By Dr Sarah-Jane Leigh

Journal articles

Rosell-Cardona C; Leigh SJ; Knox E; Tirelli E; Lyte JM; Goodson MS; Kelley-Loughnane N; Aburto MR; Cryan JF; Clarke G, 2025, 'Acute stress-induced alterations in short-chain fatty acids: Implications for the intestinal and blood brain barriers', Brain Behavior and Immunity Health, 46, http://dx.doi.org/10.1016/j.bbih.2025.100992

Knox EG; Sánchez-Díaz P; Buttimer C; Leigh SJ; Vlckova K; Hill C; Kennedy E; O'Regan J; McSweeney S; Goulding D; Aburto MR; O'Driscoll CM; Cryan JF; Gunnigle E; Clarke G, 2025, 'Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function', Journal of Functional Foods, 125, http://dx.doi.org/10.1016/j.jff.2025.106661

Tofani GSS; Leigh SJ; Gheorghe CE; Bastiaanssen TFS; Wilmes L; Sen P; Clarke G; Cryan JF, 2025, 'Gut microbiota regulates stress responsivity via the circadian system', Cell Metabolism, 37, pp. 138 - 153.e5, http://dx.doi.org/10.1016/j.cmet.2024.10.003

Gheorghe CE; Leigh SJ; Tofani GSS; Bastiaanssen TFS; Lyte JM; Gardellin E; Govindan A; Strain C; Martinez-Herrero S; Goodson MS; Kelley-Loughnane N; Cryan JF; Clarke G, 2024, 'The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut', Cell Reports, 43, http://dx.doi.org/10.1016/j.celrep.2024.114079

Yu J; Youngson NA; Laybutt DR; Morris MJ; Leigh SJ, 2024, 'Complementary yet divergent effects of exercise and an exercise mimetic on microbiome in high-fat diet-induced obesity', Physiological Genomics, 56, pp. 136 - 144, http://dx.doi.org/10.1152/physiolgenomics.00066.2023

Schneider E; Leigh SJ; Lynch CMK; Hilbert A; Clarke G; Higgs S; Cryan JF, 2024, 'Microbiota-gut-brain axis in binge-eating disorder: Towards microbiome-based therapies', Neuroscience Applied, 3, http://dx.doi.org/10.1016/j.nsa.2024.104088

Rosell Cardona C; Collins MK; O'Riordan KJ; Leigh SJ; Kelley-Loughnane N; Goodson M; Cryan JF; Clarke G, 2024, 'Effects of acute stress and microbial metabolites on hippocampal plasticity', Neuroscience Applied, 3, pp. 105059 - 105059, http://dx.doi.org/10.1016/j.nsa.2024.105059

Leigh SJ; Uhlig F; Wilmes L; Sanchez-Diaz P; Gheorghe CE; Goodson MS; Kelley-Loughnane N; Hyland NP; Cryan JF; Clarke G, 2023, 'The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective', Journal of Physiology, 601, pp. 4491 - 4538, http://dx.doi.org/10.1113/JP281951

Kendig MD; Leigh SJ; Hasebe K; Kaakoush NO; Westbrook RF; Morris MJ, 2023, 'Obesogenic Diet Cycling Produces Graded Effects on Cognition and Microbiota Composition in Rats', Molecular Nutrition and Food Research, 67, http://dx.doi.org/10.1002/mnfr.202200809

Tofani G; Leigh SJ; Gheorghe CE; Bastiaanssen TFS; Clarke G; Cryan JF, 2023, 'Gut microbiota regulates diurnal oscillations in stress responsiveness', Neuroscience Applied, 2, pp. 102547 - 102547, http://dx.doi.org/10.1016/j.nsa.2023.102547

Bastiaanssen TFS; Leigh S; Tofani GSS; Gheorghe CE; Clarke G; Cryan JF, 2023, 'Kronos: Circadian rhythmicity analysis in microbiome and other 'omics datasets', NEUROGASTROENTEROLOGY AND MOTILITY, 35

Tofani G; Leigh SJ; Gheorghe CE; Bastiaanssen TFS; Clarke G; Cryan JF, 2023, 'Regulation of the stress response by the gut microbiota is time-of-day dependent', Neuroscience Applied, 2, pp. 101054 - 101054, http://dx.doi.org/10.1016/j.nsa.2023.101054

Leigh SJ; Clarke G; Cryan JF, 2022, 'Rewiring bugs: Diet, the gut microbiome, and nerve regeneration', Developmental Cell, 57, pp. 1917 - 1919, http://dx.doi.org/10.1016/j.devcel.2022.07.013

Kendig MD; Hasebe K; McCague R; Lee F; Leigh SJ; Arnold R; Morris MJ, 2022, 'Adolescent exposure to a solid high-fat, high-sugar ‘cafeteria’ diet leads to more pronounced changes in metabolic measures and gut microbiome composition than liquid sugar in female rats', Appetite, 172, http://dx.doi.org/10.1016/j.appet.2022.105973

Boscaini S; Leigh SJ; Lavelle A; García-Cabrerizo R; Lipuma T; Clarke G; Schellekens H; Cryan JF, 2022, 'Microbiota and body weight control: Weight watchers within?', Molecular Metabolism, 57, http://dx.doi.org/10.1016/j.molmet.2021.101427

Leigh SJ; Lynch CMK; Bird BRH; Griffin BT; Cryan JF; Clarke G, 2022, 'Gut microbiota-drug interactions in cancer pharmacotherapies: implications for efficacy and adverse effects', Expert Opinion on Drug Metabolism and Toxicology, 18, pp. 5 - 26, http://dx.doi.org/10.1080/17425255.2022.2043849

Kendig MD; Leigh SJ; Morris MJ, 2021, 'Unravelling the impacts of western-style diets on brain, gut microbiota and cognition', Neuroscience and Biobehavioral Reviews, 128, pp. 233 - 243, http://dx.doi.org/10.1016/j.neubiorev.2021.05.031

Leigh SJ; Kaakoush NO; Bertoldo MJ; Westbrook RF; Morris MJ, 2020, 'Intermittent cafeteria diet identifies fecal microbiome changes as a predictor of spatial recognition memory impairment in female rats', Translational Psychiatry, 10, http://dx.doi.org/10.1038/s41398-020-0734-9

Leigh SJ; Kaakoush NO; Westbrook RF; Morris MJ, 2020, 'Minocycline-induced microbiome alterations predict cafeteria diet-induced spatial recognition memory impairments in rats', Translational Psychiatry, 10, http://dx.doi.org/10.1038/s41398-020-0774-1

Leigh SJ; Kaakoush NO; Escorihuela RM; Westbrook RF; Morris MJ, 2020, 'Treadmill exercise has minimal impact on obesogenic diet-related gut microbiome changes but alters adipose and hypothalamic gene expression in rats', Nutrition and Metabolism, 17, http://dx.doi.org/10.1186/s12986-020-00492-6

Leigh SJ; Morris MJ, 2020, 'Diet, inflammation and the gut microbiome: Mechanisms for obesity-associated cognitive impairment', Biochimica Et Biophysica Acta Molecular Basis of Disease, 1866, http://dx.doi.org/10.1016/j.bbadis.2020.165767

Leigh SJ; Kendig MD; Morris MJ, 2019, 'Palatable western-style cafeteria diet as a reliable method for modeling diet-induced obesity in rodents', Journal of Visualized Experiments, 2019, http://dx.doi.org/10.3791/60262

Leigh S-J; Kendig MD; Morris MJ, 2019, 'Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents', Journal of Visualized Experiments, http://dx.doi.org/10.3791/60262-v

Leigh SJ; Lee F; Morris MJ, 2018, 'Hyperpalatability and the Generation of Obesity: Roles of Environment, Stress Exposure and Individual Difference', Current Obesity Reports, 7, pp. 6 - 18, http://dx.doi.org/10.1007/s13679-018-0292-0

Leigh SJ; Morris MJ, 2018, 'The role of reward circuitry and food addiction in the obesity epidemic: An update', Biological Psychology, 131, pp. 31 - 42, http://dx.doi.org/10.1016/j.biopsycho.2016.12.013

Austin PJ; Berglund AM; Siu S; Fiore NT; Gerke-Duncan MB; Ollerenshaw SL; Leigh SJ; Kunjan PA; Kang JWM; Keay KA, 2015, 'Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury', Journal of Neuroinflammation, 12, http://dx.doi.org/10.1186/s12974-015-0318-4

Conference Papers

Leigh S; Sanchez-Diaz P; Cryan JF; Clarke G, 2023, 'The gut microbiome contributes to chemotherapy-associated behavioural impairments', in NEUROGASTROENTEROLOGY AND MOTILITY, WILEY

Gheorghe CE; Leigh S; Tofani GS; Bastiaanssen TF; Gardellin E; Cryan JF; Clarke G, 2023, 'The gut microbiome drives diurnal rhythms of tryptophan metabolism in the stressed gut', in NEUROGASTROENTEROLOGY AND MOTILITY, WILEY

Leigh S; Martinez-Herrero S; Lyte J; Goodson MS; Kelley-Loughnane N; Dinan TG; Cryan JF; Leigh S, 2021, 'Gut microbiota modulates acute stress-induced alterations in the gut metabolome', in NEUROGASTROENTEROLOGY AND MOTILITY, WILEY

Conference Abstracts

Leigh S-J; Kaakoush NO; Westbrook F; Morris MJ, 2019, 'Cafeteria diet-induced cognitive impairment is prevented by oral minocycline in association with changes in the microbiome', in Obesity Research & Clinical Practice, Elsevier BV, Vol. 13, pp. 249 - 250, http://dx.doi.org/10.1016/j.orcp.2018.11.040

Preprints

Bastiaanssen TFS; Leigh S-J; Tofani GSS; Gheorghe CE; Clarke G; Cryan JF, 2023, Kronos: A computational tool to facilitate biological rhythmicity analysis, http://dx.doi.org/10.1101/2023.04.21.537503

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