By Professor Kyle Lee Hoehn

Journal articles

Byrne FL; Olzomer EM; Brink R; Hoehn KL, 2018, 'Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice', American Journal of Physiology Endocrinology and Metabolism, 315, pp. E286 - E293, http://dx.doi.org/10.1152/ajpendo.00082.2018

Childress ES; Alexopoulos SJ; Hoehn KL; Santos WL, 2018, 'Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential', Journal of Medicinal Chemistry, 61, pp. 4641 - 4655, http://dx.doi.org/10.1021/acs.jmedchem.7b01182

Fazakerley DJ; Chaudhuri R; Yang P; Maghzal GJ; Thomas KC; Krycer JR; Humphrey SJ; Parker BL; Fisher-Wellman KH; Meoli CC; Hoffman NJ; Diskin C; Burchfield JG; Cowley MJ; Kaplan W; Modrusan Z; Kolumam G; Yang JYH; Chen DL; Samocha-Bonet D; Greenfield JR; Hoehn KL; Stocker R; James DE; Chen D; Southwell Keely P, 2018, 'Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance', eLife, 7, pp. e32111, http://dx.doi.org/10.7554/eLife.32111

Serasinghe MN; Gelles JD; Li K; Zhao L; Abbate F; Syku M; Mohammed JN; Badal B; Rangel CA; Hoehn KL; Celebi JT; Chipuk JE, 2018, 'Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition', Cell Death and Disease, 9, pp. 29, http://dx.doi.org/10.1038/s41419-017-0044-1

Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2018, 'Analysis of the circular RNA transcriptome in endometrial cancer', Oncotarget, 9, pp. 5786 - 5796, http://dx.doi.org/10.18632/oncotarget.23534

Burchfield JG; Kebede MA; Meoli CC; Stöckli J; Whitworth PT; Wright AL; Hoffman NJ; Minard AY; Ma X; Krycer JR; Nelson ME; Tan SX; Yau B; Thomas KC; Wee NKY; Khor EC; Enriquez RF; Vissel B; Biden TJ; Baldock PA; Hoehn KL; Cantley J; Cooney GJ; James DE; Fazakerley DJ; Wright A, 2018, 'High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice', Journal of Biological Chemistry, 293, pp. 5731 - 5745, http://dx.doi.org/10.1074/jbc.RA117.000808

Meher AK; Serbulea V; Upchurch CM; Osinski V; Sahu S; Hargett S; Hoehn KL; Harris TE; Klibanov AL; McNamara CA; Leitinger N, 2018, 'Abstract 428: An Unexpected Role for ACC in Lipid Droplet Formation in Macrophages in Response to Acellular Adipocyte Fat', Arteriosclerosis, Thrombosis, and Vascular Biology, 38, http://dx.doi.org/10.1161/atvb.38.suppl_1.428

Krycer JR; Yugi K; Hirayama A; Fazakerley DJ; Quek LE; Scalzo R; Ohno S; Hodson MP; Ikeda S; Shoji F; Suzuki K; Domanova W; Parker BL; Nelson ME; Humphrey SJ; Turner N; Hoehn KL; Cooney GJ; Soga T; Kuroda S; James DE, 2017, 'Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism', Cell Reports, 21, pp. 3536 - 3547, http://dx.doi.org/10.1016/j.celrep.2017.11.085

Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2017, 'Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer', Gynecologic Oncology, 147, pp. 654 - 662, http://dx.doi.org/10.1016/j.ygyno.2017.10.006

Gordon HM; Majithia N; MacDonald PE; Fox JEM; Sharma PR; Byrne FL; Hoehn KL; Evans-Molina C; Langman L; Brayman KL; Nunemaker CS, 2017, 'STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation', Endocrine, 56, pp. 528 - 537, http://dx.doi.org/10.1007/s12020-017-1297-2

Caruana BT; Hoehn KL, 2017, 'The race to find endometrial cancer biomarkers', Surgery for Obesity and Related Diseases, 13, pp. 869 - 870, http://dx.doi.org/10.1016/j.soard.2017.01.042

Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, 8, pp. 14689, http://dx.doi.org/10.1038/ncomms14689

Taddeo EP; Hargett SR; Lahiri S; Nelson ME; Liao JA; Li C; Slack-Davis JK; Tomsig JL; Lynch KR; Yan Z; Harris TE; Hoehn KL, 2017, 'Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3', Scientific Reports, 7, pp. 127, http://dx.doi.org/10.1038/s41598-017-00210-y

Laker RC; Taddeo EP; Akhtar YN; Zhang M; Hoehn KL; Yan Z, 2016, 'The mitochondrial permeability transition pore regulator cyclophilin D exhibits tissue-specific control of metabolic homeostasis', Plos One, 11, pp. e0167910, http://dx.doi.org/10.1371/journal.pone.0167910

Takenaka K; Chen BJ; Modesitt SC; Byrne FL; Hoehn KL; Janitz M, 2016, 'The emerging role of long non-coding RNAs in endometrial cancer', Cancer Genetics, 209, pp. 445 - 455, http://dx.doi.org/10.1016/j.cancergen.2016.09.005

Biwer LA; Taddeo EP; Kenwood BM; Hoehn KL; Straub AC; Isakson BE, 2016, 'Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition', Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, 1861, pp. 671 - 679, http://dx.doi.org/10.1016/j.bbalip.2016.04.014

Narayanan S; Nieh AH; Kenwood BM; Davis CA; Tosello-Trampont AC; Elich TD; Breazeale SD; Ward E; Anderson RJ; Caldwell SH; Hoehn KL; Hahn YS, 2016, 'Distinct roles for intracellular and extracellular lipids in hepatitis C virus infection', Plos One, 11, pp. e0156996, http://dx.doi.org/10.1371/journal.pone.0156996

Byrne FL; Hoehn KL, 2016, 'Subclassification of fatty liver by its pathogenesis: CIEFing is believing', Journal of Pathology, 239, pp. 3 - 5, http://dx.doi.org/10.1002/path.4702

Healy ME; Lahiri S; Hargett SR; Chow JDY; Byrne FL; Breen DS; Kenwood BM; Taddeo EP; Lackner C; Caldwell SH; Hoehn KL, 2016, 'Dietary sugar intake increases liver tumor incidence in female mice', Scientific Reports, 6, pp. 22292, http://dx.doi.org/10.1038/srep22292

Brandon AE; Stuart E; Leslie SJ; Hoehn KL; James DE; Kraegen EW; Turner N; Cooney GJ, 2016, 'Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice', Journal of Endocrinology, 228, pp. 127 - 134, http://dx.doi.org/10.1530/JOE-15-0444

Biwer L; Taddeo E; Hoehn K; Straub A; Isakson B, 2016, 'Lipid composition of the myoendothelial junction allows for compartmentalized eNOS function', The FASEB Journal, 30, http://dx.doi.org/10.1096/fasebj.30.1_supplement.727.9

Baker W; Paquette C; Byrne FL; Atkins KA; Shupnik M; Modesitt SC; Hoehn KL; Slack-Davis JK, 2016, 'Postmenopausal endometrial cancer patients have significantly higher expression of GLUT6 in the endometrium', Gynecologic Oncology, 141, pp. 175 - 176, http://dx.doi.org/10.1016/j.ygyno.2016.04.456

Saur SJ; Märklin M; Ganser M; Hoehn K; David JE; Borst O; Kanz L; Kopp H-G; Mueller MR, 2015, 'C-Cbl Regulates c-Mpl Receptor Trafficking and Its Internalization', Blood, 126, pp. 2388 - 2388, http://dx.doi.org/10.1182/blood.v126.23.2388.2388

Chaudhuri R; Khoo PS; Tonks K; Junutula JR; Kolumam G; Modrusan Z; Samocha-Bonet D; Meoli CC; Hocking S; Fazakerley DJ; Stöckli J; Hoehn KL; Greenfield JR; Yang JYH; James DE; Milliken S; Goodnow C, 2015, 'Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity', Npj Systems Biology and Applications, 1, pp. 15010, http://dx.doi.org/10.1038/npjsba.2015.10

Kenwood BM; Calderone JA; Taddeo EP; Hoehn KL; Santos WL, 2015, 'Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers', Bioorganic and Medicinal Chemistry Letters, 25, pp. 4858 - 4861, http://dx.doi.org/10.1016/j.bmcl.2015.06.040

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602

Lee JE; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y, 2015, 'Acetyl CoA carboxylase 2 is dispensable for CD8+ T cell responses', Plos One, 10, pp. e0137776, http://dx.doi.org/10.1371/journal.pone.0137776

Hargett SR; Walker NN; Hussain SS; Hoehn KL; Keller SR, 2015, 'Deletion of the rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice', American Journal of Physiology Endocrinology and Metabolism, 309, pp. E233 - E245, http://dx.doi.org/10.1152/ajpendo.00007.2015

Modesitt SC; Hallowell PT; Slack-Davis JK; Michalek RD; Atkins KA; Kelley SL; Arapovic S; Shupnik MA; Hoehn K, 2015, 'Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life', Gynecologic Oncology, 138, pp. 238 - 245, http://dx.doi.org/10.1016/j.ygyno.2015.05.015

Bajwa A; Rosin DL; Chroscicki P; Lee S; Dondeti K; Ye H; Kinsey GR; Stevens BK; Jobin K; Kenwood BM; Hoehn KL; Lynch KR; Okusa MD, 2015, 'Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury', Journal of the American Society of Nephrology, 26, pp. 908 - 925, http://dx.doi.org/10.1681/ASN.2013121351

Healy ME; Chow JDY; Byrne FL; Breen DS; Leitinger N; Li C; Lackner C; Caldwell SH; Hoehn KL, 2015, 'Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine', Journal of Hepatology, 62, pp. 599 - 606, http://dx.doi.org/10.1016/j.jhep.2014.10.024

Kashatus JA; Nascimento A; Myers LJ; Sher A; Byrne FL; Hoehn KL; Counter CM; Kashatus DF, 2015, 'Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth', Molecular Cell, 57, pp. 537 - 551, http://dx.doi.org/10.1016/j.molcel.2015.01.002

Serasinghe MN; Wieder SY; Renault TT; Elkholi R; Asciolla JJ; Yao JL; Jabado O; Hoehn K; Kageyama Y; Sesaki H; Chipuk JE, 2015, 'Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors', Molecular Cell, 57, pp. 521 - 536, http://dx.doi.org/10.1016/j.molcel.2015.01.003

Cronk SM; Kelly-Goss MR; Ray HC; Mendel TA; Hoehn KL; Bruce AC; Dey BK; Guendel AM; Tavakol DN; Herman IM; Peirce SM; Yates PA, 2015, 'Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy', Stem Cells Translational Medicine, 4, pp. 459 - 467, http://dx.doi.org/10.5966/sctm.2014-0108

Modesitt SC; Hallowell PT; Hoehn KL; Slack-Davis JK; Kelley SL; Arapovic S; Shupnik M, 2015, 'Changes in metabolic profiles before and after bariatric surgery in high risk morbidly obese women: Obesity-related carcinogenesis is not all about hormones', Gynecologic Oncology, 137, pp. 26 - 26, http://dx.doi.org/10.1016/j.ygyno.2015.01.060

Laker R; Taddeo E; Zhang M; Hoehn K; Yan Z, 2015, 'The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue‐Specific Control of Metabolic Homeostasis', The FASEB Journal, 29, http://dx.doi.org/10.1096/fasebj.29.1_supplement.1036.14

Byrne FL; Poon IKH; Modesitt SC; Tomsig JL; Chow JDY; Healy ME; Baker WD; Atkins KA; Lancaster JM; Marchion DC; Moley KH; Ravichandran KS; Slack-Davis JK; Hoehn KL, 2014, 'Metabolic vulnerabilities in endometrial cancer', Cancer Research, 74, pp. 5832 - 5845, http://dx.doi.org/10.1158/0008-5472.CAN-14-0254

Narayanan S; Hoehn K; Kenwood B; Nieh A; Tosello-Trampont A; Davis C; Caldwell S; Hahn Y, 2014, 'Altered lipid metabolism influences course of hepatitis C virus infection and hepatocyte cytokine production', JOURNAL OF IMMUNOLOGY, 192, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209765005005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Bupp MG; Litvin S; Edwards R; Mihalcoe B; Byrne F; Hoehn K; Anoff J, 2014, 'The forkhead transcription factor, Foxo1, may coordinate naive CD8+T cell homeostasis with energy availability in mice.', JOURNAL OF IMMUNOLOGY, 192, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209765005135&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Laker RC; Xu P; Ryall KA; Sujkowski A; Kenwood BM; Chain KH; Zhang M; Royal MA; Hoehn KL; Driscoll M; Adler PN; Wessells RJ; Saucerman JJ; Yan Z, 2014, 'A novel mitotimer reporter gene for mitochondrial content, structure, stress, and damage in vivo', Journal of Biological Chemistry, 289, pp. 12005 - 12015, http://dx.doi.org/10.1074/jbc.M113.530527

Lee JE; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y, 2014, 'Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity', Journal of Immunology, 192, pp. 3190 - 3199, http://dx.doi.org/10.4049/jimmunol.1302985

Laker RC; Lillard TS; Okutsu M; Zhang M; Hoehn KL; Connelly JJ; Yan Z, 2014, 'Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring', Diabetes, 63, pp. 1605 - 1611, http://dx.doi.org/10.2337/db13-1614

Chow JDY; Lawrence RT; Healy ME; Dominy JE; Liao JA; Breen DS; Byrne FL; Kenwood BM; Lackner C; Okutsu S; Mas VR; Caldwell SH; Tomsig JL; Cooney GJ; Puigserver PB; Turner N; James DE; Villén J; Hoehn KL, 2014, 'Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation', Molecular Metabolism, 3, pp. 419 - 431, http://dx.doi.org/10.1016/j.molmet.2014.02.004

Kenwood BM; Weaver JL; Bajwa A; Poon IK; Byrne FL; Murrow BA; Calderone JA; Huang L; Divakaruni AS; Tomsig JL; Okabe K; Lo RH; Cameron Coleman G; Columbus L; Yan Z; Saucerman JJ; Smith JS; Holmes JW; Lynch KR; Ravichandran KS; Uchiyama S; Santos WL; Rogers GW; Okusa MD; Bayliss DA; Hoehn KL, 2014, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, 3, pp. 114 - 123, http://dx.doi.org/10.1016/j.molmet.2013.11.005

Taddeo EP; Laker RC; Breen DS; Akhtar YN; Kenwood BM; Liao JA; Zhang M; Fazakerley DJ; Tomsig JL; Harris TE; Keller SR; Chow JD; Lynch KR; Chokki M; Molkentin JD; Turner N; James DE; Yan Z; Hoehn KL, 2014, 'Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle', Molecular Metabolism, 3, pp. 124 - 134, http://dx.doi.org/10.1016/j.molmet.2013.11.003

Lira VA; Okutsu M; Zhang M; Greene NP; Laker RC; Breen DS; Hoehn KL; Yan Z, 2013, 'Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance', FASEB Journal, 27, pp. 4184 - 4193, http://dx.doi.org/10.1096/fj.13-228486

Caldwell S; Hoehn KL; Hahn YS, 2013, 'The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil', Hepatology, 57, pp. 1684 - 1687, http://dx.doi.org/10.1002/hep.26091

Cantley J; Whitworth PT; Davenport A; Hoehn KL; James DE; Biden TJ, 2013, 'Acetyl-CoA carboxylase-1 is a critical regulator of beta cell size and proliferation', DIABETIC MEDICINE, 30, pp. 8 - 9, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000316263400049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Kenwood BM; Weaver JL; Byrne FL; Murrow BA; Tomsig JL; Cameron Coleman G; Yan Z; Lynch KR; Bayliss DA; Hoehn KL; Bajwa A; Huang L; Okusa MD; Poon IK; Ravichandran KS; Divakaruni AS; Saucerman JJ; Smith JS; Holmes JW; Rogers GW; Lo RH; Columbus L; Okabe K; Uchiyama S; Calderone JA; Santos WL, 2013, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, http://dx.doi.org/10.1016/j.molmet.2013.11.005

Cleasby ME; Hoehn KL; Patel SA; Lawrence RT; Sawbridge L; Talbot NA; Turner N; Cooney GJ; Whitehead JP; Kraegen EW, 2012, 'Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity', DIABETOLOGIA, 55, pp. S244 - S245, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208826501338&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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