By Professor Michael John Rogers

Book Chapters

Munoz MA; Rogers MJ, 2021, 'Cellular and molecular actions of bisphosphonates', in Bone Cancer Bone Sarcomas and Bone Metastases from Bench to Bedside, pp. 921 - 942, http://dx.doi.org/10.1016/B978-0-12-821666-8.00025-6

Munoz MA; Rogers MJ, 2020, 'Bisphosphonates and bone cells-molecular mechanisms', in Encyclopedia of Bone Biology, pp. 565 - 578, http://dx.doi.org/10.1016/b978-0-12-801238-3.11261-9

Cremers S; Drake MT; Ebetino FH; Rogers MJ; Bilezikian JP; Russell RGG, 2020, 'Chapter 72 Clinical and translational pharmacology of bisphosphonates', in Principles of Bone Biology, pp. 1671 - 1687, http://dx.doi.org/10.1016/b978-0-12-814841-9.00072-5

Cremers S; Drake MT; Ebetino FH; Rogers MJ; Bilezikian JP; Russell RG, 2019, 'Clinical and translational pharmacology of bisphosphonates', in Principles of Bone Biology, pp. 1671 - 1687, http://dx.doi.org/10.1016/B978-0-12-814841-9.00072-5

Junankar S; Rogers MJ, 2015, 'Chapter 51 Cellular and molecular actions of bisphosphonates', in Bone Cancer, Elsevier, pp. 615 - 627, http://dx.doi.org/10.1016/b978-0-12-416721-6.00051-0

Junankar S; Rogers MJ, 2014, 'Cellular and molecular actions of bisphosphonates', in Bone Cancer: Primary Bone Cancers and Bone Metastases: Second Edition, Elsevier/Academic Press, San Diego, California, pp. 615 - 627, http://dx.doi.org/10.1016/B978-0-12-416721-6.00051-0

Roelofs AJ; Ebetino FH; Reszka AA; Russell RGG; Rogers MJ, 2008, 'Bisphosphonates: Mechanisms of Action', in Principles of Bone Biology Volume 1 2 Third Edition, pp. 1737 - 1767, http://dx.doi.org/10.1016/B978-0-12-373884-4.00095-1

Roelofs AJ; Ebetino FH; Reszka AA; Russell RGG; Rogers MJ, 2008, 'Chapter 81 Bisphosphonates Mechanisms of Action', in Principles of Bone Biology, Elsevier, pp. 1737 - 1767, http://dx.doi.org/10.1016/b978-0-12-373884-4.00095-1

Coleman RE; Rogers MJ, 2006, 'Mechanisms of Action of Bisphosphonates', in Textbook of Bone Metastases, pp. 323 - 343, http://dx.doi.org/10.1002/0470011610.ch25

McGowan NWA; Harmey D; Coxon FP; Stenbeck G; Rogers MJ; Grigoriadis AE, 2005, 'Bacterial toxins and bone remodelling', in Bacterial Protein Toxins, Cambridge University Press, pp. 147 - 168, http://dx.doi.org/10.1017/cbo9780511546280.008

Coxon FP; Frith JC; Benford HL; Rogers MJ, 2003, 'Isolation and Purification of Rabbit Osteoclasts', in Bone Research Protocols, Springer Nature, pp. 89 - 99, http://dx.doi.org/10.1385/1-59259-366-6:89

Fleisch H; Reszka A; Rodan G; Rogers M, 2002, 'Bisphosphonates', in Principles of Bone Biology, Elsevier, pp. 1361 - XLIII, http://dx.doi.org/10.1016/b978-012098652-1.50180-3

Rogers MJ; Russell RGG, 1996, 'Mechanisms of Action of Bisphosphonates as Inhibitors of Bone Resorption', in Medical Intelligence Unit, Springer Berlin Heidelberg, pp. 147 - 177, http://dx.doi.org/10.1007/978-3-662-22505-9_7

Journal articles

Munoz MA; Skinner OP; Masle-Farquhar E; Jurczyluk J; Xiao Y; Fletcher EK; Kristianto E; Hodson MP; O’Donoghue SI; Kaur S; Brink R; Zahra DG; Deenick EK; Perry KA; Robertson AAB; Mehr S; Hissaria P; Mulders-Manders CM; Simon A; Rogers MJ, 2022, 'Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency', Journal of Clinical Investigation, 132, http://dx.doi.org/10.1172/JCI160929

Munoz MA; Fletcher EK; Skinner OP; Jurczyluk J; Kristianto E; Hodson MP; Sun S; Ebetino FH; Croucher DR; Hansbro PM; Center JR; Rogers MJ, 2021, 'Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages', Elife, 10, http://dx.doi.org/10.7554/eLife.72430

Brown AJ; Sharpe LJ; Rogers MJ, 2021, 'Oxysterols: From physiological tuners to pharmacological opportunities', British Journal of Pharmacology, 178, pp. 3089 - 3103, http://dx.doi.org/10.1111/bph.15073

McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Corr A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG, 2021, 'Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))', Cell, 184, pp. 1940, http://dx.doi.org/10.1016/j.cell.2021.03.010

Kamble S; Valtchev P; Dao A; Pelras T; Rogers MJ; Savage PB; Dehghani F; Schindeler A, 2021, 'Synthesis and characterization of bone binding antibiotic-1 (Bba-1), a novel antimicrobial for orthopedic applications', Molecules, 26, http://dx.doi.org/10.3390/molecules26061541

McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG; Corr A, 2021, 'Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption', Cell, 184, pp. 1330 - 1347.e13, http://dx.doi.org/10.1016/j.cell.2021.02.002

Munoz M; Fletcher E; Skinner O; Jurczyluk J; Kristianto E; Hodson M; Sun S; Ebetino F; Croucher D; Hansbro P; Center J; Rogers M, 2021, 'Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages', , http://dx.doi.org/10.1101/2021.08.09.455652

Rogers MJ; Mönkkönen J; Munoz MA, 2020, 'Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton', Bone, 139, http://dx.doi.org/10.1016/j.bone.2020.115493

Skinner OP; Jurczyluk J; Baker PJ; Masters SL; Rios Wilks AG; Clearwater MS; Robertson AAB; Schroder K; Mehr S; Munoz MA; Rogers MJ, 2019, 'Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes', Journal of Allergy and Clinical Immunology, 143, pp. 2315 - 2317.e3, http://dx.doi.org/10.1016/j.jaci.2019.02.013

Munoz MA; Jurczyluk J; Simon A; Hissaria P; Arts RJW; Coman D; Boros C; Mehr S; Rogers MJ, 2019, 'Defective protein prenylation in a spectrum of patients with mevalonate kinase deficiency', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2019.01900

Lee NJ; Ali N; Zhang L; Qi Y; Clarke I; Enriquez RF; Brzozowska M; Lee IC; Rogers MJ; Laybutt DR; Center JR; Baldock PA; Herzog H, 2019, 'Osteoglycin, a novel coordinator of bone and glucose homeostasis', Obesity Research & Clinical Practice, 13, pp. 256 - 256, http://dx.doi.org/10.1016/j.orcp.2018.11.063

Rogers MJ; Munoz MA, 2018, 'From vesicle to cytosol', Elife, 7, pp. e38847, http://dx.doi.org/10.7554/eLife.38847

Lee NJ; Ali N; Qi J; Clarke RF; Enriquez RF; Brzozowska M; Lee IC; Rogers MJ; Laybutt DR; Center JR; Baldock PA; Herzog H, 2018, 'Osteoglycin, an Osteoblast-derived Regulator of Bone Mass and Glucose Homeostasis', Molecular Metabolism, http://dx.doi.org/10.1016/j.molmet.2018.05.004

Chai RC; McDonald MM; Terry RL; Kovačić N; Down JM; Pettitt JA; Mohanty ST; Shah S; Haffari G; Xu J; Gillespie MT; Rogers MJ; Price JT; Croucher PI; Quinn JMW, 2017, 'Melphalan modifies the bone microenvironment by enhancing osteoclast formation', Oncotarget, 8, pp. 68047 - 68058, http://dx.doi.org/10.18632/oncotarget.19152

Munoz MA; Jurczyluk J; Mehr S; Chai RC; Arts RJW; Sheu A; McMahon C; Center JR; Singh-Grewal D; Chaitow J; Campbell DE; Quinn JMW; Alexandrov K; Tnimov Z; Tangye SG; Simon A; Phan TG; Rogers MJ, 2017, 'Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency', Journal of Allergy and Clinical Immunology, 140, pp. 873 - 875.e6, http://dx.doi.org/10.1016/j.jaci.2017.02.033

Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', Immunology and Cell Biology, 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58

Lawson MA; McDonald MM; Kovacic N; Khoo WH; Terry RL; Down J; Kaplan W; Paton-Hough J; Fellows C; Pettitt JA; Dear TN; Van Valckenborgh E; Baldock PA; Rogers MJ; Eaton CL; Vanderkerken K; Pettit AR; Quinn JMW; Zannettino ACW; Phan TG; Croucher PI, 2015, 'Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms9983

Ali N; Jurczyluk J; Shay G; Tnimov Z; Alexandrov K; Munoz MA; Skinner OP; Pavlos NJ; Rogers MJ, 2015, 'A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton', Small Gtpases, 6, pp. 202 - 211, http://dx.doi.org/10.1080/21541248.2015.1085485

Croucher PI; Parker BS; Corcoran N; Rogers MJ, 2015, 'Bone turnover markers and prostate cancer: Not just a measure of bone disease?', European Urology, 68, pp. 51 - 52, http://dx.doi.org/10.1016/j.eururo.2014.10.041

Junankar S; Shay G; Jurczyluk J; Ali N; Down J; Pocock N; Parker A; Nguyen A; Sun S; Kashemirov B; McKenna CE; Croucher PI; Swarbrick A; Weilbaecher K; Phan TG; Rogers MJ, 2015, 'Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer', Cancer Discovery, 5, pp. 35 - 42, http://dx.doi.org/10.1158/2159-8290.CD-14-0621

Das S; Edwards PA; Crockett JC; Rogers MJ, 2014, 'Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells', Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, 1841, pp. 569 - 573, http://dx.doi.org/10.1016/j.bbalip.2013.12.010

Rumpler M; Würger T; Roschger P; Zwettler E; Sturmlechner I; Altmann P; Fratzl P; Rogers MJ; Klaushofer K, 2013, 'Osteoclasts on bone and dentin in vitro: Mechanism of trail formation and comparison of resorption behavior', Calcified Tissue International, 93, pp. 526 - 539, http://dx.doi.org/10.1007/s00223-013-9786-7

Su X; Floyd DH; Hughes A; Xiang J; Schneider JG; Uluckan O; Heller E; Deng H; Zou W; Craft CS; Wu K; Hirbe AC; Grabowska D; Eagleton MC; Townsley S; Collins L; Piwnica-Worms D; Steinberg TH; Novack DV; Conley PB; Hurchla MA; Rogers M; Weilbaecher KN, 2012, 'The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling', Journal of Clinical Investigation, 122, pp. 3579 - 3592, http://dx.doi.org/10.1172/JCI38576

Naylor AJ; Azzam E; Smith S; Croft A; Poyser C; Duffield JS; Huso DL; Gay S; Ospelt C; Cooper MS; Isacke C; Goodyear SR; Rogers MJ; Buckley CD, 2012, 'The mesenchymal stem cell marker CD248 (Endosialin) is a negative regulator of bone formation in mice', Arthritis and Rheumatism, 64, pp. 3334 - 3343, http://dx.doi.org/10.1002/art.34556

Whyte LS; Ford L; Ridge SA; Cameron GA; Rogers MJ; Ross RA, 2012, 'Cannabinoids and bone: Endocannabinoids modulate human osteoclast function in vitro', British Journal of Pharmacology, 165, pp. 2584 - 2597, http://dx.doi.org/10.1111/j.1476-5381.2011.01519.x

Roelofs AJ; Stewart CA; Sun S; Błazewska KM; Kashemirov BA; McKenna CE; Russell RGG; Rogers MJ; Lundy MW; Ebetino FH; Coxon FP, 2012, 'Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo', Journal of Bone and Mineral Research, 27, pp. 835 - 847, http://dx.doi.org/10.1002/jbmr.1543

Hughes A; Kleine-Albers J; Helfrich MH; Ralston SH; Rogers MJ, 2012, 'A Class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro', Calcified Tissue International, 90, pp. 151 - 162, http://dx.doi.org/10.1007/s00223-011-9560-7

Moriceau G; Roelofs AJ; Brion R; Redini F; Ebetion FH; Rogers MJ; Heymann D, 2012, 'Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth', Cancer, 118, pp. 750 - 760, http://dx.doi.org/10.1002/cncr.26336

Coxon FP; Rogers MJ; Crockett JC, 2012, 'Isolation and purification of rabbit osteoclasts', Methods in Molecular Biology, 816, pp. 145 - 158, http://dx.doi.org/10.1007/978-1-61779-415-5_10

Błaewska KM; Ni F; Haiges R; Kashemirov BA; Coxon FP; Stewart CA; Baron R; Rogers MJ; Seabra MC; Ebetino FH; McKenna CE, 2011, 'Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors', European Journal of Medicinal Chemistry, 46, pp. 4820 - 4826, http://dx.doi.org/10.1016/j.ejmech.2011.04.063

Crockett JC; Mellis DJ; Shennan KIJ; Duthie A; Greenhorn J; Wilkinson DI; Ralston SH; Helfrich MH; Rogers MJ, 2011, 'Signal peptide mutations in RANK prevent downstream activation of NF-κB', Journal of Bone and Mineral Research, 26, pp. 1926 - 1938, http://dx.doi.org/10.1002/jbmr.399

Rogers MJ; Crockett JC; Coxon FP; Mönkkönen J, 2011, 'Biochemical and molecular mechanisms of action of bisphosphonates', Bone, 49, pp. 34 - 41, http://dx.doi.org/10.1016/j.bone.2010.11.008

Thompson K; Keech F; McLernon DJ; Vinod K; May RJ; Simpson WG; Rogers MJ; Reid DM, 2011, 'Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women', Bone, 49, pp. 140 - 145, http://dx.doi.org/10.1016/j.bone.2010.10.177

Coxon FP; Taylor A; Stewart CA; Baron R; Seabra MC; Ebetino FH; Rogers MJ, 2011, 'The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates', Bone, 49, pp. 111 - 121, http://dx.doi.org/10.1016/j.bone.2011.03.686

Crockett JC; Rogers MJ; Coxon FP; Hocking LJ; Helfrich MH, 2011, 'Bone remodelling at a glance', Journal of Cell Science, 124, pp. 991 - 998, http://dx.doi.org/10.1242/jcs.063032

Taylor A; Mules EH; Seabra MC; Helfrich MH; Rogers MJ; Coxon FP, 2011, 'Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function', Small Gtpases, 2, pp. 131 - 142, http://dx.doi.org/10.4161/sgtp.2.3.16488

Itzstein C; Coxon FP; Rogers MJ, 2011, 'The regulation of osteoclast function and bone resorption by small GTPases', Small Gtpases, 2, pp. 117 - 130, http://dx.doi.org/10.4161/sgtp.2.3.16453

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