By Dr Vicky Wang-Wei Tsai

Journal articles

Breit SN; Tsai VW, 2025, 'Metabolic Messenger: growth differentiation factor 15', Nature Metabolism, http://dx.doi.org/10.1038/s42255-025-01353-3

Isik FI; Thomson S; Cueto JF; Spathos J; Breit SN; Tsai VWW; Brown DA; Finney CA, 2024, 'A systematic review of the neuroprotective role and biomarker potential of GDF15 in neurodegeneration', Frontiers in Immunology, 15, http://dx.doi.org/10.3389/fimmu.2024.1514518

Breit SN; Manandhar R; Zhang HP; Lee-Ng M; Brown DA; Tsai VWW, 2023, 'GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway', Cell Metabolism, 35, pp. 1341 - 1355.e3, http://dx.doi.org/10.1016/j.cmet.2023.06.009

Thai LM; O'Reilly L; Reibe-Pal S; Sue N; Holliday H; Small L; Schmitz-Peiffer C; Dhenni R; Wang-Wei Tsai V; Norris N; Yau B; Zhang X; Lee K; Yan C; Shi YC; Kebede MA; Brink R; Cooney GJ; Irvine KM; Breit SN; Phan TG; Swarbrick A; Biden TJ, 2023, 'β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling', Iscience, 26, http://dx.doi.org/10.1016/j.isci.2023.106477

Breit SN; Brown DA; Tsai VWW, 2023, 'GDF15 analogs as obesity therapeutics', Cell Metabolism, 35, pp. 227 - 228, http://dx.doi.org/10.1016/j.cmet.2023.01.002

Breit SN; Brown DA; Tsai VWW, 2021, 'The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?', Annual Review of Physiology, 83, pp. 127 - 151, http://dx.doi.org/10.1146/annurev-physiol-022020-045449

Husaini Y; Tsai VWW; Manandhar R; Zhang HP; Lee-Ng KKM; Lebhar H; Marquis CP; Brown DA; Breit SN, 2020, 'Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity', Plos One, 15, http://dx.doi.org/10.1371/journal.pone.0233846

Tsai VWW; Zhang HP; Manandhar R; Schofield P; Christ D; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Brown DA; Breit SN, 2019, 'GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS', International Journal of Obesity, 43, pp. 2370 - 2380, http://dx.doi.org/10.1038/s41366-019-0365-5

Tsai VWW; Brown DA; Breit SN, 2018, 'Targeting the divergent TGFb superfamily cytokine MIC-1/GDF15 for therapy of anorexia/ cachexia syndromes', Current Opinion in Supportive and Palliative Care, 12, pp. 404 - 409, http://dx.doi.org/10.1097/SPC.0000000000000384

Tsai VWW; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases', Cell Metabolism, 28, pp. 353 - 368, http://dx.doi.org/10.1016/j.cmet.2018.07.018

Tsai VW; Zhang HP; Manandhar R; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity', International Journal of Obesity, 42, pp. 561 - 571, http://dx.doi.org/10.1038/ijo.2017.258

Breit SN; Tsai VWW; Brown DA, 2017, 'Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway', Trends in Molecular Medicine, 23, pp. 1065 - 1067, http://dx.doi.org/10.1016/j.molmed.2017.10.005

Danta M; Barber DA; Zhang HP; Lee-Ng M; Baumgart SWL; Tsai VWW; Husaini Y; Saxena M; Marquis CP; Errington W; Kerr S; Breit SN; Brown DA, 2017, 'Macrophage inhibitory cytokine-1/growth differentiation factor-15 as a predictor of colonic neoplasia', Alimentary Pharmacology and Therapeutics, 46, pp. 347 - 354, http://dx.doi.org/10.1111/apt.14156

Low JK; Ambikairajah A; Shang K; Brown DA; Tsai VWW; Breit SN; Karl T, 2017, 'First behavioural characterisation of a knockout mouse model for the transforming growth factor (TGF)-β superfamily cytokine, MIC-1/GDF15', Plos One, 12, pp. e0168416, http://dx.doi.org/10.1371/journal.pone.0168416

Salao K; Jiang L; Li H; Tsai VWW; Husaini Y; Curmi PMG; Brown LJ; Brown DA; Breit SN, 2016, 'CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis', Biology Open, 5, pp. 620 - 630, http://dx.doi.org/10.1242/bio.018119

Tsai VWW; Lin S; Brown DA; Salis A; Breit SN, 2016, 'Anorexia-cachexia and obesity treatment may be two sides of the same coin: Role of the TGF-b superfamily cytokine MIC-1/GDF15', International Journal of Obesity, 40, pp. 193 - 197, http://dx.doi.org/10.1038/ijo.2015.242

Tsai VWW; Macia L; Feinle-Bisset C; Manandhar R; Astrup A; Raben A; Lorenzen JK; Schmidt PT; Wiklund F; Pedersen NL; Campbell L; Kriketos A; Xu A; Pengcheng Z; Jia W; Curmi PMG; Angstmann CN; Lee-Ng KKM; Zhang HP; Marquis CP; Husaini Y; Beglinger C; Lin S; Herzog H; Brown DA; Sainsbury A; Breit SN; Lee-Ng M, 2015, 'Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI', Plos One, 10, pp. e0133362, http://dx.doi.org/10.1371/journal.pone.0133362

Husaini Y; Lockwood GP; Nguyen TV; Tsai VWW; Mohammad MG; Russell PJ; Brown DA; Breit SN, 2015, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice', Plos One, 10, pp. e0115189, http://dx.doi.org/10.1371/journal.pone.0115189

, 2015, 'Abstracts of the 2(nd) Cancer Cachexia Conference, Montreal, Canada, 26-28 September 2014.', J Cachexia Sarcopenia Muscle, 6, pp. 2 - 31, http://dx.doi.org/10.1002/jcsm.12004

Tsai VWW; Manandhar R; Jrøgensen SB; Lee-Ng KKM; Zhang HP; Marquis CP; Jiang L; Husaini Y; Lin S; Sainsbury A; Sawchenko PE; Brown DA; Breit SN; Lee-Ng M, 2014, 'The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract', Plos One, 9, pp. e100370, http://dx.doi.org/10.1371/journal.pone.0100370

Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA; Hassanpour Golakani M, 2014, 'Immune cell trafficking from the brain maintains CNS immune tolerance', Journal of Clinical Investigation, 124, pp. 1228 - 1241, http://dx.doi.org/10.1172/JCI71544

Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA, 2014, 'A forebrain-immune cell pathway for the maintenance of CNS immune tolerance', Neurology, Psychiatry and Brain Research, 20, pp. 8 - 9, http://dx.doi.org/10.1016/j.npbr.2014.01.144

Tsai VW-W; Macia L; Manandhar R; Wiklund F; Grönberg H; Pedersen N; Lee-Ng M; Zhang HP; Brown D; Herzog H; Sainsbury A; Breit SN, 2014, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15), a novel regulator of body weight and appetite and a potential therapeutic for obesity', Obesity Research & Clinical Practice, 8, pp. 105 - 105, http://dx.doi.org/10.1016/j.orcp.2014.10.191

Mohammad MG; Hassanpour M; Tsai VW-W; Li H; Ruitenberg MJ; Booth D; Serrats J; Hart PH; Symonds GP; Sawchenko P; Breit SN; Brown DA; Hassanpour Golakani M, 2013, 'Dendritic cells and multiple sclerosis: Disease, tolerance and therapy', International Journal of Molecular Sciences, 14, pp. 547 - 562, http://dx.doi.org/10.3390/ijms14010547

Macia L; Tsai VWW; Nguyen AD; Johnen H; Kuffner T; Shi Y; Lin S; Herzog H; Brown DA; Breit SN; Sainsbury-Salis A, 2012, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets', PLoS One, 7, pp. e34868, http://dx.doi.org/10.1371/journal.pone.0034868

Breit SN; Carrero JJ; Tsai VWW; Yagoutifam N; Luo XW; Kuffner T; Bauskin AR; Wu L; Jiang L; Baranyi P; Heimburer O; Murikami M; Apple F; Marquis C; Macia L; Lin S; Sainsbury-Salis A; Herzog H; Law MG; Stenvinkel P; Brown DA; Han A, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease', Nephrology Dialysis Transplantation, 27, pp. 70 - 75, http://dx.doi.org/10.1093/ndt/gfr575

Husaini Y; Qiu MR; Lockwood G; Luo X; Shang P; Kuffner T; Tsai VW-W; Lele J; Russell PJ; Brown DA; Breit SN; Jiang L; Qiu M-R, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice', PLoS One, 7, pp. e43833, http://dx.doi.org/10.1371/journal.pone.0043833

Brown DA; Tsai VWW; Mohammad MG; Tolhurst O; Breit SN; Sawchenko PE, 2011, 'CCAAT/enhancer binding protein-delta (C/EBPdelta) regulates Th17/Treg balance via an antigen presenting cell - interleukin-10 dependent mechanism in neuroinflammation', MULTIPLE SCLEROSIS JOURNAL, 17, pp. S344 - S344, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209137301142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Breit SN; Johnen H; Cook AD; Tsai VWW; Mohammad MG; Tamara K; Hong PZ; Marquis C; Lele J; Lockwood G; Lee-Ng M; Husaini Y; Wu L; Hamilton JA; Brown DA, 2011, 'The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism', Growth Factors, 29, pp. 187 - 195, http://dx.doi.org/10.3109/08977194.2011.607137

Kuo L-H; Hu M-K; Hsu W-M; Tung Y-T; Wang B-J; Tsai W-W; Yen C-T; Liao Y-F, 2008, 'Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin.', Mol Biol Cell, 19, pp. 4201 - 4212, http://dx.doi.org/10.1091/mbc.e07-09-0987

Johnen H; Lin S; Kuffner T; Brown DA; Tsai V; Bauskin AR; Wu L; Pankhurst G; Jiang L; Junankar S; Hunter M; Fairlie WD; Lee NJ; Enriquez R; Baldock P; Corey E; Apple F; Murakami M; Lin E; Wang CC; During M; Sainsbury A; Herzog H; Breit SN, 2007, 'Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1', Nature Medicine, 13, pp. 1333 - 1340

Tsai VWW; Scott HL; Lewis RJ; Dodd PR, 2005, 'The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in alzheimer's disease', Neurotoxicity Research, 7, pp. 125 - 141, http://dx.doi.org/10.1007/BF03033782

Tsai VWW; Dodd PR; Lewis RJ, 2005, 'The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor', Neuroscience, 130, pp. 457 - 464, http://dx.doi.org/10.1016/j.neuroscience.2004.09.039

Andersen DL; Eckert AL; Tsai VWW; Burke CJ; Tannenberg AEG; Dodd PR, 2002, 'GABAA receptor sites in the developing human foetus', Developmental Brain Research, 139, pp. 107 - 119, http://dx.doi.org/10.1016/S0165-3806(02)00534-5

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