By Dr Joyce Chiu

Journal articles

Lv K; Chen S; Xu X; Chiu J; Wang HJ; Han Y; Yang X; Bowley SR; Wang H; Tang Z; Tang N; Yang A; Yang S; Wang J; Jin S; Wu Y; Schmaier AH; Ju LA; Hogg PJ; Fang C, 2024, 'Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis', Nature Communications, 15, pp. 3129, http://dx.doi.org/10.1038/s41467-024-47493-0

Kong YX; Chiu J; Passam FH, 2024, '“Sticki-ER”: Functions of the Platelet Endoplasmic Reticulum', Antioxidants and Redox Signaling, 41, pp. 637 - 660, http://dx.doi.org/10.1089/ars.2024.0566

Li Y; Xu X; Wang HJ; Chen YC; Chen Y; Chiu J; Li L; Wang L; Wang J; Tang Z; Ren L; Li H; Wang X; Jin S; Wu Y; Huang M; Ju LA; Fang C, 2024, 'Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity to Influence Neutrophil Recruitment', Arteriosclerosis Thrombosis and Vascular Biology, 44, pp. E82 - E98, http://dx.doi.org/10.1161/ATVBAHA.123.319771

Kutzki F; Butera D; Lay AJ; Maag D; Chiu J; Woon HG; Kubař T; Elstner M; Aponte-Santamaría C; Hogg PJ; Gräter F, 2023, 'Disulfide bond reduction and exchange in C4 domain of von Willebrand factor undermines platelet binding', Journal of Thrombosis and Haemostasis, 21, pp. 2089 - 2100, http://dx.doi.org/10.1016/j.jtha.2023.03.039

Yang M; Chiu J; Scartelli C; Ponzar N; Patel S; Patel A; Ferreira RB; Keyes RF; Carroll KS; Pozzi N; Hogg PJ; Smith BC; Flaumenhaft R, 2023, 'Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation', Journal of Thrombosis and Haemostasis, 21, pp. 2137 - 2150, http://dx.doi.org/10.1016/j.jtha.2023.03.034

Lay AJ; Dupuy A; Hagimola L; Tieng J; Larance M; Zhang Y; Yang J; Kong Y; Chiu J; Gray E; Qin Z; Schmidt D; Maclean J; Hofma B; Ellis M; Kalev-Zylinska M; Argon Y; Jackson SP; Hogg P; Passam FH, 2023, 'Endoplasmic reticulum protein 5 attenuates platelet endoplasmic reticulum stress and secretion in a mouse model', Blood Advances, 7, pp. 1650 - 1665, http://dx.doi.org/10.1182/bloodadvances.2022008457

Dupuy A; Aponte-Santamaria C; Yeheskel A; Hortle E; Oehlers SH; Grater F; Hogg PJ; Passam FH; Chiu J, 2023, 'Mechano-Redox Control of Mac-1 De-Adhesion by PDI Promotes Directional Movement under Flow', Circulation Research, 132, pp. E151 - E168, http://dx.doi.org/10.1161/CIRCRESAHA.122.321926

Dupuy A; Ju LA; Chiu J; Passam FH, 2022, 'Mechano-Redox Control of Integrins in Thromboinflammation', Antioxidants and Redox Signaling, 37, pp. 1072 - 1093, http://dx.doi.org/10.1089/ars.2021.0265

Chiu J; Uaprasert N; Eriksson O; Lin L; Guo S; Hogg P; Flaumenhaft R, 2021, 'PDI Cleavage of Disulfide Bonds within the TP Receptor Inhibits Signaling through Gα 13', Blood, 138, pp. 579 - 579, http://dx.doi.org/10.1182/blood-2021-151753

Florido M; Chiu J; Hogg PJ, 2021, 'Influenza A Virus Hemagglutinin Is Produced in Different Disulfide-Bonded States', Antioxidants and Redox Signaling, 35, pp. 1081 - 1092, http://dx.doi.org/10.1089/ars.2021.0033

Pijning AE; Blyth MT; Coote ML; Passam F; Chiu J; Hogg PJ, 2021, 'An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function', Blood, 138, pp. 1359 - 1372, http://dx.doi.org/10.1182/blood.2021012441

Xu X; Chiu J; Chen S; Fang C, 2021, 'Pathophysiological roles of cell surface and extracellular protein disulfide isomerase and their molecular mechanisms', British Journal of Pharmacology, 178, pp. 2911 - 2930, http://dx.doi.org/10.1111/bph.15493

Chen S; Xu X-L; Chiu J; Bowley S; Wu Y; Hogg PJ; Fang C, 2020, 'Extracellular Protein Disulfide Isomerase Cleaves Allosteric Disulfides in Histidine-Rich Glycoprotein to Regulate Thrombus Formation', Blood, 136, pp. 11 - 12, http://dx.doi.org/10.1182/blood-2020-137810

Lu ZF; Chiu J; Lee LR; Schindeler A; Jackson M; Ramaswamy Y; Dunstan CR; Hogg PJ; Zreiqat H, 2020, 'Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7', Stem Cells Translational Medicine, 9, pp. 403 - 415, http://dx.doi.org/10.1002/sctm.19-0281

Su Z; Burchfield JG; Yang P; Humphrey SJ; Yang G; Francis D; Yasmin S; Shin SY; Norris DM; Kearney AL; Astore MA; Scavuzzo J; Fisher-Wellman KH; Wang QP; Parker BL; Neely GG; Vafaee F; Chiu J; Yeo R; Hogg PJ; Fazakerley DJ; Nguyen LK; Kuyucak S; James DE, 2019, 'Global redox proteome and phosphoproteome analysis reveals redox switch in Akt', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-13114-4

Passam FJ; Chiu J, 2019, 'Allosteric disulphide bonds as reversible mechano-sensitive switches that control protein functions in the vasculature', Biophysical Reviews, 11, pp. 419 - 430, http://dx.doi.org/10.1007/s12551-019-00543-0

Eriksson O; Chiu J; Hogg PJ; Atkinson JP; Liszewski MK; Flaumenhaft R; Furie B, 2019, 'Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation', Journal of Biological Chemistry, 294, pp. 4878 - 4888, http://dx.doi.org/10.1074/jbc.RA118.006792

Li J; Kim K; Jeong SY; Chiu J; Xiong B; Petukhov PA; Dai X; Li X; Andrews RK; Du X; Hogg PJ; Cho J, 2019, 'Platelet protein disulfide isomerase promotes glycoprotein ib&-mediated platelet-neutrophil interactions under thromboinflammatory conditions', Circulation, 139, pp. 1300 - 1319, http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036323

Chiu J; Hogg PJ, 2019, 'Allosteric disulfides: Sophisticated molecular structures enabling flexible protein regulation', Journal of Biological Chemistry, 294, pp. 2949 - 2960, http://dx.doi.org/10.1074/jbc.REV118.005604

Chiu J, 2019, 'Measurement of Redox States of the β3 Integrin Disulfide Bonds by Mass Spectrometry', Bio Protocol, 9, http://dx.doi.org/10.21769/BioProtoc.3156

Bekendam RH; Iyu D; Passam F; Stopa JD; De Ceunynck K; Muse O; Bendapudi PK; Garnier CL; Gopal S; Crescence L; Chiu J; Furie B; Panicot-Dubois L; Hogg PJ; Dubois C; Flaumenhaft R, 2018, 'Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation', Journal of Thrombosis and Haemostasis, 16, pp. 2322 - 2335, http://dx.doi.org/10.1111/jth.14291

Passam F; Chiu J; Ju L; Pijning A; Jahan Z; Mor-Cohen R; Yeheskel A; Kolšek K; Thärichen L; Aponte-Santamaría C; Gräter F; Hogg PJ, 2018, 'Mechano-redox control of integrin de-adhesion', Elife, 7, http://dx.doi.org/10.7554/eLife.34843

Pijning AE; Chiu J; Yeo RX; Wong JWH; Hogg PJ, 2018, 'Identification of allosteric disulfides from labile bonds in X-ray structures', Royal Society Open Science, 5, http://dx.doi.org/10.1098/rsos.171058

Bekendam RH; Bendapudi PK; Lin L; Nag PP; Pu J; Kennedy DR; Feldenzer A; Chiu J; Cook KM; Furie B; Huang M; Hogg PJ; Flaumenhaft R, 2016, 'A substrate-driven allosteric switch that enhances PDI catalytic activity', Nature Communications, 7, http://dx.doi.org/10.1038/ncomms12579

Chiu J; Passam F; Butera D; Hogg PJ, 2015, 'Protein Disulfide Isomerase in Thrombosis', Seminars in Thrombosis and Hemostasis, 41, pp. 765 - 773, http://dx.doi.org/10.1055/s-0035-1564047

Butera D; Cook K; Chiu J; Wong JWH; Hogg PJ, 2014, 'Control of blood proteins by functional disulfide bonds', Blood, 123, pp. 2000 - 2007, http://dx.doi.org/10.1182/blood-2014-01-549816

Chiu J; Wong JWH; Gerometta M; Hogg PJ, 2014, 'Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C', Biochemistry, 53, pp. 7 - 9, http://dx.doi.org/10.1021/bi401518b

Chiu J; Wong JWH; Hogg PJ, 2014, 'Redox regulation of Methionine aminopeptidase 2 activity', Journal of Biological Chemistry, 289, pp. 15035 - 15043, http://dx.doi.org/10.1074/jbc.M114.554253

Ng JY; Chiu J; Hogg PJ; Wong JWH, 2013, 'Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2', Biochemical and Biophysical Research Communications, 440, pp. 37 - 42, http://dx.doi.org/10.1016/j.bbrc.2013.09.035

Chiu J; Dawes IW, 2012, 'Redox control of cell proliferation', Trends in Cell Biology, 22, pp. 592 - 601, http://dx.doi.org/10.1016/j.tcb.2012.08.002

Park D; Chiu J; Perrone G; Dilda P; Hogg PJ, 2012, 'The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase', Cancer Cell International, 12, pp. online open access, http://dx.doi.org/10.1186/1475-2867-12-11

Chiu J; Tactacan CM; Tan S; Lin RCY; Wouters MA; Dawes IW, 2011, 'Cell cycle sensing of oxidative stress in Saccharomyces cerevisiae by oxidation of a specific cysteine residue in the transcription factor Swi6p', The Journal of Biological Chemistry, 286, pp. 5204 - 5214, http://dx.doi.org/10.1074/jbc.M110.172973

Tsoi BM; Beckhouse AG; Gelling CL; Raftery MJ; Chiu J; Tsoi AM; Lauterbach L; Rogers PL; Higgins VJ; Dawes IW, 2009, 'Essential role of one-carbon metabolism and Gcn4p and Bas1p transcriptional regulators during adaptation to anaerobic growth of Saccharomyces cerevisiae', The Journal of Biological Chemistry, 284, pp. 11205 - 11215

Fong C; Temple MD; Alic N; Chiu II; Durchdewald M; Thorpe GW; Higgins VJ; Dawes IW, 2008, 'Oxidant-induced cell-cycle delay in Saccharomyces cerevisiae: the involvement of the SWI6 transcription factor', FEMS Yeast Research, 8, pp. 386 - 399, http://dx.doi.org/10.1111/j.1567-1364.2007.00349.x

Chiu II; Tillett D; Dawes IW; March PE, 2008, 'Site-directed, Ligase-Independent Mutagenesis (SLIM) for highly efficient mutagenesis of plasmids greater than 8kb', Journal of Microbiological Methods, 73, pp. 195 - 198, http://dx.doi.org/10.1016/j.mimet.2008.02.013

Chiu J; Tillett D; March PE, 2006, 'Coexpression of the subunits of T7 DNA polymerase from an artificial operon allows one-step purification of active gp5/Trx complex', Protein Expression and Purification, 47, pp. 264 - 272

Chiu J; Tillett D; March PE, 2006, 'Mutation Of PHE102 to Ser in the carboxyl terminal helix of Escherichia coli thioredoxin affects the stability and processivity of T7 DNA polymerase', Proteins - Structure Function and Bioinformatics, 64, pp. 477 - 485

Chiu J; March PE; Lee R; Tillett D, 2004, 'Site-directed, Ligase-Independent Mutagenesis (SLIM): a single-tube methodology approaching 100% efficiency in 4 h', Nucleic Acids Research, 32, pp. e174 - e174, http://www.sciencedirect.com/science/article/B6WVB-4F08SS4-2HR/2/b98d5e9c1bf5baf1397486a6cec49834

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