By Professor Kate Louise Seib

Journal articles

Atack JM; Tan A; Bakaletz LO; Jennings MP; Seib KL, 2018, 'Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies', Trends in Microbiology, 26, pp. 715 - 726, http://dx.doi.org/10.1016/j.tim.2018.01.008

Atack JM; Murphy TF; Bakaletz LO; Seib KL; Jennings MP, 2018, 'Closed complete genome sequences of two nontypeable haemophilus influenzae strains containing novel modA alleles from the sputum of patients with chronic obstructive pulmonary disease', Microbiology Resource Announcements, 7, http://dx.doi.org/10.1128/MRA.00821-18

Edwards JL; Jennings MP; Seib KL, 2018, 'Neisseria gonorrhoeae vaccine development: Hope on the horizon?', Current Opinion in Infectious Diseases, 31, pp. 246 - 250, http://dx.doi.org/10.1097/QCO.0000000000000450

Atack JM; Yang Y; Seib KL; Zhou Y; Jennings MP, 2018, 'A survey of Type III restriction-modification systems reveals numerous, novel epigenetic regulators controlling phase-variable regulons; phasevarions', Nucleic Acids Research, 46, pp. 3532 - 3542, http://dx.doi.org/10.1093/NAR/GKY192

Seib KL; Jennings MP; Day CJ, 2018, 'Characterizing the meningococcal glycointeractome: What is new?', Future Microbiology, 13, pp. 279 - 282, http://dx.doi.org/10.2217/fmb-2017-0222

Blakeway LV; Tan A; Lappan R; Ariff A; Pickering JL; Peacock CS; Blyth CC; Kahler CM; Chang BJ; Lehmann D; Kirkham LAS; Murphy TF; Jennings MP; Bakaletz LO; Atack JM; Peak IR; Seib KL, 2018, 'Moraxella catarrhalis Restriction–Modification Systems Are Associated with Phylogenetic Lineage and Disease', Genome Biology and Evolution, 10, pp. 2932 - 2946, http://dx.doi.org/10.1093/gbe/evy226

Seib K, 2018, 'Report from ASM 2018', Microbiology Australia, 39, pp. 173 - 173, http://dx.doi.org/10.1071/ma18051

Day CJ; Paton AW; Harvey RM; Hartley-Tassell LE; Seib KL; Tiralongo J; Bovin N; Savino S; Masignani V; Paton JC; Jennings MP, 2017, 'Lectin activity of the pneumococcal pilin proteins', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-17850-9

Mubaiwa TD; Hartley-Tassell LE; Semchenko EA; Jen FEC; Srikhanta YN; Day CJ; Jennings MP; Seib KL, 2017, 'The glycointeractome of serogroup B Neisseria meningitidis strain MC58', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-05894-w

Blakeway LV; Tan A; Peak IRA; Seib KL, 2017, 'Virulence determinants of moraxella catarrhalis: Distribution and considerations for vaccine development', Microbiology United Kingdom, 163, pp. 1371 - 1384, http://dx.doi.org/10.1099/mic.0.000523

Seib KL, 2017, 'Gonorrhoea vaccines: a step in the right direction', Lancet, 390, pp. 1567 - 1569, http://dx.doi.org/10.1016/S0140-6736(17)31605-7

Seib KL; Jen FEC; Scott AL; Tan A; Jennings MP, 2017, 'Phase variation of DNA methyltransferases and the regulation of virulence and immune evasion in the pathogenic Neisseria', Pathogens and Disease, 75, http://dx.doi.org/10.1093/femspd/ftx080

Mubaiwa TD; Semchenko EA; Hartley-Tassell LE; Day CJ; Jennings MP; Seib KL, 2017, 'The sweet side of the pathogenic Neisseria: The role of glycan interactions in colonisation and disease', Pathogens and Disease, 75, http://dx.doi.org/10.1093/femspd/ftx063

Tan A; Blakeway LV; Bakaletz LO; Boitano M; Clark TA; Korlach J; Jennings MP; Peak IR; Seib KL, 2017, 'Complete genome sequence of Moraxella catarrhalis strain CCRI- 195ME, isolated from the middle ear', Genome Announcements, 5, http://dx.doi.org/10.1128/genomeA.00384-17

Semchenko EA; Day CJ; Seib KL, 2017, 'MetQ of Neisseria gonorrhoeae is a surfaceexpressed antigen that elicits bactericidal and functional blocking antibodies', Infection and Immunity, 85, http://dx.doi.org/10.1128/IAI.00898-16

Semchenko EA; Seib KL, 2016, 'Intractable problems require novel solutions: It's time to get serious about developing a gonorrhoea vaccine', Sexually Transmitted Infections, 92, pp. 561 - 562, http://dx.doi.org/10.1136/sextrans-2015-052378

Edwards JL; Jennings MP; Apicella MA; Seib KL, 2016, 'Is gonococcal disease preventable? The importance of understanding immunity and pathogenesis in vaccine development', Critical Reviews in Microbiology, 42, pp. 928 - 941, http://dx.doi.org/10.3109/1040841X.2015.1105782

Vacca I; Del Tordello E; Gasperini G; Pezzicoli A; Di Fede M; Paccani SR; Marchi S; Mubaiwa TD; Hartley-Tassell LE; Jennings MP; Seib KL; Masignani V; Pizza M; Serruto D; Aricò B; Delany I, 2016, 'Neisserial heparin binding antigen (NHBA) contributes to the adhesion of Neisseria meningitidis to human epithelial cells', Plos One, 11, http://dx.doi.org/10.1371/journal.pone.0162878

Tan A; Hill DMC; Harrison OB; Srikhanta YN; Jennings MP; Maiden MCJ; Seib KL, 2016, 'Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: Implications for gene regulation and virulence', Scientific Reports, 6, http://dx.doi.org/10.1038/srep21015

Tan A; Atack JM; Jennings MP; Seib KL, 2016, 'The capricious nature of bacterial pathogens: Phasevarions and vaccine development', Frontiers in Immunology, 7, http://dx.doi.org/10.3389/fimmu.2016.00586

Craig AP; Gray RT; Edwards JL; Apicella MA; Jennings MP; Wilson DP; Seib KL, 2015, 'The potential impact of vaccination on the prevalence of gonorrhea', Vaccine, 33, pp. 4520 - 4525, http://dx.doi.org/10.1016/j.vaccine.2015.07.015

Seib KL; Scarselli M; Comanducci M; Toneatto D; Masignani V, 2015, 'Neisseria meningitidis factor H-binding protein fHbp: Key virulence factor and vaccine antigen', Expert Review of Vaccines, 14, pp. 841 - 859, http://dx.doi.org/10.1586/14760584.2015.1016915

Seib KL; Jen FEC; Tan A; Scott AL; Kumar R; Power PM; Chen LT; Wu HJ; Wang AHJ; Hill DMC; Luyten YA; Morgan RD; Roberts RJ; Maiden MCJ; Boitano M; Clark TA; Korlach J; Rao DN; Jennings MP, 2015, 'Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N6-adenine DNA methyltransferases of Neisseria meningitidis', Nucleic Acids Research, 43, pp. 4150 - 4162, http://dx.doi.org/10.1093/nar/gkv219

Newton HJ; Seib KL, 2015, 'Science meets Parliament 2015', Microbiology Australia, 36, pp. 141 - 141, http://dx.doi.org/10.1071/ma15048

Blakeway LV; Power PM; Jen FEC; Worboys SR; Boitano M; Clark TA; Korlach J; Bakaletz LO; Jennings MP; Peak IR; Seib KL, 2014, 'ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media', FASEB Journal, 28, pp. 5197 - 5207, http://dx.doi.org/10.1096/fj.14-256578

Jen FEC; Seib KL; Jennings MP, 2014, 'Phasevarions mediate epigenetic regulation of antimicrobial susceptibility in Neisseria meningitidis', Antimicrobial Agents and Chemotherapy, 58, pp. 4219 - 4221, http://dx.doi.org/10.1128/AAC.00004-14

Nesta B; Valeri M; Spagnuolo A; Rosini R; Mora M; Donato P; Alteri CJ; Del Vecchio M; Buccato S; Pezzicoli A; Bertoldi I; Buzzigoli L; Tuscano G; Falduto M; Rippa V; Ashhab Y; Bensi G; Fontana MR; Seib KL; Mobley HLT; Pizza M; Soriani M; Serino L, 2014, 'SslE Elicits Functional Antibodies That Impair In Vitro Mucinase Activity and In Vivo Colonization by Both Intestinal and Extraintestinal Escherichia coli Strains', Plos Pathogens, 10, http://dx.doi.org/10.1371/journal.ppat.1004124

Delany I; Rappuoli R; Seib KL, 2013, 'Vaccines, reverse vaccinology, and bacterial pathogenesis', Cold Spring Harbor Perspectives in Medicine, 3, http://dx.doi.org/10.1101/cshperspect.a012476

Veggi D; Gentile MA; Cantini F; Lo Surdo P; Nardi-Dei V; Seib KL; Pizza M; Rappuoli R; Banci L; Savino S; Scarselli M, 2012, 'The factor h binding protein of neisseria meningitidis interacts with xenosiderophores in vitro', Biochemistry, 51, pp. 9384 - 9393, http://dx.doi.org/10.1021/bi301161w

Seib KL; Zhao X; Rappuoli R, 2012, 'Developing vaccines in the era of genomics: A decade of reverse vaccinology', Clinical Microbiology and Infection, 18, pp. 109 - 116, http://dx.doi.org/10.1111/j.1469-0691.2012.03939.x

Moriel DG; Rosini R; Seib KL; Serino L; Pizza M; Rappuoli R, 2012, 'Escherichia coli: Great diversity around a common core', Mbio, 3, http://dx.doi.org/10.1128/mBio.00118-12

Seib KL; Pigozzi E; Muzzi A; Gawthorne JA; Delany I; Jennings MP; Rappuoli R, 2011, 'A novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44', FASEB Journal, 25, pp. 3622 - 3633, http://dx.doi.org/10.1096/fj.11-183590

Echenique-Rivera H; Muzzi A; Del Tordello E; Seib KL; Francois P; Rappuoli R; Pizza M; Serruto D, 2011, 'Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival', Plos Pathogens, 7, http://dx.doi.org/10.1371/journal.ppat.1002027

Budroni S; Siena E; Dunning Hotopp JC; Seib KL; Serruto D; Nofroni C; Comanducci M; Riley DR; Daugherty SC; Angiuoli SV; Covacci A; Pizza M; Rappuoli R; Moxon ER; Tettelin H; Medini D, 2011, 'Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 4494 - 4499, http://dx.doi.org/10.1073/pnas.1019751108

Seib KL; Brunelli B; Brogioni B; Palumbo E; Bambini S; Muzzi A; DiMarcello F; Marchi S; Van Der Ende A; Aricó B; Savino S; Scarselli M; Comanducci M; Rappuoli R; Giuliani MM; Pizza M, 2011, 'Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies', Infection and Immunity, 79, pp. 970 - 981, http://dx.doi.org/10.1128/IAI.00891-10

Seib KL; Oriente F; Adu-Bobie J; Montanari P; Ferlicca F; Giuliani MM; Rappuoli R; Pizza M; Delany I, 2010, 'Influence of serogroup B meningococcal vaccine antigens on growth and survival of the meningococcus in vitro and in ex vivo and in vivo models of infection', Vaccine, 28, pp. 2416 - 2427, http://dx.doi.org/10.1016/j.vaccine.2009.12.082

Wu HJ; Seib KL; Srikhanta YN; Edwards J; Kidd SP; Maguire TL; Hamilton A; Pan KT; Hsiao HH; Yao CW; Grimmond SM; Apicella MA; McEwan AG; Wang AHJ; Jennings MP, 2010, 'Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae', Journal of Proteomics, 73, pp. 899 - 916, http://dx.doi.org/10.1016/j.jprot.2009.12.001

Serruto D; Spadafina T; Ciucchi L; Lewis LA; Ram S; Tontini M; Santini L; Biolchi A; Seib KL; Giuliani MM; Donnelly JJ; Berti F; Savino S; Scarselli M; Costantino P; Simon Kroll J; O'Dwyer C; Qiu J; Plaut AG; Moxon R; Rappuoli R; Pizza M; Aricò B, 2010, 'Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans', Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 3770 - 3775, http://dx.doi.org/10.1073/pnas.0915162107

Seib KL; Dougan G; Rappuoli R, 2009, 'The key role of genomics in modern vaccine and drug design for emerging infectious diseases', Plos Genetics, 5, http://dx.doi.org/10.1371/journal.pgen.1000612

Rinaudo CD; Telford JL; Rappuoli R; Seib KL, 2009, 'Vaccinology in the genome era', Journal of Clinical Investigation, 119, pp. 2515 - 2525, http://dx.doi.org/10.1172/JCI38330

Fantappiè L; Metruccio MME; Seib KL; Oriente F; Cartocci E; Ferlicca F; Giuliani MM; Scarlato V; Delany I, 2009, 'The RNA chaperone Hfq is involved in stress response and virulence in Neisseria meningitidis and is a pleiotropic regulator of protein expression', Infection and Immunity, 77, pp. 1842 - 1853, http://dx.doi.org/10.1128/IAI.01216-08

Srikhanta YN; Dowideit SJ; Edwards JL; Falsetta ML; Wu HJ; Harrison OB; Fox KL; Seib KL; Maguire TL; Wang AHJ; Maiden MC; Grimmond SM; Apicella MA; Jennings MP, 2009, 'Phasevarions mediate random switching of gene expression in pathogenic Neisseria', Plos Pathogens, 5, http://dx.doi.org/10.1371/journal.ppat.1000400

Seib KL; Serruto D; Oriente F; Delany I; Adu-Bobie J; Veggi D; Aricò B; Rappuoli R; Pizza M, 2009, 'Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37', Infection and Immunity, 77, pp. 292 - 299, http://dx.doi.org/10.1128/IAI.01071-08

Ieva R; Roncarati D; Metruccio MME; Seib KL; Scarlato V; Delany I, 2008, 'OxyR tightly regulates catalase expression in Neisseria meningitidis through both repression and activation mechanisms', Molecular Microbiology, 70, pp. 1152 - 1165, http://dx.doi.org/10.1111/j.1365-2958.2008.06468.x

Seib KL; Wu HJ; Srikhanta YN; Edwards JL; Falsetta ML; Hamilton AJ; Maguire TL; Grimmond SM; Apicella MA; McEwan AG; Jennings MP, 2007, 'Characterization of the OxyR regulon of Neisseria gonorrhoeae', Molecular Microbiology, 63, pp. 54 - 68, http://dx.doi.org/10.1111/j.1365-2958.2006.05478.x

Power PM; Seib KL; Jennings MP, 2006, 'Pilin glycosylation in Neisseria meningitidis occurs by a similar pathway to wzy-dependent O-antigen biosynthesis in Escherichia coli', Biochemical and Biophysical Research Communications, 347, pp. 904 - 908, http://dx.doi.org/10.1016/j.bbrc.2006.06.182

Seib KL; Wu HJ; Kidd SP; Apicella MA; Jennings MP; McEwan AG, 2006, 'Defenses against oxidative stress in Neisseria gonorrhoeae: A system tailored for a challenging environment', Microbiology and Molecular Biology Reviews, 70, pp. 344 - 361, http://dx.doi.org/10.1128/MMBR.00044-05

Wu HJ; Seib KL; Srikhanta YN; Kidd SP; Edwards JL; Maguire TL; Grimmond SM; Apicella MA; McEwan AG; Jennings MP, 2006, 'PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae', Molecular Microbiology, 60, pp. 401 - 416, http://dx.doi.org/10.1111/j.1365-2958.2006.05079.x

Wu HJ; Seib KL; Edwards JL; Apicella MA; McEwan AG; Jennings MP, 2005, 'Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells', Infection and Immunity, 73, pp. 8444 - 8448, http://dx.doi.org/10.1128/IAI.73.12.8444-8448.2005

Seib KL; Simons MP; Wu HJ; McEwan AG; Nauseef WM; Apicella MA; Jennings MP, 2005, 'Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay', Infection and Immunity, 73, pp. 5269 - 5272, http://dx.doi.org/10.1128/IAI.73.8.5269-5272.2005

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