By Professor Richard John Epstein

Journal articles

Chan W; Mak JCS; Richard E, 2011, 'Impact of income and education on drug purchasing decisions in Hong Kong Chinese cancer patients', Asian Pacific Journal of Cancer Prevention, 12, pp. 2093 - 2097

Zhao YZ; Richard E, 2011, 'Unexpected functional similarities between gatekeeper tumor suppressor genes and proto-oncogenes revealed by systems biology', Journal of Human Genetics, 56, pp. 369 - 376

Epstein RJ; Tang CSM, 2010, 'Adaptive evolution hotspots at the GC-extremes of the human genome: Evidence for two functionally distinct pathways of positive selection', Advances in Bioinformatics, 2010, http://dx.doi.org/10.1155/2010/856825

Hutson TE; Davis ID; MacHiels JP; De Souza PL; Rottey S; Hong BF; Epstein RJ; Baker KL; McCann L; Crofts T; Pandite L; Figlin RA, 2010, 'Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma', Journal of Urology, 184, pp. 1303, http://dx.doi.org/10.1016/j.juro.2010.06.075

Wong H; Lau S; Yau T; Cheung P; Epstein RJ, 2010, 'Presence of an in situ component is associated with reduced biological aggressiveness of size-matched invasive breast cancer', British Journal of Cancer, 102, pp. 1391 - 1396, http://dx.doi.org/10.1038/sj.bjc.6605655

Yau T; Wong H; Chan P; Chan T; Mak J; Epstein R, 2010, 'Transient carcinoembryonic antigen elevations during adjuvant chemotherapy for colorectal cancer reflect the burden of residual micrometastatic disease', Clinical Colorectal Cancer, 9, pp. 108 - 112, http://dx.doi.org/10.3816/CCC.2010.n.015

Wong H; Yau T; Chan P; Ng IOL; Chan G; Hui P; Law WL; Lo CM; Hedley AJ; Epstein RJ, 2010, 'PPI-delayed diagnosis of gastrinoma: Oncologic victim of pharmacologic success', Pathology and Oncology Research, 16, pp. 87 - 91, http://dx.doi.org/10.1007/s12253-009-9192-7

Hutson TE; Davis ID; Machiels JPH; De Souza PL; Rottey S; Hong BF; Epstein RJ; Baker KL; McCann L; Crofts T; Pandite L; Figlin RA, 2010, 'Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma', Journal of Clinical Oncology, 28, pp. 475 - 480, http://dx.doi.org/10.1200/JCO.2008.21.6994

Hsu CH; Yang TS; Hsu C; Toh HC; Epstein RJ; Hsiao LT; Chen PJ; Lin ZZ; Chao TY; Cheng AL, 2010, 'Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma', British Journal of Cancer, 102, pp. 981 - 986, http://dx.doi.org/10.1038/sj.bjc.6605580

Richard E, 2010, 'Digitization and its discontents: future shock in predictive oncology', Seminars in Oncology, 37, pp. 60 - 64

Wong H; Yau T; Man CW; Epstein RJ, 2009, 'Hoarseness during treatment with bevacizumab and other vascular endothelial growth factor signalling inhibitors', Acta Oncologica, 48, pp. 1213 - 1215, http://dx.doi.org/10.3109/02841860902980453

Epstein RJ, 2009, 'TNM: Therapeutically Not Mandatory', European Journal of Cancer, 45, pp. 1111 - 1116, http://dx.doi.org/10.1016/j.ejca.2009.02.020

Xiong J; Epstein RJ, 2009, 'Growth inhibition of human cancer cells by 5-aza-2′-deoxycytidine does not correlate with its effects on INK4a/ARF expression or initial promoter methylation status', Molecular Cancer Therapeutics, 8, pp. 779 - 785, http://dx.doi.org/10.1158/1535-7163.MCT-08-0926

Chiu J; Yau T; Epstein RJ, 2009, 'Complications of traditional Chinese/herbal medicines (TCM)-a guide for perplexed oncologists and other cancer caregivers', Supportive Care in Cancer, 17, pp. 231 - 240, http://dx.doi.org/10.1007/s00520-008-0526-x

Epstein CR; Yam WC; Peiris JSM; Epstein RJ, 2009, 'Methicillin-resistant commensal staphylococci in healthy dogs as a potential zoonotic reservoir for community-acquired antibiotic resistance', Infection Genetics and Evolution, 9, pp. 283 - 285, http://dx.doi.org/10.1016/j.meegid.2008.11.003

Yau T; Yao TJ; Chan P; Epstein RJ; Ng KK; Chok SH; Cheung TT; Fan ST; Poon RTP, 2009, 'The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization', Cancer, 115, pp. 5507 - 5515, http://dx.doi.org/10.1002/cncr.24636

Yau T; Chan P; Epstein R; Poon RTP, 2009, 'Management of advanced hepatocellular carcinoma in the era of targeted therapy', Liver International, 29, pp. 10 - 17, http://dx.doi.org/10.1111/j.1478-3231.2008.01916.x

Epstein RJ; Zhao Y, 2009, 'The threat that dare not speak its name: Human extinction', Perspectives in Biology and Medicine, 52, pp. 116 - 125, http://dx.doi.org/10.1353/pbm.0.0066

Epstein RJ, 2009, 'Unblocking blockbusters: Using boolean text-mining to optimise clinical trial design and timeline for novel anticancer drugs', Cancer Informatics, 7, pp. 231 - 238, http://dx.doi.org/10.4137/cin.s2666

Epstein RJ, 2009, 'Visual impairment in myopic patients with breast cancer receiving adjuvant therapy with aromatase inhibitors', Clinical Breast Cancer, 9, pp. 184 - 186, http://dx.doi.org/10.3816/CBC.2009.n.030

Wong H; Yau T; Man CW; Epstein R, 2009, 'Hoarseness during treatment with bevacizumab and other vascular endothelial growth factor signalling inhibitors', Acta Oncologica, pp. 1 - 2, http://dx.doi.org/10.1080/02841860902980453

Yau T; Chan P; Epstein R; Poon RT, 2008, 'Evolution of systemic therapy of advanced hepatocellular carcinoma', World Journal of Gastroenterology, 14, pp. 6437 - 6441, http://dx.doi.org/10.3748/wjg.14.6437

Tsang H; Yau T; Khong PL; Epstein RJ, 2008, 'Bevacizumab-based therapy for advanced small bowel adenocarcinoma', Gut, 57, pp. 1631 - 1632, http://dx.doi.org/10.1136/gut.2008.153866

Epstein RJ; Leung TW, 2008, 'Tumor resensitization to erlotinib following brief substitution of cetuximab', Cancer Chemotherapy and Pharmacology, 62, pp. 1111 - 1112, http://dx.doi.org/10.1007/s00280-008-0698-6

Yau T; Lo CY; Epstein RJ; Lam AKY; Wan KY; Lang BH, 2008, 'Treatment outcomes in anaplastic thyroid carcinoma: Survival improvement in young patients with localized disease treated by combination of surgery and radiotherapy', Annals of Surgical Oncology, 15, pp. 2500 - 2505, http://dx.doi.org/10.1245/s10434-008-0005-0

Zhao Y; Epstein RJ, 2008, 'Programmed genetic instability: A tumor-permissive mechanism for maintaining the evolvability of higher species through methylation-dependent mutation of DNA repair genes in the male germ line', Molecular Biology and Evolution, 25, pp. 1737 - 1749, http://dx.doi.org/10.1093/molbev/msn126

Leung AWH; Mak J; Cheung PSY; Epstein RJ, 2008, 'Evidence for a programing effect of early menarche on the rise of breast cancer incidence in Hong Kong', Cancer Detection and Prevention, 32, pp. 156 - 161, http://dx.doi.org/10.1016/j.cdp.2008.05.004

Epstein RJ; Cheung BMY, 2008, 'Loading doses for costly cancer biologicals: Sound pharmacology or unnecessary extravagance?', European Journal of Cancer, 44, pp. 1488 - 1492, http://dx.doi.org/10.1016/j.ejca.2007.12.006

Yau T; Chan P; Ching Chan Y; Wong BCY; Liang R; Epstein RJ, 2008, 'Review article: Current management of metastatic colorectal cancer - The evolving impact of targeted drug therapies', Alimentary Pharmacology and Therapeutics, 27, pp. 997 - 1005, http://dx.doi.org/10.1111/j.1365-2036.2008.03684.x

Yau T; Leong CH; Chan WK; Chan JK; Liang RHS; Epstein RJ, 2008, 'A case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO)', Cancer Chemotherapy and Pharmacology, 61, pp. 717 - 720, http://dx.doi.org/10.1007/s00280-007-0529-1

Tang CSM; Epstein RJ, 2007, 'A Structural Split in the Human Genome', Plos One, 2, pp. e603, http://dx.doi.org/10.1371/journal.pone.0000603

Epstein RJ, 2007, 'VEGF signaling inhibitors: More pro-apoptotic than anti-angiogenic', Cancer and Metastasis Reviews, 26, pp. 443 - 452, http://dx.doi.org/10.1007/s10555-007-9071-1

Epstein RJ, 2007, 'Growth of the Asian health-care market: Global implications for the pharmaceutical industry', Nature Reviews Drug Discovery, 6, pp. 785 - 792, http://dx.doi.org/10.1038/nrd2360

Yau T; Chan P; Tsang J; Liang R; Epstein R, 2007, 'XELOX causes less disabling peripheral neuropathy than FOLFOX 4 for Chinese colorectal cancer patients', Journal of Clinical Oncology, 25, pp. 14592 - 14592, http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14592

Leung AW; Mak J; Cheung PSY; Epstein RJ, 2007, 'Clinicopathological correlates in a cohort of Hong Kong breast cancer patients presenting with screen-detected or symptomatic disease', Hong Kong Medical Journal, 13, pp. 194 - 198

Epstein RJ, 2007, 'Adjuvant breast cancer chemotherapy during late-trimester pregnancy: Not quite a standard of care', BMC Cancer, 7, http://dx.doi.org/10.1186/1471-2407-7-92

Epstein RJ; Leung TW, 2007, 'Reversing hepatocellular carcinoma progression by using networked biological therapies', Clinical Cancer Research, 13, pp. 11 - 17, http://dx.doi.org/10.1158/1078-0432.CCR-06-1619

Tang CS; Zhao YZ; Smith DK; Epstein RJ, 2006, 'Intron length and accelerated 3′ gene evolution', Genomics, 88, pp. 682 - 689, http://dx.doi.org/10.1016/j.ygeno.2006.06.017

Chan WF; Cheung PSY; Epstein RJ; Mak J, 2006, 'Multidisciplinary approach to the management of breast cancer in Hong Kong', World Journal of Surgery, 30, pp. 2095 - 2100, http://dx.doi.org/10.1007/s00268-005-0370-9

Epstein RJ; Leung TWT; Cheung PSY, 2006, 'Panmucositis and chemosensitisation associated with betel quid chewing during dose-dense adjuvant breast cancer chemotherapy', Cancer Chemotherapy and Pharmacology, 58, pp. 835 - 837, http://dx.doi.org/10.1007/s00280-006-0218-5

Epstein RJ; Zhao Y, 2006, 'Racial differences in lung cancer [4]', New England Journal of Medicine, 354, pp. 1951 - 1952, http://dx.doi.org/10.1056/NEJMc060512

Epstein R; Leung T; Mak J; Cheung P, 2006, 'Utility of a web-based breast cancer predictive algorithm for adjuvant chemotherapeutic decision making in a multidisciplinary oncology center', Cancer Investigation, 24, pp. 367 - 373, http://dx.doi.org/10.1080/07357900600705292

Epstein RJ, 2005, '"Leaving town" versus "taking leave": The case for re-thinking academic leave restrictions', Postgraduate Medical Journal, 81, pp. 732 - 733, http://dx.doi.org/10.1136/pgmj.2005.038232

Yau TC; Chu KW; Mok MY; Liang RH; Epstein RJ, 2005, 'Acute presentation of rheumatoid arthritis following cancer chemotherapy using the topoisomerase I inhibitor irinotecan [3]', Acta Oncologica, 44, pp. 771 - 772, http://dx.doi.org/10.1080/02841860500218652

Epstein RJ, 2005, 'Maintenance therapy to suppress micrometastasis: The new challenge for adjuvant cancer treatment', Clinical Cancer Research, 11, pp. 5337 - 5341, http://dx.doi.org/10.1158/1078-0432.CCR-05-0437

Kok LA; Diong SL; Wong WK; Epstein RJ, 2005, 'Upregulated Akt signaling adjacent to gastric cancers: Implications for screening and chemoprevention', Cancer Letters, 225, pp. 53 - 59, http://dx.doi.org/10.1016/j.canlet.2004.11.021

Epstein RJ, 2005, 'Primary prevention of human papillomavirus-dependent neoplasia: No condom, no sex', European Journal of Cancer, 41, pp. 2595 - 2600, http://dx.doi.org/10.1016/j.ejca.2005.06.023

Epstein RJ, 2004, 'The CXCL12-CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies', Nature Reviews Cancer, 4, pp. 901 - 909, http://dx.doi.org/10.1038/nrc1473

Cheung YB; Wong LC; Tay MH; Toh CK; Koo WH; Epstein R; Goh C, 2004, 'Order effects in the assessment of quality of life in cancer patients', Quality of Life Research, 13, pp. 1217 - 1223, http://dx.doi.org/10.1023/B:QURE.0000037499.80080.07

Lim YP; Wong CY; Ooi LL; Druker BJ; Epstein RJ, 2004, 'Selective tyrosine hyperphosphorylation of cytoskeletal and stress proteins in primary human breast cancers: Implications for adjuvant use of kinase-inhibitory drugs', Clinical Cancer Research, 10, pp. 3980 - 3987, http://dx.doi.org/10.1158/1078-0432.CCR-03-0663

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