By Dr Daisy Y. Shu

Journal articles

Ng PQ; Huang K; McLellan FC; Yang M; Lennikov A; Hu Z; Chaudhary S; Appiah AC; Vuong ML; Shu DY, 2025, 'Dimethyl fumarate is an inhibitor of pathological angiogenesis', Cellular Signalling, 136, http://dx.doi.org/10.1016/j.cellsig.2025.112106

McLellan FC; Huang K; Wong E; Shu DY, 2025, 'The Angiofibrotic Switch in Retinal and Choroidal Vascular Diseases: Mechanistic Drivers of Angiogenesis and Endothelial-Mesenchymal Transition', American Journal of Pathology, 195, pp. 1363 - 1375, http://dx.doi.org/10.1016/j.ajpath.2025.05.004

Shu DY; Nakano Y; Cho KS; Lennikov A, 2025, 'Editorial: Electric stimulation in the eye and brain: advancements and applications', Frontiers in Cell and Developmental Biology, 13, http://dx.doi.org/10.3389/fcell.2025.1643111

Kriukov E; Shu DY; Yan W; Romano G; Tai WL, 2025, 'Editorial: Multiomics approaches in the central nervous system and neuropathies', Frontiers in Neuroscience, 19, http://dx.doi.org/10.3389/fnins.2025.1670706

O Hare M; Miller WP; Arevalo-Alquichire S; Amarnani D; Apryani E; Perez-Corredor P; Marino C; Shu DY; Vanderleest TE; Muriel-Torres A; Gordon HB; Gunawan AL; Kaplan BA; Barake KW; Bejjani RP; Doan TH; Lin R; Delgado-Tirado S; Gonzalez-Buendia L; Rossin EJ; Zhao G; Eliott D; Weinl-Tenbruck C; Chevessier-Tönnesen F; Rejman J; Montrasio F; Kim LA; Arboleda-Velasquez JF, 2024, 'An mRNA-encoded dominant-negative inhibitor of transcription factor RUNX1 suppresses vitreoretinal disease in experimental models', Science Translational Medicine, 16, pp. eadh0994 - eadh0994, http://dx.doi.org/10.1126/scitranslmed.adh0994

Shu DY; Meadows V; Alvidrez RM; Bai M, 2024, 'The publish or perish game: an interview with the inventor', FEBS Letters, 598, pp. 2619 - 2622, http://dx.doi.org/10.1002/1873-3468.15039

Zhang Q; Shu DY; Bryan RA; Han JYS; Gulette GA; Lo K; Kim LA; Miller JML, 2024, 'Long-term Monitoring of Oxygen Consumption Rates in Highly Differentiated and Polarized Retinal Pigment Epithelial Cultures', Journal of Visualized Experiments, 2024-August, http://dx.doi.org/10.3791/67038

Kocherlakota S; Hurley JB; Shu DY, 2024, 'Editorial: Retinal metabolism in health and disease', Frontiers in Ophthalmology, 4, http://dx.doi.org/10.3389/fopht.2024.1459318

Karg MM; Moorefield M; Hoffmann E; Philipose H; Krasniqi D; Hoppe C; Shu DY; Shirahama S; Ksander BR; Saint-Geniez M, 2023, 'Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health (Immunity & Ageing, (2023), 20, 1, (53), 10.1186/s12979-023-00358-4)', Immunity and Ageing, 20, http://dx.doi.org/10.1186/s12979-023-00388-y

Karg MM; Moorefield M; Hoffmann E; Philipose H; Krasniqi D; Hoppe C; Shu DY; Shirahama S; Ksander BR; Saint-Geniez M, 2023, 'Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health', Immunity and Ageing, 20, http://dx.doi.org/10.1186/s12979-023-00358-4

Ng PQ; Saint-Geniez M; Kim LA; Shu DY, 2023, 'Divergent Metabolomic Signatures of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition', Metabolites, 13, http://dx.doi.org/10.3390/metabo13020213

Fitch TC; Frank SI; Li YK; Saint-Geniez M; Kim LA; Shu DY, 2023, 'Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry', Journal of Visualized Experiments, 2023, http://dx.doi.org/10.3791/64572

Shu DY; Chaudhary S; Cho KS; Lennikov A; Miller WP; Thorn DC; Yang M; McKay TB, 2023, 'Role of Oxidative Stress in Ocular Diseases: A Balancing Act', Metabolites, 13, http://dx.doi.org/10.3390/metabo13020187

Shyam R; Shu DY; Zuniga-Sanchez E; Vasudevan D, 2023, 'Editorial: Molecular mechanisms in ocular development and disease', Frontiers in Cell and Developmental Biology, 11, http://dx.doi.org/10.3389/fcell.2023.1244123

Shu DY; Frank SI; Fitch TC; Karg MM; Butcher ER; Nnuji-John E; Kim LA; Saint-Geniez M, 2022, 'Dimethyl Fumarate Blocks Tumor Necrosis Factor-Alpha-Driven Inflammation and Metabolic Rewiring in the Retinal Pigment Epithelium', Frontiers in Molecular Neuroscience, 15, http://dx.doi.org/10.3389/fnmol.2022.896786

Shu DY; Frank SI; Karg MM; Butcher ER; Nnuji-John E; Shah R; Gollapalli D; Saint-Geniez M, 2022, 'Contrasting Metabolic Profiles of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition (EMT)', FASEB JOURNAL, 36, http://dx.doi.org/10.1096/fasebj.2022.36.S1.0R785

Karg MM; Moorefield M; Hoffmann E; Shu D; Krasniqi D; Philipose H; Ksander BR; Saint-Geniez M, 2022, 'Microglia Prevent the Loss of Visual Function in the Aging Retina by Maintaining the Health of Retinal Pigment Epithelial Cells', FASEB JOURNAL, 36, http://dx.doi.org/10.1096/fasebj.2022.36.S1.R5839

Butcher ER; Shu DY; Frank S; Saint-Geniez M, 2022, 'Mitochondrial Transplantation as a Novel Therapeutic for Retinal Metabolic Dysfunction-Driven Disease', FASEB JOURNAL, 36, http://dx.doi.org/10.1096/fasebj.2022.36.S1.R2669

Shu DY; Lovicu FJ, 2021, 'Insights into bone morphogenetic protein—(BMP-) signaling in ocular lens biology and pathology', Cells, 10, http://dx.doi.org/10.3390/cells10102604

Wishart TFL; Flokis M; Shu DY; Das SJ; Lovicu FJ, 2021, 'Hallmarks of lens aging and cataractogenesis', Experimental Eye Research, 210, http://dx.doi.org/10.1016/j.exer.2021.108709

Shu DY; Ng K; Wishart TFL; Chui J; Lundmark M; Flokis M; Lovicu FJ, 2021, 'Contrasting roles for BMP-4 and ventromorphins (BMP agonists) in TGFβ-induced lens EMT', Experimental Eye Research, 206, http://dx.doi.org/10.1016/j.exer.2021.108546

Shu DY; Butcher ER; Saint-Geniez M, 2021, 'Suppression of pgc-1α drives metabolic dysfunction in tgfβ2-induced emt of retinal pigment epithelial cells', International Journal of Molecular Sciences, 22, http://dx.doi.org/10.3390/ijms22094701

Shu D; Butcher E; Cai S; Senthilkumar I; Frank S; Gollapalli D; Saint-Geniez M, 2021, 'Metabolic Reprogramming of the Retinal Pigment Epithelium Drives TGFβ2-Induced Epithelial-Mesenchymal Transition', FASEB JOURNAL, 35, http://dx.doi.org/10.1096/fasebj.2021.35.S1.03272

Zheng Q; Jones FK; Leavitt SV; Ung L; Labrique AB; Peters DH; Lee EC; Azman AS; Adhikari B; Wahl B; Sarnowski C; Antiporta DA; Erchick DJ; Perez-Saez J; Ssekasanvu J; Lee KH; White L; Kostandova NS; Menezes NP; Albaugh NW; Gupta N; Jiwani SS; Hegde ST; Srivastava S; Aung T; Zhang Y; Norton G; Kalra A; Khaitan A; Shah D; Kaur J; Kasi K; Patel L; Dhingra LS; Agarwal M; Garg S; Goel U; Gill VJS; Khan E; Patwari A; Khaloo P; Joshi D; Blagg E; Pence E; Nelson HK; Fan J; Forbes L; Schlussel M; Etyemez S; Song S; Mohan U; Sun Y; Jang S; Frumento N; Sivakumar A; Hartner AM; Karandikar V; Yan Z; Beiter ER; Song J; Wedlund L; Singer M; Rahman RS; Virk ZM; Abar A; Tiu B; Adamson TM; Paudel K; Yao H; Wang Y; Li-Rodenborn ER; Ozdemir I; McLean MG; Rattigan S; Borgert BA; Moreno CA; Quigley NE; Li C; Kaur N; Gimbrone C; Scales SE; Zuniga-Moya JC; Babigumira PA; Igwe CC; Wang HE; Hsieh L; Misra S; Bruton K; Byng D; Miranda-Schaeubinger M; Uddin MN; Ticehurst JR; Laney E; Bhadauria A; Gupta V; Selles MC; Kartik A; Singh A; Garg D; Saini J, 2020, 'HIT-COVID, a global database tracking public health interventions to COVID-19', Scientific Data, 7, http://dx.doi.org/10.1038/s41597-020-00610-2

Shu DY; Butcher E; Saint-Geniez M, 2020, 'EMT and ENDMT: Emerging roles in age-related macular degeneration', International Journal of Molecular Sciences, 21, pp. 1 - 26, http://dx.doi.org/10.3390/ijms21124271

Ong K; Shu D, 2020, 'Evaluating the difference between autorefraction and subjective refraction may guide “fudge factor” for IOL power selection for cataract surgery after previous LASIK', Asian Journal of Ophthalmology, 17, pp. 98 - 100

Lovicu FJ; Flokis M; Wojciechowski M; Mao B; Shu D, 2020, 'Understanding Fibrotic Cataract: Regulation of TGFβ-Mediated Pathways Leading to Lens Epithelial to Mesenchymal Transition (EMT)', 日本白内障学会誌, 32, pp. 23 - 32, http://dx.doi.org/10.14938/cataract.12-004

Shu D; Butcher E; Cai S; Senthilkumar I; Frank S; Saint-Geniez M, 2020, 'Paradoxical Effect of TNFα on Mitochondrial Function and Metabolic Activity in the Retinal Pigment Epithelium (RPE)', FASEB JOURNAL, 34, http://dx.doi.org/10.1096/fasebj.2020.34.s1.02450

Saint-Geniez M; Cai S; Satish S; Senthilkumar I; Shu D; Butcher E; Frank S, 2020, 'Pathological induction of PGC-1β by RelB/NF-κB promotes RPE oxidative damage and choroidal neovascularization', FASEB JOURNAL, 34, http://dx.doi.org/10.1096/fasebj.2020.34.s1.05249

Shu DY; Hutcheon AEK; Zieske JD; Guo X, 2019, 'Epidermal Growth Factor Stimulates Transforming Growth Factor-Beta Receptor Type II Expression In Corneal Epithelial Cells', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-42969-2

Shu DY; Lovicu FJ, 2019, 'Enhanced EGF receptor-signaling potentiates TGFβ-induced lens epithelial-mesenchymal transition', Experimental Eye Research, 185, http://dx.doi.org/10.1016/j.exer.2019.107693

Rosales MAB; Shu DY; Iacovelli J; Saint-Geniez M, 2019, 'Erratum: Correction: Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration (Life science alliance (2019) 2 3 PII: e201900436)', Life Science Alliance, 2, http://dx.doi.org/10.26508/lsa.201900436

Ong K; Ong RM; Shu D, 2019, 'Diluting 5-fluorouracil with normal saline reduces patient discomfort', Asian Journal of Ophthalmology, 16, pp. 229 - 230, http://dx.doi.org/10.35119/asjoo.v16i4.573

Shu DY; Wojciechowski M; Lovicu FJ, 2019, 'ERK1/2-mediated EGFR-signaling is required for TGFβ-induced lens epithelial-mesenchymal transition', Experimental Eye Research, 178, pp. 108 - 121, http://dx.doi.org/10.1016/j.exer.2018.09.021

Rosales MAB; Shu DY; Iacovelli J; Saint-Geniez M, 2019, 'Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration', Life Science Alliance, 2, http://dx.doi.org/10.26508/lsa.201800212

Wojciechowski MC; Shu DY; Lovicu FJ, 2018, 'ERK1/2-Dependent Gene Expression Contributing to TGFβ-Induced Lens EMT', Current Eye Research, 43, pp. 986 - 997, http://dx.doi.org/10.1080/02713683.2018.1464193

Shu DY; Lovicu FJ, 2017, 'Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis', Progress in Retinal and Eye Research, 60, pp. 44 - 65, http://dx.doi.org/10.1016/j.preteyeres.2017.08.001

Wojciechowski MC; Mahmutovic L; Shu DY; Lovicu FJ, 2017, 'ERK1/2 signaling is required for the initiation but not progression of TGFβ-induced lens epithelial to mesenchymal transition (EMT)', Experimental Eye Research, 159, pp. 98 - 113, http://dx.doi.org/10.1016/j.exer.2017.03.012

Shu DY; Wojciechowski MC; Lovicu FJ, 2017, 'Bone morphogenetic protein-7 suppresses TGFβ2-induced epithelial-mesenchymal transition in the lens: Implications for cataract prevention', Investigative Ophthalmology and Visual Science, 58, pp. 781 - 796, http://dx.doi.org/10.1167/iovs.16-20611

Kichkin E; Visvanathan A; Lovicu FJ; Shu DY; Das SJ; Reddel SW; McCann EP; Zhang KY; Williams KL; Blair IP; Phillips WD, 2017, 'Postnatal Development of Spasticity Following Transgene Insertion in the Mouse βIV Spectrin Gene (SPTBN4)', Journal of Neuromuscular Diseases, 4, pp. 159 - 164, http://dx.doi.org/10.3233/JND-160197

Conference Papers

Shu DY; Ong K; Lovicu FJ, 2017, 'Histopathology of Subcapsular Cataract in a Patient with Atopic Dermatitis', in Optometry and Vision Science, pp. 270 - 276, http://dx.doi.org/10.1097/OPX.0000000000001011

Conference Abstracts

Lu YR; Karg M; Chew LA; Kajderowicz K; Shu DY; Qiu X; Refaian N; Shirahama S; Hu Z; Bertozzi T; Sinclair D; Saint-Geniez M; D'Amorc PA; Rickman CB; Ksander B; Weissman J, 2024, 'Genome-wide Screening Identifies Novel Genetic and Epigenetic Factors for the Rejuvenation and Enhancement of RPE to Alleviate Age-related Macular Degeneration', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, WA, Seattle, Vol. 65, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), WA, Seattle, 05 May 2024 - 09 May 2024

Wu DM; Shinde V; Ivanchenko M; Margolin S; Shu DY; Cepko CL; Wu DM; Shinde V; Ivanchenko M; Margolin S; Shu DY; Cepko CL, 2024, 'Photoreceptor derived lactate supports RPE health and metabolic homeostasis', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, WA, Seattle, Vol. 65, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), WA, Seattle, 05 May 2024 - 09 May 2024

Reports

Daisy Shu DS, How do cataracts form and how can they be prevented?, Experiment, http://dx.doi.org/10.18258/9993, https://doi.org/10.18258/9993

Preprints

Lu YR; Cameron JC; Hu Y; Shen H; Shirahama S; Tyshkovskiy A; Chen Z; Ai J; Zhu DY; Karg MM; Chew LA; Bell GW; Jena SG; He Y; Seifert P; Shu DY; Ei-Brolosy MA; Lou Q; Zhang B; Puszynska AM; Qiu X; Tian X; Gregory-Ksander M; Gladyshev VN; Sinclair DA; Saint-Geniez M; Buenrostro JD; Rickman CB; Ksander BR; Weissman JS, 2025, Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision., http://dx.doi.org/10.1101/2025.08.30.673239

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