By Dr Paul Timpson

Conference Abstracts

Tyma V; Liew Y-F; Tran A; Howell A; Ritchie S; Atlas AAPCM; Cox T; Pajic M; Herrmann D; Pereira B; Timpson P; Gordon K, 2024, 'Identifying and targeting FOLFIRINOX resistance mechanisms to improve outcomes in pancreatic cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MA, Boston, Vol. 84, presented at AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research, MA, Boston, 15 September 2024 - 18 September 2024, http://dx.doi.org/10.1158/1538-7445.PANCREATIC24-A067

Timpson P; Pereira B; Ritchie S; Gordon K; Cox T, 2024, 'Temporally resolved proteomics identifies nidogen-2 as a co-target in pancreatic cancer that modulates fibrosis and therapy response', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MA, Boston, Vol. 84, presented at AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research, MA, Boston, 15 September 2024 - 18 September 2024, http://dx.doi.org/10.1158/1538-7445.PANCREATIC24-PR-09

Pajic M; McLean B; Fajardo DC; Porazinski S; Upton DH; Schuhmacher D; Istadi A; Cox T; Timpson P; Wilcock DJ; Anderson KJ; Mason H; Guisot NE; Jones CD; Phillips C; Armer R, 2024, 'Combining zelasudil, a small molecule ROCK2 inhibitor, with chemotherapy or immunotherapy improves response in preclinical models of pancreatic cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, Vol. 84, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2024 - 10 April 2024, http://dx.doi.org/10.1158/1538-7445.AM2024-720

Jiao X; Ashton AW; Li Z; Harish R; Li D; Robertson G; Shen D; Ju X; Chen K; Zhang W; Archilefu S; Iczkowski KA; Rui H; Knudsen B; Timpson P; Nobis M; Pestell RG, 2024, 'Cyclin D1 induces Akt1 activity in RB deficient prostate cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, Vol. 84, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2024 - 10 April 2024, http://dx.doi.org/10.1158/1538-7445.AM2024-1634

Golo M; Finkbeiner M; Piastra-Facon F; Heu C; Colakoglu F; Tay S; Herrmann D; Whan R; Timpson P; Kempe D; Biro M, 2024, '1354 The impact of the pancreatic tumour microenvironment on cytotoxic T lymphocyte migration and tumour eradication', in Regular and Young Investigator Award Abstracts, BMJ Publishing Group Ltd, pp. A1517 - A1517, presented at SITC 39th Annual Meeting (SITC 2024) Abstracts, http://dx.doi.org/10.1136/jitc-2024-sitc2024.1354

Pitiyarachchi O; Lin FP; Spooner A; Sharbeen G; Barker HP; Thornton K; Collignon E; Ballinger ML; Thomas DM; Magenau A; Porazinski S; Raina A; Sjoquist KM; Chantrill LA; Gebski V; Sowmya A; Timpson P; Pajic M; Goldstein D; Phillips PA, 2024, '1513P Impact of symptom and functional burden on survival in pancreatic ductal adenocarcinoma (PDAC)', in Annals of Oncology, Elsevier BV, Vol. 35, pp. S925 - S925, http://dx.doi.org/10.1016/j.annonc.2024.08.1576

Murphy KJ; Reed DA; Chambers CR; Channon LM; Pajic M; Herrmann D; Timpson P, 2023, 'Anti-fibrotic FAK 'priming' to improve contemporary chemotherapy in pancreatic cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MA, Boston, Vol. 84, presented at AACR Special Conference - Pancreatic Cancer, MA, Boston, 27 September 2023 - 30 September 2023, http://dx.doi.org/10.1158/1538-7445.PANCA2023-B037

Pinho AV; Bulck MV; Chantrill L; Arshi M; Sklyarova T; Herrmann D; Vennin C; Gallego-Ortega D; Mawson A; Giry-Laterriere M; Magenau A; Baeyens L; Gill AJ; Phillips P; Timpson P; Biankin AV; Wu J; Rooman I, 2018, 'ROBO2 is a Stroma Suppressor Gene in the Pancreas Through Regulation of TGF-beta', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 47, pp. 1417 - 1417, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449304600212&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chin VT; Nagrial A; Conway J; Vennin C; Chantrill LA; Chou A; Steinmann A; Gill AJ; Humprhis J; Drury A; Froio D; Morgan A; Biankin A; Timpson P; Pajic M, 2017, 'Effect of Rho/ROCK pathway inhibition on metastasis-free and overall survival in biomarker selected, orthotopic, patient-derived models of pancreatic cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, IL, Chicago, Vol. 35, presented at 53rd Annual Clinical Science Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Symposium on Old Targets, New Drugs - Her2 and MET, IL, Chicago, 02 June 2017 - 07 June 2017, http://dx.doi.org/10.1200/JCO.2017.35.15_suppl.e15759

Huo CW; Chew G; Waltham M; Ingman W; Brown K; Timpson P; Khoo C; Fox S; Hill P; Chen S; Price J; Nguyen CH; Williams ED; Henderson M; Thompson EW; Britt K, 2016, 'THE BIOLOGY UNDERLYING MAMMOGRAPHIC DENSITY AND PRECLINICAL MOUSE MODELS TO TEST NEW THERAPIES', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 12, pp. 100 - 101, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387769900121&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Ooms LM; Binge LC; Rahman P; Conway JR; Ferguson DT; Fedele CG; Gurung R; Vieusseux JL; Chai RC; Price JT; Tiganis T; Timpson P; McLean CA; Mitchell CA, 2015, 'REGULATION OF PI3K/AKT-DEPENDENT BREAST CANCER GROWTH AND METASTASIS', in JOURNAL OF GENE MEDICINE, WILEY-BLACKWELL, AUSTRALIA, Univ Melbourne, Univ Coll, Parkville, Vol. 17, pp. 177 - 178, presented at 9th Biennial Meeting of the Australasian-Gene-and-Cell-Therapy-Society (AGCTS), AUSTRALIA, Univ Melbourne, Univ Coll, Parkville, 29 April 2015 - 01 May 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000362592700009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chin VT; Conway J; Nagrial A; Chantrill LA; Chou A; Steinmann A; Gill A; Pinese M; Wu J; Johns A; Dury A; Biankin A; Timpson P; Pajic M, 2015, 'Targeting the Rho-ROCK pathway to treat pancreatic cancer: The use of unique preclinical models to ascertain the effects on cancer growth and metastasis', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, CA, San Francisco, Vol. 33, presented at Gastrointestinal Cancers Symposium, CA, San Francisco, 15 January 2015 - 17 January 2015, http://dx.doi.org/10.1200/jco.2015.33.3_suppl.312

Macpherson IR; Rainero E; van den Berghe PVE; Speirs C; Dozynkiewicz MA; Chaudhary S; Kalna G; Edwards J; Timpson P; Norman JC, 2014, 'CLIC3 controls delivery of late endosomal MT1-MMP to the ventral plasma membrane and dictates invasion and metastasis in estrogen receptor-negative breast cancer', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SCOTLAND, Glasgow, Vol. 50, pp. S112 - S112, presented at 9th European Breast Cancer Conference (EBCC), SCOTLAND, Glasgow, 19 March 2014 - 21 March 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335106700240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chin VT; Nagrial A; Chantrill LA; Chang DK; Chou A; Humprhis J; Cowley M; Wu J; DiPetro R; Watson C; Spielman C; Steinmann A; Pinese M; Pettitt J; Johns A; Waddell N; Grimmond S; Timpson P; Biankin AV; Pajic M, 2013, 'From functional genomics to precision medicine: The therapeutic potential of targeting ROCK signaling in pancreatic cancer.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, Vol. 31, presented at 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 31 May 2013 - 04 June 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335419603693&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Doyle B; Tan EH; Timpson P; Machesky LM; Ridgway RR; Jeffery RR; Poulsom B; Morton JP; Sansom OJ, 2012, 'The Tumor Suppressor ARF Can Promote Invasion in the Absence of p53 Activity', in MODERN PATHOLOGY, NATURE PUBLISHING GROUP, CANADA, Vancouver, Vol. 25, pp. 461A - 461A, presented at 101st Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, CANADA, Vancouver, 17 March 2012 - 23 March 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000299986902434&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Doyle B; Tan EH; Timpson P; Machesky LM; Ridgway RR; Jeffrey RR; Poulsom R; Morton JP; Sansom OJ, 2012, 'The Tumor Suppressor ARF Can Promote Invasion in the Absence of p53 Activity', in LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, CANADA, Vancouver, Vol. 92, pp. 461A - 461A, presented at 101st Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), CANADA, Vancouver, 17 March 2012 - 23 March 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000299799902434&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Doyle B; Tan EH; Timpson P; Machesky LM; Ridgway RA; Jeffery RE; Poulsom R; Morton JP; Sansom OJ, 2011, 'The Tumour Suppressor ARF Can Promote Invasion in a p53 Null Setting', in JOURNAL OF PATHOLOGY, WILEY-BLACKWELL, ENGLAND, Univ Cambridge, Dept Pathol, Cambridge, Vol. 224, pp. S3 - S3, presented at 199th Scientific Meeting of the Pathological-Society-of-Great-Britain-and-Ireland, ENGLAND, Univ Cambridge, Dept Pathol, Cambridge, 06 January 2011 - 07 January 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000288613700006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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