By Dr Lei Zhang

Journal articles

Ip CK; Zhang L; Tasan R; Herzog H, 2025, 'Stress and high fat diet reconfigure the active translatome of CeA-NPY neurons', Molecular Metabolism, 98, http://dx.doi.org/10.1016/j.molmet.2025.102176

Herzog H; Zhang L; Fontana L; Neely GG, 2025, 'Impact of non-sugar sweeteners on metabolism beyond sweet taste perception', Trends in Endocrinology and Metabolism, 36, pp. 563 - 576, http://dx.doi.org/10.1016/j.tem.2024.10.008

Chambers CR; Watakul S; Schofield P; Howell AE; Zhu J; Tran AMH; Kuepper N; Reed DA; Murphy KJ; Channon LM; Pereira BA; Tyma VM; Lee V; Trpceski M; Henry J; Melenec P; Abdulkhalek L; Nobis M; Metcalf XL; Ritchie S; Cadell A; Stoehr J; Magenau A; Chacon-Fajardo D; Chitty JL; O’Connell S; Zaratzian A; Tayao M; Silva AD; Lyons RJ; Goldstein LD; Dale A; Rookyard A; Connolly A; Crossett B; Tran YTH; Kaltzis P; Vennin C; Dinevska M; Croucher DR; Samra J; Mittal A; Weatheritt RJ; Philp A; Monte-Nieto GD; Zhang L; Enriquez RF; Cox TR; Shi YCC; Pinese M; Waddell N; Sim HW; Chtanova T; Wang Y; Joshua AM; Chantrill L; Jeffry Evans TR; Gill AJ; Morton JP; Pajic M; Christ D; Herzog H; Timpson P; Herrmann D, 2025, 'Targeting the NPY/NPY1R signaling axis in mutant p53–dependent pancreatic cancer impairs metastasis', Science Advances, 11, http://dx.doi.org/10.1126/sciadv.adq4416

Zhang L; Herzog H, 2024, 'Important role of NPY-Y4R signalling in the dual control of feeding and physical activity', Neuropeptides, 105, http://dx.doi.org/10.1016/j.npep.2024.102425

Ip CK; Rezitis J; Qi Y; Bajaj N; Koller J; Farzi A; Shi YC; Tasan R; Zhang L; Herzog H, 2023, 'Critical role of lateral habenula circuits in the control of stress-induced palatable food consumption', Neuron, 111, pp. 2583 - 2600.e6, http://dx.doi.org/10.1016/j.neuron.2023.05.010

Qi Y; Lee NJ; Ip CK; Enriquez R; Tasan R; Zhang L; Herzog H, 2023, 'Agrp-negative arcuate NPY neurons drive feeding under positive energy balance via altering leptin responsiveness in POMC neurons', Cell Metabolism, 35, pp. 979 - 995.e7, http://dx.doi.org/10.1016/j.cmet.2023.04.020

Conway JRW; Warren SC; Lee YK; McCulloch AT; Magenau A; Lee V; Metcalf XL; Stoehr J; Haigh K; Abdulkhalek L; Guaman CS; Reed DA; Murphy KJ; Pereira BA; Mélénec P; Chambers C; Latham SL; Lenthall H; Deenick EK; Ma Y; Phan T; Lim E; Joshua AM; Walters S; Grey ST; Shi YC; Zhang L; Herzog H; Croucher DR; Philp A; Scheele CLGJ; Herrmann D; Sansom OJ; Morton JP; Papa A; Haigh JJ; Nobis M; Timpson P, 2023, 'Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.adf9063

Zhang L; Koller J; Gopalasingam G; Herzog H, 2022, 'NPFF signalling is critical for thermosensory and dietary regulation of thermogenesis', Neuropeptides, 96, http://dx.doi.org/10.1016/j.npep.2022.102292

Zhang L; Koller J; Gopalasingam G; Qi Y; Herzog H, 2022, 'Central NPFF signalling is critical in the regulation of glucose homeostasis', Molecular Metabolism, 62, http://dx.doi.org/10.1016/j.molmet.2022.101525

Qi Y; Lee NJ; Ip CK; Enriquez R; Tasan R; Zhang L; Herzog H, 2022, 'NPY derived from AGRP neurons controls feeding via Y1 and energy expenditure and food foraging behaviour via Y2 signalling', Molecular Metabolism, 59, http://dx.doi.org/10.1016/j.molmet.2022.101455

Mitchell CS; Goodman EK; Tedesco CR; Nguyen K; Zhang L; Herzog H; Begg DP, 2022, 'The Effect of Dietary Fat and Sucrose on Cognitive Functioning in Mice Lacking Insulin Signaling in Neuropeptide Y Neurons', Frontiers in Physiology, 13, http://dx.doi.org/10.3389/fphys.2022.841935

Goodman EK; Mitchell CS; Teo JD; Gladding JM; Abbott KN; Rafiei N; Zhang L; Herzog H; Begg DP, 2022, 'The effect of insulin receptor deletion in neuropeptide Y neurons on hippocampal dependent cognitive function in aging mice', Journal of Integrative Neuroscience, 21, http://dx.doi.org/10.31083/j.jin2101006

Yan C; Zeng T; Lee K; Nobis M; Loh K; Gou L; Xia Z; Gao Z; Bensellam M; Hughes W; Lau J; Zhang L; Ip CK; Enriquez R; Gao H; Wang QP; Wu Q; Haigh JJ; Laybutt DR; Timpson P; Herzog H; Shi YC, 2021, 'Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-22925-3

Koller J; Herzog H; Zhang L, 2021, 'The distribution of Neuropeptide FF and Neuropeptide VF in central and peripheral tissues and their role in energy homeostasis control', Neuropeptides, 90, http://dx.doi.org/10.1016/j.npep.2021.102198

Zhang L; Koller J; Ip CK; Gopalasingam G; Bajaj N; Lee NJ; Enriquez RF; Herzog H, 2021, 'Lack of neuropeptide FF signalling in mice leads to reduced repetitive behavior, altered drinking behavior, and fuel type selection', FASEB Journal, 35, http://dx.doi.org/10.1096/fj.202100703R

Kakall ZM; Gopalasingam G; Herzog H; Zhang L, 2021, 'Dynamic regional alterations in mouse brain neuronal activity following short-term changes in energy balance', Obesity, 29, pp. 1650 - 1663, http://dx.doi.org/10.1002/oby.23253

Zhang L; Gopalasingam G; Herzog H, 2021, 'Ninjin'yoeito, a herbal medicine, enhances glucose tolerance in mice', Neuropeptides, 88, http://dx.doi.org/10.1016/j.npep.2021.102150

Zhang L; Clark T; Gopalasingam G; Neely GG; Herzog H, 2021, 'Ninjin'yoeito modulates feeding and activity under negative energy balance conditions via the NPY system', Neuropeptides, 87, http://dx.doi.org/10.1016/j.npep.2021.102149

Farzi A; Ip CK; Reed F; Enriquez R; Zenz G; Durdevic M; Zhang L; Holzer P; Herzog H, 2021, 'Lack of peptide YY signaling in mice disturbs gut microbiome composition in response to high-fat diet', FASEB Journal, 35, http://dx.doi.org/10.1096/fj.202002215R

Zhang L, 2021, 'Method for voluntary oral administration of drugs in mice', STAR Protocols, 2, http://dx.doi.org/10.1016/j.xpro.2021.100330

Wee NKY; Nguyen AD; Enriquez RF; Zhang L; Herzog H; Baldock PA, 2020, 'Neuropeptide Y Regulation of Energy Partitioning and Bone Mass During Cold Exposure', Calcified Tissue International, 107, pp. 510 - 523, http://dx.doi.org/10.1007/s00223-020-00745-9

Chen J; Cheng M; Wang L; Zhang L; Xu D; Cao P; Wang F; Herzog H; Song S; Zhan C, 2020, 'A Vagal-NTS Neural Pathway that Stimulates Feeding', Current Biology, 30, pp. 3986 - 3998.e5, http://dx.doi.org/10.1016/j.cub.2020.07.084

Zhang L; Reed F; Herzog H, 2020, 'Leptin signalling on arcuate NPY neurones controls adiposity independent of energy balance or diet composition', Journal of Neuroendocrinology, 32, http://dx.doi.org/10.1111/jne.12898

Ip CK; Zhang L; Farzi A; Qi Y; Clarke I; Reed F; Shi YC; Enriquez R; Dayas C; Graham B; Begg D; Brüning JC; Lee NJ; Hernandez-Sanchez D; Gopalasingam G; Koller J; Tasan R; Sperk G; Herzog H, 2019, 'Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions', Cell Metabolism, 30, pp. 111 - 128.e6, http://dx.doi.org/10.1016/j.cmet.2019.04.001

Zhang L; Hernandez-Sanchez D; Herzog H, 2019, 'Regulation of feeding-related behaviors by arcuate neuropeptide Y neurons', Endocrinology, 160, pp. 1411 - 1420, http://dx.doi.org/10.1210/en.2019-00056

Ip CK; Herzog H; Zhang L, 2019, 'Chronic stress and energy homoeostasis', Aging, 11, pp. 9963 - 9964, http://dx.doi.org/10.18632/aging.102500

Ip CKK; Zhang L; Farzi A; Clarke I; Reed F; Shi Y-C; Enriquez R; Qi Y; Tasan R; Sperk G; Herzog H, 2019, 'Coordinated activation of central amygdala–arcuate nucleus NPY circuits are required for the development of stress-induced obesity', Obesity Research & Clinical Practice, 13, pp. 284 - 284, http://dx.doi.org/10.1016/j.orcp.2018.11.141

Yue Q; Lee N; Zhang L; Enriquez R; Herzog H, 2019, 'Distinct populations of Arc NPY neurons control specific aspects of energy homeostasis', Obesity Research & Clinical Practice, 13, pp. 277 - 277, http://dx.doi.org/10.1016/j.orcp.2018.11.123

Lee NJ; Ali N; Zhang L; Qi Y; Clarke I; Enriquez RF; Brzozowska M; Lee IC; Rogers MJ; Laybutt DR; Center JR; Baldock PA; Herzog H, 2019, 'Osteoglycin, a novel coordinator of bone and glucose homeostasis', Obesity Research & Clinical Practice, 13, pp. 256 - 256, http://dx.doi.org/10.1016/j.orcp.2018.11.063

Zhang L; Ip CK; Lee ICJ; Qi Y; Reed F; Karl T; Low JK; Enriquez RF; Lee NJ; Baldock PA; Herzog H, 2018, 'Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-06462-0

Farzi A; Lau J; Ip CK; Qi Y; Shi YC; Zhang L; Tasan R; Sperk G; Herzog H, 2018, 'Arcuate nucleus and lateral hypothalamic cart neurons in the mouse brain exert opposing effects on energy expenditure', Elife, 7, http://dx.doi.org/10.7554/eLife.36494

Lee NJ; Ali N; Qi J; Clarke RF; Enriquez RF; Brzozowska M; Lee IC; Rogers MJ; Laybutt DR; Center JR; Baldock PA; Herzog H, 2018, 'Osteoglycin, an Osteoblast-derived Regulator of Bone Mass and Glucose Homeostasis', Molecular Metabolism, http://dx.doi.org/10.1016/j.molmet.2018.05.004

Nguyen AD; Lee NJ; Wee NKY; Zhang L; Enriquez RF; Khor EC; Nie T; Wu D; Sainsbury A; Baldock PA; Herzog H, 2018, 'Uncoupling protein-1 is protective of bone mass under mild cold stress conditions', Bone, 106, pp. 167 - 178, http://dx.doi.org/10.1016/j.bone.2015.05.037

Loh K; Zhang L; Brandon A; Wang Q; Begg D; Qi Y; Fu M; Kulkarni R; Teo J; Baldock P; Bruning JC; Cooney G; Neely GG; Herzog H, 2017, 'Corrigendum to “Insulin controls food intake and energy balance via NPY neurons” [Mol Metabol 6 (2017) 574–584], (S2212877817301552), (10.1016/j.molmet.2017.03.013))', Molecular Metabolism, 6, pp. 1562, http://dx.doi.org/10.1016/j.molmet.2017.06.017

Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JRW; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JMW; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AKE; Sansom OJ; Welch HCE; Morton JP; Strathdee D; Anderson KI; Timpson P; del Monte Nieto G, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022

Qi Y; Purtell L; Fu M; Zhang L; Zolotukhin S; Campbell L; Herzog H, 2017, 'Hypothalamus Specific Re-Introduction of SNORD116 into Otherwise Snord116 Deficient Mice Increased Energy Expenditure', Journal of Neuroendocrinology, 29, http://dx.doi.org/10.1111/jne.12457

Zhang L; Fu Y; Zhou N; Cheng X; Chen C, 2017, 'Circulating neuregulin 4 concentrations in patients with newly diagnosed type 2 diabetes: a cross-sectional study', Endocrine, 57, pp. 535 - 538, http://dx.doi.org/10.1007/s12020-017-1324-3

Loh K; Zhang L; Brandon A; Wang Q; Begg D; Qi Y; Fu M; Kulkarni R; Teo J; Baldock P; Brüning JC; Cooney G; Neely G; Herzog H, 2017, 'Insulin controls food intake and energy balance via NPY neurons', Molecular Metabolism, 6, pp. 574 - 584, http://dx.doi.org/10.1016/j.molmet.2017.03.013

Qi Y; Purtell L; Fu M; Sengmany K; Loh K; Zhang L; Zolotukhin S; Sainsbury A; Campbell L; Herzog H, 2017, 'Ambient temperature modulates the effects of the Prader-Willi syndrome candidate gene Snord116 on energy homeostasis', Neuropeptides, 61, pp. 87 - 93, http://dx.doi.org/10.1016/j.npep.2016.10.006

Liu M; Richardson RR; Mountford SJ; Zhang L; Tempone MH; Herzog H; Holliday ND; Thompson PE, 2016, 'Identification of a Cyanine-Dye Labeled Peptidic Ligand for Y1R and Y4R, Based upon the Neuropeptide y C-Terminal Analogue, BVD-15', Bioconjugate Chemistry, 27, pp. 2166 - 2175, http://dx.doi.org/10.1021/acs.bioconjchem.6b00376

Wang QP; Lin YQ; Zhang L; Wilson YA; Oyston LJ; Cotterell J; Qi Y; Khuong TM; Bakhshi N; Planchenault Y; Browman DT; Lau MT; Cole TA; Wong ACN; Simpson SJ; Cole AR; Penninger JM; Herzog H; Neely GG, 2016, 'Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response', Cell Metabolism, 24, pp. 75 - 90, http://dx.doi.org/10.1016/j.cmet.2016.06.010

Khor EC; Yulyaningsih E; Driessler F; Kovaĉić N; Wee NKY; Kulkarni RN; Lee NJ; Enriquez RF; Xu J; Zhang L; Herzog H; Baldock PA, 2016, 'The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay', Bone, 84, pp. 139 - 147, http://dx.doi.org/10.1016/j.bone.2015.12.011

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P; Zhang L, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Qi Y; Purtell L; Fu M; Lee NJ; Aepler J; Zhang L; Loh K; Enriquez RF; Baldock PA; Zolotukhin S; Campbell LV; Herzog H, 2016, 'Snord116 is critical in the regulation of food intake and body weight', Scientific Reports, 6, pp. 18614, http://dx.doi.org/10.1038/srep18614

Seimon RV; Shi YC; Slack K; Lee K; Fernando HA; Nguyen AD; Zhang L; Lin S; Enriquez RF; Lau J; Herzog H; Sainsbury A, 2016, 'Intermittent Moderate Energy Restriction Improves Weight Loss Efficiency in Diet-Induced Obese Mice', Plos One, 11, http://dx.doi.org/10.1371/journal.pone.0145157

Lengkeek NA; Roberts MP; Zhang L; Lee ICJ; Fookes CJR; Dikic B; Herzog H; Katsifis A; Greguric I, 2016, 'Synthesis and Binding Affinity of Fluorine Containing NG-acyl and -sulfonyl BIBP3226 Derivatives: Ligands for the NPY Y1 Receptor', Australian Journal of Chemistry, 69, pp. 746 - 752, http://dx.doi.org/10.1071/CH15569

Mountford S; Liu O; Zhang L; Richardson R; Groenen M; Herzog H; Holliday N; Thompson P, 2016, 'Developing superior peptide conjugates for studying Y receptor biology', Neuropeptides, 55, pp. 10 - 10, http://dx.doi.org/10.1016/j.npep.2015.11.024

Zhang L; Lee I-CJ; Herzog H, 2016, 'Hypothalamic neuropeptide FF receptor-2 signaling is critical for the regulation of energy homeostasis', Neuropeptides, 55, pp. 13 - 13, http://dx.doi.org/10.1016/j.npep.2015.11.034

Khor E-C; Yulyaningsih E; Lee NJ; Driessler F; Kovaĉić N; Wee NKY; Kulkarni RN; Enriquez RF; Xu J; Zhang L; Herzog H; Baldock PA, 2016, 'The y6 receptor suppresses bone resorption and stimulates bone formation in mice', Neuropeptides, 55, pp. 24 - 24, http://dx.doi.org/10.1016/j.npep.2015.11.068

Tactacan CM; Phua YW; Liu L; Zhang L; Humphrey ES; Cowley M; Pinese M; Biankin AV; Daly RJ, 2015, 'The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling', Molecular Cancer, 14, http://dx.doi.org/10.1186/s12943-015-0412-3

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