Keywords
Fields of Research (FoR)
Receptors and Membrane Biology, Basic Pharmacology, Cardiology (incl. Cardiovascular Diseases)SEO tags
Biography
Associate Professor Nicola J. Smith is Head of the Department of Pharmacology in the School of Biomedical Sciences and member-elected 2026-2028 President of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT). She is a molecular pharmacologist who is passionate about all things G protein-coupled receptor – the largest family of membrane proteins in the human genome.
Nicola completed her...view more
Associate Professor Nicola J. Smith is Head of the Department of Pharmacology in the School of Biomedical Sciences and member-elected 2026-2028 President of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT). She is a molecular pharmacologist who is passionate about all things G protein-coupled receptor – the largest family of membrane proteins in the human genome.
Nicola completed her undergraduate training in pharmacology and biochemistry at the University of Melbourne in 2002 (first class Honours) before commencing a PhD at the Baker Heart Research Institute under the tutelage of Profs Walter Thomas and Ross Hannan, where she studied the role of EGFR transactivation by the angiotensin II receptor in left ventricular hypertrophy (Uni Melb, 2003-7). In 2006, Nicola was awarded a joint NHMRC/NHF CJ Martin Overseas Fellowship to work in the laboratory of Prof Graeme Milligan, a world expert on G protein-coupled receptors (University of Glasgow, 2007-2011). In early 2011, Nicola returned to the Victor Chang Cardiac Research Institute to join the laboratory of Prof Robert Graham, a leader in the role of G protein-coupled receptors in cardiac physiology and pathophysiology, where she established a research program based upon orphan, or un-liganded, receptors (2011-2015). Nicola was appointed Group Leader in 2016 and was awarded a National Heart Foundation Future Leader Fellowship the following year. In mid-2019, Nicola accepted a senior lecturer appointment at UNSW Sydney School of Medical Sciences where she has established the Orphan Receptor Laboratory, as well as teaching into several pharmacology and pharmacy courses. Nicola is actively involved in peer review for major funding agencies (NHMRC, National Heart Foundation of Australia, Medical Research Council UK, BBSRC, Wellcome Trust, NWO and others) and journals and has served on university and external committees including HDR review panels, Gene Technology Research Committees, AthenaSWAN Self-Assessment Team, UNSW Health 25 Strategy Project Lead and the Australian Cardiovascular Association's inaugural Emerging Leaders Committee, Basic Science Advisory Group and Disease Mechanisms Flagship. In recognition of her contribution to research, teaching and community engagement, Nicola was promoted to Associate Professor at the beginning of 2022.
In addition to her pharmacological studies, Nicola is a passionate science communicator and has worked as a radio science presenter, acted as Ambassador for IMB’s ‘When I Grow Up’ campaign and has spoken to many school and community groups about the joys of science and discovery; she received a 2012 NSW Young Tall Poppy Award in recognition of this work. She is very active within the pharmacology community having served several roles within ASCEPT since she was elected to the Board of Directors, including Chair/Co-chair roles for the 2021 ASCEPT Virtual Annual Scientific Meeting, 2022 APSA-ASCEPT Annual Scientific Meeting, 2023 ASCEPT Annual Scientific Meeting and 2024 ASCEPT-APFP-APSA Joint Congress, as well as terms as Prize Co-ordinator and Chair of the Student Forum. She is highly motivated to serve her pharmacology community after benefiting from the collegiality, support and wisdom of those senior to her throughout her own research career.
For current projects, please contact Nicola for more information.
My Grants
Perpetual Impact Grant (auspiced by Thoracic Oncology Group of Australasia) (CIA) New drug hope for deadly lung adenocarcinoma (2025-2026)
59BUNSW SBMS & BABS Collaborative Grant Seed Funding (lead SBMS CI): “Structural biology of a novel lung cancer target”
61BUNSW SBMS Seed Funding (CIA): “Purchase of human lung adenocarcinoma organoid line for pilot testing”
National Heart Foundation Future Leader Fellowship (Level 2) “Understanding orphan G protein-coupled receptors in cardiovascular health and disease” (2017-2021)
NHMRC Project Grant 1120483 (CIC) “Role of RNA-binding proteins in cardiomyocyte physiology” (2017-2020)
St Vincent’s Clinic Foundation Froulop Research Grant (CIA) “Investigating the interplay between the sympathetic nervous system, anxiety and gender on blood pressure homeostasis” (2018)
Australian Government (CIA) Global Connections Fund Seed Grant (2017)
St Vincent’s Clinic Foundation Annual Grant 6 (CIA) “A new cardioprotective factor in left ventricular hypertrophy?” (2016)
Mostyn Family Foundation Ongoing Bequest (CIA) “To fund drug discovery addressing the underlying causes of hypertension”
NHMRC Project Grant 1061804 (CIB) “Does GPR84 mediate the beneficial effects of medium chain fatty acids?” (2014-2016)
NHMRC/NHF CJ Martin Fellowship (459413) “Molecular determinants of GPR40 signalling and regulation in disease” (2007-2013)
UNSW Research Infrastructure Scheme 2016 Grant #RG 163080, Housley, Bryce, Finch, Jones, Liu, Moorhouse, Ong, Power, SMITH, Turner, Vandenberg “Faculty infrastructure project: benchtop system integrating multi-mode microplate optics with precision, programmable liquid handling”.
6571BNHMRC Equipment Grant, UNSW Research Infrastructure Scheme 2022 (CIA), $193,000, “PheraStar FSX multi-modal plate reader”
BUNSW Research Infrastructure Scheme Equipment Grant 2024, $330,000: “AI Capable GPU Node for Molecular Basis of Disease and Drug Discovery”
63BUNSW Research Infrastructure Scheme Equipment Grant 2024, $453,042: “An Australian-first robotically integrated, high-speed, high-throughput liquid-handling and imaging platform for automated phenotyping and drug discovery”
63BUNSW Research Infrastructure Scheme Equipment Grant 2025, $122,467: "Strengthening Laboratory Performance: Replacement of Critical histology Equipment for STAT laboratory"
My Qualifications
PhD, University of Melbourne, 2007
BSc (First Class), University of Melbourne, 2002
BSc, University of Melbourne, 2001
BA, University of Melbourne, 2001
My Awards
2024 ASCEPT Outstanding Contribution and Leadership as a Board Member and Scientific Advisory Committee Chair 2015 Garvan Institute Oral Prize 2014 St Vincent’s Precinct Rising Star 2012 Paul Korner Seminar Speaker Award, Victor Chang Cardiac Research Institute 2012 37th Lorne Conference on Protein Structure and Function Young Investigator Award 2011 Young Tall Poppy Award, NSW 2011 ASCEPT Denis Wade New Investigator Award 2009 ‘Paper of the Week’, Journal of Biological Chemistry 2007 Highest ranked applicant for the National Heart Foundation of Australia Overseas Fellowship (accepted joint funding with NHMRC) 2004 Winner of the Best Poster Prize, Gordon Research Conference on Angiotensin 2004 Winner, Rod Andrews Poster Prize at the Baker Heart Research Institute 2001 Awarded the Pharmacology Prize for top final year student, University of Melbourne
My Research Supervision
Supervision keywords
Areas of supervision
Molecular pharmacology of G protein-coupled receptors.
Currently supervising
Ms Mariah Stavrou, PhD student
Mr Jack (Hejie) Zhang, co-supervised PhD student
Mr Riley Sell, co-supervised PhD student
Ms Ishika Jaitly, co-supervised PhD student
Ms Olivia Clink, Hons
Lab alumni:
Kinjal Patel, PhD
Brendan Wilkins, research assistant & PhD
Margaret (Meg/Maz) Mouat, PhD and Hons
Sean Souchiart So, PhD
James Coleman, post-doc, PhD and Hons
Tony Ngo, PhD
Amy Nicks, PhD (Uni Leeds)
Peter Keov, post-doc
Eric Cheung, Hons
Rhyll Smythe, Hons
Andrew Cleave, Hons
Theodore Nettleton, Hons
Justin Moon, Hons
Annie Chen, co-supervised Hons student
Jennifer Grant, co-supervised Hons student
Georgia Crowley, co-supervised Hons student
Henry Parkins, co-supervised Hons student (School of Chemistry)
Alexander Lara-Watson, Hons student
Ian Reininger-Chatzigiannakis, co-supervised Hons student
Haoyi Han, research intern, co-supervised Hons student
Zoe Eastwood, Hons
Paige Pfeiffer, Hons
Oscar Stokoe, Hons
My Teaching
I mainly teach 3rd year undergraduate pharmacology courses, contributing lectures, tutorials, practicals, online lessons, assessment task design and marking; plus subject co-ordination. I also teach subjects within the pharmacy, medicine and optometry courses. My main area of expertise is molecular pharmacology, particularly G protein-coupled receptors.
Subjects include:
PHAR3102 Molecular Pharmacology
PHAR3101 Drug Discovery, Design & Development
PHAR3521 Clinical & Experimental Pharmacology
PHAR3306 Pharmacology for Optometry
BGD-B Beginnings, Growth & Development - B
Foundations (Medicine)
PHAR2111 Introduction to Pharmacology
PHAR2911 Introductory Pharmacology for Pharmacy