By Dr William Brooks

Journal articles

Kwok JB; Halliday GM; Brooks WS; Dolios G; Laudon H; Murayama O; Hallupp M; Vickers J; Wang R; Naslund J; Takashima A; Gandy SE; Badenhop RF; Schofield PR, 2003, 'Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy', The Journal of Biological Chemistry, 278, pp. 6748 - 6754

Miklossy J; Taddei K; Suva D; Verdile G; Fonte J; Fisher C; Ghika JA; Suard F; Mehta PD; McLean CA; Masters CL; Brooks WS; Martins RN, 2003, 'Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer`s disease', Neurobiology of Aging, 24, pp. 655 - 662

Piguet O; Grayson DA; Creasey H; Bennett HP; Brooks WS; Waite LM; Broe T, 2003, 'Vascular risk factors, cognition and dementia incidence over 6 years in the Sydney Older Persons Study', Neuroepidemiology, 22, pp. 165 - 171

Brooks WS; Broe GA; Kwok JBJ; Schofield PR; Kril JJ, 2002, 'Familial Alzheimer's disease with spastic paraparesis: Two pedigrees with PS-1 exon 9 deletion due to splice acceptor mutations', NEUROBIOLOGY OF AGING, 23, pp. S313 - S313, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000177465301145&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Kwok J; Hallupp M; Badenhop RF; Schofield PR; Halliday GM; Brooks WS; Dolois G; Wang R; Murayama O; Takashima A; Vickers J; Gandy SE, 2002, 'Presenilin-1 mutation (L271V) results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy', NEUROBIOLOGY OF AGING, 23, pp. S277 - S277, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000177465301016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hedley R; Hallmayer J; Groth DM; Brooks WS; Gandy SE; Martins RN, 2002, 'Association of interleukin-1 polymorphisms with Alzheimer's disease in Australia [3]', Annals of Neurology, 51, pp. 795 - 797, http://dx.doi.org/10.1002/ana.10196

Taddei K; Fisher C; Laws SM; Martins G; Paton A; Clarnette RM; Chung C; Brooks WS; Hallmayer J; Miklossy J; Relkin N; St George-Hyslop PH; Gandy SE; Martins RN, 2002, 'Association between presenilin-1 Glu318Gly mutation and familial Alzheimer's disease in the Australian population', Molecular Psychiatry, 7, pp. 776 - 781, http://dx.doi.org/10.1038/sj.mp.4001072

Broe T; Grayson DA; Waite LM; Creasey H; Edelbrock D; Bennett HP; Brooks WS, 2002, 'Determinants of service use among the elderly:the Sydney older persons study', Australasian Journal on Ageing, 21, pp. 61 - 66

Munch G; Shepherd CE; Mccann H; Brooks WS; Kwok JB; Arendt T; Hallupp M; Schofield PR; Martins RN; Halliday GM, 2002, 'Intraneuronal advanced glycation endproducts in presenilin-l Alzheimer's disease', Neuroreport, 13, pp. 601 - 604

Mann DMA; Pickering-Brown SM; Takeuchi A; Iwatsubo T; Arango J; Bird T; Van Broeckhoven C; Brooks W; Brown R; Cairns N; Cras P; Ellison D; Haltia M; Ii K; Jorgensen A; Krill J; Lantos P; Lippa C; Martins R; Nochlin D; Pollen D; Rosenberg C; Rossor M; Tabira T, 2001, 'Amyloid angiopathy and variability in amyloid β deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease', American Journal of Pathology, 158, pp. 2165 - 2175, http://dx.doi.org/10.1016/S0002-9440(10)64688-3

Piguet O; Grayson DA; Ridley L; Bennett HP; Lye TC; Brooks WS; Creasey H; Broe GA, 2001, 'Executive functions in very old individuals and MRI white matter lesions: Do they matter? Evidence from the Sydney Older Persons Study', AUSTRALIAN JOURNAL OF PSYCHOLOGY, 53, pp. 198 - 198, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000202876001407&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Waite LM; Creasey H; Grayson DA; Edelbrock D; Cullen J; Brooks WS; Casey B; Bennett HP; Broe T, 2001, 'Clinical diagnosis and disability among community dwellers aged 75 and over: The Sydney older persons study.', Australasian Journal on Ageing, 20, pp. 67 - 72

Stanford PM; Halliday GM; Brooks WS; Kwok JB; Schofield PR, 2001, 'Progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17 and familial tauopathies.', Brain, 124, pp. 1668 - 1670

Kwok JB; Mclean C; Kril J; Broe T; Nicholson GA; Cappai R; Hallupp M; Cotton R; Schofield PR; Brooks WS; Smith MJ, 2001, 'Variable phenotypes of Alzheimer`s disease with spastic paraparesis', Annals of Neurology, pp. 125 - 129

Milward E; Grayson D; Creasey H; Kyngdon B; Janu M; Brooks W; Broe GA, 2000, 'Clinical issues - Anaemia and dementia in community-dwelling Australian elderly', AUSTRALASIAN JOURNAL ON AGEING, 19, pp. 25 - 25, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000086449500094&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Broe T; Grayson DA; Creasey H; Waite LM; Casey B; Bennett HP; Brooks WS; Halliday GM, 2000, 'Anti-inflammatory drugs protect against Alzheimer's disease at low doses', Archives of Neurology, pp. 1586 - 1591

Stanford PM; Halliday GM; Brooks WS; Kwok JB; Storey CE; Creasey H; Morris J; Fulham MJ; Schofield PR, 2000, 'Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene. Expansion of the disease phenotype caused by tau gene mutations', Brain, 123, pp. 880 - 893

Stanford PM; Halliday GM; Brooks WS; Kwok JB; Storey CE; Creasey H; Morris JG; Fulham MJ, 2000, 'Tau gene mutations are pleiotropic: Identification of two novel mutations in the tau gene', Neurobiology of Aging, 21, pp. 36 - 36, http://dx.doi.org/10.1016/s0197-4580(00)82837-7

Kwok JBJ; Smith MJ; Brooks WS; Kril J; Mclean C; Hallupp M; Schofield PR, 2000, 'Variable presentation of Alzheimer's disease and/or spastic paraparesis phenotypes in pedigrees with a novel PS-1 exon 9 gene deletion or exon 9 splice acceptor mutations', Neurobiology of Aging, 21, pp. 25 - 25, http://dx.doi.org/10.1016/s0197-4580(00)82789-x

Milward EA; Grayson DA; Creasey H; Janu MR; Brooks WS; Broe GA, 1999, 'Evidence for association of anaemia with vascular dementia', Neuroreport, 10, pp. 2377 - 2381, http://dx.doi.org/10.1097/00001756-199908020-00029

Laws SM; Taddei K; Martins G; Paton A; Fisher C; Clarnette R; Hallmayer J; Brooks WS; Gandy SE; Martins RN, 1999, 'The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease', Neuroreport, 10, pp. 879 - 882, http://dx.doi.org/10.1097/00001756-199903170-00038

Laws SM; Taddei K; Fisher C; Small D; Clarnette R; Hallmayer J; Brooks WS; Kwok JB; Schofield PR; Gandy SE; Martins RN, 1999, 'Evidence that the butyrylcholinesterase K variant can protect against late-onset Alzheimer`s disease', Alzheimers Reports, 2, pp. 219 - 223

Mcritchie DA; Reid WG; Halliday GM; Hely MA; Brooks WS; Morris J, 1999, 'Neuropathology of three clinical cases prospectively diagnosed with diffuse Lewy body disease', Journal of Clinical Neuroscience, pp. 149 - 154

Taddei K; Yang D; Fisher C; Clarnette R; Hallmayer J; Barnetson R; Maller R; Brooks WS; Whyte S; Nicholson GA; Masters CL; Broe GA; Gandy SE; Martins RN, 1998, 'No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia', Neuroscience Letters, 246, pp. 178 - 180, http://dx.doi.org/10.1016/S0304-3940(98)00248-1

Taddei K; Kwok JB; Kril J; Halliday GM; Creasey H; Hallupp M; Fisher C; Brooks WS; Chung C; Andrews C; Masters C; Schofield PR; Martins RN, 1998, 'Two novel presenilin-1 mutations (Ser169Leu and Pro436Gln) associated with very early onset Alzheimer's disease.', Neuroreport, pp. 3335 - 3339

Cullen KM; Halliday GM; Double KL; Brooks WS; Creasey H; Broe GA, 1997, 'Cell loss in the nucleus basalis is related to regional cortical atrophy in Alzheimer's disease', Neuroscience, 78, pp. 641 - 652, http://dx.doi.org/10.1016/S0306-4522(96)00569-6

Halliday GM; Brooks WS; Arthur HA; Creasey H; Broe T, 1997, 'Further evidence for an association between a mutation in the APP gene and Lewy body formation', Neuroscience Letters, pp. 49 - 52

Cullen K; Halliday GM; Double KL; Brooks WS; Creasey H; Broe T, 1997, 'Nucleus basalis cell loss is related to regional volumetric brain changes in Alzheimer's disease', Neuroscience, pp. 641 - 652

Kwok JB; Taddei K; Hallupp M; Fisher C; Brooks WS; Broe T; Hardy J; Fulham MJ; Nicholson GA; Stell R; St George-Hyslop PH; Fraser PE; Kakulas B; Clarnette R; Relkin N; Gandy SE; Schofield PR; Martins RN, 1997, 'Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer`s disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype', Neuroreport, pp. 1537 - 1542

Yang JG; Poropat RA; Brooks WS; Broe GA; Nicholson GA, 1996, 'Apolipoprotein E genotyping in Alzheimer's disease in an Australian sample', Australian and New Zealand Journal of Medicine, 26, pp. 658 - 661, http://dx.doi.org/10.1111/j.1445-5994.1996.tb02936.x

Hely MA; Reid WG; Halliday GM; Mcritchie DA; Leicester J; Joffe R; Brooks WS; Broe T; Morris J, 1996, 'Diffuse Lewy body disease: Clinical features in nine cases without co-existent Alzheimer's disease', Journal of Neurology Neurosurgery and Psychiatry, pp. 532 - 538

Harasty JA; Halliday GM; Code C; Brooks WS, 1996, 'Quantification of cortical atrophy in a case of progressive fluent asphsia', Brain, 119, pp. 181 - 190

Double KL; Halliday GM; Kril J; Harasty JA; Cullen K; Brooks WS; Creasey H; Broe T, 1996, 'Topography of brain atrophy during normal aging and Alzheimer's disease', Neurobiology of Aging, 17, pp. 513 - 521

Brooks WS; Martins RN; De Voecht J; Nicholson GA; Schofield PR; Kwok JBJ; Fisher C; Yeung LU; Van Broeckhoven C, 1995, 'A mutation in codon 717 of the amyloid precursor protein gene in an Australian family with Alzheimer's disease', Neuroscience Letters, 199, pp. 183 - 186, http://dx.doi.org/10.1016/0304-3940(95)12046-7

Martins RN; Clarnette R; Fisher C; Broe GA; Brooks WS; Montgomery P; Gandy SE, 1995, 'ApoE genotypes in australia: Roles in early and late onset alzheimer’s disease and down’s syndrome', Neuroreport, 6, pp. 1513 - 1516, http://dx.doi.org/10.1097/00001756-199507310-00012

Maltby N; Broe GA; Creasey H; Jorm AF; Christensen H; Brooks WS, 1994, 'Efficacy of tacrine and lecithin in mild to moderate Alzheimer's disease: Double blind trial', BMJ, 308, pp. 879, http://dx.doi.org/10.1136/bmj.308.6933.879

Martins RN; Muir J; Brooks WS; Creasey H; Montgomery P; Sellers P; Broe GA, 1993, 'Plasma amyloid precursor protein is decreased in alzheimer’s disease', Neuroreport, 4, pp. 757 - 759, http://dx.doi.org/10.1097/00001756-199306000-00040

Halliday GM; McCann HL; Pamphlett R; Brooks WS; Creasey H; McCusker E; Cotton RGH; Broe GA; Harper CG, 1992, 'Brain stem serotonin-synthesizing neurons in Alzheimer's disease: a clinicopathological correlation', Acta Neuropathologica, 84, pp. 638 - 650, http://dx.doi.org/10.1007/BF00227741

Conference Papers

Dobson-Stone C; Luty A; Thompson E; Blumbergs P; Brooks W; Shepherd C; Yerbury J; Halliday G; Schofield P; Kwok J, 2016, 'Identification Of A novel FTD-MND gene on chromosome 16', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, GERMANY, Munich, pp. 230 - 230, presented at 10th International Conference on Frontotemporal Dementias, GERMANY, Munich, 31 August 2016 - 02 September 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000382568400030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dobson-Stone C; Luty AA; Thompson EM; Blumbergs P; Brooks WS; Halliday GM; Schofield PR; Kwok JBJ, 2012, 'Identification Of A Locus For Frontotemporal Dementia - Motor Neuron Disease On Chromosome 16p12.1-q12.2', in DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, KARGER, ENGLAND, Manchester, pp. 82 - 82, presented at 8th International Conference on Frontotemporal Dementias, ENGLAND, Manchester, 05 September 2012 - 07 September 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308612400120&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Schofield PR; Luty A; Kwok JB; Thompson E; Blumbergs P; Brooks WS; Loy CT; Dobson-Stone C; Panegyres P; Hecker J; Nicholson GA; Halliday GM, 2008, 'Linkage to chromosome 9 and examination of candidate genes in a pedigree with FTLD-MND and TDP-43 positive neuropathology', in Dementia and Geriatric Cognitive Disorders, Karger, Basel, Switzerland, pp. 9 - 9, presented at 6th International Conference on Frontotemporal Dementias, Rotterdam, Netherlands, 03 September 2008 - 05 September 2008

Song YC; Halliday GM; Creasey H; Morris JG; Brooks WS; Kril J, 2005, 'Neuropathology in the S305S tau gene mutation', in Journal of the Neurological Sciences, Elsevier Science BV, Amsterdam, Netherlands, pp. S302 - S302, presented at XVIIIth World Congress of Neurology, Sydney, 05 November 2005 - 11 November 2005

Huang Y; Hayes M; Harding AJ; Brooks WS; Fung VS; Rowe DB; Hely MA; Halliday GM, 2005, 'Genetic anticipation in familial Lewy body disease', in Parkinsonism and Related Disorders, Elsevier Sci Ltd, Kidlington, Oxford, England, pp. 254 - 254, presented at 16th International Congress on Parkinson`s Disease and Related Disorders, Berlin, Germany, 05 June 2005 - 09 June 2005

Brooks WS; Kwok JB; Halliday GM; Godbolt AK; Rossor MN; Creasey H; Jones A; Schofield PR, 2004, 'Familial Alzheimer's disease and cerebral haemorrhage: A second family with the Flemish APP ALA692GLY mutation', in Neurobiology of Aging, Elsevier Science Inc, New York, NY, USA, pp. S499 - S499, presented at 9th International Conference on Alzheimer's Disease and Related Disorders, Philadelphia, Pennsylvania, 17 July 2004 - 22 July 2004

Brooks WS; Stanford PM; Teber ET; Hallupp M; Mclean C; Halliday GM; Martins RN; Kwok JB; Schofield PR, 2004, 'Screening for tau mutations: an Australian series', in Internal Medicine Journal, Blackwell Publishing Asia, Carlton, VIC, pp. A59 - A59, presented at Annual Scientific Meeting of the Australian Society for Geriatric Medicine, Fremantle, WA, 27 April 2004 - 30 April 2004

Gregory GC; Kwok JB; Shepherd CE; Brooks WS; Xuereb J; Schofield PR; Halliday GM, 2004, 'Beta-amyloid toxicity in Alzheimer's disease', in Proceedings of Aust Neuroscience Society, Melbourne Convention Centre, pp. 42 - 42, presented at 24th Annual Meeting of the Australian Neuroscience Society, Melbourne Convention Centre, 27 January 2004 - 30 January 2004

Shepherd CE; Stanford PM; Brooks WS; Kwok JB; Schofield PR; Brodaty H; Martins RN; Halliday GM, 2003, 'Absence of tau pathology in a familial frontotemporal dementia case with a mutation in the tau gene', in Proceedings of Aust Neuroscience Society, Adelaide, Sth Aust, pp. 375 - 375, presented at 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, 28 January 2003 - 31 January 2003

Gregory GC; Kril J; Macdonald V; Png F; Patel S; Brooks WS; Schofield PR; Halliday GM, 2003, 'Familial Alzheimer's disease differs from sporadic in the severity of degeneration', in Proceedings of Aust Neuroscience Society, Adelaide, Sth Aust, pp. 376 - 376, presented at 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, 28 January 2003 - 31 January 2003

Harding AJ; Das A; Kril J; Brooks WS; Halliday GM, 2002, 'The frequency of familial lewy body diseases', in Proceedings of Aust Neuroscience Society, Darling Harbour, Sydney, pp. 134 - 134, presented at 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, 04 February 2002 - 06 February 2002

Harding AJ; Das A; Kril J; Brooks WS; Halliday GM, 2002, 'Frequency of familial Lewy body diseases', in Australian New Zealand Society of Neuropathology Annual General Meeting, presented at Australian New Zealand Society of Neuropathology Annual General Meeting

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