By Dr Brenna Osborne

Journal articles

Petr MA; Matiyevskaya F; Osborne B; Berglind M; Reves S; Zhang B; Ezra MB; Carmona-Marin LM; Syadzha MF; Mediavilla MC; Keijzers G; Bakula D; Mkrtchyan GV; Scheibye-Knudsen M, 2024, 'Pharmacological interventions in human aging', Ageing Research Reviews, 95, http://dx.doi.org/10.1016/j.arr.2024.102213

Osborne B; Wright LE; Brandon AE; Stuart E; Small L; Hoeks J; Schrauwen P; Sinclair DA; Montgomery MK; Cooney GJ; Turner N, 2023, 'SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance', Journal of Endocrinology, 258, pp. e220101, http://dx.doi.org/10.1530/JOE-22-0101

Heckenbach I; Mkrtchyan GV; Ezra MB; Bakula D; Madsen JS; Nielsen MH; Oró D; Osborne B; Covarrubias AJ; Idda ML; Gorospe M; Mortensen L; Verdin E; Westendorp R; Scheibye-Knudsen M, 2022, 'Nuclear morphology is a deep learning biomarker of cellular senescence', Nature Aging, 2, pp. 742 - 755, http://dx.doi.org/10.1038/s43587-022-00263-3

Osborne B; Reznick J; Wright LE; Sinclair DA; Cooney GJ; Turner N, 2022, 'Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice', Biochemical and Biophysical Research Communications, 607, pp. 131 - 137, http://dx.doi.org/10.1016/j.bbrc.2022.03.088

Mkrtchyan GV; Abdelmohsen K; Andreux P; Bagdonaite I; Barzilai N; Brunak S; Cabreiro F; Cabo RD; Campisi J; Cuervo AM; Demaria M; Ewald CY; Fang EF; Faragher R; Ferrucci L; Freund A; Silva-García CG; Georgievskaya A; Gladyshev VN; Glass DJ; Gorbunova V; Grey AD; He WW; Hoeijmakers J; Hoffmann E; Horvath S; Houtkooper RH; Jensen MK; Jensen MB; Kane A; Kassem M; Keizer PD; Kennedy B; Karsenty G; Lamming DW; Lee KF; MacAulay N; Mamoshina P; Mellon J; Molenaars M; Moskalev A; Mund A; Niedernhofer L; Osborne B; Pak HH; Parkhitko A; Raimundo N; Rando TA; Rasmussen LJ; Reis C; Riedel CG; Franco-Romero A; Schumacher B; Sinclair DA; Suh Y; Taub PR; Toiber D; Treebak JT; Valenzano DR; Verdin E; Vijg J; Young S; Zhang L; Bakula D; Zhavoronkov A; Scheibye-Knudsen M, 2020, 'ARDD 2020: from aging mechanisms to interventions', Aging, 12, pp. 24486 - 24503, http://dx.doi.org/10.18632/aging.202454

Xi CR; Di Fazio A; Nadvi NA; Patel K; Xiang MSW; Zhang HE; Deshpande C; Low JKK; Wang XT; Chen Y; McMillan CLD; Isaacs A; Osborne B; de Ribeiro AJV; McCaughan GW; Mackay JP; Church WB; Gorrell MD, 2020, 'A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2', Molecules, 25, http://dx.doi.org/10.3390/MOLECULES25225392

Osborne B; Bakula D; Ben Ezra M; Dresen C; Hartmann E; Kristensen SM; Mkrtchyan GV; Nielsen MH; Petr MA; Scheibye-Knudsen M, 2020, 'New methodologies in ageing research', Ageing Research Reviews, 62, http://dx.doi.org/10.1016/j.arr.2020.101094

, 2020, 'Next generation diabetes scientists shape global research culture: A reflective proposal from postdoctoral researchers in diabetes research', Acta Physiologica, 229, http://dx.doi.org/10.1111/apha.13455

Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, 219, http://dx.doi.org/10.1083/jcb.201905162

Montgomery MK; Osborne B; Brandon AE; O'Reilly L; Fiveash CE; Brown SHJ; Wilkins BP; Samsudeen A; Yu J; Devanapalli B; Hertzog A; Tolun AA; Kavanagh T; Cooper AA; Mitchell TW; Biden TJ; Smith NJ; Cooney GJ; Turner N, 2019, 'Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84', FASEB Journal, 33, pp. 12264 - 12276, http://dx.doi.org/10.1096/fj.201900234R

Liu M; Hancock SE; Sultani G; Wilkins BP; Ding E; Osborne B; Quek LE; Turner N, 2019, 'Snail-overexpression induces epithelialmesenchymal transition and metabolic reprogramming in human pancreatic ductal adenocarcinoma and non-tumorigenic ductal cells', Journal of Clinical Medicine, 8, http://dx.doi.org/10.3390/jcm8060822

Somers K; Wen VW; Middlemiss SMC; Osborne B; Forgham H; Jung MS; Karsa M; Clifton M; Bongers A; Gao J; Mayoh C; Raoufi-Rad N; Kusnadi EP; Hannan KM; Scott DA; Kwek A; Liu B; Flemming C; Chudakova DA; Pandher R; Failes TW; Lim J; Angeli A; Osterman AL; Imamura T; Kees UR; Supuran CT; Pearson RB; Hannan RD; Davis TP; McCarroll J; Kavallaris M; Turner N; Gudkov AV; Haber M; Norris MD; Henderson MJ, 2019, 'A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction', Oncogene, 38, pp. 3824 - 3842, http://dx.doi.org/10.1038/s41388-018-0666-5

Keijzers G; Bakula D; Petr MA; Madsen NGK; Teklu A; Mkrtchyan G; Osborne B; Scheibye-Knudsen M, 2019, 'Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer', International Journal of Molecular Sciences, 20, pp. 74, http://dx.doi.org/10.3390/ijms20010074

Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS; Brandon A, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, 9, pp. 3165, http://dx.doi.org/10.1038/s41467-018-05613-7

Bentley NL; Fiveash CE; Osborne B; Quek LE; Ogura M; Inagaki N; Cooney GJ; Polly P; Montgomery MK; Turner N, 2018, 'Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice', Biochemical and Biophysical Research Communications, 503, pp. 1349 - 1355, http://dx.doi.org/10.1016/j.bbrc.2018.07.047

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, 173, pp. 74 - 89.e20, http://dx.doi.org/10.1016/j.cell.2018.02.008

Sultani G; Samsudeen AF; Osborne B; Turner N, 2017, 'NAD+: A key metabolic regulator with great therapeutic potential', Journal of Neuroendocrinology, 29, http://dx.doi.org/10.1111/jne.12508

Montgomery MK; Brown SHJ; Lim XY; Fiveash CE; Osborne B; Bentley NL; Braude JP; Mitchell TW; Coster ACF; Don AS; Cooney GJ; Schmitz-Peiffer C; Turner N, 2016, 'Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species', Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, 1861, pp. 1828 - 1839, http://dx.doi.org/10.1016/j.bbalip.2016.08.016

Osborne B; Bentley NL; Montgomery MK; Turner N, 2016, 'The role of mitochondrial sirtuins in health and disease', Free Radical Biology and Medicine, 100, pp. 164 - 174, http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.197

Turner N; Zeng XY; Osborne B; Rogers S; Ye JM, 2016, 'Repurposing Drugs to Target the Diabetes Epidemic', Trends in Pharmacological Sciences, 37, pp. 379 - 389, http://dx.doi.org/10.1016/j.tips.2016.01.007

Hayward B; Molero JC; Windmill K; Sanigorski A; Weir J; McRae NL; Aston-Mourney K; Osborne B; Liao B; Walder KR; Meikle PJ; Konstantopoulos N; Schmitz-Peiffer C, 2016, 'Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate', Experimental and Clinical Endocrinology and Diabetes, 124, pp. 602 - 612, http://dx.doi.org/10.1055/s-0042-111516

Montgomery MK; Fiveash CE; Braude JP; Osborne B; Brown SHJ; Mitchell TW; Turner N, 2015, 'Disparate metabolic response to fructose feeding between different mouse strains', Scientific Reports, 5, http://dx.doi.org/10.1038/srep18474

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602

Liu M; Montgomery MK; Fiveash CE; Osborne B; Cooney GJ; Bell-Anderson K; Turner N, 2014, 'PPARα -independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis', Scientific Reports, 4, http://dx.doi.org/10.1038/srep05538

Osborne B; Yao TW; Wang XM; Chen Y; Kotan LD; Nadvi NA; Herdem M; McCaughan GW; Allen JD; Yu DMT; Topaloglu AK; Gorrell MD, 2014, 'A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation', Biochimica Et Biophysica Acta Proteins and Proteomics, 1844, pp. 1248 - 1259, http://dx.doi.org/10.1016/j.bbapap.2014.03.015

Osborne B; Cooney GJ; Turner N, 2014, 'Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?', Biochimica Et Biophysica Acta General Subjects, 1840, pp. 1295 - 1302, http://dx.doi.org/10.1016/j.bbagen.2013.08.016

Montgomery MK; Osborne B; Brown SHJ; Small L; Mitchell TW; Cooney GJ; Turner N, 2013, 'Contrasting metabolic effects of medium-versus long-chain fatty acids in skeletal muscle', Journal of Lipid Research, 54, pp. 3322 - 3333, http://dx.doi.org/10.1194/jlr.M040451

Keane FM; Yao TW; Seelk S; Gall MG; Chowdhury S; Poplawski SE; Lai JH; Li Y; Wu W; Farrell P; Vieira de Ribeiro AJ; Osborne B; Yu DM; Seth D; Rahman K; Haber P; Topaloglu AK; Wang C; Thomson S; Hennessy A; Prins J; Twigg SM; McLennan SV; McCaughan GW; Bachovchin WW; Gorrell MD, 2013, 'Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs.', FEBS Open Bio, 4, pp. 43 - 54, http://dx.doi.org/10.1016/j.fob.2013.12.001

Osborne B; Montgomery M; Reznick J; Cooney GJ; Turner N, 2012, 'Effect of acute hepatic overexpression of SIRT3 on metabolic parameters in short-term high fat fed mice', DIABETOLOGIA, 55, pp. S263 - S263, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208826501385&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Yu DMT; Yao TW; Chowdhury S; Nadvi NA; Osborne B; Church WB; McCaughan GW; Gorrell MD, 2010, 'The dipeptidyl peptidase IV family in cancer and cell biology', FEBS Journal, 277, pp. 1126 - 1144, http://dx.doi.org/10.1111/j.1742-4658.2009.07526.x

Xin MW; Yao TW; Nadvi NA; Osborne B; McCaughan GW; Gorrell MD, 2008, 'Fibroblast activation protein and chronic liver disease', Frontiers in Bioscience, 13, pp. 3168 - 3180, http://dx.doi.org/10.2741/2918

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