, http://dx.doi.org/10.1016/j.ajhg.2008.06.015

Roelofs AJ; Jauhiainen M; Monkkonen H; Rogers MJ; Monkkonen J; Thompson K, 2008, 'Nitrogen-containing bisphosphonates induce IPP/DMAPP accumulation selectively in peripheral blood monocytes due to efficient drug uptake', Bone, 42, pp. S84 - S85, http://dx.doi.org/10.1016/j.bone.2007.12.159

Dunford JE; Kwaasi AA; Kavanagh KL; Rogers MJ; Oppermann U; Barnett BB; Ebetino FH; Graham R; Russell G, 2008, 'Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase', Bone, 42, pp. S71 - S71, http://dx.doi.org/10.1016/j.bone.2007.12.129

Stewart CA; Baron R; Marma MS; Blazewska KM; Kashemirov BA; Ebetino FH; McKenna CE; Rogers MJ; Coxon FP, 2008, 'Structure activity relationships of phosphonocarboxylate inhibitors of rab geranylgeranyl transferase', Bone, 42, pp. S86 - S87, http://dx.doi.org/10.1016/j.bone.2007.12.163

Roelofs AJ; Coxon FP; Ebetino FH; Bala JF; Kashemirov BA; McKenna CE; Rogers MJ, 2008, 'Use of a fluorescent analogue of risedronate to study localisation and cellular uptake of bisphosphonates in vivo', Bone, 42, pp. S85 - S85, http://dx.doi.org/10.1016/j.bone.2007.12.160

Kuokkanen J; Crockett JC; Rogers MJ; Mönkkönen H; Auriola S; Mönkkönen J, 2008, 'Zoledronic Acid-Induced IPP/ApppI Formation In Vivo and In Vitro', Bone, 42, pp. S38 - S39, http://dx.doi.org/10.1016/j.bone.2007.12.060

Samanna V; Ma T; Mak TW; Rogers M; Chellaiah MA, 2007, 'Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function', Journal of Cellular Physiology, 213, pp. 710 - 720, http://dx.doi.org/10.1002/jcp.21137

Crockett JC; Schütze N; Tosh D; Jatzke S; Duthie A; Jakob F; Rogers MJ, 2007, 'The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of αvβ3 and α vβ5', Endocrinology, 148, pp. 5761 - 5768, http://dx.doi.org/10.1210/en.2007-0473

Hughes A; Rogers MJ; Idris AI; Crockett JC, 2007, 'A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo', Calcified Tissue International, 81, pp. 403 - 413, http://dx.doi.org/10.1007/s00223-007-9078-1

Thompson K; Rogers MJ, 2007, 'The molecular mechanisms of action of bisphosphonates', Clinical Reviews in Bone and Mineral Metabolism, 5, pp. 130 - 144, http://dx.doi.org/10.1007/s12018-007-9004-0

Sobacchi C; Frattini A; Guerrini MM; Abinun M; Pangrazio A; Susani L; Bredius R; Mancini G; Cant A; Bishop N; Grabowski P; Del Fattore A; Messina C; Errigo G; Coxon FP; Scott DI; Teti A; Rogers MJ; Vezzoni P; Villa A; Helfrich MH, 2007, 'Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL', Nature Genetics, 39, pp. 960 - 962, http://dx.doi.org/10.1038/ng2076

Roelofs AJ; Edwards CM; Russell RGG; Ebetino FH; Rogers MJ; Hulley PA, 2007, 'Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase', Journal of Pharmacology and Experimental Therapeutics, 322, pp. 228 - 235, http://dx.doi.org/10.1124/jpet.106.116467

Van Wesenbeeck L; Odgren PR; Coxon FP; Frattini A; Moens P; Perdu B; MacKay CA; Van Hul E; Timmermans JP; Vanhoenacker F; Jacobs R; Peruzzi B; Teti A; Helfrich MH; Rogers MJ; Villa A; Van Hul W, 2007, 'Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans', Journal of Clinical Investigation, 117, pp. 919 - 930, http://dx.doi.org/10.1172/JCI30328

Desai B; Rogers MJ; Chellaiah MA, 2007, 'Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells', Molecular Cancer, 6, http://dx.doi.org/10.1186/1476-4598-6-18

Taylor A; Rogers MJ; Tosh D; Coxon FP, 2007, 'A novel method for efficient generation of transfected human osteoclasts', Calcified Tissue International, 80, pp. 132 - 136, http://dx.doi.org/10.1007/s00223-006-0245-6

Roelofs AJ; Thompson K; Gordon S; Rogers MJ; Boyce ; Roodman ; Suva ; Coleman ; Weilbaecher ; Bruland ; Vessella ; Lipton , 2006, 'Molecular mechanisms of action of bisphosphonates: Current status', Clinical Cancer Research, 12, http://dx.doi.org/10.1158/1078-0432.CCR-06-0843

Coxon FP; Thompson K; Rogers MJ, 2006, 'Recent advances in understanding the mechanism of action of bisphosphonates', Current Opinion in Pharmacology, 6, pp. 307 - 312, http://dx.doi.org/10.1016/j.coph.2006.03.005

Kavanagh KL; Guo K; Dunford JE; Wu X; Knapp S; Ebetino FH; Rogers MJ; Russell RGG; Oppermann U, 2006, 'The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 7829 - 7834, http://dx.doi.org/10.1073/pnas.0601643103

Thompson K; Rogers MJ; Coxon FP; Crockett JC, 2006, 'Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis', Molecular Pharmacology, 69, pp. 1624 - 1632, http://dx.doi.org/10.1124/mol.105.020776

Dunford JE; Rogers MJ; Ebetino FH; Phipps RJ; Coxon FP, 2006, 'Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases', Journal of Bone and Mineral Research, 21, pp. 684 - 694, http://dx.doi.org/10.1359/jbmr.060118

Thompson K; Rojas-Navea J; Rogers MJ, 2006, 'Alkylamines cause Vγ9Vδ2 T-cell activation and proliferation by inhibiting the mevalonate pathway', Blood, 107, pp. 651 - 654, http://dx.doi.org/10.1182/blood-2005-03-1025

Thompson K; Kikuvi TM; Rogers MJ, 2006, 'Alkylamines prevent osteoclast formation and activity by inhibiting the mevalonate pathway', Bone, 38, pp. 31 - 31, http://dx.doi.org/10.1016/j.bone.2006.01.124

Kavanagh KL; Guo K; Wu X; Knapp S; Ebetino FH; Dunford JE; Rogers MJ; Russell RGG; Oppermann U, 2006, 'Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase', Bone, 38, pp. 53 - 53, http://dx.doi.org/10.1016/j.bone.2005.12.050

Thompson K; Rogers MJ; Coxon FP; Crockett JC, 2006, 'Cytosolic entry of Bisphosphonates into macrophages and osteoclasts requires fluid-phase endocytosis and endosomal acidification', Bone, 38, pp. 47 - 47, http://dx.doi.org/10.1016/j.bone.2005.12.035

Coxon FP; Dunford JE; Rogers MJ, 2006, 'Inhibition of post-translational prenylation causes sustained activation of RAC, Cdc42 and Rho GTPases', Bone, 38, pp. 45 - 45, http://dx.doi.org/10.1016/j.bone.2005.12.031

Dunford JE; Kavanagh K; Oppermann U; Ebetino FH; Russell RGG; Rogers MJ, 2006, 'Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates', Bone, 38, pp. 47 - 48, http://dx.doi.org/10.1016/j.bone.2005.12.037

Ebetino FH; Kashemirov B; McKenna CE; Evdokimov A; Pokross M; Barnett BL; Dunford J; Kavanagh K; Rogers MJ; Lundy MW; Oppermann U; Russell RGG, 2006, 'Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase', Bone, 38, pp. 49 - 50, http://dx.doi.org/10.1016/j.bone.2005.12.042

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