By Associate Professor Elissa Deenick

Journal articles

Suan D; Nguyen A; Moran I; Bourne K; Hermes JR; Arshi M; Hampton HR; Tomura M; Miwa Y; Kelleher AD; Kaplan W; Deenick EK; Tangye SG; Brink R; Chtanova T; Phan TG, 2015, 'T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses', Immunity, 42, pp. 704 - 718, http://dx.doi.org/10.1016/j.immuni.2015.03.002

Kuehn HS; Ouyang W; Lo B; Deenick EK; Niemela JE; Avery DT; Schickel JN; Tran DQ; Stoddard J; Zhang Y; Frucht DM; Dumitriu B; Scheinberg P; Folio LR; Frein CA; Price S; Koh C; Heller T; Seroogy CM; Huttenlocher A; Rao VK; Su HC; Kleiner D; Notarangelo LD; Rampertaap Y; Olivier KN; McElwee J; Hughes J; Pittaluga S; Oliveira JB; Meffre E; Fleisher TA; Holland SM; Lenardo MJ; Tangye SG; Uzel G, 2014, 'Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4', Science, 345, pp. 1623 - 1627, http://dx.doi.org/10.1126/science.1255904

Kane A; Deenick EK; Ma CS; Cook MC; Uzel G; Tangye SG, 2014, 'STAT3 is a central regulator of lymphocyte differentiation and function', Current Opinion in Immunology, 28, pp. 49 - 57, http://dx.doi.org/10.1016/j.coi.2014.01.015

Lucas CL; Kuehn HS; Zhao F; Niemela JE; Deenick EK; Palendira U; Avery DT; Moens L; Cannons JL; Biancalana M; Stoddard J; Ouyang W; Frucht DM; Rao VK; Atkinson TP; Agharahimi A; Hussey AA; Folio LR; Olivier KN; Fleisher TA; Pittaluga S; Holland SM; Cohen JI; Oliveira JB; Tangye SG; Schwartzberg PL; Lenardo MJ; Uzel G, 2014, 'Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency', Nature Immunology, 15, pp. 88 - 97, http://dx.doi.org/10.1038/ni.2771

Ma CS; Deenick EK, 2014, 'Human T follicular helper (Tfh) cells and disease', Immunology and Cell Biology, 92, pp. 64 - 71, http://dx.doi.org/10.1038/icb.2013.55

Berglund LJ; Avery DT; Ma CS; Moens L; Deenick EK; Bustamante J; Boisson-Dupuis S; Wong M; Adelstein S; Arkwright PD; Bacchetta R; Bezrodnik L; Dadi H; Roifman CM; Fulcher DA; Ziegler JB; Smart JM; Kobayashi M; Picard C; Durandy A; Cook MC; Casanova JL; Uzel G; Tangye SG, 2013, 'IL-21 signalling via STAT3 primes human näive B cells to respond to IL-2 to enhance their differentiation into plasmablasts', Blood, 122, pp. 3940 - 3950, http://dx.doi.org/10.1182/blood-2013-06-506865

Deenick EK; Avery DT; Chan A; Berglund LJ; Ives ML; Moens L; Stoddard JL; Bustamante J; Boisson-Dupuis S; Tsumura M; Kobayashi M; Arkwright PD; Averbuch D; Engelhard D; Roesler J; Peake J; Wong M; Adelstein S; Choo S; Smart JM; French MA; Fulcher DA; Cook MC; Picard C; Durandy A; Klein C; Holland SM; Uzel G; Casanova JL; Ma CS; Tangye SG, 2013, 'Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells', Journal of Experimental Medicine, 210, pp. 2739 - 2753, http://dx.doi.org/10.1084/jem.20130323

Ives ML; Ma CS; Palendira U; Chan A; Bustamante J; Boisson-Dupuis S; Arkwright PD; Engelhard D; Averbuch D; Magdorf K; Roesler J; Peake J; Wong M; Adelstein S; Choo S; Smart JM; French MA; Fulcher DA; Cook MC; Picard C; Durandy A; Tsumura M; Kobayashi M; Uzel G; Casanova JL; Tangye SG; Deenick EK, 2013, 'Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8+ T-cell memory formation and function', Journal of Allergy and Clinical Immunology, 132, pp. 400 - 411.e9, http://dx.doi.org/10.1016/j.jaci.2013.05.029

Tangye SG; Ma CS; Brink R; Deenick EK, 2013, 'The good, the bad and the ugly-T FH cells in human health and disease', Nature Reviews Immunology, 13, pp. 412 - 426, http://dx.doi.org/10.1038/nri3447

Ma C; Avery D; Chan A; Batten ML; Bustamante J; Boisson-Dupuis S; Arkwright PD; Kreins AY; Averbuch D; Engelhard D; Magdorf K; Kilic S; Minegishi Y; Gray PE, 2012, 'Functional STAT3 deficiency compromises the generation of human T follicular helper cells', Blood, 119, pp. 3997 - 4008, http://dx.doi.org/10.1182/blood-2011-11-392985

Tangye SG; Deenick EK; Palendira U; Ma CS, 2012, 'T cell-B cell interactions in primary immunodeficiencies', Annals of the New York Academy of Sciences, 1250, pp. 1 - 13, http://dx.doi.org/10.1111/j.1749-6632.2011.06361.x

Deenick EK; Ma CS; Brink R; Tangye SG, 2011, 'Regulation of T follicular helper cell formation and function by antigen presenting cells', Current Opinion in Immunology, 23, pp. 111 - 118, http://dx.doi.org/10.1016/j.coi.2010.10.007

Deenick EK; Ma CS, 2011, 'The regulation and role of T follicular helper cells in immunity', Immunology, 134, pp. 361 - 367, http://dx.doi.org/10.1111/j.1365-2567.2011.03487.x

Ma CS; Deenick EK, 2011, 'The role of SAP and SLAM family molecules in the humoral immune response', Annals of the New York Academy of Sciences, 1217, pp. 32 - 44, http://dx.doi.org/10.1111/j.1749-6632.2010.05824.x

Randall KL; Lambe T; Johnson A; Treanor B; Kucharska E; Domaschenz H; Whittle B; Tze LE; Enders A; Crockford TL; Bouriez-Jones T; Alston D; Cyster JG; Lenardo MJ; MacKay F; Deenick EK; Tangye SG; Chan TD; Camidge T; Brink R; Vinuesa CG; Batista FD; Cornall RJ; Goodnow CC, 2010, 'Erratum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production (Nature Immunology (2009) 10 (1283-1291))', Nature Immunology, 11, pp. 644, http://dx.doi.org/10.1038/ni0710-644a

Deenick EK; Elford AR; Pellegrini M; Hall H; Mak TW; Ohashi PS, 2010, 'c-Rel but not NF-κB1 is important for T regulatory cell development', European Journal of Immunology, 40, pp. 677 - 681, http://dx.doi.org/10.1002/eji.201040298

Deenick EK; Po L; Chapatte L; Murakami K; Lu YC; Elford AR; Saibil SD; Ruland J; Gerondakis S; Mak TW; Ohashi PS, 2010, 'c-Rel phenocopies PKCθ but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance', European Journal of Immunology, 40, pp. 867 - 877, http://dx.doi.org/10.1002/eji.200939445

Tangye SG; Palendira U; Low C; Deenick EK; Chan A; Ma CS; Brink R; Alvaro F; Cook MC; Sean Riminton D; Nichols KE; Schwartzberg PL, 2010, 'Sap is necessary for mediating antigen-specific effector functions of CD4+ AND CD8+ T cells', Pathology, 42, pp. S45 - S45, http://dx.doi.org/10.1097/01268031-201042001-00085

Randall KL; Lambe T; Johnson A; Treanor B; Kucharska E; Domaschenz H; Whittle B; Tze LE; Enders A; Crockford TL; Bouriez-Jones T; Alston D; Cyster JG; Lenardo MJ; Mackay F; Deenick EK; Tangye SG; Chan TD; Camidge T; Brink R; Vinuesa C; Batista FD; Cornall RJ; Goodnow CC, 2009, 'Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production', Nature Immunology, 10, pp. 1283 - 1291, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19898472

Deenick EK; Tangye SG, 2008, 'Autoimmunity: IL-21: A new player in Th17-cell differentiation (Immunology and Cell Biology (2007) 85, (503-505) DOI: 10.1038/sj.icb.7100114)', Immunology and Cell Biology, 86, pp. 478, http://dx.doi.org/10.1038/sj.icb.7100152

Saibil SD; Deenick EK; Ohashi PS, 2007, 'The sound of silence: modulating anergy in T lymphocytes', Current Opinion in Immunology, 19, pp. 658 - 664, http://dx.doi.org/10.1016/j.coi.2007.08.005

Saibil SD; Jones RG; Deenick EK; Liadis N; Elford AR; Vainberg MG; Baerg H; Woodgett JA; Gerondakis S; Ohashi PS, 2007, 'CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Cθ c-Rel, and protein kinase B', Journal of Immunology, 178, pp. 2932 - 2939, http://dx.doi.org/10.4049/jimmunol.178.5.2932

Suh WK; Wang S; Duncan GS; Miyazaki Y; Cates E; Walker T; Gajewska BU; Deenick E; Dawicki W; Okada H; Wakeham A; Itie A; Watts TH; Ohashi PS; Jordana M; Yoshida H; Mak TW, 2006, 'Generation and characterization of B7-H4/B7S1/B7x-deficient mice', Molecular and Cellular Biology, 26, pp. 6403 - 6411, http://dx.doi.org/10.1128/MCB.00755-06

Deenick EK; Hasbold J; Hodgkin PD, 2005, 'Decision criteria for resolving isotype switching conflicts by B cells', European Journal of Immunology, 35, pp. 2949 - 2955, http://dx.doi.org/10.1002/eji.200425719

Gronski MA; Boulter JM; Moskophidis D; Nguyen LT; Holmberg K; Elford AR; Deenick EK; Kim HO; Penninger JM; Odermatt B; Gallimore A; Gascoigne NRJ; Ohashi PS, 2004, 'TCR affinity and negative regulation limit autoimmunity', Nature Medicine, 10, pp. 1234 - 1239, http://dx.doi.org/10.1038/nm1114

Berg-Brown NN; Gronski MA; Jones RG; Elford AR; Deenick EK; Odermatt B; Littman DR; Ohashi PS, 2004, 'PKCθ Signals Activation versus Tolerance In Vivo', Journal of Experimental Medicine, 199, pp. 743 - 752, http://dx.doi.org/10.1084/jem.20031022

Deenick EK; Gett AV; Hodgkin PD, 2003, 'Stochastic model of T cell proliferation: A calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival', Journal of Immunology, 170, pp. 4963 - 4972, http://dx.doi.org/10.4049/jimmunol.170.10.4963

Tangye SG; Avery DT; Deenick EK; Hodgkin PD, 2003, 'Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses', Journal of Immunology, 170, pp. 686 - 694, http://dx.doi.org/10.4049/jimmunol.170.2.686

Hasbold J; Gett AV; Rush JS; Deenick E; Avery D; Jun J; Hodgkin PD, 1999, 'Quantitative analysis of lymphocyte differentiation and proliferation in vitro using carboxyfluorescein diacetate succinimidyl ester', Immunology and Cell Biology, 77, pp. 516 - 522, http://dx.doi.org/10.1046/j.1440-1711.1999.00874.x

Deenick EK; Hasbold J; Hodgkin PD, 1999, 'Switching to IgG3, IgG2b, and IgA is division linked and independent, revealing a stochastic framework for describing differentiation', Journal of Immunology, 163, pp. 4707 - 4714, http://dx.doi.org/10.4049/jimmunol.163.9.4707

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