By Professor Hongyuan (Robert) Yang

Journal articles

Zhao T; Jin K; Wang X; Su X; Wang Y; Gao M; Luo W; Yang H; Yang Z, 2025, 'GPAT4 sustains endoplasmic reticulum homeostasis in endocardial cells and safeguards heart development', Nature Communications, 16, http://dx.doi.org/10.1038/s41467-025-58722-5

Chen S; Wang Y; Zhou Q; Qian Q; Jiang Q; Liu C; Liu Y; Zhou P; Xiong J; Zhang Y; Wang N; Li YE; Yin L; Yang H; Liu J, 2025, 'Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity', Nature Communications, 16, http://dx.doi.org/10.1038/s41467-025-56026-2

Wu J; Zhao Y; Qiu L; Chen Q; Wang X; Gu J; Liang Y; Zhang Y; Wang HY; Liu Y; Wu X; Chen S; Chen FJ; Gao M; Yang H, 2025, 'ORP2 regulates free cholesterol accumulation in hepatocytes during MASH', Hepatology Communications, 9, http://dx.doi.org/10.1097/HC9.0000000000000737

Wu J; Gao M; Wu X; Liu Y; Zhang T; Liang Y; Yang H; Ma C; Ye Y; Chang C; Li P; Chen FJ; Yang H, 2025, 'PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis', Proceedings of the National Academy of Sciences of the United States of America, 122, http://dx.doi.org/10.1073/pnas.2504219122

Wang X; Peng K; Zhao Y; Qiu L; Liang C; Dou Y; Dong Q; Ma X; Tang J; Ma Y; Liu L; Zheng M; Yang H; Gao M, 2025, 'The macrophage sterol transport protein ORP2 promotes cholesterol efflux and prevents foam cell formation and atherosclerosis', Journal of Biological Chemistry, 301, http://dx.doi.org/10.1016/j.jbc.2025.110228

Coates HW; Nguyen TB; Du X; Olzomer EM; Farrell R; Byrne FL; Yang H; Brown AJ, 2024, 'The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues', Journal of Biological Chemistry, 300, http://dx.doi.org/10.1016/j.jbc.2024.107232

Liu Y; Yang H, 2024, 'WIPI4 loss linked to ferroptosis', Nature Cell Biology, 26, pp. 506 - 507, http://dx.doi.org/10.1038/s41556-024-01359-1

Peng K; Chen X; Pei K; Wang X; Ma X; Liang C; Dong Q; Liu Z; Han M; Liu G; Yang H; Zheng M; Liu G; Gao M, 2024, 'Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr−/− mice', Biochimica Et Biophysica Acta Molecular Basis of Disease, 1870, http://dx.doi.org/10.1016/j.bbadis.2023.166850

Li YE; Norris DM; Xiao FN; Pandzic E; Whan RM; Fok S; Zhou M; Du G; Liu Y; Du X; Yang H, 2024, 'Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains', Journal of Cell Biology, 223, http://dx.doi.org/10.1083/jcb.202307041

Lin Y; Ran L; Du X; Yang H; Wu Y, 2023, 'Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases', Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, 1868, http://dx.doi.org/10.1016/j.bbalip.2023.159365

Zadoorian A; Du X; Yang H, 2023, 'Lipid droplet biogenesis and functions in health and disease', Nature Reviews Endocrinology, 19, pp. 443 - 459, http://dx.doi.org/10.1038/s41574-023-00845-0

Tao B; Yang H; Fan R, 2023, 'Seeing the Action of Lipid Droplets in Aging and Longevity', GEN Biotechnology, 2, pp. 287 - 289, http://dx.doi.org/10.1089/genbio.2023.29106.bta

Norris D; Aw Y; Yang H, 2023, 'Nonvesicular trafficking of cholesterol by Aster proteins', Life Metabolism, 2, http://dx.doi.org/10.1093/lifemeta/load003

Coates HW; Capell-Hattam IM; Olzomer EM; Du X; Farrell R; Yang H; Byrne FL; Brown AJ, 2023, 'Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase', Elife, 12, http://dx.doi.org/10.7554/eLife.82843

Lukmantara I; Chen F; Mak HY; Zadoorian A; Du X; Xiao FN; MacMurray Norris D; Pandzic E; Whan R; Zhong Q; Yang H, 2022, 'PI(3)P and DFCP1 regulate the biogenesis of lipid droplets', Molecular Biology of the Cell, 33, http://dx.doi.org/10.1091/mbc.E22-07-0279

Tang G; Ma C; Li L; Zhang S; Li F; Wu J; Yin Y; Zhu Q; Liang Y; Wang R; Huang H; Zhao TJ; Yang H; Li P; Chen FJ, 2022, 'PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure', Science China Life Sciences, 65, pp. 2287 - 2300, http://dx.doi.org/10.1007/s11427-022-2157-y

Keable R; Hu S; Pfundstein G; Kozlova I; Su F; Du X; Yang H; Gunnersen J; Schachner M; Leshchyns’ka I; Sytnyk V, 2022, 'The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes', Cellular and Molecular Life Sciences, 79, http://dx.doi.org/10.1007/s00018-022-04575-w

Ye JY; Huang AJ; Fu ZZ; Gong YY; Yang HY; Zhou HW, 2022, 'A study of congenital generalized lipodystrophy (CGL) caused by BSCL2 gene mutation', Yi Chuan Hereditas, 44, pp. 926 - 936, http://dx.doi.org/10.16288/j.yczz.22-222

Xu J; Chen S; Wang W; Man Lam S; Xu Y; Zhang S; Pan H; Liang J; Huang X; Wang Y; Li T; Jiang Y; Wang Y; Ding M; Shui G; Yang H; Huang X, 2022, 'Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis', Science Bulletin, 67, pp. 299 - 314, http://dx.doi.org/10.1016/j.scib.2021.10.014

Liang C; Wang X; Peng K; Lai P; Liu Z; Ma J; Chen X; Liu G; Zheng M; Wang Y; Yang H; Liu G; Xian X; Gao M, 2022, 'Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia', Oxidative Medicine and Cellular Longevity, 2022, http://dx.doi.org/10.1155/2022/1889632

Mak HY; Ouyang Q; Tumanov S; Xu J; Rong P; Dong F; Lam SM; Wang X; Lukmantara I; Du X; Gao M; Brown AJ; Gong X; Shui G; Stocker R; Huang X; Chen S; Yang H, 2021, 'AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-27279-4

Molenaar MR; Yadav KK; Toulmay A; Wassenaar TA; Mari MC; Caillon L; Chorlay A; Lukmantara IE; Haaker MW; Wubbolts RW; Houweling M; Vaandrager AB; Prieur X; Reggiori F; Choudhary V; Yang H; Schneiter R; Thiam AR; Prinz WA; Helms JB, 2021, 'Retinyl esters form lipid droplets independently of triacylglycerol and seipin', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/jcb.202011071

Li YE; Wang Y; Du X; Zhang T; Mak H; Hancock SE; McEwen H; Pandzic E; Whan RM; Aw YC; Lukmantara IE; Yuan Y; Dong X; Don A; Turner N; Qi S; Yang H, 2021, 'TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/jcb.202103105

Xiang J; Zhang S; Xu R; Chu H; Biswas S; Yu S; Miao D; Li W; Li S; Brown AJ; Yang H; Xu Y; Li B; Liu H, 2021, 'Elevated HB-EGF expression in neural stem cells causes middle age obesity by suppressing Hypocretin/Orexin expression', FASEB Journal, 35, http://dx.doi.org/10.1096/fj.202001945R

Zoni V; Khaddaj R; Lukmantara I; Shinoda W; Yang H; Schneiter R; Vanni S, 2021, 'Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2017205118

Yan R; Cao P; Song W; Qian H; Du X; Coates HW; Zhao X; Li Y; Gao S; Gong X; Liu X; Sui J; Lei J; Yang H; Brown AJ; Zhou Q; Yan C; Yan N, 2021, 'A structure of human scap bound to insig-2 suggests how their interaction is regulated by sterols', Science, 371, pp. 1012 - +, http://dx.doi.org/10.1126/science.abb2224

Chu BB; Liao YC; Qi W; Xie C; Du X; Wang J; Yang H; Miao HH; Li BL; Song BL, 2021, 'Erratum: Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (2015) 161(2) (291–306), (S0092867415001853), (10.1016/j.cell.2015.02.019))', Cell, 184, pp. 289, http://dx.doi.org/10.1016/j.cell.2020.12.023

Du X; Yang H, 2021, 'Seipin regulates the formation of nuclear lipid droplets from a distance', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/JCB.202011166

Zhang T; Li YE; Yuan Y; Du X; Wang Y; Dong X; Yang H; Qi S, 2021, 'TMEM41B and VMP1 are phospholipid scramblases', Autophagy, 17, pp. 2048 - 2050, http://dx.doi.org/10.1080/15548627.2021.1937898

Gao M; Yang C; Wang X; Guo M; Yang L; Gao S; Zhang X; Ruan G; Li X; Tian W; Lu G; Dong X; Ma S; Li W; Wang Y; Zhu H; He J; Yang H; Liu G; Xian X, 2020, 'ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death', Metabolism Clinical and Experimental, 109, http://dx.doi.org/10.1016/j.metabol.2020.154296

Zhao M; Zhao L; Xiong X; He Y; Huang W; Liu Z; Ji L; Pan B; Guo X; Wang L; Cheng S; Xu M; Yang H; Yin Y; Garcia-Barrio MT; Chen YE; Meng X; Zheng L, 2020, 'TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice', Gastroenterology, 158, pp. 2266 - 2281.e27, http://dx.doi.org/10.1053/j.gastro.2020.02.033

Luo J; Yang H; Song BL, 2020, 'Mechanisms and regulation of cholesterol homeostasis', Nature Reviews Molecular Cell Biology, 21, pp. 225 - 245, http://dx.doi.org/10.1038/s41580-019-0190-7

Liu L; Liang C; Wang X; Ding X; Lu Y; Dong J; Han M; Yang H; Gao M; Liao J, 2020, 'Erratum: Author Correction: Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR-/- mice fed on high-fat diet (Scientific reports (2019) 9 1 (17848))', Scientific Reports, 10, pp. 2181, http://dx.doi.org/10.1038/s41598-020-58201-5

Gao M; Liu L; Wang X; Mak HY; Liu G; Yang H, 2020, 'GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy', Human Molecular Genetics, 29, pp. 432 - 443, http://dx.doi.org/10.1093/hmg/ddz300

Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, 219, http://dx.doi.org/10.1083/jcb.201905162

Aw YC; Brown AJ; Wu JW; Yang H, 2020, 'ORP1L, ORP1S, and ORP2: Lipid Sensors and Transporters', Contact, 3, http://dx.doi.org/10.1177/2515256420956818

Dou YQ; Kong P; Li CL; Sun HX; Li WW; Yu Y; Nie L; Zhao LL; Miao SB; Li XK; Dong C; Zhang JW; Liu Y; Huo XX; Chi K; Gao X; Zhang N; Weng L; Yang H; Zhang F; Han M, 2020, 'Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia', Theranostics, 10, pp. 1197 - 1212, http://dx.doi.org/10.7150/thno.39320

Du X; Yang H, 2020, 'Triacylglycerol Measurement in HeLa Cells', Bio Protocol, 10, http://dx.doi.org/10.21769/BioProtoc.3852

Qian H; Zhao X; Yan R; Yao X; Gao S; Sun X; Du X; Yang H; Wong CCL; Yan N, 2020, 'Structural basis for catalysis and substrate specificity of human ACAT1', Nature, 581, pp. 333 - 338

Qian H; Wu X; Du X; Yao X; Zhao X; Lee J; Yang H; Yan N, 2020, 'Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2', Cell

Xu Y; Du X; Turner N; Brown AJ; Yang H, 2019, 'Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function', Journal of Biological Chemistry, 294, pp. 19306 - 19321, http://dx.doi.org/10.1074/jbc.RA119.011160

Dong J; Du X; Wang H; Wang J; Lu C; Chen X; Zhu Z; Luo Z; Yu L; Brown AJ; Yang H; Wu JW, 2019, 'Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P 2 /PI(3,4)P 2', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-08791-0

Gao G; Sheng Y; Yang H; Chua BT; Xu L, 2019, 'DFCP1 associates with lipid droplets', Cell Biology International, 43, pp. 1492 - 1504, http://dx.doi.org/10.1002/cbin.11199

Liu L; Liang C; Wang X; Ding X; Lu Y; Dong J; Han M; Yang H; Liao J; Gao M, 2019, 'Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR−/− mice fed on high-fat diet', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-54392-8

Xu Y; Mak HY; Lukmantara I; Li YE; Hoehn KL; Huang X; Du X; Yang H, 2019, 'CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms', Journal of Biological Chemistry, 294, pp. 16740 - 16755, http://dx.doi.org/10.1074/jbc.RA119.009992

Yang H, 2019, 'Extended synaptotagmins, peroxisome-endoplasmic reticulum contact and cholesterol transport', Science China Life Sciences, 62, pp. 1266 - 1269, http://dx.doi.org/10.1007/s11427-019-9573-9

Gao M; Huang X; Song BL; Yang H, 2019, 'The biogenesis of lipid droplets: Lipids take center stage', Progress in Lipid Research, 75, http://dx.doi.org/10.1016/j.plipres.2019.100989

Luo J; Jiang LY; Yang H; Song BL, 2019, 'Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites', Trends in Biochemical Sciences, 44, pp. 273 - 292, http://dx.doi.org/10.1016/j.tibs.2018.10.001

Wang H; Ma Q; Qi Y; Dong J; Du X; Rae J; Wang J; Wu WF; Brown AJ; Parton RG; Wu JW; Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P 2 )', Molecular Cell, 73, pp. 458 - 473.e7, http://dx.doi.org/10.1016/j.molcel.2018.11.014

Lv X; Liu J; Qin Y; Liu Y; Jin M; Dai J; Chua BT; Yang H; Li P, 2019, 'Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis', Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, 1864, pp. 113 - 127, http://dx.doi.org/10.1016/j.bbalip.2018.11.001

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